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Genetic improvement of hip-extended scores in 3 breeds of guide dogs using estimated breeding values: Notable progress but more improvement is needed.

Leighton EA, Holle D, Biery DN, Gregor TP, McDonald-Lynch MB, Wallace ML, Reagan JK, Smith GK.

PLoS One. 2019 Feb 22;14(2):e0212544. doi: 10.1371/journal.pone.0212544. eCollection 2019.


Shifting faunal baselines through the Quaternary revealed by cave fossils of eastern Australia.

Price GJ, Louys J, Smith GK, Cramb J.

PeerJ. 2019 Jan 22;6:e6099. doi: 10.7717/peerj.6099. eCollection 2019.


Mind-wandering rates fluctuate across the day: evidence from an experience-sampling study.

Smith GK, Mills C, Paxton A, Christoff K.

Cogn Res Princ Implic. 2018 Dec 29;3(1):54. doi: 10.1186/s41235-018-0141-4.


'Imitation is the Sincerest of Flattery'…Except When It Negatively Impacts Canine and Client Welfare.

Smith GK.

Vet Comp Orthop Traumatol. 2018 Jul;31(4):311-312. doi: 10.1055/s-0038-1653961. Epub 2018 Jul 4. No abstract available.


Prospective Bundled Payments in a Changing Environment: The Experience of a Self-Funded, State-Sponsored Plan.

Lawler FH, Wilson FR, Smith GK, Mitchell LV.

Am Health Drug Benefits. 2017 Dec;10(9):441-447.


Adaptation of the Arizona Cognitive Task Battery for use with the Ts65Dn mouse model (Mus musculus) of Down syndrome.

Hunsaker MR, Smith GK, Kesner RP.

J Comp Psychol. 2017 Aug;131(3):189-206. doi: 10.1037/com0000069. Epub 2017 Mar 23.


Patterns and scales of connectivity: temporal stability and variation within a marine metapopulation.

Le Corie N, Johnson LE, Smith GK, Guichard F.

Ecology. 2015 Aug;96(8):2245-56.


Dentate gyrus mediates cognitive function in the Ts65Dn/DnJ mouse model of Down syndrome.

Smith GK, Kesner RP, Korenberg JR.

Hippocampus. 2014 Mar;24(3):354-62. doi: 10.1002/hipo.22229. Epub 2013 Dec 13.


Differential diagnosis of an unusual shoulder articular lesion in an ancient domestic dog (Canis lupus familiaris L., 1758).

Lawler DF, Rubin DA, Evans RH, Hildebolt CF, Smith KE, Widga C, Martin TJ, Siegel M, Sackman JE, Smith GK, Patel TK.

Int J Paleopathol. 2013 Dec;3(4):282-287. doi: 10.1016/j.ijpp.2013.06.001. Epub 2013 Jul 12.


Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.

Maynard A, Crosby RM, Ellis B, Hamatake R, Hong Z, Johns BA, Kahler KM, Koble C, Leivers A, Leivers MR, Mathis A, Peat AJ, Pouliot JJ, Roberts CD, Samano V, Schmidt RM, Smith GK, Spaltenstein A, Stewart EL, Thommes P, Turner EM, Voitenleitner C, Walker JT, Waitt G, Weatherhead J, Weaver K, Williams S, Wright L, Xiong ZZ, Haigh D, Shotwell JB.

J Med Chem. 2014 Mar 13;57(5):1902-13. doi: 10.1021/jm400317w. Epub 2013 May 29.


The CO oxidation mechanism and reactivity on PdZn alloys.

Johnson RS, DeLaRiva A, Ashbacher V, Halevi B, Villanueva CJ, Smith GK, Lin S, Datye AK, Guo H.

Phys Chem Chem Phys. 2013 May 28;15(20):7768-76. doi: 10.1039/c3cp00126a. Epub 2013 Apr 19.


Lessons from a non-domestic canid: joint disease in captive raccoon dogs (Nyctereutes procyonoides).

