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Items: 1 to 50 of 196

1.

CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry.

Van Hout A, Klarenbeek A, Bobkov V, Doijen J, Arimont M, Zhao C, Heukers R, Rimkunas R, de Graaf C, Verrips T, van der Woning B, de Haard H, Rucker JB, Vermeire K, Handel T, Van Loy T, Smit MJ, Schols D.

Biochem Pharmacol. 2018 Oct 17. pii: S0006-2952(18)30436-2. doi: 10.1016/j.bcp.2018.10.015. [Epub ahead of print]

PMID:
30342024
2.

Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions.

Bobkov V, Zarca AM, Van Hout A, Arimont M, Doijen J, Bialkowska M, Toffoli E, Klarenbeek A, van der Woning B, van der Vliet HJ, Van Loy T, de Haard H, Schols D, Heukers R, Smit MJ.

Biochem Pharmacol. 2018 Oct 17. pii: S0006-2952(18)30435-0. doi: 10.1016/j.bcp.2018.10.014. [Epub ahead of print]

PMID:
30342023
3.

Serious complications after button battery ingestion in children.

Krom H, Visser M, Hulst JM, Wolters VM, Van den Neucker AM, de Meij T, van der Doef HPJ, Norbruis OF, Benninga MA, Smit MJM, Kindermann A.

Eur J Pediatr. 2018 Jul;177(7):1063-1070. doi: 10.1007/s00431-018-3154-6. Epub 2018 May 2.

4.

The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth.

Heukers R, Fan TS, de Wit RH, van Senten JR, De Groof TWM, Bebelman MP, Lagerweij T, Vieira J, de Munnik SM, Smits-de Vries L, van Offenbeek J, Rahbar A, van Hoorick D, Söderberg-Naucler C, Würdinger T, Leurs R, Siderius M, Vischer HF, Smit MJ.

Oncogene. 2018 Jul;37(30):4110-4121. doi: 10.1038/s41388-018-0255-7. Epub 2018 Apr 30.

5.

Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma.

Zomerman WW, Plasschaert SLA, Conroy S, Scherpen FJ, Meeuwsen-de Boer TGJ, Lourens HJ, Guerrero Llobet S, Smit MJ, Slagter-Menkema L, Seitz A, Gidding CEM, Hulleman E, Wesseling P, Meijer L, van Kempen LC, van den Berg A, Warmerdam DO, Kruyt FAE, Foijer F, van Vugt MATM, den Dunnen WFA, Hoving EW, Guryev V, de Bont ESJM, Bruggeman SWM.

Cell Rep. 2018 Mar 20;22(12):3206-3216. doi: 10.1016/j.celrep.2018.02.089.

6.

Biogenesis and function of extracellular vesicles in cancer.

Bebelman MP, Smit MJ, Pegtel DM, Baglio SR.

Pharmacol Ther. 2018 Aug;188:1-11. doi: 10.1016/j.pharmthera.2018.02.013. Epub 2018 Feb 21. Review.

7.

Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology.

Hauwert NJ, Mocking TAM, Da Costa Pereira D, Kooistra AJ, Wijnen LM, Vreeker GCM, Verweij EWE, De Boer AH, Smit MJ, De Graaf C, Vischer HF, de Esch IJP, Wijtmans M, Leurs R.

J Am Chem Soc. 2018 Mar 28;140(12):4232-4243. doi: 10.1021/jacs.7b11422. Epub 2018 Mar 14.

8.

Correction: Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

Verweij FJ, Bebelman MP, Jimenez CR, Garcia-Vallejo JJ, Janssen H, Neefjes J, Knol JC, de Goeij-de Haas R, Piersma SR, Baglio SR, Verhage M, Middeldorp JM, Zomer A, van Rheenen J, Coppolino MG, Hurbain I, Raposo G, Smit MJ, Toonen RFG, van Niel G, Pegtel DM.

J Cell Biol. 2018 Mar 5;217(3):1157. doi: 10.1083/JCB.20170320601192018c. Epub 2018 Jan 23. No abstract available.

9.

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

Verweij FJ, Bebelman MP, Jimenez CR, Garcia-Vallejo JJ, Janssen H, Neefjes J, Knol JC, de Goeij-de Haas R, Piersma SR, Baglio SR, Verhage M, Middeldorp JM, Zomer A, van Rheenen J, Coppolino MG, Hurbain I, Raposo G, Smit MJ, Toonen RFG, van Niel G, Pegtel DM.

