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Items: 1 to 50 of 58


Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas.

Rosario SR, Long MD, Affronti HC, Rowsam AM, Eng KH, Smiraglia DJ.

Nat Commun. 2018 Dec 14;9(1):5330. doi: 10.1038/s41467-018-07232-8.


Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma.

Bianchi-Smiraglia A, Bagati A, Fink EE, Affronti HC, Lipchick BC, Moparthy S, Long MD, Rosario SR, Lightman SM, Moparthy K, Wolff DW, Yun DH, Han Z, Polechetti A, Roll MV, Gitlin II, Leonova KI, Rowsam AM, Kandel ES, Gudkov AV, Bergsagel PL, Lee KP, Smiraglia DJ, Nikiforov MA.

J Clin Invest. 2018 Oct 1;128(10):4682-4696. doi: 10.1172/JCI70712. Epub 2018 Sep 10.


The miR-96 and RARγ signaling axis governs androgen signaling and prostate cancer progression.

Long MD, Singh PK, Russell JR, Llimos G, Rosario S, Rizvi A, van den Berg PR, Kirk J, Sucheston-Campbell LE, Smiraglia DJ, Campbell MJ.

Oncogene. 2019 Jan;38(3):421-444. doi: 10.1038/s41388-018-0450-6. Epub 2018 Aug 17.


Dietary folate levels alter the kinetics and molecular mechanism of prostate cancer recurrence in the CWR22 model.

Affronti HC, Long MD, Rosario SR, Gillard BM, Karasik E, Boerlin CS, Pellerite AJ, Foster BA, Attwood K, Pili R, Wilton JH, Campbell MJ, Smiraglia DJ.

Oncotarget. 2017 Oct 20;8(61):103758-103774. doi: 10.18632/oncotarget.21911. eCollection 2017 Nov 28.


Internally ratiometric fluorescent sensors for evaluation of intracellular GTP levels and distribution.

Bianchi-Smiraglia A, Rana MS, Foley CE, Paul LM, Lipchick BC, Moparthy S, Moparthy K, Fink EE, Bagati A, Hurley E, Affronti HC, Bakin AV, Kandel ES, Smiraglia DJ, Feltri ML, Sousa R, Nikiforov MA.

Nat Methods. 2017 Oct;14(10):1003-1009. doi: 10.1038/nmeth.4404. Epub 2017 Sep 4.


LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer.

Battaglia S, Karasik E, Gillard B, Williams J, Winchester T, Moser MT, Smiraglia DJ, Foster BA.

Clin Epigenetics. 2017 Aug 11;9:82. doi: 10.1186/s13148-017-0382-y. eCollection 2017.


The Genomic Impact of DNA CpG Methylation on Gene Expression; Relationships in Prostate Cancer.

Long MD, Smiraglia DJ, Campbell MJ.

Biomolecules. 2017 Feb 14;7(1). pii: E15. doi: 10.3390/biom7010015. Review.


The essential role of methylthioadenosine phosphorylase in prostate cancer.

Bistulfi G, Affronti HC, Foster BA, Karasik E, Gillard B, Morrison C, Mohler J, Phillips JG, Smiraglia DJ.

Oncotarget. 2016 Mar 22;7(12):14380-93. doi: 10.18632/oncotarget.7486.


Hormone stimulation of androgen receptor mediates dynamic changes in DNA methylation patterns at regulatory elements.

Dhiman VK, Attwood K, Campbell MJ, Smiraglia DJ.

Oncotarget. 2015 Dec 15;6(40):42575-89. doi: 10.18632/oncotarget.6471.


Metastatic phenotype in CWR22 prostate cancer xenograft following castration.

Seedhouse SJ, Affronti HC, Karasik E, Gillard BM, Azabdaftari G, Smiraglia DJ, Foster BA.

Prostate. 2016 Mar;76(4):359-68. doi: 10.1002/pros.23127. Epub 2015 Dec 8.


KLLN epigenotype-phenotype associations in Cowden syndrome.

Nizialek EA, Mester JL, Dhiman VK, Smiraglia DJ, Eng C.

Eur J Hum Genet. 2015 Nov;23(11):1538-43. doi: 10.1038/ejhg.2015.8. Epub 2015 Feb 11.


