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Canadian Stroke Best Practice Recommendations for Acute Stroke Management: Prehospital, Emergency Department, and Acute Inpatient Stroke Care, 6th Edition, Update 2018.

Boulanger JM, Lindsay MP, Gubitz G, Smith EE, Stotts G, Foley N, Bhogal S, Boyle K, Braun L, Goddard T, Heran M, Kanya-Forster N, Lang E, Lavoie P, McClelland M, O'Kelly C, Pageau P, Pettersen J, Purvis H, Shamy M, Tampieri D, vanAdel B, Verbeek R, Blacquiere D, Casaubon L, Ferguson D, Hegedus Y, Jacquin GJ, Kelly M, Kamal N, Linkewich B, Lum C, Mann B, Milot G, Newcommon N, Poirier P, Simpkin W, Snieder E, Trivedi A, Whelan R, Eustace M, Smitko E, Butcher K; Acute Stroke Management Best Practice Writing Group, and the Canadian Stroke Best Practices and Quality Advisory Committees; in collaboration with the Canadian Stroke Consortium and the Canadian Association of Emergency Physicians.

Int J Stroke. 2018 Jan 1:1747493018786616. doi: 10.1177/1747493018786616. [Epub ahead of print]


Canadian Stroke Best Practice Consensus Statement: Acute Stroke Management during pregnancy.

Ladhani NNN, Swartz RH, Foley N, Nerenberg K, Smith EE, Gubitz G, Dowlatshahi D, Potts J, Ray JG, Barrett J, Bushnell C, Bal S, Chan WS, Chari R, El Amrani M, Gandhi S, Hill MD, James A, Jeerakathil T, Jin A, Kirton A, Lanthier S, Lausman A, Leffert LR, Mandzia J, Menon B, Pikula A, Poppe A, Saposnik G, Sharma M, Bhogal S, Smitko E, Lindsay MP; Heart and Stroke Foundation Canadian Stroke Best Practice and Quality Advisory Committees; Canadian Stroke Consortium.

Int J Stroke. 2018 Jan 1:1747493018786617. doi: 10.1177/1747493018786617. [Epub ahead of print]


Connectome-derived diffusion characteristics of the fornix in Alzheimer's disease.

Perea RD, Rabin JS, Fujiyoshi MG, Neal TE, Smith EE, Van Dijk KRA, Hedden T.

Neuroimage Clin. 2018 Apr 27;19:331-342. doi: 10.1016/j.nicl.2018.04.029. eCollection 2018.


A longitudinal magnetic resonance imaging study of neurodegenerative and small vessel disease, and clinical cognitive trajectories in non demented patients with transient ischemic attack: the PREVENT study.

Tariq S, d'Esterre CD, Sajobi TT, Smith EE, Longman RS, Frayne R, Coutts SB, Forkert ND, Barber PA.

BMC Geriatr. 2018 Jul 16;18(1):163. doi: 10.1186/s12877-018-0858-4.


Cortical Microinfarcts on 3T Magnetic Resonance Imaging in Cerebral Amyloid Angiopathy: Relations With Other Magnetic Resonance Imaging Markers of Cerebral Amyloid Angiopathy and Cognition.

van den Brink H, Zwiers A, Switzer AR, Charlton A, McCreary CR, Goodyear BG, Frayne R, Biessels GJ, Smith EE.

Stroke. 2018 Jul 9. pii: STROKEAHA.118.020810. doi: 10.1161/STROKEAHA.118.020810. [Epub ahead of print]


Rationale and design for the detection and neurological impact of cerebrovascular events in non-cardiac surgery patients cohort evaluation (NeuroVISION) study: a prospective international cohort study.

