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Items: 1 to 50 of 102

1.

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates.

Goveia J, Rohlenova K, Taverna F, Treps L, Conradi LC, Pircher A, Geldhof V, de Rooij LPMH, Kalucka J, Sokol L, García-Caballero M, Zheng Y, Qian J, Teuwen LA, Khan S, Boeckx B, Wauters E, Decaluwé H, De Leyn P, Vansteenkiste J, Weynand B, Sagaert X, Verbeken E, Wolthuis A, Topal B, Everaert W, Bohnenberger H, Emmert A, Panovska D, De Smet F, Staal FJT, Mclaughlin RJ, Impens F, Lagani V, Vinckier S, Mazzone M, Schoonjans L, Dewerchin M, Eelen G, Karakach TK, Yang H, Wang J, Bolund L, Lin L, Thienpont B, Li X, Lambrechts D, Luo Y, Carmeliet P.

Cancer Cell. 2020 Jan 13;37(1):21-36.e13. doi: 10.1016/j.ccell.2019.12.001.

PMID:
31935371
2.

Linking single-cell measurements of mass, growth rate, and gene expression.

Kimmerling RJ, Prakadan SM, Gupta AJ, Calistri NL, Stevens MM, Olcum S, Cermak N, Drake RS, Pelton K, De Smet F, Ligon KL, Shalek AK, Manalis SR.

Genome Biol. 2018 Nov 27;19(1):207. doi: 10.1186/s13059-018-1576-0.

3.

FGF-dependent metabolic control of vascular development.

Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M.

Nature. 2017 May 11;545(7653):224-228. doi: 10.1038/nature22322. Epub 2017 May 3.

4.

Nuclear inclusion bodies of mutant and wild-type p53 in cancer: a hallmark of p53 inactivation and proteostasis remodelling by p53 aggregation.

De Smet F, Saiz Rubio M, Hompes D, Naus E, De Baets G, Langenberg T, Hipp MS, Houben B, Claes F, Charbonneau S, Delgado Blanco J, Plaisance S, Ramkissoon S, Ramkissoon L, Simons C, van den Brandt P, Weijenberg M, Van England M, Lambrechts S, Amant F, D'Hoore A, Ligon KL, Sagaert X, Schymkowitz J, Rousseau F.

J Pathol. 2017 May;242(1):24-38. doi: 10.1002/path.4872. Epub 2017 Mar 23.

PMID:
28035683
5.

De novo design of a biologically active amyloid.

Gallardo R, Ramakers M, De Smet F, Claes F, Khodaparast L, Khodaparast L, Couceiro JR, Langenberg T, Siemons M, Nyström S, Young LJ, Laine RF, Young L, Radaelli E, Benilova I, Kumar M, Staes A, Desager M, Beerens M, Vandervoort P, Luttun A, Gevaert K, Bormans G, Dewerchin M, Van Eldere J, Carmeliet P, Vande Velde G, Verfaillie C, Kaminski CF, De Strooper B, Hammarström P, Nilsson KP, Serpell L, Schymkowitz J, Rousseau F.

Science. 2016 Nov 11;354(6313). pii: aah4949.

6.

Molecular Mechanism of SSR128129E, an Extracellularly Acting, Small-Molecule, Allosteric Inhibitor of FGF Receptor Signaling.

Herbert C, Schieborr U, Saxena K, Juraszek J, De Smet F, Alcouffe C, Bianciotto M, Saladino G, Sibrac D, Kudlinzki D, Sreeramulu S, Brown A, Rigon P, Herault JP, Lassalle G, Blundell TL, Rousseau F, Gils A, Schymkowitz J, Tompa P, Herbert JM, Carmeliet P, Gervasio FL, Schwalbe H, Bono F.

Cancer Cell. 2016 Jul 11;30(1):176-178. doi: 10.1016/j.ccell.2016.06.015. Epub 2016 Jul 11. No abstract available.

7.

Sequence-Specific Protein Aggregation Generates Defined Protein Knockdowns in Plants.

Betti C, Vanhoutte I, Coutuer S, De Rycke R, Mishev K, Vuylsteke M, Aesaert S, Rombaut D, Gallardo R, De Smet F, Xu J, Van Lijsebettens M, Van Breusegem F, Inzé D, Rousseau F, Schymkowitz J, Russinova E.

Plant Physiol. 2016 Jun;171(2):773-87. doi: 10.1104/pp.16.00335. Epub 2016 May 4.

