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Polymorphisms in the Most Oncolytic Reovirus Strain Confer Enhanced Cell Attachment, Transcription, and Single-Step Replication Kinetics.

Mohamed A, Smiley JR, Shmulevitz M.

J Virol. 2020 Jan 31;94(4). pii: e01937-19. doi: 10.1128/JVI.01937-19. Print 2020 Jan 31.


Single Amino Acid Differences between Closely Related Reovirus T3D Lab Strains Alter Oncolytic Potency In Vitro and In Vivo.

Mohamed A, Clements DR, Gujar SA, Lee PW, Smiley JR, Shmulevitz M.

J Virol. 2020 Jan 31;94(4). pii: e01688-19. doi: 10.1128/JVI.01688-19. Print 2020 Jan 31.


The herpes simplex virus host shutoff (vhs) RNase limits accumulation of double stranded RNA in infected cells: Evidence for accelerated decay of duplex RNA.

Dauber B, Saffran HA, Smiley JR.

PLoS Pathog. 2019 Oct 18;15(10):e1008111. doi: 10.1371/journal.ppat.1008111. eCollection 2019 Oct.


Correction for Dauber et al., "The Herpes Simplex Virus 1 vhs Protein Enhances Translation of Viral True Late mRNAs and Virus Production in a Cell Type-Dependent Manner".

Dauber B, Pelletier J, Smiley JR.

J Virol. 2019 Aug 13;93(17). pii: e00985-19. doi: 10.1128/JVI.00985-19. Print 2019 Sep 1. No abstract available.


Immunization of Alpacas (Lama pacos) with Protein Antigens and Production of Antigen-specific Single Domain Antibodies.

Chow KM, Whiteheart SW, Smiley JR, Sharma S, Boaz K, Coleman MJ, Maynard A, Hersh LB, Vander Kooi CW.

J Vis Exp. 2019 Jan 26;(143). doi: 10.3791/58471.


Remodeling mTORC1 Responsiveness to Amino Acids by the Herpes Simplex Virus UL46 and Us3 Gene Products Supports Replication during Nutrient Insufficiency.

Vink EI, Lee S, Smiley JR, Mohr I.

J Virol. 2018 Nov 27;92(24). pii: e01377-18. doi: 10.1128/JVI.01377-18. Print 2018 Dec 15.


Expression of the Vaccinia Virus Antiapoptotic F1 Protein Is Blocked by Protein Kinase R in the Absence of the Viral E3 Protein.

Mehta N, Enwere EK, Santos TD, Saffran HA, Hazes B, Evans D, Barry M, Smiley JR.

J Virol. 2018 Sep 12;92(19). pii: e01167-18. doi: 10.1128/JVI.01167-18. Print 2018 Oct 1.


Herpes simplex virus 1 infection of T cells causes VP11/12-dependent phosphorylation and degradation of the cellular protein Dok-2.

Lahmidi S, Strunk U, Smiley JR, Pearson A, Duplay P.

Virology. 2017 Nov;511:66-73. doi: 10.1016/j.virol.2017.08.018. Epub 2017 Aug 23.


Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.

Vink EI, Smiley JR, Mohr I.

J Virol. 2017 Jun 26;91(14). pii: e00295-17. doi: 10.1128/JVI.00295-17. Print 2017 Jul 15.


Role of Herpes simplex virus 1 VP11/12 tyrosine-based binding motifs for Src family kinases, p85, Grb2 and Shc in activation of the phosphoinositide 3-kinase-Akt pathway.

Strunk U, Ramos DG, Saffran HA, Smiley JR.

Virology. 2016 Nov;498:31-35. doi: 10.1016/j.virol.2016.08.007. Epub 2016 Aug 17.


The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation.

Dauber B, Poon D, Dos Santos T, Duguay BA, Mehta N, Saffran HA, Smiley JR.

J Virol. 2016 Jun 10;90(13):6049-6057. doi: 10.1128/JVI.03180-15. Print 2016 Jul 1.


Mitochondrial DNA stress primes the antiviral innate immune response.

West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS.

Nature. 2015 Apr 23;520(7548):553-7. doi: 10.1038/nature14156. Epub 2015 Feb 2.


The herpes simplex virus 2 virion-associated ribonuclease vhs interferes with stress granule formation.

Finnen RL, Hay TJ, Dauber B, Smiley JR, Banfield BW.

J Virol. 2014 Nov;88(21):12727-39. doi: 10.1128/JVI.01554-14. Epub 2014 Aug 20.


The herpes simplex virus 1 virion host shutoff protein enhances translation of viral late mRNAs by preventing mRNA overload.

Dauber B, Saffran HA, Smiley JR.

J Virol. 2014 Sep 1;88(17):9624-32. doi: 10.1128/JVI.01350-14. Epub 2014 Jun 11.


Herpes simplex virus protein kinases US3 and UL13 modulate VP11/12 phosphorylation, virion packaging, and phosphatidylinositol 3-kinase/Akt signaling activity.

Eaton HE, Saffran HA, Wu FW, Quach K, Smiley JR.

J Virol. 2014 Jul;88(13):7379-88. doi: 10.1128/JVI.00712-14. Epub 2014 Apr 16.


Elimination of mitochondrial DNA is not required for herpes simplex virus 1 replication.

Duguay BA, Saffran HA, Ponomarev A, Duley SA, Eaton HE, Smiley JR.

J Virol. 2014 Mar;88(5):2967-76. doi: 10.1128/JVI.03129-13. Epub 2013 Dec 26.


Mitochondrial nucleases ENDOG and EXOG participate in mitochondrial DNA depletion initiated by herpes simplex virus 1 UL12.5.

