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Items: 1 to 50 of 556

1.

Predisposition to childhood acute lymphoblastic leukemia caused by a constitutional translocation disrupting ETV6.

Järviaho T, Bang B, Zachariadis V, Taylan F, Moilanen J, Möttönen M, Smith CIE, Harila-Saari A, Niinimäki R, Nordgren A.

Blood Adv. 2019 Sep 24;3(18):2722-2731. doi: 10.1182/bloodadvances.2018028795.

2.

Chemical Development of Therapeutic Oligonucleotides.

Lundin KE, Gissberg O, Smith CIE, Zain R.

Methods Mol Biol. 2019;2036:3-16. doi: 10.1007/978-1-4939-9670-4_1.

PMID:
31410788
3.

Targeted Oligonucleotides for Treating Neurodegenerative Tandem Repeat Diseases.

Zain R, Smith CIE.

Neurotherapeutics. 2019 Apr;16(2):248-262. doi: 10.1007/s13311-019-00712-9. Review.

4.

Total Alanine Aminotransferase (ALT) Flares in Pregnant North American Women With Chronic Hepatitis B Infection: Results From a Prospective Observational Study.

Bzowej NH, Tran TT, Li R, Belle SH, Smith CI, Khalili M, Chung R, Tsai N, Terrault N; Hepatitis B Research Network (HBRN).

Am J Gastroenterol. 2019 Aug;114(8):1283-1291. doi: 10.14309/ajg.0000000000000221.

PMID:
31082876
5.

Oligonucleotide⁻Palladacycle Conjugates as Splice-Correcting Agents.

Hande M, Saher O, Lundin KE, Smith CIE, Zain R, Lönnberg T.

Molecules. 2019 Mar 26;24(6). pii: E1180. doi: 10.3390/molecules24061180.

6.

Oligonucleotide Binding to Non-B-DNA in MYC.

Umek T, Sollander K, Bergquist H, Wengel J, Lundin KE, Smith CIE, Zain R.

Molecules. 2019 Mar 12;24(5). pii: E1000. doi: 10.3390/molecules24051000.

7.

The ability of locked nucleic acid oligonucleotides to pre-structure the double helix: A molecular simulation and binding study.

Xu Y, Gissberg O, Pabon-Martinez YV, Wengel J, Lundin KE, Smith CIE, Zain R, Nilsson L, Villa A.

PLoS One. 2019 Feb 12;14(2):e0211651. doi: 10.1371/journal.pone.0211651. eCollection 2019.

8.

Long-Term Outcome of WHIM Syndrome in 18 Patients: High Risk of Lung Disease and HPV-Related Malignancies.

Dotta L, Notarangelo LD, Moratto D, Kumar R, Porta F, Soresina A, Lougaris V, Plebani A, Smith CIE, Norlin AC, Gòmez Raccio AC, Bubanska E, Bertolini P, Amendola G, Visentini M, Fiorilli M, Venuti A, Badolato R.

J Allergy Clin Immunol Pract. 2019 May - Jun;7(5):1568-1577. doi: 10.1016/j.jaip.2019.01.045. Epub 2019 Feb 2.

PMID:
30716504
9.

Precursor B-cell development in bone marrow of Good syndrome patients.

Del Pino Molina L, Wentink M, van Deuren M, van Hagen PM, Smith CIE, van der Burg M.

Clin Immunol. 2019 Mar;200:39-42. doi: 10.1016/j.clim.2018.11.009. Epub 2019 Jan 25.

PMID:
30690192
10.

Therapeutic Oligonucleotides: State of the Art.

Smith CIE, Zain R.

Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:605-630. doi: 10.1146/annurev-pharmtox-010818-021050. Epub 2018 Oct 9.

PMID:
30285540
11.

Translocation-generated ITK-FER and ITK-SYK fusions induce STAT3 phosphorylation and CD69 expression.

Fathi NN, Mohammad DK, Görgens A, Andaloussi SE, Zain R, Nore BF, Smith CIE.

Biochem Biophys Res Commun. 2018 Oct 12;504(4):749-752. doi: 10.1016/j.bbrc.2018.09.019. Epub 2018 Sep 11.

PMID:
30217447
12.

Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity.

Saher O, Rocha CSJ, Zaghloul EM, Wiklander OPB, Zamolo S, Heitz M, Ezzat K, Gupta D, Reymond JL, Zain R, Hollfelder F, Darbre T, Lundin KE, El Andaloussi S, Smith CIE.

Eur J Pharm Biopharm. 2018 Nov;132:29-40. doi: 10.1016/j.ejpb.2018.09.002. Epub 2018 Sep 4.

PMID:
30193928
13.

Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell.