8.

Structural hot spots for the solubility of globular proteins.

Ganesan A, Siekierska A, Beerten J, Brams M, Van Durme J, De Baets G, Van der Kant R, Gallardo R, Ramakers M, Langenberg T, Wilkinson H, De Smet F, Ulens C, Rousseau F, Schymkowitz J.

Nat Commun. 2016 Feb 24;7:10816. doi: 10.1038/ncomms10816.

9.

Did Large-Scale Vaccination Drive Changes in the Circulating Rotavirus Population in Belgium?

Pitzer VE, Bilcke J, Heylen E, Crawford FW, Callens M, De Smet F, Van Ranst M, Zeller M, Matthijnssens J.

Sci Rep. 2015 Dec 21;5:18585. doi: 10.1038/srep18585.

10.

Mortality in Individuals Treated With Glucose-Lowering Agents: A Large, Controlled Cohort Study.

Claesen M, Gillard P, De Smet F, Callens M, De Moor B, Mathieu C.

J Clin Endocrinol Metab. 2016 Feb;101(2):461-9. doi: 10.1210/jc.2015-3184. Epub 2015 Dec 17.

PMID:
26678656
11.

Community-acquired pneumonia (CAP) hospitalizations and deaths: is there a role for quality improvement through inter-hospital comparisons?

Aelvoet W, Terryn N, Blommaert A, Molenberghs G, Hens N, De Smet F, Callens M, Beutels P.

Int J Qual Health Care. 2016 Feb;28(1):22-32. doi: 10.1093/intqhc/mzv092. Epub 2015 Nov 20.

PMID:
26590376
12.

From non school-based, co-payment to school-based, free Human Papillomavirus vaccination in Flanders (Belgium): a retrospective cohort study describing vaccination coverage, age-specific coverage and socio-economic inequalities.

Lefevere E, Theeten H, Hens N, De Smet F, Top G, Van Damme P.

Vaccine. 2015 Sep 22;33(39):5188-95. doi: 10.1016/j.vaccine.2015.07.088. Epub 2015 Aug 5.

PMID:
26254978
13.

The impact of non-financial and financial encouragements on participation in non school-based human papillomavirus vaccination: a retrospective cohort study.

Lefevere E, Hens N, De Smet F, Beutels P.

Eur J Health Econ. 2016 Apr;17(3):305-15. doi: 10.1007/s10198-015-0680-2. Epub 2015 Mar 14.

PMID:
25773050
14.

Sequence-dependent internalization of aggregating peptides.

Couceiro JR, Gallardo R, De Smet F, De Baets G, Baatsen P, Annaert W, Roose K, Saelens X, Schymkowitz J, Rousseau F.

J Biol Chem. 2015 Jan 2;290(1):242-58. doi: 10.1074/jbc.M114.586636. Epub 2014 Nov 12.

15.

Allosteric targeting of receptor tyrosine kinases.

De Smet F, Christopoulos A, Carmeliet P.

Nat Biotechnol. 2014 Nov;32(11):1113-20. doi: 10.1038/nbt.3028.

PMID:
25380447
16.

Flow cytometry of microencapsulated colonies for genetics analysis of filamentous fungi.

Delgado-Ramos L, Marcos AT, Ramos-Guelfo MS, Sánchez-Barrionuevo L, Smet F, Chávez S, Cánovas D.

G3 (Bethesda). 2014 Sep 19;4(11):2271-8. doi: 10.1534/g3.114.014357.

17.

Fibroblast growth factor signaling affects vascular outgrowth and is required for the maintenance of blood vessel integrity.

De Smet F, Tembuyser B, Lenard A, Claes F, Zhang J, Michielsen C, Van Schepdael A, Herbert JM, Bono F, Affolter M, Dewerchin M, Carmeliet P.

Chem Biol. 2014 Oct 23;21(10):1310-1317. doi: 10.1016/j.chembiol.2014.07.018. Epub 2014 Sep 4.

18.

The health and economic burden of haemophilia in Belgium: a rare, expensive and challenging disease.

Henrard S, Devleesschauwer B, Beutels P, Callens M, De Smet F, Hermans C, Speybroeck N.

Orphanet J Rare Dis. 2014 Mar 21;9:39. doi: 10.1186/1750-1172-9-39.

19.

Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling.

