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Items: 1 to 50 of 116

1.

Nanocrystal formulations of a poorly soluble drug. 2. Evaluation of nanocrystal liver uptake and distribution after intravenous administration to mice.

Sigfridsson K, Skantze P, Skantze U, Svensson L, Löfgren L, Nordell P, Michaëlsson E, Smedsrød B, Fuglesteg B, Elvevold K, Lindfors L.

Int J Pharm. 2017 May 30;524(1-2):248-256. doi: 10.1016/j.ijpharm.2017.03.062. Epub 2017 Mar 31.

PMID:
28373104
2.

Delivery is key: lessons learnt from developing splice-switching antisense therapies.

Godfrey C, Desviat LR, Smedsrød B, Piétri-Rouxel F, Denti MA, Disterer P, Lorain S, Nogales-Gadea G, Sardone V, Anwar R, El Andaloussi S, Lehto T, Khoo B, Brolin C, van Roon-Mom WM, Goyenvalle A, Aartsma-Rus A, Arechavala-Gomeza V.

EMBO Mol Med. 2017 May;9(5):545-557. doi: 10.15252/emmm.201607199. Review.

3.

Nanocrystal formulations of a poorly soluble drug. 1. In vitro characterization of stability, stabilizer adsorption and uptake in liver cells.

Sigfridsson K, Skantze U, Skantze P, Johansson S, Grant I, Smedsrød B, Fuglesteg B, Elvevold K, Lindfors L.

Int J Pharm. 2017 Feb 25;518(1-2):29-40. doi: 10.1016/j.ijpharm.2016.12.035. Epub 2016 Dec 21.

PMID:
28012994
4.

FITC Conjugation Markedly Enhances Hepatic Clearance of N-Formyl Peptides.

Øie CI, Snapkov I, Elvevold K, Sveinbjørnsson B, Smedsrød B.

PLoS One. 2016 Aug 5;11(8):e0160602. doi: 10.1371/journal.pone.0160602. eCollection 2016.

5.

High-affinity von Willebrand factor binding does not affect the anatomical or hepatocellular distribution of factor VIII in rats.

Øie CI, Roepstorff K, Behrens C, Bøggild Kristensen J, Karpf DM, Bolt G, Gudme CN, Kjalke M, Smedsrød B, Appa RS.

J Thromb Haemost. 2016 Sep;14(9):1803-13. doi: 10.1111/jth.13406. Epub 2016 Aug 24.

6.

Pulmonary vascular clearance of harmful endogenous macromolecules in a porcine model of acute liver failure.

Nedredal GI, Elvevold K, Chedid MF, Ytrebø LM, Rose CF, Sen S, Smedsrød B, Jalan R, Revhaug A.

Ann Hepatol. 2016 May-Jun;15(3):427-35. doi: 10.5604/16652681.1198821.

PMID:
27049497
7.

Liver Sinusoidal Endothelial Cells.

Sørensen KK, Simon-Santamaria J, McCuskey RS, Smedsrød B.

Compr Physiol. 2015 Sep 20;5(4):1751-74. doi: 10.1002/cphy.c140078. Review.

PMID:
26426467
8.

Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells.

El Taghdouini A, Sørensen AL, Reiner AH, Coll M, Verhulst S, Mannaerts I, Øie CI, Smedsrød B, Najimi M, Sokal E, Luttun A, Sancho-Bru P, Collas P, van Grunsven LA.

Oncotarget. 2015 Sep 29;6(29):26729-45. doi: 10.18632/oncotarget.4925.

9.

Efficient uptake of blood-borne BK and JC polyomavirus-like particles in endothelial cells of liver sinusoids and renal vasa recta.

Simon-Santamaria J, Rinaldo CH, Kardas P, Li R, Malovic I, Elvevold K, McCourt P, Smedsrød B, Hirsch HH, Sørensen KK.

PLoS One. 2014 Nov 6;9(11):e111762. doi: 10.1371/journal.pone.0111762. eCollection 2014.

10.

Imaging fenestrations in liver sinusoidal endothelial cells by optical localization microscopy.