J Cell Biol. 2018 Mar 5;217(3):1129-1142. doi: 10.1083/jcb.201703206. Epub 2018 Jan 16. Erratum in: J Cell Biol. 2018 Jan 23;:.

10.

Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways To Maintain Latent Infection.

Krishna BA, Poole EL, Jackson SE, Smit MJ, Wills MR, Sinclair JH.

MBio. 2017 Dec 5;8(6). pii: e01754-17. doi: 10.1128/mBio.01754-17.

11.

CXCR4-Specific Nanobodies as Potential Therapeutics for WHIM syndrome.

de Wit RH, Heukers R, Brink HJ, Arsova A, Maussang D, Cutolo P, Strubbe B, Vischer HF, Bachelerie F, Smit MJ.

J Pharmacol Exp Ther. 2017 Oct;363(1):35-44. doi: 10.1124/jpet.117.242735. Epub 2017 Aug 2.

12.

Bridging the translational innovation gap through good biomarker practice.

van Gool AJ, Bietrix F, Caldenhoven E, Zatloukal K, Scherer A, Litton JE, Meijer G, Blomberg N, Smith A, Mons B, Heringa J, Koot WJ, Smit MJ, Hajduch M, Rijnders T, Ussi A.

Nat Rev Drug Discov. 2017 Sep;16(9):587-588. doi: 10.1038/nrd.2017.72. Epub 2017 Apr 28. No abstract available.

PMID:
28450744
13.

Autoantibodies against citrullinated histone H3 in rheumatoid arthritis and periodontitis patients.

Janssen KMJ, de Smit MJ, Withaar C, Brouwer E, van Winkelhoff AJ, Vissink A, Westra J.

J Clin Periodontol. 2017 Jun;44(6):577-584. doi: 10.1111/jcpe.12727. Epub 2017 May 23.

PMID:
28370244
14.

Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1α/PKM2 axis in glioblastoma cells.

de Wit RH, Mujić-Delić A, van Senten JR, Fraile-Ramos A, Siderius M, Smit MJ.

Oncotarget. 2016 Oct 18;7(42):67966-67985. doi: 10.18632/oncotarget.11817.

15.

Regulatory CD4+ T-Cell Subsets and Anti-Citrullinated Protein Antibody Repertoire: Potential Biomarkers for Arthritis Development in Seropositive Arthralgia Patients?

Janssen KM, Westra J, Chalan P, Boots AM, de Smit MJ, van Winkelhoff AJ, Vissink A, Brouwer E.

PLoS One. 2016 Sep 1;11(9):e0162101. doi: 10.1371/journal.pone.0162101. eCollection 2016.

16.

Human Cytomegalovirus-Encoded Receptor US28 Is Expressed in Renal Allografts and Facilitates Viral Spreading In Vitro.

Lollinga WT, de Wit RH, Rahbar A, Vasse GF, Davoudi B, Diepstra A, Riezebos-Brilman A, Harmsen MC, Hillebrands JL, Söderberg-Naucler C, van Son WJ, Smit MJ, Sanders JS, van den Born J.

Transplantation. 2017 Mar;101(3):531-540. doi: 10.1097/TP.0000000000001289.

PMID:
27362315
17.

Construction and Experimental Validation of a Petri Net Model of Wnt/β-Catenin Signaling.

Jacobsen A, Heijmans N, Verkaar F, Smit MJ, Heringa J, van Amerongen R, Feenstra KA.

PLoS One. 2016 May 24;11(5):e0155743. doi: 10.1371/journal.pone.0155743. eCollection 2016.

18.

The viral G protein-coupled receptor ORF74 unmasks phospholipase C signaling of the receptor tyrosine kinase IGF-1R.

de Munnik SM, van der Lee R, Velders DM, van Offenbeek J, Smits-de Vries L, Leurs R, Smit MJ, Vischer HF.

Cell Signal. 2016 Jun;28(6):595-605. doi: 10.1016/j.cellsig.2016.02.017. Epub 2016 Feb 27.

PMID:
26931381
19.

Molecular Pharmacology of Chemokine Receptors.

de Wit RH, de Munnik SM, Leurs R, Vischer HF, Smit MJ.