Mrkobrada M, Chan MTV, Cowan D, Spence J, Campbell D, Wang CY, Torres D, Malaga G, Sanders RD, Brown C, Sigamani A, Szczeklik W, Dmytriw AA, Agid R, Smith EE, Hill MD, Sharma M, Sharma M, Tsai S, Mensinkai A, Sahlas DJ, Guyatt G, Pettit S, Copland I, Wu WKK, Yu SCH, Gin T, Loh PS, Ramli N, Siow YL, Short TG, Waymouth E, Kumar J, Dasgupta M, Murkin JM, Fuentes M, Ortiz-Soriano V, Lindroth H, Simpson S, Sessler D, Devereaux PJ.

BMJ Open. 2018 Jul 6;8(7):e021521. doi: 10.1136/bmjopen-2018-021521.


Expanding the Potential Therapeutic Options for Remote Ischemic Preconditioning: Use in Multiple Sclerosis.

Camara-Lemarroy CR, Metz L, Smith EE, Dunn JF, Yong VW.

Front Neurol. 2018 Jun 19;9:475. doi: 10.3389/fneur.2018.00475. eCollection 2018. No abstract available.


Qualitative and quantitative drug residue analyses: Chlortetracycline in white-tailed deer (Odocoileus virginianus) and supermarket meat by liquid chromatography tandem-mass spectrometry.

Anderson SC, Subbiah S, Gentles A, Oliver D, Stonum P, Brooks TA, Smith EE.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:237-243. doi: 10.1016/j.jchromb.2018.05.027. Epub 2018 May 18.


A Hospital Level Analysis of 30-Day Readmission Performance for Heart Failure Patients and Long-Term Survival: Findings from Get With The Guidelines-Heart Failure.

Jalnapurkar S, Zhao X, Heidenreich PA, Bhatt DL, Smith EE, DeVore AD, Hernandez AF, Matsouaka R, Yancy CW, Fonarow GC.

Am Heart J. 2018 Jun;200:127-133. doi: 10.1016/j.ahj.2017.11.018. Epub 2018 Jan 8.


Bioengineered Tooth Buds Exhibit Features of Natural Tooth Buds.

Smith EE, Angstadt S, Monteiro N, Zhang W, Khademhosseini A, Yelick PC.

J Dent Res. 2018 Jun 1:22034518779075. doi: 10.1177/0022034518779075. [Epub ahead of print]


The power of meaning: the quest for an existential roadmap.

Paulson S, Lombard J, Pigliucci M, Ruse M, Smith EE.

Ann N Y Acad Sci. 2018 May 24. doi: 10.1111/nyas.13699. [Epub ahead of print]


Comparison of Acute Ischemic Stroke Care and Outcomes Between Comprehensive Stroke Centers and Primary Stroke Centers in the United States.

Man S, Zhao X, Uchino K, Hussain MS, Smith EE, Bhatt DL, Xian Y, Schwamm LH, Shah S, Khan Y, Fonarow GC.

Circ Cardiovasc Qual Outcomes. 2018 Jun;11(6):e004512. doi: 10.1161/CIRCOUTCOMES.117.004512.


Outcomes in Hospitalized Ischemic Stroke Patients with Dementia on Admission: A Population-Based Cohort Study.

Zerna C, Lindsay MP, Fang J, Swartz RH, Smith EE.

Can J Neurol Sci. 2018 May;45(3):290-294. doi: 10.1017/cjn.2018.9. Epub 2018 Apr 16.


Association of White Matter Hyperintensities With Short-Term Outcomes in Patients With Minor Cerebrovascular Events.

Zerna C, Yu AYX, Modi J, Patel SK, Coulter JI, Smith EE, Coutts SB.

Stroke. 2018 Apr;49(4):919-923. doi: 10.1161/STROKEAHA.117.017429. Epub 2018 Mar 14.


Sustained sex-based treatment differences in acute coronary syndrome care: Insights from the American Heart Association Get With The Guidelines Coronary Artery Disease Registry.

Udell JA, Fonarow GC, Maddox TM, Cannon CP, Frank Peacock W, Laskey WK, Grau-Sepulveda MV, Smith EE, Hernandez AF, Peterson ED, Bhatt DL; Get With The Guidelines Steering Committee and Investigators.