Lawler DF, Evans RH, Nieminen P, Mustonen AM, Smith GK.

Vet Ital. 2012 Oct-Dec;48(4):367-78.


Radiographic hip joint phenotype of the Pembroke Welsh Corgi.

Karbe GT, Biery DN, Gregor TP, Giger U, Smith GK.

Vet Surg. 2012 Jan;41(1):34-41. doi: 10.1111/j.1532-950X.2011.00938.x.


Chronology of hip dysplasia development in a cohort of 48 Labrador retrievers followed for life.

Smith GK, Lawler DF, Biery DN, Powers MY, Shofer F, Gregor TP, Karbe GT, McDonald-Lynch MB, Evans RH, Kealy RD.

Vet Surg. 2012 Jan;41(1):20-33. doi: 10.1111/j.1532-950X.2011.00935.x.


Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups.

Li X, Liu Y, Zhang YK, Plattner JJ, Baker SJ, Bu W, Liu L, Zhou Y, Ding CZ, Zhang S, Kazmierski WM, Hamatake R, Duan M, Wright LL, Smith GK, Jarvest RL, Ji JJ, Cooper JP, Tallant MD, Crosby RM, Creech K, Wang A.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7351-6. doi: 10.1016/j.bmcl.2012.10.075. Epub 2012 Oct 22.


Discovery of novel urea-based hepatitis C protease inhibitors with high potency against protease-inhibitor-resistant mutants.

Kazmierski WM, Hamatake R, Duan M, Wright LL, Smith GK, Jarvest RL, Ji JJ, Cooper JP, Tallant MD, Crosby RM, Creech K, Wang A, Li X, Zhang S, Zhang YK, Liu Y, Ding CZ, Zhou Y, Plattner JJ, Baker SJ, Bu W, Liu L.

J Med Chem. 2012 Apr 12;55(7):3021-6. doi: 10.1021/jm201278q. Epub 2012 Apr 3.


Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis.

Derocq D, Prébois C, Beaujouin M, Laurent-Matha V, Pattingre S, Smith GK, Liaudet-Coopman E.

Oncogene. 2012 Jun 28;31(26):3202-12. doi: 10.1038/onc.2011.501. Epub 2011 Nov 14.


Insights into the phosphoryl transfer mechanism of cyclin-dependent protein kinases from ab initio QM/MM free-energy studies.

Smith GK, Ke Z, Guo H, Hengge AC.

J Phys Chem B. 2011 Nov 24;115(46):13713-22. doi: 10.1021/jp207532s. Epub 2011 Nov 3.


Molecular mechanism for eliminylation, a newly discovered post-translational modification.

Ke Z, Smith GK, Zhang Y, Guo H.

J Am Chem Soc. 2011 Jul 27;133(29):11103-5. doi: 10.1021/ja204378q. Epub 2011 Jun 30.


Pathways for methanol steam reforming involving adsorbed formaldehyde and hydroxyl intermediates on Cu(111): density functional theory studies.

Lin S, Johnson RS, Smith GK, Xie D, Guo H.

Phys Chem Chem Phys. 2011 May 28;13(20):9622-31. doi: 10.1039/c1cp20067d. Epub 2011 Apr 13.


Synthesis and SAR of acyclic HCV NS3 protease inhibitors with novel P4-benzoxaborole moieties.

Li X, Zhang S, Zhang YK, Liu Y, Ding CZ, Zhou Y, Plattner JJ, Baker SJ, Bu W, Liu L, Kazmierski WM, Duan M, Grimes RM, Wright LL, Smith GK, Jarvest RL, Ji JJ, Cooper JP, Tallant MD, Crosby RM, Creech K, Ni ZJ, Zou W, Wright J.

Bioorg Med Chem Lett. 2011 Apr 1;21(7):2048-54. doi: 10.1016/j.bmcl.2011.02.006. Epub 2011 Feb 23.


Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease.