Mönkemöller V, Schüttpelz M, McCourt P, Sørensen K, Smedsrød B, Huser T.

Phys Chem Chem Phys. 2014 Jun 28;16(24):12576-81. doi: 10.1039/c4cp01574f.

PMID:
24830784
11.

Hepatic disposal of advanced glycation end products during maturation and aging.

Svistounov D, Oteiza A, Zykova SN, Sørensen KK, McCourt P, McLachlan AJ, McCuskey RS, Smedsrød B.

Exp Gerontol. 2013 Jun;48(6):549-56. doi: 10.1016/j.exger.2013.03.005. Epub 2013 Mar 24.

12.

The scavenger endothelial cell: a new player in homeostasis and immunity.

Sørensen KK, McCourt P, Berg T, Crossley C, Le Couteur D, Wake K, Smedsrød B.

Am J Physiol Regul Integr Comp Physiol. 2012 Dec 15;303(12):R1217-30. doi: 10.1152/ajpregu.00686.2011. Epub 2012 Oct 17. Review.

13.

The Relationship between fenestrations, sieve plates and rafts in liver sinusoidal endothelial cells.

Svistounov D, Warren A, McNerney GP, Owen DM, Zencak D, Zykova SN, Crane H, Huser T, Quinn RJ, Smedsrød B, Le Couteur DG, Cogger VC.

PLoS One. 2012;7(9):e46134. doi: 10.1371/journal.pone.0046134. Epub 2012 Sep 24.

14.

Effects of oxidized low-density lipoproteins on the hepatic microvasculature.

Oteiza A, Li R, McCuskey RS, Smedsrød B, Sørensen KK.

Am J Physiol Gastrointest Liver Physiol. 2011 Oct;301(4):G684-93. doi: 10.1152/ajpgi.00347.2010. Epub 2011 Jul 21.

15.

Rat liver sinusoidal endothelial cells (LSECs) express functional low density lipoprotein receptor-related protein-1 (LRP-1).

Øie CI, Appa RS, Hilden I, Petersen HH, Gruhler A, Smedsrød B, Hansen JB.

J Hepatol. 2011 Dec;55(6):1346-52. doi: 10.1016/j.jhep.2011.03.013. Epub 2011 Apr 13.

PMID:
21703209
16.

Cecal ligation and puncture sepsis is associated with attenuated expression of adenylyl cyclase 9 and increased miR142-3p.

Risøe PK, Ryg U, Wang YY, Rutkovskiy A, Smedsrød B, Valen G, Dahle MK.

Shock. 2011 Oct;36(4):390-5. doi: 10.1097/SHK.0b013e318228ec6f.

PMID:
21701418
17.

Role of liver sinusoidal endothelial cells and stabilins in elimination of oxidized low-density lipoproteins.

Li R, Oteiza A, Sørensen KK, McCourt P, Olsen R, Smedsrød B, Svistounov D.

Am J Physiol Gastrointest Liver Physiol. 2011 Jan;300(1):G71-81. doi: 10.1152/ajpgi.00215.2010. Epub 2010 Oct 28.

18.

Age-related changes in scavenger receptor-mediated endocytosis in rat liver sinusoidal endothelial cells.

Simon-Santamaria J, Malovic I, Warren A, Oteiza A, Le Couteur D, Smedsrød B, McCourt P, Sørensen KK.

J Gerontol A Biol Sci Med Sci. 2010 Sep;65(9):951-60. doi: 10.1093/gerona/glq108. Epub 2010 Jun 24.

19.

Three-dimensional structured illumination microscopy of liver sinusoidal endothelial cell fenestrations.

Cogger VC, McNerney GP, Nyunt T, DeLeve LD, McCourt P, Smedsrød B, Le Couteur DG, Huser TR.

J Struct Biol. 2010 Sep;171(3):382-8. doi: 10.1016/j.jsb.2010.06.001. Epub 2010 Jun 4.

20.

Colon carcinoma cell interaction with liver sinusoidal endothelium inhibits organ-specific antitumor immunity through interleukin-1-induced mannose receptor in mice.