Herbert C, Schieborr U, Saxena K, Juraszek J, De Smet F, Alcouffe C, Bianciotto M, Saladino G, Sibrac D, Kudlinzki D, Sreeramulu S, Brown A, Rigon P, Herault JP, Lassalle G, Blundell TL, Rousseau F, Gils A, Schymkowitz J, Tompa P, Herbert JM, Carmeliet P, Gervasio FL, Schwalbe H, Bono F.

Cancer Cell. 2013 Apr 15;23(4):489-501. doi: 10.1016/j.ccr.2013.02.018. Erratum in: Cancer Cell. 2016 Jul 11;30(1):176-178.

20.

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties.

Bono F, De Smet F, Herbert C, De Bock K, Georgiadou M, Fons P, Tjwa M, Alcouffe C, Ny A, Bianciotto M, Jonckx B, Murakami M, Lanahan AA, Michielsen C, Sibrac D, Dol-Gleizes F, Mazzone M, Zacchigna S, Herault JP, Fischer C, Rigon P, Ruiz de Almodovar C, Claes F, Blanc I, Poesen K, Zhang J, Segura I, Gueguen G, Bordes MF, Lambrechts D, Broussy R, van de Wouwer M, Michaux C, Shimada T, Jean I, Blacher S, Noel A, Motte P, Rom E, Rakic JM, Katsuma S, Schaeffer P, Yayon A, Van Schepdael A, Schwalbe H, Gervasio FL, Carmeliet G, Rozensky J, Dewerchin M, Simons M, Christopoulos A, Herbert JM, Carmeliet P.

Cancer Cell. 2013 Apr 15;23(4):477-88. doi: 10.1016/j.ccr.2013.02.019.

21.

Aggregation gatekeepers modulate protein homeostasis of aggregating sequences and affect bacterial fitness.

Beerten J, Jonckheere W, Rudyak S, Xu J, Wilkinson H, De Smet F, Schymkowitz J, Rousseau F.

Protein Eng Des Sel. 2012 Jul;25(7):357-66. doi: 10.1093/protein/gzs031. Epub 2012 Jun 15.

PMID:
22706763
22.

The health and economic burden of chickenpox and herpes zoster in Belgium.

Bilcke J, Ogunjimi B, Marais C, de Smet F, Callens M, Callaert K, van Kerschaver E, Ramet J, van Damme P, Beutels P.

Epidemiol Infect. 2012 Nov;140(11):2096-109. Epub 2012 Jan 10.

PMID:
22230041
23.

Like mother, like daughter? Mother's history of cervical cancer screening and daughter's Human Papillomavirus vaccine uptake in Flanders (Belgium).

Lefevere E, Hens N, Theeten H, Van den Bosch K, Beutels P, De Smet F, Van Damme P.

Vaccine. 2011 Oct 26;29(46):8390-6. doi: 10.1016/j.vaccine.2011.08.039. Epub 2011 Aug 19.

PMID:
21856360
24.

Dynamics of HPV vaccination initiation in Flanders (Belgium) 2007-2009: a Cox regression model.

Lefevere E, Hens N, De Smet F, Van Damme P.

BMC Public Health. 2011 Jun 14;11:470. doi: 10.1186/1471-2458-11-470.

25.

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors.

Xu J, Reumers J, Couceiro JR, De Smet F, Gallardo R, Rudyak S, Cornelis A, Rozenski J, Zwolinska A, Marine JC, Lambrechts D, Suh YA, Rousseau F, Schymkowitz J.

Nat Chem Biol. 2011 May;7(5):285-95. doi: 10.1038/nchembio.546. Epub 2011 Mar 27.

PMID:
21445056
26.

Coexistence of stable stationary behavior and partial synchrony in an all-to-all coupled spiking neural network.

De Smet F, Aeyels D.

Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Dec;82(6 Pt 2):066208. Epub 2010 Dec 14.

PMID:
21230724
27.

Differential endothelial transcriptomics identifies semaphorin 3G as a vascular class 3 semaphorin.

Kutschera S, Weber H, Weick A, De Smet F, Genove G, Takemoto M, Prahst C, Riedel M, Mikelis C, Baulande S, Champseix C, Kummerer P, Conseiller E, Multon MC, Heroult M, Bicknell R, Carmeliet P, Betsholtz C, Augustin HG.

Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):151-9. doi: 10.1161/ATVBAHA.110.215871. Epub 2010 Oct 14.

PMID:
20947821
28.

Role of synectin in lymphatic development in zebrafish and frogs.

