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Items: 1 to 50 of 209

1.

Clinical characteristics of individuals with intellectual disability who have experienced sexual abuse. An overview of the literature.

Smit MJ, Scheffers M, Emck C, van Busschbach JT, Beek PJ.

Res Dev Disabil. 2019 Dec;95:103513. doi: 10.1016/j.ridd.2019.103513. Epub 2019 Oct 22. Review.

PMID:
31654947
2.

From Insight to Modulation of CXCR4 and ACKR3 (CXCR7) Function.

Smit MJ, van Muijlwijk-Koezen JE.

Mol Pharmacol. 2019 Dec;96(6):735-736. doi: 10.1124/mol.119.118364. Epub 2019 Oct 17.

3.

The human cytomegalovirus-encoded G protein-coupled receptor UL33 exhibits oncomodulatory properties.

van Senten JR, Bebelman MP, Fan TS, Heukers R, Bergkamp ND, van Gasselt P, Langemeijer EV, Slinger E, Lagerweij T, Rahbar A, Stigter-van Walsum M, Maussang D, Leurs R, Musters RJP, van Dongen GAMS, Söderberg-Nauclér C, Würdinger T, Siderius M, Smit MJ.

J Biol Chem. 2019 Nov 1;294(44):16297-16308. doi: 10.1074/jbc.RA119.007796. Epub 2019 Sep 13.

PMID:
31519750
4.

Antibodies Targeting Chemokine Receptors CXCR4 and ACKR3.

Bobkov V, Arimont M, Zarca A, De Groof TWM, van der Woning B, de Haard H, Smit MJ.

Mol Pharmacol. 2019 Dec;96(6):753-764. doi: 10.1124/mol.119.116954. Epub 2019 Sep 3.

5.

Nanobody-Targeted Photodynamic Therapy Selectively Kills Viral GPCR-Expressing Glioblastoma Cells.

De Groof TWM, Mashayekhi V, Fan TS, Bergkamp ND, Sastre Toraño J, van Senten JR, Heukers R, Smit MJ, Oliveira S.

Mol Pharm. 2019 Jul 1;16(7):3145-3156. doi: 10.1021/acs.molpharmaceut.9b00360. Epub 2019 Jun 19.

6.

Cytokines in gingivocrevicular fluid of rheumatoid arthritis patients: A review of the literature.

Rahajoe PS, Smit MJ, Kertia N, Westra J, Vissink A.

Oral Dis. 2019 Sep;25(6):1423-1434. doi: 10.1111/odi.13145. Epub 2019 Jun 28.

PMID:
31206910
7.

[Psychiatric symptoms in a child with gluten sensitivity].

Kraijenhoff GPS, Smit MJM, van Vlerken RHT, Mearin Manrique ML.

Ned Tijdschr Geneeskd. 2019 Mar 14;163. pii: D2900. Dutch.

PMID:
30945820
8.

Nanobodies detecting and modulating GPCRs outside in and inside out.

Heukers R, De Groof TWM, Smit MJ.

Curr Opin Cell Biol. 2019 Apr;57:115-122. doi: 10.1016/j.ceb.2019.01.003. Epub 2019 Mar 5. Review.

PMID:
30849632
9.

CXCR4/ACKR3 Phosphorylation and Recruitment of Interacting Proteins: Key Mechanisms Regulating Their Functional Status.

Fumagalli A, Zarca A, Neves M, Caspar B, Hill SJ, Mayor F Jr, Smit MJ, Marin P.

Mol Pharmacol. 2019 Dec;96(6):794-808. doi: 10.1124/mol.118.115360. Epub 2019 Mar 5.

10.

The Role of ACKR3 in Breast, Lung, and Brain Cancer.

Neves M, Fumagalli A, van den Bor J, Marin P, Smit MJ, Mayor F.

Mol Pharmacol. 2019 Dec;96(6):819-825. doi: 10.1124/mol.118.115279. Epub 2019 Feb 11.

11.

Nanobodies: New avenues for imaging, stabilizing and modulating GPCRs.

De Groof TWM, Bobkov V, Heukers R, Smit MJ.