Arteta B, Lasuen N, Lopategi A, Sveinbjörnsson B, Smedsrød B, Vidal-Vanaclocha F.

Hepatology. 2010 Jun;51(6):2172-82. doi: 10.1002/hep.23590.

PMID:
20513002
21.

Stabilins are expressed in bone marrow sinusoidal endothelial cells and mediate scavenging and cell adhesive functions.

Qian H, Johansson S, McCourt P, Smedsrød B, Ekblom M, Johansson S.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):883-6. doi: 10.1016/j.bbrc.2009.10.068. Epub 2009 Oct 20.

PMID:
19850011
22.

Endocytosis of advanced glycation end-products in bovine choriocapillaris endothelial cells.

Li R, McCourt P, Schledzewski K, Goerdt S, Moldenhauer G, Liu X, Smedsrød B, Sørensen KK.

Microcirculation. 2009 Oct;16(7):640-55. doi: 10.1080/10739680903133185.

PMID:
19657967
23.

Porcine liver sinusoidal endothelial cells contribute significantly to intrahepatic ammonia metabolism.

Nedredal GI, Elvevold K, Ytrebø LM, Fuskevåg OM, Pettersen I, McCourt PA, Bertheussen K, Smedsrød B, Revhaug A.

Hepatology. 2009 Sep;50(3):900-8. doi: 10.1002/hep.23076.

PMID:
19585612
24.

Hepatic sinusoidal cells in health and disease: update from the 14th International Symposium.

Smedsrød B, Le Couteur D, Ikejima K, Jaeschke H, Kawada N, Naito M, Knolle P, Nagy L, Senoo H, Vidal-Vanaclocha F, Yamaguchi N.

Liver Int. 2009 Apr;29(4):490-501. doi: 10.1111/j.1478-3231.2009.01979.x. Epub 2009 Jan 31. Review.

PMID:
19210626
25.

Liver sinusoidal endothelial cells depend on mannose receptor-mediated recruitment of lysosomal enzymes for normal degradation capacity.

Elvevold K, Simon-Santamaria J, Hasvold H, McCourt P, Smedsrød B, Sørensen KK.

Hepatology. 2008 Dec;48(6):2007-15. doi: 10.1002/hep.22527.

PMID:
19026003
26.

HB-EGF is a paracrine growth stimulator for early tumor prestages in inflammation-associated hepatocarcinogenesis.

Sagmeister S, Drucker C, Losert A, Grusch M, Daryabeigi A, Parzefall W, Rohr-Udilova N, Bichler C, Smedsrød B, Kandioler D, Grünberger T, Wrba F, Schulte-Hermann R, Grasl-Kraupp B.

J Hepatol. 2008 Dec;49(6):955-64. doi: 10.1016/j.jhep.2008.06.031. Epub 2008 Oct 7.

PMID:
18929421
27.

Old age and the hepatic sinusoid.

Le Couteur DG, Warren A, Cogger VC, Smedsrød B, Sørensen KK, De Cabo R, Fraser R, McCuskey RS.

Anat Rec (Hoboken). 2008 Jun;291(6):672-83. doi: 10.1002/ar.20661. Review.

28.

The influence of oxygen tension on the structure and function of isolated liver sinusoidal endothelial cells.

Martinez I, Nedredal GI, Øie CI, Warren A, Johansen O, Le Couteur DG, Smedsrød B.

Comp Hepatol. 2008 May 5;7:4. doi: 10.1186/1476-5926-7-4.

29.

The liver sinusoidal endothelial cell: a cell type of controversial and confusing identity.

Elvevold K, Smedsrød B, Martinez I.

Am J Physiol Gastrointest Liver Physiol. 2008 Feb;294(2):G391-400. Epub 2007 Dec 6. Review.

30.

Liver sinusoidal endothelial cells are the principal site for elimination of unfractionated heparin from the circulation.

Oie CI, Olsen R, Smedsrød B, Hansen JB.

Am J Physiol Gastrointest Liver Physiol. 2008 Feb;294(2):G520-8. Epub 2007 Dec 6.