Hermans K, Claes F, Vandevelde W, Zheng W, Geudens I, Orsenigo F, De Smet F, Gjini E, Anthonis K, Ren B, Kerjaschki D, Autiero M, Ny A, Simons M, Dewerchin M, Schulte-Merker S, Dejana E, Alitalo K, Carmeliet P.

Blood. 2010 Oct 28;116(17):3356-66. doi: 10.1182/blood-2009-11-254557. Epub 2010 Jul 14.

29.

Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish.

Geudens I, Herpers R, Hermans K, Segura I, Ruiz de Almodovar C, Bussmann J, De Smet F, Vandevelde W, Hogan BM, Siekmann A, Claes F, Moore JC, Pistocchi AS, Loges S, Mazzone M, Mariggi G, Bruyère F, Cotelli F, Kerjaschki D, Noël A, Foidart JM, Gerhardt H, Ny A, Langenberg T, Lawson ND, Duckers HJ, Schulte-Merker S, Carmeliet P, Dewerchin M.

Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1695-702. doi: 10.1161/ATVBAHA.110.203034. Epub 2010 May 13.

30.

Non-invasive diagnosis of endometriosis based on a combined analysis of six plasma biomarkers.

Mihalyi A, Gevaert O, Kyama CM, Simsa P, Pochet N, De Smet F, De Moor B, Meuleman C, Billen J, Blanckaert N, Vodolazkaia A, Fulop V, D'Hooghe TM.

Hum Reprod. 2010 Mar;25(3):654-64. doi: 10.1093/humrep/dep425. Epub 2009 Dec 9.

PMID:
20007161
31.

Cancer during pregnancy: an analysis of 215 patients emphasizing the obstetrical and the neonatal outcomes.

Van Calsteren K, Heyns L, De Smet F, Van Eycken L, Gziri MM, Van Gemert W, Halaska M, Vergote I, Ottevanger N, Amant F.

J Clin Oncol. 2010 Feb 1;28(4):683-9. doi: 10.1200/JCO.2009.23.2801. Epub 2009 Oct 19.

PMID:
19841323
32.

The neurovascular link in health and disease: an update.

Segura I, De Smet F, Hohensinner PJ, Ruiz de Almodovar C, Carmeliet P.

Trends Mol Med. 2009 Oct;15(10):439-51. doi: 10.1016/j.molmed.2009.08.005. Epub 2009 Oct 2. Review.

PMID:
19801203
33.

Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way.

Carmeliet P, De Smet F, Loges S, Mazzone M.

Nat Rev Clin Oncol. 2009 Jun;6(6):315-26. doi: 10.1038/nrclinonc.2009.64. Review.

PMID:
19483738
34.

Endothelial oxygen sensors regulate tumor vessel abnormalization by instructing phalanx endothelial cells.

De Bock K, De Smet F, Leite De Oliveira R, Anthonis K, Carmeliet P.

J Mol Med (Berl). 2009 Jun;87(6):561-9. doi: 10.1007/s00109-009-0482-z. Epub 2009 May 20. Review.

PMID:
19455291
35.

Mechanisms of vessel branching: filopodia on endothelial tip cells lead the way.

De Smet F, Segura I, De Bock K, Hohensinner PJ, Carmeliet P.

Arterioscler Thromb Vasc Biol. 2009 May;29(5):639-49. doi: 10.1161/ATVBAHA.109.185165. Epub 2009 Mar 5. Review.

PMID:
19265031
36.

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization.

Mazzone M, Dettori D, de Oliveira RL, Loges S, Schmidt T, Jonckx B, Tian YM, Lanahan AA, Pollard P, de Almodovar CR, De Smet F, Vinckier S, Aragonés J, Debackere K, Luttun A, Wyns S, Jordan B, Pisacane A, Gallez B, Lampugnani MG, Dejana E, Simons M, Ratcliffe P, Maxwell P, Carmeliet P.

Cell. 2009 Mar 6;136(5):839-851. doi: 10.1016/j.cell.2009.01.020. Epub 2009 Feb 12.

37.

Resonances and entrainment breakup in Kuramoto models with multimodal frequency densities.

De Smet F, Aeyels D.

Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Jun;77(6 Pt 2):066212. Epub 2008 Jun 19.

PMID:
18643355
38.

The health and economic burden of rotavirus disease in Belgium.

Bilcke J, Van Damme P, De Smet F, Hanquet G, Van Ranst M, Beutels P.