Clin Cardiol. 2018 Jun;41(6):758-768. doi: 10.1002/clc.22938. Epub 2018 May 11.


Assessment of gonadal and thyroid histology in Gulf killifish (Fundulus grandis) from Barataria Bay Louisiana one year after the Deepwater Horizon oil spill.

Carr DL, Smith EE, Thiyagarajah A, Cromie M, Crumly C, Davis A, Dong M, Garcia C, Heintzman L, Hopper T, Kouth K, Morris K, Ruehlen A, Snodgrass P, Vaughn K, Carr JA.

Ecotoxicol Environ Saf. 2018 Jun 15;154:245-254. doi: 10.1016/j.ecoenv.2018.01.013. Epub 2018 Feb 22.


Secondary stroke prevention services in Canada: a cross-sectional survey and geospatial analysis of resources, capacity and geographic access.

Jewett L, Harroud A, Hill MD, Côté R, Wein T, Smith EE, Gubitz G, Demchuk AM, Sahlas DJ, Gladstone DJ, Lindsay MP.

CMAJ Open. 2018 Feb 21;6(1):E95-E102. doi: 10.9778/cmajo.20170130.


Dementia clinical trial implications of mild behavioral impairment.

Mortby ME, Black SE, Gauthier S, Miller D, Porsteinsson A, Smith EE, Ismail Z.

Int Psychogeriatr. 2018 Feb;30(2):171-175. doi: 10.1017/S1041610218000042.


Diabetes and long-term outcomes of ischaemic stroke: findings from Get With The Guidelines-Stroke.

Echouffo-Tcheugui JB, Xu H, Matsouaka RA, Xian Y, Schwamm LH, Smith EE, Bhatt DL, Hernandez AF, Heidenreich PA, Fonarow GC.

Eur Heart J. 2018 Jul 1;39(25):2376-2386. doi: 10.1093/eurheartj/ehy036.


Absence of July Phenomenon in Acute Ischemic Stroke Care Quality and Outcomes.

Gonzalez-Castellon M, Ju C, Xian Y, Hernandez A, Fonarow GC, Schwamm L, Smith EE, Bhatt DL, Reeves M, Willey JZ.

J Am Heart Assoc. 2018 Jan 31;7(3). pii: e007685. doi: 10.1161/JAHA.117.007685.


Impaired memory is more closely associated with brain beta-amyloid than leukoaraiosis in hypertensive patients with cognitive symptoms.

Smith EE, Muzikansky A, McCreary CR, Batool S, Viswanathan A, Dickerson BC, Johnson K, Greenberg SM, Blacker D.

PLoS One. 2018 Jan 30;13(1):e0191345. doi: 10.1371/journal.pone.0191345. eCollection 2018.


Association of Intracerebral Hemorrhage Among Patients Taking Non-Vitamin K Antagonist vs Vitamin K Antagonist Oral Anticoagulants With In-Hospital Mortality.

Inohara T, Xian Y, Liang L, Matsouaka RA, Saver JL, Smith EE, Schwamm LH, Reeves MJ, Hernandez AF, Bhatt DL, Peterson ED, Fonarow GC.

JAMA. 2018 Feb 6;319(5):463-473. doi: 10.1001/jama.2017.21917.


Accuracy of Prediction Instruments for Diagnosing Large Vessel Occlusion in Individuals With Suspected Stroke: A Systematic Review for the 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke.

Smith EE, Kent DM, Bulsara KR, Leung LY, Lichtman JH, Reeves MJ, Towfighi A, Whiteley WN, Zahuranec DB; American Heart Association Stroke Council.

Stroke. 2018 Mar;49(3):e111-e122. doi: 10.1161/STR.0000000000000160. Epub 2018 Jan 24. Review. Erratum in: Stroke. 2018 Mar;49(3):e139.


Effect of Dysphagia Screening Strategies on Clinical Outcomes After Stroke: A Systematic Review for the 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke.

Smith EE, Kent DM, Bulsara KR, Leung LY, Lichtman JH, Reeves MJ, Towfighi A, Whiteley WN, Zahuranec DB; American Heart Association Stroke Council.