Methods Enzymol. 2016;570:457-515. doi: 10.1016/bs.mie.2015.12.002. Epub 2016 Jan 19.

PMID:
26921959
20.

Combined CXCR3/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative co-operativity of the receptors.

Ganghammer S, Gutjahr J, Hutterer E, Krenn PW, Pucher S, Zelle-Rieser C, Jöhrer K, Wijtmans M, Leurs R, Smit MJ, Gattei V, Greil R, Hartmann TN.

Haematologica. 2016 Mar;101(3):e99-102. doi: 10.3324/haematol.2015.133470. Epub 2015 Nov 20. No abstract available.

21.

At-line coupling of LC-MS to bioaffinity and selectivity assessment for metabolic profiling of ligands towards chemokine receptors CXCR1 and CXCR2.

Mladic M, Scholten DJ, Niessen WM, Somsen GW, Smit MJ, Kool J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:42-53. doi: 10.1016/j.jchromb.2015.08.004. Epub 2015 Aug 10.

PMID:
26301479
22.

Metabolic profiling of ligands for the chemokine receptor CXCR3 by liquid chromatography-mass spectrometry coupled to bioaffinity assessment.

Mladic M, Scholten DJ, Wijtmans M, Falck D, Leurs R, Niessen WM, Smit MJ, Kool J.

Anal Bioanal Chem. 2015 Sep;407(23):7067-81. doi: 10.1007/s00216-015-8867-z. Epub 2015 Jul 12.

23.

G Protein-Coupled Receptor Signaling Networks from a Systems Perspective.

Roth S, Kholodenko BN, Smit MJ, Bruggeman FJ.

Mol Pharmacol. 2015 Sep;88(3):604-16. doi: 10.1124/mol.115.100057. Epub 2015 Jul 10. Review.

24.

Exploring the Biology of G Protein-Coupled Receptors from In Vitro to In Vivo.

Bohn LM, Lohse MJ, Nitabach MN, Taghert PH, Smit MJ.

Mol Pharmacol. 2015 Sep;88(3):534-5. doi: 10.1124/mol.115.100750. Epub 2015 Jul 10.

25.

Rheumatoid arthritis-associated autoantibodies in non-rheumatoid arthritis patients with mucosal inflammation: a case-control study.

Janssen KM, de Smit MJ, Brouwer E, de Kok FA, Kraan J, Altenburg J, Verheul MK, Trouw LA, van Winkelhoff AJ, Vissink A, Westra J.

Arthritis Res Ther. 2015 Jul 9;17:174. doi: 10.1186/s13075-015-0690-6.

26.

Novel Human Cytomegalovirus Viral Chemokines, vCXCL-1s, Display Functional Selectivity for Neutrophil Signaling and Function.

Heo J, Dogra P, Masi TJ, Pitt EA, de Kruijf P, Smit MJ, Sparer TE.

J Immunol. 2015 Jul 1;195(1):227-36. doi: 10.4049/jimmunol.1400291. Epub 2015 May 18.

27.

Periodontitis and Rheumatoid Arthritis: What Do We Know?

de Smit MJ, Westra J, Brouwer E, Janssen KM, Vissink A, van Winkelhoff AJ.

J Periodontol. 2015 Sep;86(9):1013-9. doi: 10.1902/jop.2015.150088. Epub 2015 May 13.

PMID:
25968957
28.

The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines.

de Munnik SM, Kooistra AJ, van Offenbeek J, Nijmeijer S, de Graaf C, Smit MJ, Leurs R, Vischer HF.

PLoS One. 2015 Apr 20;10(4):e0124486. doi: 10.1371/journal.pone.0124486. eCollection 2015.

29.

Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.

de Munnik SM, Smit MJ, Leurs R, Vischer HF.

Front Pharmacol. 2015 Mar 9;6:40. doi: 10.3389/fphar.2015.00040. eCollection 2015. Review.

30.

Pharmacological characterization of [3H]VUF11211, a novel radiolabeled small-molecule inverse agonist for the chemokine receptor CXCR3.

Scholten DJ, Wijtmans M, van Senten JR, Custers H, Stunnenberg A, de Esch IJ, Smit MJ, Leurs R.