Mol Cell Endocrinol. 2019 Mar 15;484:15-24. doi: 10.1016/j.mce.2019.01.021. Epub 2019 Jan 26. Review.

12.

Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists.

Adlere I, Sun S, Zarca A, Roumen L, Gozelle M, Viciano CP, Caspar B, Arimont M, Bebelman JP, Briddon SJ, Hoffmann C, Hill SJ, Smit MJ, Vischer HF, Wijtmans M, de Graaf C, de Esch IJP, Leurs R.

Eur J Med Chem. 2019 Jan 15;162:631-649. doi: 10.1016/j.ejmech.2018.10.060. Epub 2018 Oct 30.

PMID:
30476826
13.

Heterogeneity assessment of antibody-derived therapeutics at the intact and middle-up level by low-flow sheathless capillary electrophoresis-mass spectrometry.

Haselberg R, De Vijlder T, Heukers R, Smit MJ, Romijn EP, Somsen GW, Domínguez-Vega E.

Anal Chim Acta. 2018 Dec 31;1044:181-190. doi: 10.1016/j.aca.2018.08.024. Epub 2018 Aug 15.

14.

CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry.

Van Hout A, Klarenbeek A, Bobkov V, Doijen J, Arimont M, Zhao C, Heukers R, Rimkunas R, de Graaf C, Verrips T, van der Woning B, de Haard H, Rucker JB, Vermeire K, Handel T, Van Loy T, Smit MJ, Schols D.

Biochem Pharmacol. 2018 Dec;158:402-412. doi: 10.1016/j.bcp.2018.10.015. Epub 2018 Oct 17.

PMID:
30342024
15.

Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions.

Bobkov V, Zarca AM, Van Hout A, Arimont M, Doijen J, Bialkowska M, Toffoli E, Klarenbeek A, van der Woning B, van der Vliet HJ, Van Loy T, de Haard H, Schols D, Heukers R, Smit MJ.

Biochem Pharmacol. 2018 Dec;158:413-424. doi: 10.1016/j.bcp.2018.10.014. Epub 2018 Oct 17.

16.

Serious complications after button battery ingestion in children.

Krom H, Visser M, Hulst JM, Wolters VM, Van den Neucker AM, de Meij T, van der Doef HPJ, Norbruis OF, Benninga MA, Smit MJM, Kindermann A.

Eur J Pediatr. 2018 Jul;177(7):1063-1070. doi: 10.1007/s00431-018-3154-6. Epub 2018 May 2.

17.

The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth.

Heukers R, Fan TS, de Wit RH, van Senten JR, De Groof TWM, Bebelman MP, Lagerweij T, Vieira J, de Munnik SM, Smits-de Vries L, van Offenbeek J, Rahbar A, van Hoorick D, Söderberg-Naucler C, Würdinger T, Leurs R, Siderius M, Vischer HF, Smit MJ.

Oncogene. 2018 Jul;37(30):4110-4121. doi: 10.1038/s41388-018-0255-7. Epub 2018 Apr 30.

18.

Identification of Two Protein-Signaling States Delineating Transcriptionally Heterogeneous Human Medulloblastoma.

Zomerman WW, Plasschaert SLA, Conroy S, Scherpen FJ, Meeuwsen-de Boer TGJ, Lourens HJ, Guerrero Llobet S, Smit MJ, Slagter-Menkema L, Seitz A, Gidding CEM, Hulleman E, Wesseling P, Meijer L, van Kempen LC, van den Berg A, Warmerdam DO, Kruyt FAE, Foijer F, van Vugt MATM, den Dunnen WFA, Hoving EW, Guryev V, de Bont ESJM, Bruggeman SWM.

Cell Rep. 2018 Mar 20;22(12):3206-3216. doi: 10.1016/j.celrep.2018.02.089.

19.

Biogenesis and function of extracellular vesicles in cancer.

Bebelman MP, Smit MJ, Pegtel DM, Baglio SR.

Pharmacol Ther. 2018 Aug;188:1-11. doi: 10.1016/j.pharmthera.2018.02.013. Epub 2018 Feb 21. Review.

20.

Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology.