Eur J Pediatr. 2008 Dec;167(12):1409-19. doi: 10.1007/s00431-008-0684-3. Epub 2008 Mar 4.

PMID:
18317802
39.

Expression profiling to predict the clinical behaviour of ovarian cancer fails independent evaluation.

Gevaert O, De Smet F, Van Gorp T, Pochet N, Engelen K, Amant F, De Moor B, Timmerman D, Vergote I.

BMC Cancer. 2008 Jan 22;8:18. doi: 10.1186/1471-2407-8-18.

40.

Body mass index and HER-2 overexpression in breast cancer patients over 50 years of age.

Van Mieghem T, Leunen K, Pochet N, De Moor B, De Smet F, Amant F, Berteloot P, Timmerman D, Vanden Bempt I, Drijkoningen R, Wildiers H, Paridaens R, Smeets A, Hendrickx W, Van Limbergen E, Christiaens MR, Vergote I, Neven P.

Breast Cancer Res Treat. 2007 Nov;106(1):127-33. Epub 2007 Jan 9.

PMID:
17211534
41.

Predicting the prognosis of breast cancer by integrating clinical and microarray data with Bayesian networks.

Gevaert O, De Smet F, Timmerman D, Moreau Y, De Moor B.

Bioinformatics. 2006 Jul 15;22(14):e184-90.

PMID:
16873470
42.

Bishop score and ultrasound assessment of the cervix for prediction of time to onset of labor and time to delivery in prolonged pregnancy.

Strobel E, Sladkevicius P, Rovas L, De Smet F, Karlsson ED, Valentin L.

Ultrasound Obstet Gynecol. 2006 Sep;28(3):298-305.

43.

Three-dimensional ultrasound assessment of the cervix for predicting time to spontaneous onset of labor and time to delivery in prolonged pregnancy.

Rovas L, Sladkevicius P, Strobel E, De Smet F, De Moor B, Valentin L.

Ultrasound Obstet Gynecol. 2006 Sep;28(3):306-11.

44.

Progesterone receptor in estrogen receptor-positive breast cancer: the association between HER-2 and lymph node involvement is age related.

Neven P, Pochet N, Drijkoningen M, Amant F, De Smet F, Paridaens R, Christiaens MR, Vergote I.

J Clin Oncol. 2006 Jun 1;24(16):2595; author reply 2595-7. No abstract available.

PMID:
16735717
45.

New models to predict depth of infiltration in endometrial carcinoma based on transvaginal sonography.

De Smet F, De Brabanter J, Van den Bosch T, Pochet N, Amant F, Van Holsbeke C, Moerman P, De Moor B, Vergote I, Timmerman D.

Ultrasound Obstet Gynecol. 2006 Jun;27(6):664-71.

46.

Gene prioritization through genomic data fusion.

Aerts S, Lambrechts D, Maity S, Van Loo P, Coessens B, De Smet F, Tranchevent LC, De Moor B, Marynen P, Hassan B, Carmeliet P, Moreau Y.

Nat Biotechnol. 2006 May;24(5):537-44. Erratum in: Nat Biotechnol. 2006 Jun;24(6):719.

PMID:
16680138
47.

Molecular profiling of platinum resistant ovarian cancer: use of the model in clinical practice.

Gevaert O, Pochet N, De Smet F, Van Gorp T, De Moor B, Timmerman D, Amant F, Vergote I.

Int J Cancer. 2006 Sep 15;119(6):1511; author reply 1512. No abstract available.

48.

Fishing and frogging for anti-angiogenic drugs.

De Smet F, Carmeliet P, Autiero M.

Nat Chem Biol. 2006 May;2(5):228-9. No abstract available.

PMID:
16619017
49.

Predicting the outcome of pregnancies of unknown location: Bayesian networks with expert prior information compared to logistic regression.

Gevaert O, De Smet F, Kirk E, Van Calster B, Bourne T, Van Huffel S, Moreau Y, Timmerman D, De Moor B, Condous G.

Hum Reprod. 2006 Jul;21(7):1824-31. Epub 2006 Apr 6.

PMID:
16601010
50.

Predicting the clinical behavior of ovarian cancer from gene expression profiles.

De Smet F, Pochet NL, Engelen K, Van Gorp T, Van Hummelen P, Marchal K, Amant F, Timmerman D, De Moor BL, Vergote IB.

Int J Gynecol Cancer. 2006 Jan-Feb;16 Suppl 1:147-51.

PMID:
16515583

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