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Yersinia pestis Pla Protein Thwarts T Cell Defense against Plague.

Smiley ST, Szaba FM, Kummer LW, Duso DK, Lin JS.

Infect Immun. 2019 Apr 23;87(5). pii: e00126-19. doi: 10.1128/IAI.00126-19. Print 2019 Mar.


Vaccine efficacy and T helper cell differentiation change with aging.

Lefebvre JS, Lorenzo EC, Masters AR, Hopkins JW, Eaton SM, Smiley ST, Haynes L.

Oncotarget. 2016 Jun 7;7(23):33581-94. doi: 10.18632/oncotarget.9254.


Factor XI Deficiency Alters the Cytokine Response and Activation of Contact Proteases during Polymicrobial Sepsis in Mice.

Bane CE Jr, Ivanov I, Matafonov A, Boyd KL, Cheng Q, Sherwood ER, Tucker EI, Smiley ST, McCarty OJ, Gruber A, Gailani D.

PLoS One. 2016 Apr 5;11(4):e0152968. doi: 10.1371/journal.pone.0152968. eCollection 2016.


Progress toward curing HIV infections with hematopoietic stem cell transplantation.

Smiley ST, Singh A, Read SW, Sharma OK, Finzi D, Lane C, Rice JS.

Clin Infect Dis. 2015 Jan 15;60(2):292-7. doi: 10.1093/cid/ciu766. Epub 2014 Oct 1. Review.


TNFα and IFNγ but not perforin are critical for CD8 T cell-mediated protection against pulmonary Yersinia pestis infection.

Szaba FM, Kummer LW, Duso DK, Koroleva EP, Tumanov AV, Cooper AM, Bliska JB, Smiley ST, Lin JS.

PLoS Pathog. 2014 May 22;10(5):e1004142. doi: 10.1371/journal.ppat.1004142. eCollection 2014 May.


Intranasal prophylaxis with CpG oligodeoxynucleotide can protect against Yersinia pestis infection.

Hickey AJ, Lin JS, Kummer LW, Szaba FM, Duso DK, Tighe M, Parent MA, Smiley ST.

Infect Immun. 2013 Jun;81(6):2123-32. doi: 10.1128/IAI.00316-13. Epub 2013 Apr 1.


Fibrin facilitates both innate and T cell-mediated defense against Yersinia pestis.

Luo D, Lin JS, Parent MA, Mullarky-Kanevsky I, Szaba FM, Kummer LW, Duso DK, Tighe M, Hill J, Gruber A, Mackman N, Gailani D, Smiley ST.

J Immunol. 2013 Apr 15;190(8):4149-61. doi: 10.4049/jimmunol.1203253. Epub 2013 Mar 13.


Gammaherpesvirus latency induces antibody-associated thrombocytopenia in mice.

Freeman ML, Burkum CE, Lanzer KG, Roberts AD, Pinkevych M, Itakura A, Kummer LW, Szaba FM, Davenport MP, McCarty OJ, Woodland DL, Smiley ST, Blackman MA.

J Autoimmun. 2013 May;42:71-9. doi: 10.1016/j.jaut.2012.11.005. Epub 2012 Dec 14.


Immunity to the conserved influenza nucleoprotein reduces susceptibility to secondary bacterial infections.

Haynes L, Szaba FM, Eaton SM, Kummer LW, Lanthier PA, Petell AH, Duso DK, Luo D, Lin JS, Lefebvre JS, Randall TD, Johnson LL, Kohlmeier JE, Woodland DL, Smiley ST.

J Immunol. 2012 Nov 15;189(10):4921-9. doi: 10.4049/jimmunol.1201916. Epub 2012 Oct 1.


A protective epitope in type III effector YopE is a major CD8 T cell antigen during primary infection with Yersinia pseudotuberculosis.

Zhang Y, Mena P, Romanov G, Lin JS, Smiley ST, Bliska JB.

Infect Immun. 2012 Jan;80(1):206-14. doi: 10.1128/IAI.05971-11. Epub 2011 Nov 7.


Factor XI-deficient mice display reduced inflammation, coagulopathy, and bacterial growth during listeriosis.

Luo D, Szaba FM, Kummer LW, Johnson LL, Tucker EI, Gruber A, Gailani D, Smiley ST.

Infect Immun. 2012 Jan;80(1):91-9. doi: 10.1128/IAI.05568-11. Epub 2011 Oct 17.


Live attenuated influenza vaccine (LAIV) impacts innate and adaptive immune responses.

Lanthier PA, Huston GE, Moquin A, Eaton SM, Szaba FM, Kummer LW, Tighe MP, Kohlmeier JE, Blair PJ, Broderick M, Smiley ST, Haynes L.

Vaccine. 2011 Oct 13;29(44):7849-56. doi: 10.1016/j.vaccine.2011.07.093. Epub 2011 Aug 2.


Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica.

Luo D, Szaba FM, Kummer LW, Plow EF, Mackman N, Gailani D, Smiley ST.

J Immunol. 2011 Aug 15;187(4):1866-76. doi: 10.4049/jimmunol.1101094. Epub 2011 Jul 1.