Epigenetic DNA methylation of antioxidative stress regulator NRF2 in human prostate cancer.

Khor TO, Fuentes F, Shu L, Paredes-Gonzalez X, Yang AY, Liu Y, Smiraglia DJ, Yegnasubramanian S, Nelson WG, Kong AN.

Cancer Prev Res (Phila). 2014 Dec;7(12):1186-97. doi: 10.1158/1940-6207.CAPR-14-0127. Epub 2014 Sep 29.


Epigenetic changes in hypothalamic appetite regulatory genes may underlie the developmental programming for obesity in rat neonates subjected to a high-carbohydrate dietary modification.

Mahmood S, Smiraglia DJ, Srinivasan M, Patel MS.

J Dev Orig Health Dis. 2013 Dec;4(6):479-90. doi: 10.1017/S2040174413000238.


Gene silencing associated with SWI/SNF complex loss during NSCLC development.

Song S, Walter V, Karaca M, Li Y, Bartlett CS, Smiraglia DJ, Serber D, Sproul CD, Plass C, Zhang J, Hayes DN, Zheng Y, Weissman BE.

Mol Cancer Res. 2014 Apr;12(4):560-70. doi: 10.1158/1541-7786.MCR-13-0427. Epub 2014 Jan 20.


Developmental programming in skeletal muscle in response to overnourishment in the immediate postnatal life in rats.

Liu HW, Mahmood S, Srinivasan M, Smiraglia DJ, Patel MS.

J Nutr Biochem. 2013 Nov;24(11):1859-69. doi: 10.1016/j.jnutbio.2013.05.002. Epub 2013 Aug 19.


Adult-onset obesity induced by early life overnutrition could be reversed by moderate caloric restriction.

Liu HW, Srinivasan M, Mahmood S, Smiraglia DJ, Patel MS.

Am J Physiol Endocrinol Metab. 2013 Oct 1;305(7):E785-94. doi: 10.1152/ajpendo.00280.2013. Epub 2013 Jul 30.


Gene silencing of SLC5A8 identified by genome-wide methylation profiling in lung cancer.

Park JY, Kim D, Yang M, Park HY, Lee SH, Rincon M, Kreahling J, Plass C, Smiraglia DJ, Tockman MS, Kim SJ.

Lung Cancer. 2013 Mar;79(3):198-204. doi: 10.1016/j.lungcan.2012.11.019. Epub 2012 Dec 27.


Epigenetic distortion to VDR transcriptional regulation in prostate cancer cells.

Singh PK, Doig CL, Dhiman VK, Turner BM, Smiraglia DJ, Campbell MJ.

J Steroid Biochem Mol Biol. 2013 Jul;136:258-63. doi: 10.1016/j.jsbmb.2012.10.002. Epub 2012 Oct 23. Review.


Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patterns.

Doig CL, Singh PK, Dhiman VK, Thorne JL, Battaglia S, Sobolewski M, Maguire O, O'Neill LP, Turner BM, McCabe CJ, Smiraglia DJ, Campbell MJ.

Carcinogenesis. 2013 Feb;34(2):248-56. doi: 10.1093/carcin/bgs331. Epub 2012 Oct 20.


IMA: an R package for high-throughput analysis of Illumina's 450K Infinium methylation data.

Wang D, Yan L, Hu Q, Sucheston LE, Higgins MJ, Ambrosone CB, Johnson CS, Smiraglia DJ, Liu S.

Bioinformatics. 2012 Mar 1;28(5):729-30. doi: 10.1093/bioinformatics/bts013. Epub 2012 Jan 16.


Dietary folate deficiency blocks prostate cancer progression in the TRAMP model.

Bistulfi G, Foster BA, Karasik E, Gillard B, Miecznikowski J, Dhiman VK, Smiraglia DJ.

Cancer Prev Res (Phila). 2011 Nov;4(11):1825-34. doi: 10.1158/1940-6207.CAPR-11-0140. Epub 2011 Aug 11.


Mild folate deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cells.

Bistulfi G, Vandette E, Matsui S, Smiraglia DJ.

BMC Biol. 2010 Jan 21;8:6. doi: 10.1186/1741-7007-8-6.


