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Items: 1 to 50 of 94

1.

Uncoupling conformational states from activity in an allosteric enzyme.

Pisco JP, de Chiara C, Pacholarz KJ, Garza-Garcia A, Ogrodowicz RW, Walker PA, Barran PE, Smerdon SJ, de Carvalho LPS.

Nat Commun. 2017 Aug 7;8(1):203. doi: 10.1038/s41467-017-00224-0.

2.

MRE11 stability is regulated by CK2-dependent interaction with R2TP complex.

von Morgen P, Burdova K, Flower TG, O'Reilly NJ, Boulton SJ, Smerdon SJ, Macurek L, Hořejší Z.

Oncogene. 2017 Aug 24;36(34):4943-4950. doi: 10.1038/onc.2017.99. Epub 2017 Apr 24.

3.

Three-Dimensional Architecture of the Human BRCA1-A Histone Deubiquitinase Core Complex.

Kyrieleis OJP, McIntosh PB, Webb SR, Calder LJ, Lloyd J, Patel NA, Martin SR, Robinson CV, Rosenthal PB, Smerdon SJ.

Cell Rep. 2016 Dec 20;17(12):3099-3106. doi: 10.1016/j.celrep.2016.11.063.

4.

HF-Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization.

Raz R, Burlina F, Ismail M, Downward J, Li J, Smerdon SJ, Quibell M, White PD, Offer J.

Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13174-13179. doi: 10.1002/anie.201607657.

5.

Versatility in phospho-dependent molecular recognition of the XRCC1 and XRCC4 DNA-damage scaffolds by aprataxin-family FHA domains.

Cherry AL, Nott TJ, Kelly G, Rulten SL, Caldecott KW, Smerdon SJ.

DNA Repair (Amst). 2015 Nov;35:116-25. doi: 10.1016/j.dnarep.2015.10.002. Epub 2015 Oct 23.

6.

Synergic interplay of the La motif, RRM1 and the interdomain linker of LARP6 in the recognition of collagen mRNA expands the RNA binding repertoire of the La module.

Martino L, Pennell S, Kelly G, Busi B, Brown P, Atkinson RA, Salisbury NJ, Ooi ZH, See KW, Smerdon SJ, Alfano C, Bui TT, Conte MR.

Nucleic Acids Res. 2015 Jan;43(1):645-60. doi: 10.1093/nar/gku1287. Epub 2014 Dec 8.

7.

The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage.

Larsen DH, Hari F, Clapperton JA, Gwerder M, Gutsche K, Altmeyer M, Jungmichel S, Toledo LI, Fink D, Rask MB, Grøfte M, Lukas C, Nielsen ML, Smerdon SJ, Lukas J, Stucki M.

Nat Cell Biol. 2014 Aug;16(8):792-803. doi: 10.1038/ncb3007. Epub 2014 Jul 27.

8.

FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain.

Pennell S, Déclais AC, Li J, Haire LF, Berg W, Saldanha JW, Taylor IA, Rouse J, Lilley DM, Smerdon SJ.

Cell Rep. 2014 Jul 10;8(1):84-93. doi: 10.1016/j.celrep.2014.06.001. Epub 2014 Jun 26.

9.

IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases.

Ben-Addi A, Mambole-Dema A, Brender C, Martin SR, Janzen J, Kjaer S, Smerdon SJ, Ley SC.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2394-403. doi: 10.1073/pnas.1320440111. Epub 2014 May 27.

10.

Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex.

Hořejší Z, Stach L, Flower TG, Joshi D, Flynn H, Skehel JM, O'Reilly NJ, Ogrodowicz RW, Smerdon SJ, Boulton SJ.

Cell Rep. 2014 Apr 10;7(1):19-26. doi: 10.1016/j.celrep.2014.03.013. Epub 2014 Mar 20.

11.

A year in structural signaling: mTOR--the PIKK of the bunch?

Smerdon SJ.

Sci Signal. 2014 Mar 4;7(315):pe6. doi: 10.1126/scisignal.2005174. Review.

PMID:
24595107
12.

