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Items: 1 to 50 of 100

1.

MCL1 as a Therapeutic Target in Parkinson's Disease?

Robinson EJ, Aguiar S, Smidt MP, van der Heide LP.

Trends Mol Med. 2019 Dec;25(12):1056-1065. doi: 10.1016/j.molmed.2019.08.009. Epub 2019 Nov 6. Review.

PMID:
31706839
2.

Characterization of transgenic mouse models targeting neuromodulatory systems reveals organizational principles of the dorsal raphe.

Cardozo Pinto DF, Yang H, Pollak Dorocic I, de Jong JW, Han VJ, Peck JR, Zhu Y, Liu C, Beier KT, Smidt MP, Lammel S.

Nat Commun. 2019 Oct 11;10(1):4633. doi: 10.1038/s41467-019-12392-2.

3.

EZH2 Is Essential for Fate Determination in the Mammalian Isthmic Area.

Wever I, Wagemans CMRJ, Smidt MP.

Front Mol Neurosci. 2019 Apr 9;12:76. doi: 10.3389/fnmol.2019.00076. eCollection 2019.

4.

Entanglement of Genetics and Epigenetics in Parkinson's Disease.

van Heesbeen HJ, Smidt MP.

Front Neurosci. 2019 Mar 29;13:277. doi: 10.3389/fnins.2019.00277. eCollection 2019. Review.

5.

Lmx1b Influences Correct Post-mitotic Coding of Mesodiencephalic Dopaminergic Neurons.

Wever I, Largo-Barrientos P, Hoekstra EJ, Smidt MP.

Front Mol Neurosci. 2019 Mar 14;12:62. doi: 10.3389/fnmol.2019.00062. eCollection 2019.

6.

EZH2 Influences mdDA Neuronal Differentiation, Maintenance and Survival.

Wever I, von Oerthel L, Wagemans CMRJ, Smidt MP.

Front Mol Neurosci. 2019 Jan 17;11:491. doi: 10.3389/fnmol.2018.00491. eCollection 2018.

7.

Survival of midbrain dopamine neurons depends on the Bcl2 factor Mcl1.

Robinson EJ, Aguiar SP, Kouwenhoven WM, Starmans DS, von Oerthel L, Smidt MP, van der Heide LP.

Cell Death Discov. 2018 Nov 21;4:107. doi: 10.1038/s41420-018-0125-7. eCollection 2018.

8.

miR-34b/c Regulates Wnt1 and Enhances Mesencephalic Dopaminergic Neuron Differentiation.

De Gregorio R, Pulcrano S, De Sanctis C, Volpicelli F, Guatteo E, von Oerthel L, Latagliata EC, Esposito R, Piscitelli RM, Perrone-Capano C, Costa V, Greco D, Puglisi-Allegra S, Smidt MP, di Porzio U, Caiazzo M, Mercuri NB, Li M, Bellenchi GC.

Stem Cell Reports. 2018 Apr 10;10(4):1237-1250. doi: 10.1016/j.stemcr.2018.02.006. Epub 2018 Mar 8.

9.

Tcf12 Is Involved in Early Cell-Fate Determination and Subset Specification of Midbrain Dopamine Neurons.

Mesman S, Smidt MP.

Front Mol Neurosci. 2017 Nov 1;10:353. doi: 10.3389/fnmol.2017.00353. eCollection 2017.

10.

Expression analyzes of early factors in midbrain differentiation programs.

Mesman S, Krüse SJ, Smidt MP.

Gene Expr Patterns. 2018 Jan;27:8-15. doi: 10.1016/j.gep.2017.09.001. Epub 2017 Sep 27.

PMID:
28958789
11.

Pitx3 and En1 determine the size and molecular programming of the dopaminergic neuronal pool.

Kouwenhoven WM, von Oerthel L, Smidt MP.

PLoS One. 2017 Aug 11;12(8):e0182421. doi: 10.1371/journal.pone.0182421. eCollection 2017.

12.

Molecular Programming of Mesodiencephalic Dopaminergic Neuronal Subsets.

Smidt MP.

Front Neuroanat. 2017 Jul 19;11:59. doi: 10.3389/fnana.2017.00059. eCollection 2017. Review.

13.

Embryonic development of selectively vulnerable neurons in Parkinson's disease.

Oliveira MAP, Balling R, Smidt MP, Fleming RMT.