Yersinia pestis YopE contains a dominant CD8 T cell epitope that confers protection in a mouse model of pneumonic plague.

Lin JS, Szaba FM, Kummer LW, Chromy BA, Smiley ST.

J Immunol. 2011 Jul 15;187(2):897-904. doi: 10.4049/jimmunol.1100174. Epub 2011 Jun 8.


IL-17 contributes to cell-mediated defense against pulmonary Yersinia pestis infection.

Lin JS, Kummer LW, Szaba FM, Smiley ST.

J Immunol. 2011 Feb 1;186(3):1675-84. doi: 10.4049/jimmunol.1003303. Epub 2010 Dec 20.


TNFα and IFNγ contribute to F1/LcrV-targeted immune defense in mouse models of fully virulent pneumonic plague.

Lin JS, Park S, Adamovicz JJ, Hill J, Bliska JB, Cote CK, Perlin DS, Amemiya K, Smiley ST.

Vaccine. 2010 Dec 16;29(2):357-62. doi: 10.1016/j.vaccine.2010.08.099. Epub 2010 Sep 15.


Mycobacterium tuberculosis infection induces il12rb1 splicing to generate a novel IL-12Rbeta1 isoform that enhances DC migration.

Robinson RT, Khader SA, Martino CA, Fountain JJ, Teixeira-Coelho M, Pearl JE, Smiley ST, Winslow GM, Woodland DL, Walter MJ, Conejo-Garcia JR, Gubler U, Cooper AM.

J Exp Med. 2010 Mar 15;207(3):591-605. doi: 10.1084/jem.20091085. Epub 2010 Mar 8. Erratum in: J Exp Med. 2010 Apr 12;207(4):897.


Fibrinogen regulates the cytotoxicity of mycobacterial trehalose dimycolate but is not required for cell recruitment, cytokine response, or control of mycobacterial infection.

Sakamoto K, Geisel RE, Kim MJ, Wyatt BT, Sellers LB, Smiley ST, Cooper AM, Russell DG, Rhoades ER.

Infect Immun. 2010 Mar;78(3):1004-11. doi: 10.1128/IAI.00451-09. Epub 2009 Dec 22.


Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells.

Perona-Wright G, Mohrs K, Szaba FM, Kummer LW, Madan R, Karp CL, Johnson LL, Smiley ST, Mohrs M.

Cell Host Microbe. 2009 Dec 17;6(6):503-12. doi: 10.1016/j.chom.2009.11.003.


D27-pLpxL, an avirulent strain of Yersinia pestis, primes T cells that protect against pneumonic plague.

Szaba FM, Kummer LW, Wilhelm LB, Lin JS, Parent MA, Montminy-Paquette SW, Lien E, Johnson LL, Smiley ST.

Infect Immun. 2009 Oct;77(10):4295-304. doi: 10.1128/IAI.00273-09. Epub 2009 Jul 20.


Anti-CD25 antibody-mediated depletion of effector T cell populations enhances susceptibility of mice to acute but not chronic Toxoplasma gondii infection.

Couper KN, Lanthier PA, Perona-Wright G, Kummer LW, Chen W, Smiley ST, Mohrs M, Johnson LL.

J Immunol. 2009 Apr 1;182(7):3985-94. doi: 10.4049/jimmunol.0803053.


gamma-Herpesvirus-induced protection against bacterial infection is transient.

Yager EJ, Szaba FM, Kummer LW, Lanzer KG, Burkum CE, Smiley ST, Blackman MA.

Viral Immunol. 2009 Feb;22(1):67-72. doi: 10.1089/vim.2008.0086.


Neither fibrin nor plasminogen activator inhibitor-1 deficiency protects lung function in a mouse model of acute lung injury.

Allen GB, Cloutier ME, Larrabee YC, Tetenev K, Smiley ST, Bates JH.

Am J Physiol Lung Cell Mol Physiol. 2009 Mar;296(3):L277-85. doi: 10.1152/ajplung.90475.2008. Epub 2008 Dec 5.


Antibodies and cytokines independently protect against pneumonic plague.

Kummer LW, Szaba FM, Parent MA, Adamovicz JJ, Hill J, Johnson LL, Smiley ST.

Vaccine. 2008 Dec 9;26(52):6901-7. doi: 10.1016/j.vaccine.2008.09.063. Epub 2008 Oct 14.


Immune defense against pneumonic plague.

Smiley ST.

Immunol Rev. 2008 Oct;225:256-71. doi: 10.1111/j.1600-065X.2008.00674.x. Review.


Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration.

Robinson RT, Khader SA, Locksley RM, Lien E, Smiley ST, Cooper AM.

J Immunol. 2008 Oct 15;181(8):5560-7.


Current challenges in the development of vaccines for pneumonic plague.

Smiley ST.

Expert Rev Vaccines. 2008 Mar;7(2):209-21. doi: 10.1586/14760584.7.2.209. Review.


Cell-mediated defense against Yersinia pestis infection.

Smiley ST.

Adv Exp Med Biol. 2007;603:376-86. Review.


Gamma interferon suppresses erythropoiesis via interleukin-15.