Smith CI, Siggel-King MRF, Ingham J, Harrison P, Martin DS, Varro A, Pritchard DM, Surman M, Barrett S, Weightman P.

Analyst. 2018 Dec 3;143(24):5912-5917. doi: 10.1039/c8an01183d.

PMID:
30191233
14.

Eleven percent intact PGM3 in a severely immunodeficient patient with a novel splice-site mutation, a case report.

Lundin KE, Wang Q, Hamasy A, Marits P, Uzunel M, Wirta V, Wikström AC, Fasth A, Ekwall O, Smith CIE.

BMC Pediatr. 2018 Aug 29;18(1):285. doi: 10.1186/s12887-018-1258-9.

15.

Ibrutinib induces rapid down-regulation of inflammatory markers and altered transcription of chronic lymphocytic leukaemia-related genes in blood and lymph nodes.

Palma M, Krstic A, Peña Perez L, Berglöf A, Meinke S, Wang Q, Blomberg KEM, Kamali-Moghaddam M, Shen Q, Jaremko G, Lundin J, De Paepe A, Höglund P, Kimby E, Österborg A, Månsson R, Smith CIE.

Br J Haematol. 2018 Oct;183(2):212-224. doi: 10.1111/bjh.15516. Epub 2018 Aug 20.

PMID:
30125946
16.

Mitochondrial Divergence between Western and Eastern Great Bustards: Implications for Conservation and Species Status.

Kessler AE, Santos MA, Flatz R, Batbayar N, Natsagdorj T, Batsuuri D, Bidashko FG, Galbadrakh N, Goroshko O, Khrokov VV, Unenbat T, Vagner II, Wang M, Smith CI.

J Hered. 2018 Aug 24;109(6):641-652. doi: 10.1093/jhered/esy025.

PMID:
29917081
17.
18.

Kappa-deleting recombination excision circle levels remain low or undetectable throughout life in patients with X-linked agammaglobulinemia.

King J, Borte S, Brodszki N, von Döbeln U, Smith CIE, Hammarström L.

Pediatr Allergy Immunol. 2018 Jun;29(4):453-456. doi: 10.1111/pai.12893. Epub 2018 Apr 15. No abstract available.

PMID:
29543351
19.

Four millennia of Iberian biomolecular prehistory illustrate the impact of prehistoric migrations at the far end of Eurasia.

Valdiosera C, Günther T, Vera-Rodríguez JC, Ureña I, Iriarte E, Rodríguez-Varela R, Simões LG, Martínez-Sánchez RM, Svensson EM, Malmström H, Rodríguez L, Bermúdez de Castro JM, Carbonell E, Alday A, Hernández Vera JA, Götherström A, Carretero JM, Arsuaga JL, Smith CI, Jakobsson M.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3428-3433. doi: 10.1073/pnas.1717762115. Epub 2018 Mar 12.

20.

Terminating B cell receptor signaling.

Mohammad DK, Nore BF, Smith CIE.

Oncotarget. 2017 Dec 6;8(66):109857-109858. doi: 10.18632/oncotarget.22986. eCollection 2017 Dec 15. No abstract available.

21.

LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures.

Pabon-Martinez YV, Xu Y, Villa A, Lundin KE, Geny S, Nguyen CH, Pedersen EB, Jørgensen PT, Wengel J, Nilsson L, Smith CIE, Zain R.

Sci Rep. 2017 Sep 8;7(1):11043. doi: 10.1038/s41598-017-09147-8.

22.

Immunization with HIV-1 envelope T20-encoding DNA vaccines elicits cross-clade neutralizing antibody responses.

Stenler S, Lundin KE, Hansen L, Petkov S, Mozafari N, Isaguliants M, Blomberg P, Smith CIE, Goldenberg DM, Chang CH, Ljungberg K, Hinkula J, Wahren B.

Hum Vaccin Immunother. 2017 Dec 2;13(12):2849-2858. doi: 10.1080/21645515.2017.1338546. Epub 2017 Jul 11.

23.

Contrasting the academic and nonacademic hepatology practice settings.

Lalos AT, Smith CI.

Clin Liver Dis (Hoboken). 2017 Jun 29;9(6):144-146. doi: 10.1002/cld.638. eCollection 2017 Jun. Review. No abstract available.

24.

Specific dsDNA recognition by a mimic of the DNA binding domain of the c-Myc/Max transcription factor.

Ruiz García Y, Pabon-Martinez YV, Smith CIE, Madder A.

Chem Commun (Camb). 2017 Jun 16;53(49):6653-6656. doi: 10.1039/c7cc01705g.

PMID:
28585621
25.

Prevalence of hepatitis B antiviral drug resistance variants in North American patients with chronic hepatitis B not receiving antiviral treatment.