NPJ Parkinsons Dis. 2017 Jun 26;3:21. doi: 10.1038/s41531-017-0022-4. eCollection 2017. Review.

14.

Mest/Peg1 Is Essential for the Development and Maintenance of a SNc Neuronal Subset.

Mesman S, van Hooft JA, Smidt MP.

Front Mol Neurosci. 2017 Jan 13;9:166. doi: 10.3389/fnmol.2016.00166. eCollection 2016.

15.

FoxO6 affects Plxna4-mediated neuronal migration during mouse cortical development.

Paap RH, Oosterbroek S, Wagemans CMRJ, von Oerthel L, Schellevis RD, Vastenhouw-van der Linden AJA, Groot Koerkamp MJA, Hoekman MFM, Smidt MP.

Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):E7087-E7096. doi: 10.1073/pnas.1609111113. Epub 2016 Oct 24.

16.

Engrailed 1 shapes the dopaminergic and serotonergic landscape through proper isthmic organizer maintenance and function.

Kouwenhoven WM, Veenvliet JV, van Hooft JA, van der Heide LP, Smidt MP.

Biol Open. 2016 Feb 15;5(3):279-88. doi: 10.1242/bio.015032.

17.

FoxK2 is required for cellular proliferation and survival.

van der Heide LP, Wijchers PJ, von Oerthel L, Burbach JP, Hoekman MF, Smidt MP.

J Cell Physiol. 2015 May;230(5):1013-23. doi: 10.1002/jcp.24828.

PMID:
25216324
18.

Molecular mechanisms of dopaminergic subset specification: fundamental aspects and clinical perspectives.

Veenvliet JV, Smidt MP.

Cell Mol Life Sci. 2014 Dec;71(24):4703-27. doi: 10.1007/s00018-014-1681-5. Epub 2014 Jul 27. Review.

PMID:
25064061
19.

Mesodiencephalic dopaminergic neuronal differentiation does not involve GLI2A-mediated SHH-signaling and is under the direct influence of canonical WNT signaling.

Mesman S, von Oerthel L, Smidt MP.

PLoS One. 2014 May 27;9(5):e97926. doi: 10.1371/journal.pone.0097926. eCollection 2014.

20.

Insulin-FOXO3 signaling modulates circadian rhythms via regulation of clock transcription.

Chaves I, van der Horst GT, Schellevis R, Nijman RM, Koerkamp MG, Holstege FC, Smidt MP, Hoekman MF.

Curr Biol. 2014 Jun 2;24(11):1248-55. doi: 10.1016/j.cub.2014.04.018. Epub 2014 May 22.

21.

Distinct temporal expression of 5-HT(1A) and 5-HT(2A) receptors on cerebellar granule cells in mice.

Oostland M, Buijink MR, Teunisse GM, von Oerthel L, Smidt MP, van Hooft JA.

Cerebellum. 2014 Aug;13(4):491-500. doi: 10.1007/s12311-014-0565-4.

22.

Detailed analysis of the genetic and epigenetic signatures of iPSC-derived mesodiencephalic dopaminergic neurons.

Roessler R, Smallwood SA, Veenvliet JV, Pechlivanoglou P, Peng SP, Chakrabarty K, Groot-Koerkamp MJ, Pasterkamp RJ, Wesseling E, Kelsey G, Boddeke E, Smidt MP, Copray S.

Stem Cell Reports. 2014 Apr 3;2(4):520-33. doi: 10.1016/j.stemcr.2014.03.001. eCollection 2014 Apr 8.

23.

Subset specification of central serotonergic neurons.

Smidt MP, van Hooft JA.

Front Cell Neurosci. 2013 Oct 31;7:200. doi: 10.3389/fncel.2013.00200. Review.

24.

Molecular marker differences relate to developmental position and subsets of mesodiencephalic dopaminergic neurons.

Smits SM, von Oerthel L, Hoekstra EJ, Burbach JP, Smidt MP.

PLoS One. 2013 Oct 7;8(10):e76037. doi: 10.1371/journal.pone.0076037. eCollection 2013.

25.

Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/B-catenin signaling activator R-spondin 2.

Hoekstra EJ, von Oerthel L, van der Heide LP, Kouwenhoven WM, Veenvliet JV, Wever I, Jin YR, Yoon JK, van der Linden AJ, Holstege FC, Groot Koerkamp MJ, Smidt MP.