Stroke. 2018 Mar;49(3):e123-e128. doi: 10.1161/STR.0000000000000159. Epub 2018 Jan 24. Review. Erratum in: Stroke. 2018 Mar;49(3):e140.


Lack of Early Improvement Predicts Poor Outcome Following Acute Intracerebral Hemorrhage.

Yogendrakumar V, Smith EE, Demchuk AM, Aviv RI, Rodriguez-Luna D, Molina CA, Silva Blas Y, Dzialowski I, Kobayashi A, Boulanger JM, Lum C, Gubitz G, Padma V, Roy J, Kase CS, Bhatia R, Ali M, Lyden P, Hill MD, Dowlatshahi D; Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign [PREDICT]/Sunnybrook ICH CTA Study Group and the Virtual International Stroke Trials Archive (VISTA)-ICH Collaborators.

Crit Care Med. 2018 Apr;46(4):e310-e317. doi: 10.1097/CCM.0000000000002962.


Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data.

Campbell BCV, van Zwam WH, Goyal M, Menon BK, Dippel DWJ, Demchuk AM, Bracard S, White P, Dávalos A, Majoie CBLM, van der Lugt A, Ford GA, de la Ossa NP, Kelly M, Bourcier R, Donnan GA, Roos YBWEM, Bang OY, Nogueira RG, Devlin TG, van den Berg LA, Clarençon F, Burns P, Carpenter J, Berkhemer OA, Yavagal DR, Pereira VM, Ducrocq X, Dixit A, Quesada H, Epstein J, Davis SM, Jansen O, Rubiera M, Urra X, Micard E, Lingsma HF, Naggara O, Brown S, Guillemin F, Muir KW, van Oostenbrugge RJ, Saver JL, Jovin TG, Hill MD, Mitchell PJ; HERMES collaborators.

Lancet Neurol. 2018 Jan;17(1):47-53. doi: 10.1016/S1474-4422(17)30407-6. Epub 2017 Dec 16.


Mixed emotions: What to do with patients who have lobar and deep hemorrhages on MRI?

Smith EE, Romero JR.

Neurology. 2018 Jan 9;90(2):55-56. doi: 10.1212/WNL.0000000000004811. Epub 2017 Dec 15. No abstract available.


Detecting anxiety in individuals with Parkinson disease: A systematic review.

Mele B, Holroyd-Leduc J, Smith EE, Pringsheim T, Ismail Z, Goodarzi Z.

Neurology. 2018 Jan 2;90(1):e39-e47. doi: 10.1212/WNL.0000000000004771. Epub 2017 Dec 6.


Canadian stroke best practice consensus statement: Secondary stroke prevention during pregnancy.

Swartz RH, Ladhani NNN, Foley N, Nerenberg K, Bal S, Barrett J, Bushnell C, Chan WS, Chari R, Dowlatshahi D, Amrani ME, Gandhi S, Gubitz G, Hill MD, James A, Jeerakathil T, Jin A, Kirton A, Lanthier S, Lausman A, Leffert LR, Mandzia J, Menon B, Pikula A, Poppe A, Potts J, Ray J, Saposnik G, Sharma M, Smith EE, Bhogal S, Smitko E, Lindsay MP; Heart and Stroke Foundation Canadian Stroke Best Practice Advisory Committees.

Int J Stroke. 2018 Jun;13(4):406-419. doi: 10.1177/1747493017743801. Epub 2017 Nov 24.


Thrombolysis: Improving door-to-needle times for ischemic stroke treatment - A narrative review.

Kamal N, Smith EE, Jeerakathil T, Hill MD.

Int J Stroke. 2018 Apr;13(3):268-276. doi: 10.1177/1747493017743060. Epub 2017 Nov 15.


New insights into cerebral small vessel disease and vascular cognitive impairment from MRI.

Smith EE, Beaudin AE.

Curr Opin Neurol. 2018 Feb;31(1):36-43. doi: 10.1097/WCO.0000000000000513. Review.