Ding CZ, Zhang YK, Li X, Liu Y, Zhang S, Zhou Y, Plattner JJ, Baker SJ, Liu L, Duan M, Jarvest RL, Ji J, Kazmierski WM, Tallant MD, Wright LL, Smith GK, Crosby RM, Wang AA, Ni ZJ, Zou W, Wright J.

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7317-22. doi: 10.1016/j.bmcl.2010.10.071. Epub 2010 Oct 21.


Synthesis of new acylsulfamoyl benzoxaboroles as potent inhibitors of HCV NS3 protease.

Li X, Zhang YK, Liu Y, Zhang S, Ding CZ, Zhou Y, Plattner JJ, Baker SJ, Liu L, Bu W, Kazmierski WM, Wright LL, Smith GK, Jarvest RL, Duan M, Ji JJ, Cooper JP, Tallant MD, Crosby RM, Creech K, Ni ZJ, Zou W, Wright J.

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7493-7. doi: 10.1016/j.bmcl.2010.10.007. Epub 2010 Oct 30.


Pro-cathepsin D interacts with the extracellular domain of the beta chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth.

Beaujouin M, Prébois C, Derocq D, Laurent-Matha V, Masson O, Pattingre S, Coopman P, Bettache N, Grossfield J, Hollingsworth RE, Zhang H, Yao Z, Hyman BT, van der Geer P, Smith GK, Liaudet-Coopman E.

J Cell Sci. 2010 Oct 1;123(Pt 19):3336-46. doi: 10.1242/jcs.070938. Epub 2010 Sep 7.


Evaluation of the relationship between Orthopedic Foundation for Animals' hip joint scores and PennHIP distraction index values in dogs.

Powers MY, Karbe GT, Gregor TP, McKelvie P, Culp WT, Fordyce HH, Smith GK.

J Am Vet Med Assoc. 2010 Sep 1;237(5):532-41. doi: 10.2460/javma.237.5.532.


Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates.

Li X, Zhang YK, Liu Y, Ding CZ, Zhou Y, Li Q, Plattner JJ, Baker SJ, Zhang S, Kazmierski WM, Wright LL, Smith GK, Grimes RM, Crosby RM, Creech KL, Carballo LH, Slater MJ, Jarvest RL, Thommes P, Hubbard JA, Convery MA, Nassau PM, McDowell W, Skarzynski TJ, Qian X, Fan D, Liao L, Ni ZJ, Pennicott LE, Zou W, Wright J.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5695-700. doi: 10.1016/j.bmcl.2010.08.022. Epub 2010 Aug 10.


Distraction index as a risk factor for osteoarthritis associated with hip dysplasia in four large dog breeds.

Runge JJ, Kelly SP, Gregor TP, Kotwal S, Smith GK.

J Small Anim Pract. 2010 May;51(5):264-9. doi: 10.1111/j.1748-5827.2010.00937.x.


Synthesis and evaluation of novel alpha-amino cyclic boronates as inhibitors of HCV NS3 protease.

Li X, Zhang YK, Liu Y, Ding CZ, Li Q, Zhou Y, Plattner JJ, Baker SJ, Qian X, Fan D, Liao L, Ni ZJ, White GV, Mordaunt JE, Lazarides LX, Slater MJ, Jarvest RL, Thommes P, Ellis M, Edge CM, Hubbard JA, Somers D, Rowland P, Nassau P, McDowell B, Skarzynski TJ, Kazmierski WM, Grimes RM, Wright LL, Smith GK, Zou W, Wright J, Pennicott LE.

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3550-6. doi: 10.1016/j.bmcl.2010.04.129. Epub 2010 May 20.


Active-site dynamics of SpvC virulence factor from Salmonella typhimurium and density functional theory study of phosphothreonine lyase catalysis.

Smith GK, Ke Z, Hengge AC, Xu D, Xie D, Guo H.

J Phys Chem B. 2009 Nov 19;113(46):15327-33. doi: 10.1021/jp9052677.


Distinct concentration-dependent effects of the polo-like kinase 1-specific inhibitor GSK461364A, including differential effect on apoptosis.