Mol Pharmacol. 2015 Apr;87(4):639-48. doi: 10.1124/mol.114.095265. Epub 2015 Jan 9.

31.

The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection.

Torraca V, Cui C, Boland R, Bebelman JP, van der Sar AM, Smit MJ, Siderius M, Spaink HP, Meijer AH.

Dis Model Mech. 2015 Mar;8(3):253-69. doi: 10.1242/dmm.017756. Epub 2015 Jan 8.

32.

Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17.

Maravillas-Montero JL, Burkhardt AM, Hevezi PA, Carnevale CD, Smit MJ, Zlotnik A.

J Immunol. 2015 Jan 1;194(1):29-33. doi: 10.4049/jimmunol.1401704. Epub 2014 Nov 19.

33.

eXamine: exploring annotated modules in networks.

Dinkla K, El-Kebir M, Bucur CI, Siderius M, Smit MJ, Westenberg MA, Klau GW.

BMC Bioinformatics. 2014 Jul 10;15:201. doi: 10.1186/1471-2105-15-201.

34.

Identification and characterization of circulating variants of CXCL12 from human plasma: effects on chemotaxis and mobilization of hematopoietic stem and progenitor cells.

Richter R, Jochheim-Richter A, Ciuculescu F, Kollar K, Seifried E, Forssmann U, Verzijl D, Smit MJ, Blanchet X, von Hundelshausen P, Weber C, Forssmann WG, Henschler R.

Stem Cells Dev. 2014 Aug 15;23(16):1959-74. doi: 10.1089/scd.2013.0524. Epub 2014 May 27.

35.

GPCR-targeting nanobodies: attractive research tools, diagnostics, and therapeutics.

Mujić-Delić A, de Wit RH, Verkaar F, Smit MJ.

Trends Pharmacol Sci. 2014 May;35(5):247-55. doi: 10.1016/j.tips.2014.03.003. Epub 2014 Mar 30. Review.

PMID:
24690241
36.

Chemokine cooperativity is caused by competitive glycosaminoglycan binding.

Verkaar F, van Offenbeek J, van der Lee MMC, van Lith LHCJ, Watts AO, Rops ALWMM, Aguilar DC, Ziarek JJ, van der Vlag J, Handel TM, Volkman BF, Proudfoot AEI, Vischer HF, Zaman GJR, Smit MJ.

J Immunol. 2014 Apr 15;192(8):3908-3914. doi: 10.4049/jimmunol.1302159. Epub 2014 Mar 17.

37.

Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?

Vischer HF, Siderius M, Leurs R, Smit MJ.

Nat Rev Drug Discov. 2014 Feb;13(2):123-39. doi: 10.1038/nrd4189. Epub 2014 Jan 21. Review.

PMID:
24445563
38.

Identification of overlapping but differential binding sites for the high-affinity CXCR3 antagonists NBI-74330 and VUF11211.

Scholten DJ, Roumen L, Wijtmans M, Verkade-Vreeker MC, Custers H, Lai M, de Hooge D, Canals M, de Esch IJ, Smit MJ, de Graaf C, Leurs R.

Mol Pharmacol. 2014 Jan;85(1):116-26. doi: 10.1124/mol.113.088633. Epub 2013 Oct 30.

39.

Elimination of macrophages drives LXR-induced regression both in initial and advanced stages of atherosclerotic lesion development.

van der Stoep M, Li Z, Calpe-Berdiel L, van der Sluis RJ, Saleh P, McKinnon HJ, Smit MJ, Korporaal SJ, Van Berkel TJ, Van Eck M, Hoekstra M.

Biochem Pharmacol. 2013 Dec 1;86(11):1594-602. doi: 10.1016/j.bcp.2013.09.019. Epub 2013 Oct 2.

PMID:
24095721
40.

Llama-derived single variable domains (nanobodies) directed against chemokine receptor CXCR7 reduce head and neck cancer cell growth in vivo.

Maussang D, Mujić-Delić A, Descamps FJ, Stortelers C, Vanlandschoot P, Stigter-van Walsum M, Vischer HF, van Roy M, Vosjan M, Gonzalez-Pajuelo M, van Dongen GA, Merchiers P, van Rompaey P, Smit MJ.

J Biol Chem. 2013 Oct 11;288(41):29562-72. doi: 10.1074/jbc.M113.498436. Epub 2013 Aug 26.