An attenuated mutant of the Rv1747 ATP-binding cassette transporter of Mycobacterium tuberculosis and a mutant of its cognate kinase, PknF, show increased expression of the efflux pump-related iniBAC operon.

Spivey VL, Whalan RH, Hirst EM, Smerdon SJ, Buxton RS.

FEMS Microbiol Lett. 2013 Oct;347(2):107-15. doi: 10.1111/1574-6968.12230. Epub 2013 Aug 23.

13.

Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes.

Rock JM, Lim D, Stach L, Ogrodowicz RW, Keck JM, Jones MH, Wong CC, Yates JR 3rd, Winey M, Smerdon SJ, Yaffe MB, Amon A.

Science. 2013 May 17;340(6134):871-5. doi: 10.1126/science.1235822. Epub 2013 Apr 11.

14.

Substituted aminopyrimidine protein kinase B (PknB) inhibitors show activity against Mycobacterium tuberculosis.

Chapman TM, Bouloc N, Buxton RS, Chugh J, Lougheed KE, Osborne SA, Saxty B, Smerdon SJ, Taylor DL, Whalley D.

Bioorg Med Chem Lett. 2012 May 1;22(9):3349-53. doi: 10.1016/j.bmcl.2012.02.107. Epub 2012 Mar 14.

15.

Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.

Yata K, Lloyd J, Maslen S, Bleuyard JY, Skehel M, Smerdon SJ, Esashi F.

Mol Cell. 2012 Feb 10;45(3):371-83. doi: 10.1016/j.molcel.2011.12.028.

16.

The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator.

Jungmichel S, Clapperton JA, Lloyd J, Hari FJ, Spycher C, Pavic L, Li J, Haire LF, Bonalli M, Larsen DH, Lukas C, Lukas J, MacMillan D, Nielsen ML, Stucki M, Smerdon SJ.

Nucleic Acids Res. 2012 May;40(9):3913-28. doi: 10.1093/nar/gkr1300. Epub 2012 Jan 10.

17.

Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein.

Martino L, Pennell S, Kelly G, Bui TT, Kotik-Kogan O, Smerdon SJ, Drake AF, Curry S, Conte MR.

Nucleic Acids Res. 2012 Feb;40(3):1381-94. doi: 10.1093/nar/gkr890. Epub 2011 Oct 18.

18.

Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling.

Alexander J, Lim D, Joughin BA, Hegemann B, Hutchins JR, Ehrenberger T, Ivins F, Sessa F, Hudecz O, Nigg EA, Fry AM, Musacchio A, Stukenberg PT, Mechtler K, Peters JM, Smerdon SJ, Yaffe MB.

Sci Signal. 2011 Jun 28;4(179):ra42. doi: 10.1126/scisignal.2001796.

19.

An undecided coiled coil: the leucine zipper of Nek2 kinase exhibits atypical conformational exchange dynamics.

Croasdale R, Ivins FJ, Muskett F, Daviter T, Scott DJ, Hardy T, Smerdon SJ, Fry AM, Pfuhl M.

J Biol Chem. 2011 Aug 5;286(31):27537-47. doi: 10.1074/jbc.M110.196972. Epub 2011 Jun 13.

20.

Forkhead-associated (FHA) domain containing ABC transporter Rv1747 is positively regulated by Ser/Thr phosphorylation in Mycobacterium tuberculosis.

Spivey VL, Molle V, Whalan RH, Rodgers A, Leiba J, Stach L, Walker KB, Smerdon SJ, Buxton RS.

J Biol Chem. 2011 Jul 22;286(29):26198-209. doi: 10.1074/jbc.M111.246132. Epub 2011 May 26.

21.

Effective inhibitors of the essential kinase PknB and their potential as anti-mycobacterial agents.

Lougheed KE, Osborne SA, Saxty B, Whalley D, Chapman T, Bouloc N, Chugh J, Nott TJ, Patel D, Spivey VL, Kettleborough CA, Bryans JS, Taylor DL, Smerdon SJ, Buxton RS.