Gilmartin AG, Bleam MR, Richter MC, Erskine SG, Kruger RG, Madden L, Hassler DF, Smith GK, Gontarek RR, Courtney MP, Sutton D, Diamond MA, Jackson JR, Laquerre SG.

Cancer Res. 2009 Sep 1;69(17):6969-77. doi: 10.1158/0008-5472.CAN-09-0945. Epub 2009 Aug 18.


Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: implications for cellular potency and selectivity over insulin receptor.

Wood ER, Shewchuk L, Hassel A, Nichols J, Truesdale AT, Smith D, Carter HL, Weaver K, Barrett G, Leesnitzer T, Alvarez E, Bardera AI, Alamillo A, Cantizani J, Martin J, Smith GK, Jensen DE, Xie H, Mook R, Kumar R, Kuntz K.

Biochem Pharmacol. 2009 Dec 15;78(12):1438-47. doi: 10.1016/j.bcp.2009.07.022. Epub 2009 Aug 7.


External fixator clamp reuse degrades clamp mechanical performance.

Gilley RS, Beason DP, Snyder DM, Boston RC, Radin A, Kapatkin AS, Smith GK, Soslowsky LJ.

Vet Surg. 2009 Jun;38(4):530-6. doi: 10.1111/j.1532-950X.2009.00521.x.


Effects of osteoarthritis on radiographic measures of laxity and congruence in hip joints of Labrador Retrievers.

Gold RM, Gregor TP, Huck JL, McKelvie PJ, Smith GK.

J Am Vet Med Assoc. 2009 Jun 15;234(12):1549-54. doi: 10.2460/javma.234.12.1549.


A longitudinal study of the influence of lifetime food restriction on development of osteoarthritis in the canine elbow.

Huck JL, Biery DN, Lawler DF, Gregor TP, Runge JJ, Evans RH, Kealy RD, Smith GK.

Vet Surg. 2009 Feb;38(2):192-8. doi: 10.1111/j.1532-950X.2008.00487.x.


Un-united medial epicondyle of the humerus: radiographic prevalence and association with elbow osteoarthritis in a cohort of labrador retrievers.

Paster ER, Biery DN, Lawler DF, Evans RH, Kealy RD, Gregor TP, McKelvie PJ, Smith GK.

Vet Surg. 2009 Feb;38(2):169-72. doi: 10.1111/j.1532-950X.2008.00484.x.


PennHIP more than "complementary" to FCI hip screening method.

Smith GK.

J Small Anim Pract. 2009 Feb;50(2):105-6. doi: 10.1111/j.1748-5827.2008.00738.x. No abstract available.


Assessment of chemical coverage of kinome space and its implications for kinase drug discovery.

Bamborough P, Drewry D, Harper G, Smith GK, Schneider K.

J Med Chem. 2008 Dec 25;51(24):7898-914. doi: 10.1021/jm8011036.


Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.

Cheung M, Kuntz KW, Pobanz M, Salovich JM, Wilson BJ, Andrews CW 3rd, Shewchuk LM, Epperly AH, Hassler DF, Leesnitzer MA, Smith JL, Smith GK, Lansing TJ, Mook RA Jr.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6214-7. doi: 10.1016/j.bmcl.2008.09.100. Epub 2008 Oct 2.


Potent, selective and orally bioavailable dihydropyrimidine inhibitors of Rho kinase (ROCK1) as potential therapeutic agents for cardiovascular diseases.

Sehon CA, Wang GZ, Viet AQ, Goodman KB, Dowdell SE, Elkins PA, Semus SF, Evans C, Jolivette LJ, Kirkpatrick RB, Dul E, Khandekar SS, Yi T, Wright LL, Smith GK, Behm DJ, Bentley R, Doe CP, Hu E, Lee D.

J Med Chem. 2008 Nov 13;51(21):6631-4. doi: 10.1021/jm8005096. Epub 2008 Oct 9.


The effects of lifetime food restriction on the development of osteoarthritis in the canine shoulder.