Hauwert NJ, Mocking TAM, Da Costa Pereira D, Kooistra AJ, Wijnen LM, Vreeker GCM, Verweij EWE, De Boer AH, Smit MJ, De Graaf C, Vischer HF, de Esch IJP, Wijtmans M, Leurs R.

J Am Chem Soc. 2018 Mar 28;140(12):4232-4243. doi: 10.1021/jacs.7b11422. Epub 2018 Mar 14.

21.

Correction: Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

Verweij FJ, Bebelman MP, Jimenez CR, Garcia-Vallejo JJ, Janssen H, Neefjes J, Knol JC, de Goeij-de Haas R, Piersma SR, Baglio SR, Verhage M, Middeldorp JM, Zomer A, van Rheenen J, Coppolino MG, Hurbain I, Raposo G, Smit MJ, Toonen RFG, van Niel G, Pegtel DM.

J Cell Biol. 2018 Mar 5;217(3):1157. doi: 10.1083/JCB.20170320601192018c. Epub 2018 Jan 23. No abstract available.

22.

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.

Verweij FJ, Bebelman MP, Jimenez CR, Garcia-Vallejo JJ, Janssen H, Neefjes J, Knol JC, de Goeij-de Haas R, Piersma SR, Baglio SR, Verhage M, Middeldorp JM, Zomer A, van Rheenen J, Coppolino MG, Hurbain I, Raposo G, Smit MJ, Toonen RFG, van Niel G, Pegtel DM.

J Cell Biol. 2018 Mar 5;217(3):1129-1142. doi: 10.1083/jcb.201703206. Epub 2018 Jan 16. Erratum in: J Cell Biol. 2018 Jan 23;:.

23.

Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways To Maintain Latent Infection.

Krishna BA, Poole EL, Jackson SE, Smit MJ, Wills MR, Sinclair JH.

MBio. 2017 Dec 5;8(6). pii: e01754-17. doi: 10.1128/mBio.01754-17.

24.

CXCR4-Specific Nanobodies as Potential Therapeutics for WHIM syndrome.

de Wit RH, Heukers R, Brink HJ, Arsova A, Maussang D, Cutolo P, Strubbe B, Vischer HF, Bachelerie F, Smit MJ.

J Pharmacol Exp Ther. 2017 Oct;363(1):35-44. doi: 10.1124/jpet.117.242735. Epub 2017 Aug 2.

PMID:
28768817
25.

Bridging the translational innovation gap through good biomarker practice.

van Gool AJ, Bietrix F, Caldenhoven E, Zatloukal K, Scherer A, Litton JE, Meijer G, Blomberg N, Smith A, Mons B, Heringa J, Koot WJ, Smit MJ, Hajduch M, Rijnders T, Ussi A.

Nat Rev Drug Discov. 2017 Sep;16(9):587-588. doi: 10.1038/nrd.2017.72. Epub 2017 Apr 28. No abstract available.

PMID:
28450744
26.

Autoantibodies against citrullinated histone H3 in rheumatoid arthritis and periodontitis patients.

Janssen KMJ, de Smit MJ, Withaar C, Brouwer E, van Winkelhoff AJ, Vissink A, Westra J.

J Clin Periodontol. 2017 Jun;44(6):577-584. doi: 10.1111/jcpe.12727. Epub 2017 May 23.

PMID:
28370244
27.

Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1α/PKM2 axis in glioblastoma cells.

de Wit RH, Mujić-Delić A, van Senten JR, Fraile-Ramos A, Siderius M, Smit MJ.

Oncotarget. 2016 Oct 18;7(42):67966-67985. doi: 10.18632/oncotarget.11817.

28.

Regulatory CD4+ T-Cell Subsets and Anti-Citrullinated Protein Antibody Repertoire: Potential Biomarkers for Arthritis Development in Seropositive Arthralgia Patients?

Janssen KM, Westra J, Chalan P, Boots AM, de Smit MJ, van Winkelhoff AJ, Vissink A, Brouwer E.

PLoS One. 2016 Sep 1;11(9):e0162101. doi: 10.1371/journal.pone.0162101. eCollection 2016.

29.

Human Cytomegalovirus-Encoded Receptor US28 Is Expressed in Renal Allografts and Facilitates Viral Spreading In Vitro.