Tuberculosis (Edinb). 2011 Jul;91(4):277-86. doi: 10.1016/j.tube.2011.03.005. Epub 2011 Apr 11.

22.

Structural and functional analysis of phosphothreonine-dependent FHA domain interactions.

Pennell S, Westcott S, Ortiz-Lombardía M, Patel D, Li J, Nott TJ, Mohammed D, Buxton RS, Yaffe MB, Verma C, Smerdon SJ.

Structure. 2010 Dec 8;18(12):1587-95. doi: 10.1016/j.str.2010.09.014.

23.

Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N→S acyl transfer.

Masania J, Li J, Smerdon SJ, Macmillan D.

Org Biomol Chem. 2010 Nov 21;8(22):5113-9. doi: 10.1039/c0ob00363h. Epub 2010 Sep 9.

PMID:
20835458
24.

Structure of the amino-terminal domain from the cell-cycle regulator Swi6.

Taylor IA, Goldstone DC, Pala P, Haire LF, Smerdon SJ.

Proteins. 2010 Oct;78(13):2861-5. doi: 10.1002/prot.22795. No abstract available.

PMID:
20635421
25.

A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.

van Vugt MA, Gardino AK, Linding R, Ostheimer GJ, Reinhardt HC, Ong SE, Tan CS, Miao H, Keezer SM, Li J, Pawson T, Lewis TA, Carr SA, Smerdon SJ, Brummelkamp TR, Yaffe MB.

PLoS Biol. 2010 Jan 26;8(1):e1000287. doi: 10.1371/journal.pbio.1000287.

26.

Function of the nucleotide exchange activity of vav1 in T cell development and activation.

Saveliev A, Vanes L, Ksionda O, Rapley J, Smerdon SJ, Rittinger K, Tybulewicz VL.

Sci Signal. 2009 Dec 15;2(101):ra83. doi: 10.1126/scisignal.2000420.

27.

CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response.

Becherel OJ, Jakob B, Cherry AL, Gueven N, Fusser M, Kijas AW, Peng C, Katyal S, McKinnon PJ, Chen J, Epe B, Smerdon SJ, Taucher-Scholz G, Lavin MF.

Nucleic Acids Res. 2010 Mar;38(5):1489-503. doi: 10.1093/nar/gkp1149. Epub 2009 Dec 14.

28.

A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage.

Lloyd J, Chapman JR, Clapperton JA, Haire LF, Hartsuiker E, Li J, Carr AM, Jackson SP, Smerdon SJ.

Cell. 2009 Oct 2;139(1):100-11. doi: 10.1016/j.cell.2009.07.043.

29.

An intramolecular switch regulates phosphoindependent FHA domain interactions in Mycobacterium tuberculosis.

Nott TJ, Kelly G, Stach L, Li J, Westcott S, Patel D, Hunt DM, Howell S, Buxton RS, O'Hare HM, Smerdon SJ.

Sci Signal. 2009 Mar 24;2(63):ra12. doi: 10.1126/scisignal.2000212.

30.

Pellino proteins splitting up the FHAmily!

Pennell S, Smerdon SJ.

Structure. 2008 Dec 10;16(12):1752-4. doi: 10.1016/j.str.2008.11.002. No abstract available.

31.

Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis.

Canman JC, Lewellyn L, Laband K, Smerdon SJ, Desai A, Bowerman B, Oegema K.

Science. 2008 Dec 5;322(5907):1543-6. doi: 10.1126/science.1163086.

32.

Chk2 oligomerization studied by phosphopeptide ligation: implications for regulation and phosphodependent interactions.

Li J, Taylor IA, Lloyd J, Clapperton JA, Howell S, MacMillan D, Smerdon SJ.

J Biol Chem. 2008 Dec 19;283(51):36019-30. doi: 10.1074/jbc.M804075200. Epub 2008 Oct 23.

33.

The stimulatory RNA of the Visna-Maedi retrovirus ribosomal frameshifting signal is an unusual pseudoknot with an interstem element.

Pennell S, Manktelow E, Flatt A, Kelly G, Smerdon SJ, Brierley I.