Loss of the SMRT/NCoR2 corepressor correlates with JAG2 overexpression in multiple myeloma.

Ghoshal P, Nganga AJ, Moran-Giuati J, Szafranek A, Johnson TR, Bigelow AJ, Houde CM, Avet-Loiseau H, Smiraglia DJ, Ersing N, Chanan-Khan AA, Coignet LJ.

Cancer Res. 2009 May 15;69(10):4380-7. doi: 10.1158/0008-5472.CAN-08-3467. Epub 2009 May 5.


Polyamine biosynthesis impacts cellular folate requirements necessary to maintain S-adenosylmethionine and nucleotide pools.

Bistulfi G, Diegelman P, Foster BA, Kramer DL, Porter CW, Smiraglia DJ.

FASEB J. 2009 Sep;23(9):2888-97. doi: 10.1096/fj.09-130708. Epub 2009 May 5.


Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific.

Jun P, Hong C, Lal A, Wong JM, McDermott MW, Bollen AW, Plass C, Held WA, Smiraglia DJ, Costello JF.

Neuro Oncol. 2009 Aug;11(4):414-22. doi: 10.1215/15228517-2008-096. Epub 2008 Nov 11.


Restriction landmark genomic scanning: analysis of CpG islands in genomes by 2D gel electrophoresis.

Costello JF, Hong C, Plass C, Smiraglia DJ.

Methods Mol Biol. 2009;507:131-48. doi: 10.1007/978-1-59745-522-0_11.


Tissue specific differentially methylated regions (TDMR): Changes in DNA methylation during development.

Song F, Mahmood S, Ghosh S, Liang P, Smiraglia DJ, Nagase H, Held WA.

Genomics. 2009 Feb;93(2):130-9. doi: 10.1016/j.ygeno.2008.09.003. Epub 2008 Nov 13.


Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model.

Morey Kinney SR, Smiraglia DJ, James SR, Moser MT, Foster BA, Karpf AR.

Mol Cancer Res. 2008 Aug;6(8):1365-74. doi: 10.1158/1541-7786.MCR-08-0040. Epub 2008 Jul 30.


Phenotype-specific CpG island methylation events in a murine model of prostate cancer.

Camoriano M, Kinney SR, Moser MT, Foster BA, Mohler JL, Trump DL, Karpf AR, Smiraglia DJ.

Cancer Res. 2008 Jun 1;68(11):4173-82. doi: 10.1158/0008-5472.CAN-07-6715.


A novel role for mitochondria in regulating epigenetic modification in the nucleus.

Smiraglia DJ, Kulawiec M, Bistulfi GL, Gupta SG, Singh KK.

Cancer Biol Ther. 2008 Aug;7(8):1182-90. Epub 2008 Aug 1.


Identification of novel methylation markers in cervical cancer using restriction landmark genomic scanning.

Wang SS, Smiraglia DJ, Wu YZ, Ghosh S, Rader JS, Cho KR, Bonfiglio TA, Nayar R, Plass C, Sherman ME.

Cancer Res. 2008 Apr 1;68(7):2489-97. doi: 10.1158/0008-5472.CAN-07-3194.


Prostate-specific membrane antigen expression is a potential prognostic marker in endometrial adenocarcinoma.

Mhawech-Fauceglia P, Smiraglia DJ, Bshara W, Andrews C, Schwaller J, South S, Higgs D, Lele S, Herrmann F, Odunsi K.

Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):571-7. doi: 10.1158/1055-9965.EPI-07-0511.


Restriction landmark genomic scanning (RLGS) spot identification by second generation virtual RLGS in multiple genomes with multiple enzyme combinations.

Smiraglia DJ, Kazhiyur-Mannar R, Oakes CC, Wu YZ, Liang P, Ansari T, Su J, Rush LJ, Smith LT, Yu L, Liu C, Dai Z, Chen SS, Wang SH, Costello J, Ioshikhes I, Dawson DW, Hong JS, Teitell MA, Szafranek A, Camoriano M, Song F, Elliott R, Held W, Trasler JM, Plass C, Wenger R.

BMC Genomics. 2007 Nov 30;8:446.