PLoS One. 2013 Sep 16;8(9):e74049. doi: 10.1371/journal.pone.0074049. eCollection 2013.

26.

Specification of dopaminergic subsets involves interplay of En1 and Pitx3.

Veenvliet JV, Dos Santos MT, Kouwenhoven WM, von Oerthel L, Lim JL, van der Linden AJ, Koerkamp MJ, Holstege FC, Smidt MP.

Development. 2013 Aug;140(16):3373-84. doi: 10.1242/dev.094565. Epub 2013 Jul 17. Erratum in: Development. 2013 Oct;140(19):4116.

27.

The serotonin 5-HT3 receptor: a novel neurodevelopmental target.

Engel M, Smidt MP, van Hooft JA.

Front Cell Neurosci. 2013 May 27;7:76. doi: 10.3389/fncel.2013.00076. eCollection 2013.

28.

The BCL2 code to dopaminergic development and Parkinson's disease.

van der Heide LP, Smidt MP.

Trends Mol Med. 2013 Apr;19(4):211-6. doi: 10.1016/j.molmed.2013.02.003. Epub 2013 Mar 20.

PMID:
23523055
29.

Epigenetic mechanisms in the development and maintenance of dopaminergic neurons.

van Heesbeen HJ, Mesman S, Veenvliet JV, Smidt MP.

Development. 2013 Mar;140(6):1159-69. doi: 10.1242/dev.089359. Review.

30.

S-nitrosylation of HDAC2 regulates the expression of the chromatin-remodeling factor Brm during radial neuron migration.

Nott A, Nitarska J, Veenvliet JV, Schacke S, Derijck AA, Sirko P, Muchardt C, Pasterkamp RJ, Smidt MP, Riccio A.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3113-8. doi: 10.1073/pnas.1218126110. Epub 2013 Jan 28.

31.

LMX1B is part of a transcriptional complex with PSPC1 and PSF.

Hoekstra EJ, Mesman S, de Munnik WA, Smidt MP.

PLoS One. 2013;8(1):e53122. doi: 10.1371/journal.pone.0053122. Epub 2013 Jan 4.

32.

Phox2b influences the development of a caudal dopaminergic subset.

Hoekstra EJ, von Oerthel L, van der Linden AJ, Smidt MP.

PLoS One. 2012;7(12):e52118. doi: 10.1371/journal.pone.0052118. Epub 2012 Dec 14.

33.

Genome wide expression profiling of the mesodiencephalic region identifies novel factors involved in early and late dopaminergic development.

Chakrabarty K, Von Oerthel L, Hellemons A, Clotman F, Espana A, Groot Koerkamp M, Holstege FC, Pasterkamp RJ, Smidt MP.

Biol Open. 2012 Aug 15;1(8):693-704. doi: 10.1242/bio.20121230. Epub 2012 May 17.

34.

Morphine withdrawal enhances constitutive μ-opioid receptor activity in the ventral tegmental area.

Meye FJ, van Zessen R, Smidt MP, Adan RA, Ramakers GM.

J Neurosci. 2012 Nov 14;32(46):16120-8. doi: 10.1523/JNEUROSCI.1572-12.2012.

35.

Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons.

Hoekstra EJ, von Oerthel L, van der Linden AJ, Schellevis RD, Scheppink G, Holstege FC, Groot-Koerkamp MJ, van der Heide LP, Smidt MP.

Eur J Neurosci. 2013 Jan;37(1):23-32. doi: 10.1111/ejn.12022. Epub 2012 Oct 29.

PMID:
23106268
36.

Spatial and temporal lineage analysis of a Pitx3-driven Cre-recombinase knock-in mouse model.

Smidt MP, von Oerthel L, Hoekstra EJ, Schellevis RD, Hoekman MF.

PLoS One. 2012;7(8):e42641. doi: 10.1371/journal.pone.0042641. Epub 2012 Aug 1.

37.

Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons.

Jacobs FM, Veenvliet JV, Almirza WH, Hoekstra EJ, von Oerthel L, van der Linden AJ, Neijts R, Koerkamp MG, van Leenen D, Holstege FC, Burbach JP, Smidt MP.

Development. 2011 Dec;138(23):5213-22. doi: 10.1242/dev.071704.

38.

Prenatal fluoxetine exposure induces life-long serotonin 5-HT₃ receptor-dependent cortical abnormalities and anxiety-like behaviour.