Mullarky IK, Szaba FM, Kummer LW, Wilhelm LB, Parent MA, Johnson LL, Smiley ST.

Infect Immun. 2007 May;75(5):2630-3. Epub 2007 Feb 16.


In situ assays demonstrate that interferon-gamma suppresses infection-stimulated hepatic fibrin deposition by promoting fibrinolysis.

Mullarky IK, Szaba FM, Winchel CG, Parent MA, Kummer LW, Mackman N, Johnson LL, Smiley ST.

J Thromb Haemost. 2006 Jul;4(7):1580-7.


Tumor necrosis factor alpha and gamma interferon, but not hemorrhage or pathogen burden, dictate levels of protective fibrin deposition during infection.

Mullarky IK, Szaba FM, Berggren KN, Kummer LW, Wilhelm LB, Parent MA, Johnson LL, Smiley ST.

Infect Immun. 2006 Feb;74(2):1181-8.


Cell-mediated protection against pulmonary Yersinia pestis infection.

Parent MA, Berggren KN, Kummer LW, Wilhelm LB, Szaba FM, Mullarky IK, Smiley ST.

Infect Immun. 2005 Nov;73(11):7304-10.


Infection-stimulated fibrin deposition controls hemorrhage and limits hepatic bacterial growth during listeriosis.

Mullarky IK, Szaba FM, Berggren KN, Parent MA, Kummer LW, Chen W, Johnson LL, Smiley ST.

Infect Immun. 2005 Jul;73(7):3888-95.


Exacerbated susceptibility to infection-stimulated immunopathology in CD1d-deficient mice.

Smiley ST, Lanthier PA, Couper KN, Szaba FM, Boyson JE, Chen W, Johnson LL.

J Immunol. 2005 Jun 15;174(12):7904-11.


Yersinia pestis V protein epitopes recognized by CD4 T cells.

Parent MA, Berggren KN, Mullarky IK, Szaba FM, Kummer LW, Adamovicz JJ, Smiley ST.

Infect Immun. 2005 Apr;73(4):2197-204.


Intact type 1 immunity and immune-associated coagulative responses in mice lacking IFN gamma-inducible fibrinogen-like protein 2.

Hancock WW, Szaba FM, Berggren KN, Parent MA, Mullarky IK, Pearl J, Cooper AM, Ely KH, Woodland DL, Kim IJ, Blackman MA, Johnson LL, Smiley ST.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3005-10. Epub 2004 Feb 19.


Fibrin-mediated protection against infection-stimulated immunopathology.

Johnson LL, Berggren KN, Szaba FM, Chen W, Smiley ST.

J Exp Med. 2003 Mar 17;197(6):801-6. Epub 2003 Mar 10.


Beneficial effects of targeting CCR5 in allograft recipients.

Gao W, Faia KL, Csizmadia V, Smiley ST, Soler D, King JA, Danoff TM, Hancock WW.

Transplantation. 2001 Oct 15;72(7):1199-205.


Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4.

Smiley ST, King JA, Hancock WW.

J Immunol. 2001 Sep 1;167(5):2887-94.


CD1d-reactive T-cell activation leads to amelioration of disease caused by diabetogenic encephalomyocarditis virus.

Exley MA, Bigley NJ, Cheng O, Tahir SM, Smiley ST, Carter QL, Stills HF, Grusby MJ, Koezuka Y, Taniguchi M, Balk SP.

J Leukoc Biol. 2001 May;69(5):713-8. Erratum in: J Leukoc Biol 2001 Aug;70(2):340.


Requirement of the chemokine receptor CXCR3 for acute allograft rejection.

Hancock WW, Lu B, Gao W, Csizmadia V, Faia K, King JA, Smiley ST, Ling M, Gerard NP, Gerard C.

J Exp Med. 2000 Nov 20;192(10):1515-20.


Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection.

Gao W, Topham PS, King JA, Smiley ST, Csizmadia V, Lu B, Gerard CJ, Hancock WW.

J Clin Invest. 2000 Jan;105(1):35-44.


Stat6-dependent and -independent pathways for IL-4 production.

Kaplan MH, Wurster AL, Smiley ST, Grusby MJ.

J Immunol. 1999 Dec 15;163(12):6536-40.


Tissue-specific segregation of CD1d-dependent and CD1d-independent NK T cells.

Eberl G, Lees R, Smiley ST, Taniguchi M, Grusby MJ, MacDonald HR.

J Immunol. 1999 Jun 1;162(11):6410-9.


Selective ability of mouse CD1 to present glycolipids: alpha-galactosylceramide specifically stimulates V alpha 14+ NK T lymphocytes.

Burdin N, Brossay L, Koezuka Y, Smiley ST, Grusby MJ, Gui M, Taniguchi M, Hayakawa K, Kronenberg M.

J Immunol. 1998 Oct 1;161(7):3271-81.


Single amino acid mutations in the murine MHC class II A beta cytoplasmic domain abrogate antigen presentation.

Laufer TM, Smiley ST, Ranger A, Clements VK, Ostrand-Rosenberg S, Glimcher LH.

J Immunol. 1997 Dec 15;159(12):5914-20.


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