41.

Multiple binding sites for small-molecule antagonists at the CC chemokine receptor 2.

Zweemer AJ, Nederpelt I, Vrieling H, Hafith S, Doornbos ML, de Vries H, Abt J, Gross R, Stamos D, Saunders J, Smit MJ, Ijzerman AP, Heitman LH.

Mol Pharmacol. 2013 Oct;84(4):551-61. doi: 10.1124/mol.113.086850. Epub 2013 Jul 22.

42.

Neutralizing nanobodies targeting diverse chemokines effectively inhibit chemokine function.

Blanchetot C, Verzijl D, Mujić-Delić A, Bosch L, Rem L, Leurs R, Verrips CT, Saunders M, de Haard H, Smit MJ.

J Biol Chem. 2013 Aug 30;288(35):25173-82. doi: 10.1074/jbc.M113.467969. Epub 2013 Jul 8.

43.

Lessons to be learned from periodontitis.

Janssen KM, Vissink A, de Smit MJ, Westra J, Brouwer E.

Curr Opin Rheumatol. 2013 Mar;25(2):241-7. doi: 10.1097/BOR.0b013e32835d833d. Review.

PMID:
23370377
44.

β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR.

Watts AO, Verkaar F, van der Lee MM, Timmerman CA, Kuijer M, van Offenbeek J, van Lith LH, Smit MJ, Leurs R, Zaman GJ, Vischer HF.

J Biol Chem. 2013 Mar 8;288(10):7169-81. doi: 10.1074/jbc.M112.406108. Epub 2013 Jan 22.

45.

Identification and profiling of CXCR3-CXCR4 chemokine receptor heteromer complexes.

Watts AO, van Lipzig MM, Jaeger WC, Seeber RM, van Zwam M, Vinet J, van der Lee MM, Siderius M, Zaman GJ, Boddeke HW, Smit MJ, Pfleger KD, Leurs R, Vischer HF.

Br J Pharmacol. 2013 Apr;168(7):1662-74. doi: 10.1111/bph.12064.

46.

Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index.

van Lierop MJ, Alkema W, Laskewitz AJ, Dijkema R, van der Maaden HM, Smit MJ, Plate R, Conti PG, Jans CG, Timmers CM, van Boeckel CA, Lusher SJ, McGuire R, van Schaik RC, de Vlieg J, Smeets RL, Hofstra CL, Boots AM, van Duin M, Ingelse BA, Schoonen WG, Grefhorst A, van Dijk TH, Kuipers F, Dokter WH.

PLoS One. 2012;7(11):e48385. doi: 10.1371/journal.pone.0048385. Epub 2012 Nov 12.

47.

Chemical subtleties in small-molecule modulation of peptide receptor function: the case of CXCR3 biaryl-type ligands.

Wijtmans M, Scholten DJ, Roumen L, Canals M, Custers H, Glas M, Vreeker MC, de Kanter FJ, de Graaf C, Smit MJ, de Esch IJ, Leurs R.

J Med Chem. 2012 Dec 13;55(23):10572-83. doi: 10.1021/jm301240t. Epub 2012 Nov 14.

PMID:
23150943
48.

Constitutive β-catenin signaling by the viral chemokine receptor US28.

Langemeijer EV, Slinger E, de Munnik S, Schreiber A, Maussang D, Vischer H, Verkaar F, Leurs R, Siderius M, Smit MJ.

PLoS One. 2012;7(11):e48935. doi: 10.1371/journal.pone.0048935. Epub 2012 Nov 8.

49.

Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR.

Vinet J, van Zwam M, Dijkstra IM, Brouwer N, van Weering HR, Watts A, Meijer M, Fokkens MR, Kannan V, Verzijl D, Vischer HF, Smit MJ, Leurs R, Biber K, Boddeke HW.

Br J Pharmacol. 2013 Mar;168(6):1375-87. doi: 10.1111/bph.12042.

50.

Multitasking during patient handover in the recovery room.

van Rensen EL, Groen ES, Numan SC, Smit MJ, Cremer OL, Tates K, Kalkman CJ.

Anesth Analg. 2012 Nov;115(5):1183-7. doi: 10.1213/ANE.0b013e31826996a2. Epub 2012 Sep 13.

PMID:
22984152

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