Lollinga WT, de Wit RH, Rahbar A, Vasse GF, Davoudi B, Diepstra A, Riezebos-Brilman A, Harmsen MC, Hillebrands JL, Söderberg-Naucler C, van Son WJ, Smit MJ, Sanders JS, van den Born J.

Transplantation. 2017 Mar;101(3):531-540. doi: 10.1097/TP.0000000000001289.

PMID:
27362315
30.

Construction and Experimental Validation of a Petri Net Model of Wnt/β-Catenin Signaling.

Jacobsen A, Heijmans N, Verkaar F, Smit MJ, Heringa J, van Amerongen R, Feenstra KA.

PLoS One. 2016 May 24;11(5):e0155743. doi: 10.1371/journal.pone.0155743. eCollection 2016.

31.

The viral G protein-coupled receptor ORF74 unmasks phospholipase C signaling of the receptor tyrosine kinase IGF-1R.

de Munnik SM, van der Lee R, Velders DM, van Offenbeek J, Smits-de Vries L, Leurs R, Smit MJ, Vischer HF.

Cell Signal. 2016 Jun;28(6):595-605. doi: 10.1016/j.cellsig.2016.02.017. Epub 2016 Feb 27.

PMID:
26931381
32.

Molecular Pharmacology of Chemokine Receptors.

de Wit RH, de Munnik SM, Leurs R, Vischer HF, Smit MJ.

Methods Enzymol. 2016;570:457-515. doi: 10.1016/bs.mie.2015.12.002. Epub 2016 Jan 19.

PMID:
26921959
33.

Combined CXCR3/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative co-operativity of the receptors.

Ganghammer S, Gutjahr J, Hutterer E, Krenn PW, Pucher S, Zelle-Rieser C, Jöhrer K, Wijtmans M, Leurs R, Smit MJ, Gattei V, Greil R, Hartmann TN.

Haematologica. 2016 Mar;101(3):e99-102. doi: 10.3324/haematol.2015.133470. Epub 2015 Nov 20. No abstract available.

34.

At-line coupling of LC-MS to bioaffinity and selectivity assessment for metabolic profiling of ligands towards chemokine receptors CXCR1 and CXCR2.

Mladic M, Scholten DJ, Niessen WM, Somsen GW, Smit MJ, Kool J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:42-53. doi: 10.1016/j.jchromb.2015.08.004. Epub 2015 Aug 10.

PMID:
26301479
35.

Metabolic profiling of ligands for the chemokine receptor CXCR3 by liquid chromatography-mass spectrometry coupled to bioaffinity assessment.

Mladic M, Scholten DJ, Wijtmans M, Falck D, Leurs R, Niessen WM, Smit MJ, Kool J.

Anal Bioanal Chem. 2015 Sep;407(23):7067-81. doi: 10.1007/s00216-015-8867-z. Epub 2015 Jul 12.

36.

G Protein-Coupled Receptor Signaling Networks from a Systems Perspective.

Roth S, Kholodenko BN, Smit MJ, Bruggeman FJ.

Mol Pharmacol. 2015 Sep;88(3):604-16. doi: 10.1124/mol.115.100057. Epub 2015 Jul 10. Review.

PMID:
26162865
37.

Exploring the Biology of G Protein-Coupled Receptors from In Vitro to In Vivo.

Bohn LM, Lohse MJ, Nitabach MN, Taghert PH, Smit MJ.

Mol Pharmacol. 2015 Sep;88(3):534-5. doi: 10.1124/mol.115.100750. Epub 2015 Jul 10.

PMID:
26162863
38.

Rheumatoid arthritis-associated autoantibodies in non-rheumatoid arthritis patients with mucosal inflammation: a case-control study.

Janssen KM, de Smit MJ, Brouwer E, de Kok FA, Kraan J, Altenburg J, Verheul MK, Trouw LA, van Winkelhoff AJ, Vissink A, Westra J.

Arthritis Res Ther. 2015 Jul 9;17:174. doi: 10.1186/s13075-015-0690-6.

39.

Novel Human Cytomegalovirus Viral Chemokines, vCXCL-1s, Display Functional Selectivity for Neutrophil Signaling and Function.