Smit-Rigter LA, Noorlander CW, von Oerthel L, Chameau P, Smidt MP, van Hooft JA.

Neuropharmacology. 2012 Feb;62(2):865-70. doi: 10.1016/j.neuropharm.2011.09.015. Epub 2011 Sep 24.

PMID:
21964434
39.

En1 and Wnt signaling in midbrain dopaminergic neuronal development.

Alves dos Santos MT, Smidt MP.

Neural Dev. 2011 May 10;6:23. doi: 10.1186/1749-8104-6-23. Review.

40.

Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice.

Rosemann M, Ivashkevich A, Favor J, Dalke C, Hölter SM, Becker L, Rácz I, Bolle I, Klempt M, Rathkolb B, Kalaydjiev S, Adler T, Aguilar A, Hans W, Horsch M, Rozman J, Calzada-Wack J, Kunder S, Naton B, Gailus-Durner V, Fuchs H, Schulz H, Beckers J, Busch DH, Burbach JP, Smidt MP, Quintanilla-Martinez L, Esposito I, Klopstock T, Klingenspor M, Ollert M, Wolf E, Wurst W, Zimmer A, de Angelis MH, Atkinson M, Heinzmann U, Graw J.

Mamm Genome. 2010 Feb;21(1-2):13-27. doi: 10.1007/s00335-009-9235-0. Epub 2009 Dec 22.

PMID:
20033184
41.

Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting.

Kolk SM, Gunput RA, Tran TS, van den Heuvel DM, Prasad AA, Hellemons AJ, Adolfs Y, Ginty DD, Kolodkin AL, Burbach JP, Smidt MP, Pasterkamp RJ.

J Neurosci. 2009 Oct 7;29(40):12542-57. doi: 10.1523/JNEUROSCI.2521-09.2009.

42.

Terminal differentiation ofmesodiencephalic dopaminergic neurons: the role of Nurr1 and Pitx3.

Smidt MP, Burbach JP.

Adv Exp Med Biol. 2009;651:47-57. Review. No abstract available.

PMID:
19731549
43.

Development and engineering of dopamine neurons. Preface.

Pasterkamp RJ, Smidt MP, Burbach JP.

Adv Exp Med Biol. 2009;651:v-vi. No abstract available.

PMID:
19731545
44.

A passport to neurotransmitter identity.

Smidt MP, Burbach JP.

Genome Biol. 2009;10(7):229. doi: 10.1186/gb-2009-10-7-229. Epub 2009 Jul 1. Review.

45.

Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons.

Jacobs FM, van der Linden AJ, Wang Y, von Oerthel L, Sul HS, Burbach JP, Smidt MP.

Development. 2009 Jul;136(14):2363-73. doi: 10.1242/dev.037556. Epub 2009 Jun 10.

46.

Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression.

Jacobs FM, van Erp S, van der Linden AJ, von Oerthel L, Burbach JP, Smidt MP.

Development. 2009 Feb;136(4):531-40. doi: 10.1242/dev.029769. Epub 2009 Jan 14.

47.

Specific vulnerability of substantia nigra compacta neurons.

Smidt MP.

J Neural Transm Suppl. 2009;(73):39-47. Review.

PMID:
20411766
48.

Modulation of serotonin transporter function during fetal development causes dilated heart cardiomyopathy and lifelong behavioral abnormalities.

Noorlander CW, Ververs FF, Nikkels PG, van Echteld CJ, Visser GH, Smidt MP.

PLoS One. 2008 Jul 23;3(7):e2782. doi: 10.1371/journal.pone.0002782. Erratum in: PLoS One. 2009;4(9). doi: 10.1371/annotation/71abed9d-9ee9-4be0-a663-0d469750e13a.

49.

Alterations in serotonin signalling are involved in the hyperactivity of Pitx3-deficient mice.

Smits SM, Noorlander CW, Kas MJ, Ramakers GM, Smidt MP.

Eur J Neurosci. 2008 Jan;27(2):388-95. doi: 10.1111/j.1460-9568.2008.06032.x.

PMID:
18215235
50.

Movies of dopamine transporter occupancy with ultra-high resolution focusing pinhole SPECT.

Vastenhouw B, van der Have F, van der Linden AJ, von Oerthel L, Booij J, Burbach JP, Smidt MP, Beekman FJ.

Mol Psychiatry. 2007 Nov;12(11):984-7. Epub 2007 Jul 10.

PMID:
17957236

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