Lok AS, Ganova-Raeva L, Cloonan Y, Punkova L, Lin HS, Lee WM, Ghany MG; Hepatitis B Research Network (HBRN).

J Viral Hepat. 2017 Nov;24(11):1032-1042. doi: 10.1111/jvh.12732. Epub 2017 Jul 3.

26.

Role of Pseudoisocytidine Tautomerization in Triplex-Forming Oligonucleotides: In Silico and in Vitro Studies.

Hartono YD, Pabon-Martinez YV, Uyar A, Wengel J, Lundin KE, Zain R, Smith CIE, Nilsson L, Villa A.

ACS Omega. 2017 May 31;2(5):2165-2177. doi: 10.1021/acsomega.7b00347. Epub 2017 May 17.

27.

Characteristics of US-Born Versus Foreign-Born Americans of African Descent With Chronic Hepatitis B.

Hassan MA, Kim WR, Li R, Smith CI, Fried MW, Sterling RK, Ghany MG, Wahed AS, Ganova-Raeva LM, Roberts LR, Lok ASF; Hepatitis B Research Network.

Am J Epidemiol. 2017 Aug 1;186(3):356-366. doi: 10.1093/aje/kwx064.

28.

ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library.

Gustafsson MO, Mohammad DK, Ylösmäki E, Choi H, Shrestha S, Wang Q, Nore BF, Saksela K, Smith CI.

PLoS One. 2017 Apr 3;12(4):e0174909. doi: 10.1371/journal.pone.0174909. eCollection 2017.

29.

CTG repeat-targeting oligonucleotides for down-regulating Huntingtin expression.

Zaghloul EM, Gissberg O, Moreno PMD, Siggens L, Hällbrink M, Jørgensen AS, Ekwall K, Zain R, Wengel J, Lundin KE, Smith CIE.

Nucleic Acids Res. 2017 May 19;45(9):5153-5169. doi: 10.1093/nar/gkx111.

30.

Determination of hepatitis B phenotype using biochemical and serological markers.

Di Bisceglie AM, Lombardero M, Teckman J, Roberts L, Janssen HL, Belle SH, Hoofnagle JH; Hepatitis B Research Network (HBRN).

J Viral Hepat. 2017 Apr;24(4):320-329. doi: 10.1111/jvh.12643. Epub 2016 Dec 5.

31.

Enigmas in tumor resistance to kinase inhibitors and calculation of the drug resistance index for cancer (DRIC).

Smith CIE.

Semin Cancer Biol. 2017 Aug;45:36-49. doi: 10.1016/j.semcancer.2016.11.008. Epub 2016 Nov 16. Review.

PMID:
27865897
32.

Disruption of Higher Order DNA Structures in Friedreich's Ataxia (GAA)n Repeats by PNA or LNA Targeting.

Bergquist H, Rocha CS, Álvarez-Asencio R, Nguyen CH, Rutland MW, Smith CI, Good L, Nielsen PE, Zain R.

PLoS One. 2016 Nov 15;11(11):e0165788. doi: 10.1371/journal.pone.0165788. eCollection 2016.

33.
34.
35.

Sofosbuvir plus ledispasvir for recurrent hepatitis C in liver transplant recipients.

Kwok RM, Ahn J, Schiano TD, Te HS, Potosky DR, Tierney A, Satoskar R, Robertazzi S, Rodigas C, Lee Sang M, Wiegel J, Patel N, Gripshover J, Hassan MA, Branch A, Smith CI.

Liver Transpl. 2016 Nov;22(11):1536-1543. doi: 10.1002/lt.24614.

36.

Increased sialylation of site specific O-glycoforms of hemopexin in liver disease.

Sanda M, Benicky J, Wu J, Wang Y, Makambi K, Ahn J, Smith CI, Zhao P, Zhang L, Goldman R.

Clin Proteomics. 2016 Sep 21;13:24. doi: 10.1186/s12014-016-9125-x. eCollection 2016.

37.

From identification of the BTK kinase to effective management of leukemia.

Smith CI.

Oncogene. 2017 Apr;36(15):2045-2053. doi: 10.1038/onc.2016.343. Epub 2016 Sep 26. Review.

38.

Four Novel Splice-Switch Reporter Cell Lines: Distinct Impact of Oligonucleotide Chemistry and Delivery Vector on Biological Activity.

Rocha CS, Lundin KE, Behlke MA, Zain R, El Andaloussi S, Smith CI.

Nucleic Acid Ther. 2016 Dec;26(6):381-391. Epub 2016 Sep 15.

PMID:
27629437
39.

Anion replacement at Au(110)/electrolyte interfaces.

Harrison P, Smith CI, Gründer Y, Lucas CA, Barrett SD, Weightman P.