Heo J, Dogra P, Masi TJ, Pitt EA, de Kruijf P, Smit MJ, Sparer TE.

J Immunol. 2015 Jul 1;195(1):227-36. doi: 10.4049/jimmunol.1400291. Epub 2015 May 18.

40.

Periodontitis and Rheumatoid Arthritis: What Do We Know?

de Smit MJ, Westra J, Brouwer E, Janssen KM, Vissink A, van Winkelhoff AJ.

J Periodontol. 2015 Sep;86(9):1013-9. doi: 10.1902/jop.2015.150088. Epub 2015 May 13.

PMID:
25968957
41.

The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines.

de Munnik SM, Kooistra AJ, van Offenbeek J, Nijmeijer S, de Graaf C, Smit MJ, Leurs R, Vischer HF.

PLoS One. 2015 Apr 20;10(4):e0124486. doi: 10.1371/journal.pone.0124486. eCollection 2015.

42.

Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.

de Munnik SM, Smit MJ, Leurs R, Vischer HF.

Front Pharmacol. 2015 Mar 9;6:40. doi: 10.3389/fphar.2015.00040. eCollection 2015. Review.

43.

Pharmacological characterization of [3H]VUF11211, a novel radiolabeled small-molecule inverse agonist for the chemokine receptor CXCR3.

Scholten DJ, Wijtmans M, van Senten JR, Custers H, Stunnenberg A, de Esch IJ, Smit MJ, Leurs R.

Mol Pharmacol. 2015 Apr;87(4):639-48. doi: 10.1124/mol.114.095265. Epub 2015 Jan 9.

PMID:
25576486
44.

The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection.

Torraca V, Cui C, Boland R, Bebelman JP, van der Sar AM, Smit MJ, Siderius M, Spaink HP, Meijer AH.

Dis Model Mech. 2015 Mar;8(3):253-69. doi: 10.1242/dmm.017756. Epub 2015 Jan 8.

45.

Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17.

Maravillas-Montero JL, Burkhardt AM, Hevezi PA, Carnevale CD, Smit MJ, Zlotnik A.

J Immunol. 2015 Jan 1;194(1):29-33. doi: 10.4049/jimmunol.1401704. Epub 2014 Nov 19.

46.

eXamine: exploring annotated modules in networks.

Dinkla K, El-Kebir M, Bucur CI, Siderius M, Smit MJ, Westenberg MA, Klau GW.

BMC Bioinformatics. 2014 Jul 10;15:201. doi: 10.1186/1471-2105-15-201.

47.

Identification and characterization of circulating variants of CXCL12 from human plasma: effects on chemotaxis and mobilization of hematopoietic stem and progenitor cells.

Richter R, Jochheim-Richter A, Ciuculescu F, Kollar K, Seifried E, Forssmann U, Verzijl D, Smit MJ, Blanchet X, von Hundelshausen P, Weber C, Forssmann WG, Henschler R.

Stem Cells Dev. 2014 Aug 15;23(16):1959-74. doi: 10.1089/scd.2013.0524. Epub 2014 May 27.

48.

GPCR-targeting nanobodies: attractive research tools, diagnostics, and therapeutics.

Mujić-Delić A, de Wit RH, Verkaar F, Smit MJ.

Trends Pharmacol Sci. 2014 May;35(5):247-55. doi: 10.1016/j.tips.2014.03.003. Epub 2014 Mar 30. Review.

PMID:
24690241
49.

Chemokine cooperativity is caused by competitive glycosaminoglycan binding.

Verkaar F, van Offenbeek J, van der Lee MMC, van Lith LHCJ, Watts AO, Rops ALWMM, Aguilar DC, Ziarek JJ, van der Vlag J, Handel TM, Volkman BF, Proudfoot AEI, Vischer HF, Zaman GJR, Smit MJ.

J Immunol. 2014 Apr 15;192(8):3908-3914. doi: 10.4049/jimmunol.1302159. Epub 2014 Mar 17.

50.

Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?

Vischer HF, Siderius M, Leurs R, Smit MJ.

Nat Rev Drug Discov. 2014 Feb;13(2):123-39. doi: 10.1038/nrd4189. Epub 2014 Jan 21. Review.

PMID:
24445563

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