Duguay BA, Smiley JR.

J Virol. 2013 Nov;87(21):11787-97. doi: 10.1128/JVI.02306-13. Epub 2013 Aug 28.


Role of herpes simplex virus VP11/12 tyrosine-based motifs in binding and activation of the Src family kinase Lck and recruitment of p85, Grb2, and Shc.

Strunk U, Saffran HA, Wu FW, Smiley JR.

J Virol. 2013 Oct;87(20):11276-86. doi: 10.1128/JVI.01702-13. Epub 2013 Aug 14.


A combination cocktail improves spatial attention in a canine model of human aging and Alzheimer's disease.

Head E, Murphey HL, Dowling AL, McCarty KL, Bethel SR, Nitz JA, Pleiss M, Vanrooyen J, Grossheim M, Smiley JR, Murphy MP, Beckett TL, Pagani D, Bresch F, Hendrix C.

J Alzheimers Dis. 2012;32(4):1029-42. doi: 10.3233/JAD-2012-120937.


Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag.

Woods MW, Kelly JN, Hattlmann CJ, Tong JG, Xu LS, Coleman MD, Quest GR, Smiley JR, Barr SD.

Retrovirology. 2011 Nov 17;8:95. doi: 10.1186/1742-4690-8-95.


The herpes simplex virus 1 vhs protein enhances translation of viral true late mRNAs and virus production in a cell type-dependent manner.

Dauber B, Pelletier J, Smiley JR.

J Virol. 2011 Jun;85(11):5363-73. doi: 10.1128/JVI.00115-11. Epub 2011 Mar 23. Erratum in: J Virol. 2019 Aug 13;93(17):.


Citation for a discussion of noncompliance. Retraining required.

Croxford EJ, Smiley JR.

Lab Anim (NY). 2011 Feb;40(2):36-7. doi: 10.1038/laban0211-36b. No abstract available.


Herpes simplex virus requires VP11/12 to activate Src family kinase-phosphoinositide 3-kinase-Akt signaling.

Wagner MJ, Smiley JR.

J Virol. 2011 Mar;85(6):2803-12. doi: 10.1128/JVI.01877-10. Epub 2011 Jan 12.


Evidence for translational regulation by the herpes simplex virus virion host shutoff protein.

Saffran HA, Read GS, Smiley JR.

J Virol. 2010 Jun;84(12):6041-9. doi: 10.1128/JVI.01819-09. Epub 2010 Mar 31.


Herpes simplex virus VP16, but not ICP0, is required to reduce histone occupancy and enhance histone acetylation on viral genomes in U2OS osteosarcoma cells.

Hancock MH, Cliffe AR, Knipe DM, Smiley JR.

J Virol. 2010 Feb;84(3):1366-75. doi: 10.1128/JVI.01727-09. Epub 2009 Nov 25.


Herpes simplex virus UL12.5 targets mitochondria through a mitochondrial localization sequence proximal to the N terminus.

Corcoran JA, Saffran HA, Duguay BA, Smiley JR.

J Virol. 2009 Mar;83(6):2601-10. doi: 10.1128/JVI.02087-08. Epub 2009 Jan 7.


Cell-type-specific tyrosine phosphorylation of the herpes simplex virus tegument protein VP11/12 encoded by gene UL46.

Zahariadis G, Wagner MJ, Doepker RC, Maciejko JM, Crider CM, Jerome KR, Smiley JR.

J Virol. 2008 Jul;82(13):6098-108. doi: 10.1128/JVI.02121-07. Epub 2008 Apr 16.


The interferon response inhibits HIV particle production by induction of TRIM22.

Barr SD, Smiley JR, Bushman FD.

PLoS Pathog. 2008 Feb 29;4(2):e1000007. doi: 10.1371/journal.ppat.1000007.


Herpes simplex virus eliminates host mitochondrial DNA.

Saffran HA, Pare JM, Corcoran JA, Weller SK, Smiley JR.

EMBO Rep. 2007 Feb;8(2):188-93. Epub 2006 Dec 22.


Herpes simplex virus regulatory proteins VP16 and ICP0 counteract an innate intranuclear barrier to viral gene expression.

Hancock MH, Corcoran JA, Smiley JR.

Virology. 2006 Aug 15;352(1):237-52. Epub 2006 Jun 5.


Functional inaccessibility of quiescent herpes simplex virus genomes.

Minaker RL, Mossman KL, Smiley JR.

Virol J. 2005 Nov 21;2:85.


Control of VP16 translation by the herpes simplex virus type 1 immediate-early protein ICP27.

Ellison KS, Maranchuk RA, Mottet KL, Smiley JR.

J Virol. 2005 Apr;79(7):4120-31.


Herpes simplex virus infection stabilizes cellular IEX-1 mRNA.

Hsu WL, Saffran HA, Smiley JR.

J Virol. 2005 Apr;79(7):4090-8.


RNA degradation induced by the herpes simplex virus vhs protein proceeds 5' to 3' in vitro.

Perez-Parada J, Saffran HA, Smiley JR.

J Virol. 2004 Dec;78(23):13391-4.


Herpes simplex virus virion host shutoff protein: immune evasion mediated by a viral RNase?

Smiley JR.

J Virol. 2004 Feb;78(3):1063-8. Review. No abstract available.


Characterization of an enteropathogenic bovine calicivirus representing a potentially new calicivirus genus.

Smiley JR, Chang KO, Hayes J, Vinjé J, Saif LJ.

J Virol. 2002 Oct;76(20):10089-98.


Herpes simplex virus vhs protein.

Smiley JR, Elgadi MM, Saffran HA.

Methods Enzymol. 2001;342:440-51. No abstract available.


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