Blood pressure at age 60-65 versus age 70-75 and vascular dementia: a population based observational study.

Peng M, Chen G, Tang KL, Quan H, Smith EE, Faris P, Hachinski V, Campbell NRC.

BMC Geriatr. 2017 Oct 27;17(1):252. doi: 10.1186/s12877-017-0649-3.


Determining the impact of psychosis on rates of false-positive and false-negative diagnosis in Alzheimer's disease.

Fischer CE, Qian W, Schweizer TA, Ismail Z, Smith EE, Millikin CP, Munoz DG.

Alzheimers Dement (N Y). 2017 Jun 21;3(3):385-392. doi: 10.1016/j.trci.2017.06.001. eCollection 2017 Sep.


Multiple comorbid neuropathologies in the setting of Alzheimer's disease neuropathology and implications for drug development.

Rabinovici GD, Carrillo MC, Forman M, DeSanti S, Miller DS, Kozauer N, Petersen RC, Randolph C, Knopman DS, Smith EE, Isaac M, Mattsson N, Bain LJ, Hendrix JA, Sims JR.

Alzheimers Dement (N Y). 2016 Sep 20;3(1):83-91. doi: 10.1016/j.trci.2016.09.002. eCollection 2017 Jan. Review.


Intracranial source activity (eLORETA) related to scalp-level asymmetry scores and depression status.

Smith EE, Cavanagh JF, Allen JJB.

Psychophysiology. 2018 Jan;55(1). doi: 10.1111/psyp.13019. Epub 2017 Oct 11.


Population-based study of home-time by stroke type and correlation with modified Rankin score.

Yu AYX, Rogers E, Wang M, Sajobi TT, Coutts SB, Menon BK, Hill MD, Smith EE.

Neurology. 2017 Nov 7;89(19):1970-1976. doi: 10.1212/WNL.0000000000004631. Epub 2017 Oct 11.


Is Risk-Standardized In-Hospital Stroke Mortality an Adequate Proxy for Risk-Standardized 30-Day Stroke Mortality Data? Findings From Get With The Guidelines-Stroke.

Reeves MJ, Fonarow GC, Xu H, Matsouaka RA, Xian Y, Saver J, Schwamm L, Smith EE.

Circ Cardiovasc Qual Outcomes. 2017 Oct;10(10). pii: e003748. doi: 10.1161/CIRCOUTCOMES.117.003748.


Case series of mild behavioral impairment: toward an understanding of the early stages of neurodegenerative diseases affecting behavior and cognition.

Cieslak A, Smith EE, Lysack J, Ismail Z.

Int Psychogeriatr. 2018 Feb;30(2):273-280. doi: 10.1017/S1041610217001855. Epub 2017 Oct 11.


Increase in Endovascular Therapy in Get With The Guidelines-Stroke After the Publication of Pivotal Trials.

Smith EE, Saver JL, Cox M, Liang L, Matsouaka R, Xian Y, Bhatt DL, Fonarow GC, Schwamm LH.

Circulation. 2017 Dec 12;136(24):2303-2310. doi: 10.1161/CIRCULATIONAHA.117.031097. Epub 2017 Oct 5.


Blood pressure and in-hospital outcomes in patients presenting with ischaemic stroke.

Bangalore S, Schwamm L, Smith EE, Hellkamp AS, Suter RE, Xian Y, Schulte PJ, Fonarow GC, Bhatt DL; Get With the Guidelines-Stroke Steering Committee and Investigators.

Eur Heart J. 2017 Oct 1;38(37):2827-2835. doi: 10.1093/eurheartj/ehx330.


Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association.

Gorelick PB, Furie KL, Iadecola C, Smith EE, Waddy SP, Lloyd-Jones DM, Bae HJ, Bauman MA, Dichgans M, Duncan PW, Girgus M, Howard VJ, Lazar RM, Seshadri S, Testai FD, van Gaal S, Yaffe K, Wasiak H, Zerna C; American Heart Association/American Stroke Association.