Phys Chem Chem Phys. 2016 Sep 21;18(35):24396-400. doi: 10.1039/c6cp03576k. Epub 2016 Aug 18.

PMID:
27535898
40.

B Cell Receptor Activation Predominantly Regulates AKT-mTORC1/2 Substrates Functionally Related to RNA Processing.

Mohammad DK, Ali RH, Turunen JJ, Nore BF, Smith CI.

PLoS One. 2016 Aug 3;11(8):e0160255. doi: 10.1371/journal.pone.0160255. eCollection 2016.

41.

X-Linked Agammaglobulinemia.

Smith CIE, Berglöf A.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019.
2001 Apr 5 [updated 2016 Aug 4].

42.

Protein kinase B (AKT) regulates SYK activity and shuttling through 14-3-3 and importin 7.

Mohammad DK, Nore BF, Gustafsson MO, Mohamed AJ, Smith CIE.

Int J Biochem Cell Biol. 2016 Sep;78:63-74. doi: 10.1016/j.biocel.2016.06.024. Epub 2016 Jul 2.

PMID:
27381982
43.

Substitution scanning identifies a novel, catalytically active ibrutinib-resistant BTK cysteine 481 to threonine (C481T) variant.

Hamasy A, Wang Q, Blomberg KE, Mohammad DK, Yu L, Vihinen M, Berglöf A, Smith CI.

Leukemia. 2017 Jan;31(1):177-185. doi: 10.1038/leu.2016.153. Epub 2016 May 25.

44.

Diet and Activity Programs Are Ineffective in Nonalcoholic Steatohepatitis.

Koch TR, Shope TR, Smith CI.

Mayo Clin Proc. 2016 May;91(5):683-4. doi: 10.1016/j.mayocp.2016.02.021. No abstract available.

PMID:
27150215
45.

Lipid-based Transfection Reagents Exhibit Cryo-induced Increase in Transfection Efficiency.

Sork H, Nordin JZ, Turunen JJ, Wiklander OP, Bestas B, Zaghloul EM, Margus H, Padari K, Duru AD, Corso G, Bost J, Vader P, Pooga M, Smith CE, Wood MJ, Schiffelers RM, Hällbrink M, Andaloussi SE.

Mol Ther Nucleic Acids. 2016 Mar 8;5:e290. doi: 10.1038/mtna.2016.8.

46.

Wnt/β-Catenin Stimulation and Laminins Support Cardiovascular Cell Progenitor Expansion from Human Fetal Cardiac Mesenchymal Stromal Cells.

Månsson-Broberg A, Rodin S, Bulatovic I, Ibarra C, Löfling M, Genead R, Wärdell E, Felldin U, Granath C, Alici E, Le Blanc K, Smith CIE, Salašová A, Westgren M, Sundström E, Uhlén P, Arenas E, Sylvén C, Tryggvason K, Corbascio M, Simonson OE, Österholm C, Grinnemo KH.

Stem Cell Reports. 2016 Apr 12;6(4):607-617. doi: 10.1016/j.stemcr.2016.02.014. Epub 2016 Mar 24.

47.

mRNA and microRNA transcriptomics analyses in a murine model of dystrophin loss and therapeutic restoration.

Roberts TC, Blomberg KE, Smith CI, El Andaloussi S, Wood MJ.

Genom Data. 2015 Dec 2;7:88-9. doi: 10.1016/j.gdata.2015.11.025. eCollection 2016 Mar.

48.

Fast and efficient synthesis of Zorro-LNA type 3'-5'-5'-3' oligonucleotide conjugates via parallel in situ stepwise conjugation.

Gissberg OI, Jezowska M, Zaghloul EM, Bungsu NI, Strömberg R, Smith CI, Lundin KE, Honcharenko M.

Org Biomol Chem. 2016 Apr 14;14(14):3584-90. doi: 10.1039/c6ob00211k. Epub 2016 Mar 15.

PMID:
26975344
49.

Cells release subpopulations of exosomes with distinct molecular and biological properties.

Willms E, Johansson HJ, Mäger I, Lee Y, Blomberg KE, Sadik M, Alaarg A, Smith CI, Lehtiö J, El Andaloussi S, Wood MJ, Vader P.

Sci Rep. 2016 Mar 2;6:22519. doi: 10.1038/srep22519.

50.

Delivery, Effect on Cell Viability, and Plasticity of Modified Aptamer Constructs.

Gissberg O, Zaghloul EM, Lundin KE, Nguyen CH, Landras-Guetta C, Wengel J, Zain R, Smith CI.

Nucleic Acid Ther. 2016 Jun;26(3):183-9. doi: 10.1089/nat.2015.0592. Epub 2016 Feb 9.

PMID:
26859550

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