Developmental acquisition of genome-wide DNA methylation occurs prior to meiosis in male germ cells.

Oakes CC, La Salle S, Smiraglia DJ, Robaire B, Trasler JM.

Dev Biol. 2007 Jul 15;307(2):368-79. Epub 2007 May 8.


A unique configuration of genome-wide DNA methylation patterns in the testis.

Oakes CC, La Salle S, Smiraglia DJ, Robaire B, Trasler JM.

Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):228-33. Epub 2006 Dec 26.


DNA methylation pathway alterations in an autochthonous murine model of prostate cancer.

Morey SR, Smiraglia DJ, James SR, Yu J, Moser MT, Foster BA, Karpf AR.

Cancer Res. 2006 Dec 15;66(24):11659-67.


Genome-wide analysis of DNA methylation changes in human malignancies.

Plass C, Smiraglia DJ.

Curr Top Microbiol Immunol. 2006;310:179-98. Review.


Contour area filtering of two-dimensional electrophoresis images.

Kazhiyur-Mannar R, Smiraglia DJ, Plass C, Wenger R.

Med Image Anal. 2006 Jun;10(3):353-65. Epub 2006 Mar 13.


Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer.

Smith LT, Lin M, Brena RM, Lang JC, Schuller DE, Otterson GA, Morrison CD, Smiraglia DJ, Plass C.

Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):982-7. Epub 2006 Jan 13.


DNA copy number gains in head and neck squamous cell carcinoma.

Lin M, Smith LT, Smiraglia DJ, Kazhiyur-Mannar R, Lang JC, Schuller DE, Kornacker K, Wenger R, Plass C.

Oncogene. 2006 Mar 2;25(9):1424-33.


The development of CpG island methylation biomarkers using restriction landmark genomic scanning.

Smiraglia DJ, Plass C.

Ann N Y Acad Sci. 2003 Mar;983:110-9. Review.


A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes.

Dai Z, Zhu WG, Morrison CD, Brena RM, Smiraglia DJ, Raval A, Wu YZ, Rush LJ, Ross P, Molina JR, Otterson GA, Plass C.

Hum Mol Genet. 2003 Apr 1;12(7):791-801.


Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats.

Oakes CC, Smiraglia DJ, Plass C, Trasler JM, Robaire B.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1775-80. Epub 2003 Feb 6.


Differential targets of CpG island hypermethylation in primary and metastatic head and neck squamous cell carcinoma (HNSCC).

Smiraglia DJ, Smith LT, Lang JC, Rush LJ, Dai Z, Schuller DE, Plass C.

J Med Genet. 2003 Jan;40(1):25-33.


An AscI boundary library for the studies of genetic and epigenetic alterations in CpG islands.

Dai Z, Weichenhan D, Wu YZ, Hall JL, Rush LJ, Smith LT, Raval A, Yu L, Kroll D, Muehlisch J, Frühwald MC, de Jong P, Catanese J, Davuluri RV, Smiraglia DJ, Plass C.

Genome Res. 2002 Oct;12(10):1591-8.


The study of aberrant methylation in cancer via restriction landmark genomic scanning.

Smiraglia DJ, Plass C.

Oncogene. 2002 Aug 12;21(35):5414-26. Review.


Restriction landmark genome scanning.

Costello JF, Smiraglia DJ, Plass C.

Methods. 2002 Jun;27(2):144-9.


Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors.

Smiraglia DJ, Szymanska J, Kraggerud SM, Lothe RA, Peltomäki P, Plass C.

Oncogene. 2002 May 30;21(24):3909-16.


Global methylation profiling of lung cancer identifies novel methylated genes.

Dai Z, Lakshmanan RR, Zhu WG, Smiraglia DJ, Rush LJ, Frühwald MC, Brena RM, Li B, Wright FA, Ross P, Otterson GA, Plass C.

Neoplasia. 2001 Jul-Aug;3(4):314-23.


Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies.

Smiraglia DJ, Rush LJ, Frühwald MC, Dai Z, Held WA, Costello JF, Lang JC, Eng C, Li B, Wright FA, Caligiuri MA, Plass C.

Hum Mol Genet. 2001 Jun 15;10(13):1413-9.


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