Stroke. 2017 Oct;48(10):e284-e303. doi: 10.1161/STR.0000000000000148. Epub 2017 Sep 7. Review.


Prevalence of mild behavioral impairment in mild cognitive impairment and subjective cognitive decline, and its association with caregiver burden.

Sheikh F, Ismail Z, Mortby ME, Barber P, Cieslak A, Fischer K, Granger R, Hogan DB, Mackie A, Maxwell CJ, Menon B, Mueller P, Patry D, Pearson D, Quickfall J, Sajobi T, Tse E, Wang M, Smith EE; PROMPT registry investigators.

Int Psychogeriatr. 2018 Feb;30(2):233-244. doi: 10.1017/S104161021700151X. Epub 2017 Sep 7.


The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice.

Banerjee G, Carare R, Cordonnier C, Greenberg SM, Schneider JA, Smith EE, Buchem MV, Grond JV, Verbeek MM, Werring DJ.

J Neurol Neurosurg Psychiatry. 2017 Nov;88(11):982-994. doi: 10.1136/jnnp-2016-314697. Epub 2017 Aug 26. Review.


Cerebral amyloid angiopathy as a cause of neurodegeneration.

Smith EE.

J Neurochem. 2018 Mar;144(5):651-658. doi: 10.1111/jnc.14157. Epub 2017 Sep 21. Review.


The Antineoplastic Activity of Photothermal Ablative Therapy with Targeted Gold Nanorods in an Orthotopic Urinary Bladder Cancer Model.

Yang X, Su LJ, La Rosa FG, Smith EE, Schlaepfer IR, Cho SK, Kavanagh B, Park W, Flaig TW.

Bladder Cancer. 2017 Jul 27;3(3):201-210. doi: 10.3233/BLC-170096.


Regional Variation in 30-Day Ischemic Stroke Outcomes for Medicare Beneficiaries Treated in Get With The Guidelines-Stroke Hospitals.

Thompson MP, Zhao X, Bekelis K, Gottlieb DJ, Fonarow GC, Schulte PJ, Xian Y, Lytle BL, Schwamm LH, Smith EE, Reeves MJ.

Circ Cardiovasc Qual Outcomes. 2017 Aug;10(8). pii: e003604. doi: 10.1161/CIRCOUTCOMES.117.003604.


Prevention of Cerebral Small Vessel Disease.

Smith EE.

Semin Neurol. 2017 Jun;37(3):316-325. doi: 10.1055/s-0037-1603468. Epub 2017 Jul 31. No abstract available.


Brain hemorrhage recurrence, small vessel disease type, and cerebral microbleeds: A meta-analysis.

Charidimou A, Imaizumi T, Moulin S, Biffi A, Samarasekera N, Yakushiji Y, Peeters A, Vandermeeren Y, Laloux P, Baron JC, Hernandez-Guillamon M, Montaner J, Casolla B, Gregoire SM, Kang DW, Kim JS, Naka H, Smith EE, Viswanathan A, Jäger HR, Al-Shahi Salman R, Greenberg SM, Cordonnier C, Werring DJ.

Neurology. 2017 Aug 22;89(8):820-829. doi: 10.1212/WNL.0000000000004259. Epub 2017 Jul 26. Review.


Detection, risk factors, and functional consequences of cerebral microinfarcts.

van Veluw SJ, Shih AY, Smith EE, Chen C, Schneider JA, Wardlaw JM, Greenberg SM, Biessels GJ.

Lancet Neurol. 2017 Sep;16(9):730-740. doi: 10.1016/S1474-4422(17)30196-5. Epub 2017 Jul 14. Review.


Fascin Is Associated With Aggressive Behavior and Poor Outcome in Uterine Carcinosarcoma.

Richmond AM, Blake EA, Torkko K, Smith EE, Spillman MA, Post MD.

Int J Gynecol Cancer. 2017 Nov;27(9):1895-1903. doi: 10.1097/IGC.0000000000001077.


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