Runge JJ, Biery DN, Lawler DF, Gregor TP, Evans RH, Kealy RD, Szabo SD, Smith GK.

Vet Surg. 2008 Jan;37(1):102-7. doi: 10.1111/j.1532-950X.2007.00354.x.


Failure mode and bending moment of canine pancarpal arthrodesis constructs stabilized with two different implant systems.

Wininger FA, Kapatkin AS, Radin A, Shofer FS, Smith GK.

Vet Surg. 2007 Dec;36(8):724-8. Erratum in: Vet Surg. 2009 Jun; 38(4):552.


Diet restriction and ageing in the dog: major observations over two decades.

Lawler DF, Larson BT, Ballam JM, Smith GK, Biery DN, Evans RH, Greeley EH, Segre M, Stowe HD, Kealy RD.

Br J Nutr. 2008 Apr;99(4):793-805. Epub 2007 Dec 6. Erratum in: Br J Nutr. 2009 Apr;101(7):1112.


Evaluation of a circumferential femoral head osteophyte as an early indicator of osteoarthritis characteristic of canine hip dysplasia in dogs.

Szabo SD, Biery DN, Lawler DF, Shofer FS, Powers MY, Kealy RD, Smith GK.

J Am Vet Med Assoc. 2007 Sep 15;231(6):889-92.


Kinetic gait analysis of healthy dogs on two different surfaces.

Kapatkin AS, Arbittier G, Kass PH, Gilley RS, Smith GK.

Vet Surg. 2007 Aug;36(6):605-8.


Development of dihydropyridone indazole amides as selective Rho-kinase inhibitors.

Goodman KB, Cui H, Dowdell SE, Gaitanopoulos DE, Ivy RL, Sehon CA, Stavenger RA, Wang GZ, Viet AQ, Xu W, Ye G, Semus SF, Evans C, Fries HE, Jolivette LJ, Kirkpatrick RB, Dul E, Khandekar SS, Yi T, Jung DK, Wright LL, Smith GK, Behm DJ, Bentley R, Doe CP, Hu E, Lee D.

J Med Chem. 2007 Jan 11;50(1):6-9.


Discovery of aminofurazan-azabenzimidazoles as inhibitors of Rho-kinase with high kinase selectivity and antihypertensive activity.

Stavenger RA, Cui H, Dowdell SE, Franz RG, Gaitanopoulos DE, Goodman KB, Hilfiker MA, Ivy RL, Leber JD, Marino JP Jr, Oh HJ, Viet AQ, Xu W, Ye G, Zhang D, Zhao Y, Jolivette LJ, Head MS, Semus SF, Elkins PA, Kirkpatrick RB, Dul E, Khandekar SS, Yi T, Jung DK, Wright LL, Smith GK, Behm DJ, Doe CP, Bentley R, Chen ZX, Hu E, Lee D.

J Med Chem. 2007 Jan 11;50(1):2-5.


Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities.

Doe C, Bentley R, Behm DJ, Lafferty R, Stavenger R, Jung D, Bamford M, Panchal T, Grygielko E, Wright LL, Smith GK, Chen Z, Webb C, Khandekar S, Yi T, Kirkpatrick R, Dul E, Jolivette L, Marino JP Jr, Willette R, Lee D, Hu E.

J Pharmacol Exp Ther. 2007 Jan;320(1):89-98. Epub 2006 Oct 3.


Lifelong diet restriction and radiographic evidence of osteoarthritis of the hip joint in dogs.

Smith GK, Paster ER, Powers MY, Lawler DF, Biery DN, Shofer FS, McKelvie PJ, Kealy RD.

J Am Vet Med Assoc. 2006 Sep 1;229(5):690-3.


Expression, purification, and characterization of an enzymatically active truncated human rho-kinase I (ROCK I) domain expressed in Sf-9 insect cells.

Khandekar SS, Yi T, Dul E, Wright LL, Chen S, Scott GF, Smith GK, Lee D, Hu E, Kirkpatrick RB.

Protein Pept Lett. 2006;13(4):369-76.


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