RNA. 2008 Jul;14(7):1366-77. doi: 10.1261/rna.1042108. Epub 2008 May 21.

34.

Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface.

Withers-Martinez C, Haire LF, Hackett F, Walker PA, Howell SA, Smerdon SJ, Dodson GG, Blackman MJ.

J Mol Biol. 2008 Jan 18;375(3):773-81. Epub 2007 Nov 1.

PMID:
18036613
35.

Structure and regulation of the human Nek2 centrosomal kinase.

Rellos P, Ivins FJ, Baxter JE, Pike A, Nott TJ, Parkinson DM, Das S, Howell S, Fedorov O, Shen QY, Fry AM, Knapp S, Smerdon SJ.

J Biol Chem. 2007 Mar 2;282(9):6833-42. Epub 2006 Dec 31.

36.

Characterization of the helicase activity and substrate specificity of Mycobacterium tuberculosis UvrD.

Curti E, Smerdon SJ, Davis EO.

J Bacteriol. 2007 Mar;189(5):1542-55. Epub 2006 Dec 8.

38.

Structure of the eukaryotic initiation factor (eIF) 5 reveals a fold common to several translation factors.

Conte MR, Kelly G, Babon J, Sanfelice D, Youell J, Smerdon SJ, Proud CG.

Biochemistry. 2006 Apr 11;45(14):4550-8.

PMID:
16584190
39.

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.

Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP.

Cell. 2005 Dec 29;123(7):1213-26. Erratum in: Cell. 2008 May 2;133(3):549.

40.

An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice.

Curry JM, Whalan R, Hunt DM, Gohil K, Strom M, Rickman L, Colston MJ, Smerdon SJ, Buxton RS.

Infect Immun. 2005 Aug;73(8):4471-7.

41.

Key features of the interaction between Pcf11 CID and RNA polymerase II CTD.

Noble CG, Hollingworth D, Martin SR, Ennis-Adeniran V, Smerdon SJ, Kelly G, Taylor IA, Ramos A.

Nat Struct Mol Biol. 2005 Feb;12(2):144-51. Epub 2005 Jan 16.

PMID:
15665873
42.

High-resolution structure of a retroviral capsid hexameric amino-terminal domain.

Mortuza GB, Haire LF, Stevens A, Smerdon SJ, Stoye JP, Taylor IA.

Nature. 2004 Sep 23;431(7007):481-5. Erratum in: Nature. 2004 Oct 21;431(7011):1017.

PMID:
15386017
43.

Signaling by the sea.

Lemmon MA, Smerdon SJ.

Nat Struct Mol Biol. 2004 Aug;11(8):682-5.

PMID:
15280876
44.
45.

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer.

Clapperton JA, Manke IA, Lowery DM, Ho T, Haire LF, Yaffe MB, Smerdon SJ.

Nat Struct Mol Biol. 2004 Jun;11(6):512-8. Epub 2004 May 9.

PMID:
15133502
46.

Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6.

Geymonat M, Spanos A, Wells GP, Smerdon SJ, Sedgwick SG.

Mol Cell Biol. 2004 Mar;24(6):2277-85.

47.

The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain.

Elia AE, Rellos P, Haire LF, Chao JW, Ivins FJ, Hoepker K, Mohammad D, Cantley LC, Smerdon SJ, Yaffe MB.

Cell. 2003 Oct 3;115(1):83-95.

48.

Comment on "The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction".

Blackburn GM, Williams NH, Gamblin SJ, Smerdon SJ.

Science. 2003 Aug 29;301(5637):1184; author reply 1184. No abstract available.

49.

NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity.

Beinke S, Deka J, Lang V, Belich MP, Walker PA, Howell S, Smerdon SJ, Gamblin SJ, Ley SC.

Mol Cell Biol. 2003 Jul;23(14):4739-52.

50.

The FHA domain in DNA repair and checkpoint signaling.

Durocher D, Smerdon SJ, Yaffe MB, Jackson SP.

Cold Spring Harb Symp Quant Biol. 2000;65:423-31. Review. No abstract available.

PMID:
12760058

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