31.
32.

Age-related changes in the liver sinusoidal endothelium: a mechanism for dyslipidemia.

LE Couteur DG, Cogger VC, McCuskey RS, DE Cabo R, Smedsrød B, Sorensen KK, Warren A, Fraser R.

Ann N Y Acad Sci. 2007 Oct;1114:79-87. Epub 2007 Sep 5. Review.

PMID:
17804522
33.

Age-related changes in the hepatic microcirculation in mice.

Ito Y, Sørensen KK, Bethea NW, Svistounov D, McCuskey MK, Smedsrød BH, McCuskey RS.

Exp Gerontol. 2007 Aug;42(8):789-97. Epub 2007 Apr 29.

34.

Effects of CpG-oligonucleotides, poly I:C and LPS on Atlantic cod scavenger endothelial cells (SEC).

Martin-Armas M, Zykova S, Smedsrød B.

Dev Comp Immunol. 2008;32(2):100-7. Epub 2007 May 24.

PMID:
17560649
35.

The mannose receptor on murine liver sinusoidal endothelial cells is the main denatured collagen clearance receptor.

Malovic I, Sørensen KK, Elvevold KH, Nedredal GI, Paulsen S, Erofeev AV, Smedsrød BH, McCourt PA.

Hepatology. 2007 Jun;45(6):1454-61.

PMID:
17518370
36.

Significant contribution of liver nonparenchymal cells to metabolism of ammonia and lactate and cocultivation augments the functions of a bioartificial liver.

Nedredal GI, Elvevold K, Ytrebø LM, Fuskevåg OM, Pettersen I, Bertheussen K, Langbakk B, Smedsrød B, Revhaug A.

Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G75-83. Epub 2007 Mar 15.

37.

Endocytosis and degradation of serglycin in liver sinusoidal endothelial cells.

Falkowska-Hansen B, Oynebråten I, Uhlin-Hansen L, Smedsrød B.

Mol Cell Biochem. 2006 Jul;287(1-2):43-52. Epub 2006 May 30.

PMID:
16733805
38.

Toll-like receptor 9 (TLR9) is present in murine liver sinusoidal endothelial cells (LSECs) and mediates the effect of CpG-oligonucleotides.

Martin-Armas M, Simon-Santamaria J, Pettersen I, Moens U, Smedsrød B, Sveinbjørnsson B.

J Hepatol. 2006 May;44(5):939-46. Epub 2005 Nov 7.

PMID:
16458386
39.

Osteoprotegerin is expressed in colon carcinoma cells.

Pettersen I, Bakkelund W, Smedsrød B, Sveinbjørnsson B.

Anticancer Res. 2005 Nov-Dec;25(6B):3809-16.

40.

Long-term preservation of high endocytic activity in primary cultures of pig liver sinusoidal endothelial cells.

Elvevold K, Nedredal GI, Revhaug A, Bertheussen K, Smedsrød B.

Eur J Cell Biol. 2005 Sep;84(9):749-64.

PMID:
16218189
41.

Hepatic clearance of advanced glycation end products (AGEs)--myth or truth?

Svistounov D, Smedsrød B.

J Hepatol. 2004 Dec;41(6):1038-40. Review. No abstract available.

PMID:
15582139
42.

Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding.

Hansen B, Longati P, Elvevold K, Nedredal GI, Schledzewski K, Olsen R, Falkowski M, Kzhyshkowska J, Carlsson F, Johansson S, Smedsrød B, Goerdt S, Johansson S, McCourt P.

Exp Cell Res. 2005 Feb 1;303(1):160-73.

PMID:
15572036
43.
44.

[Receptor mediated endocytosis of retinal pigment epithelial cell].

Li RM, Sorensen KK, Smedsrod B, Liu XP.

Zhonghua Yan Ke Za Zhi. 2004 Aug;40(8):539-44. Chinese.

PMID:
15454042
45.

Scavenger properties of cultivated pig liver endothelial cells.

Elvevold KH, Nedredal GI, Revhaug A, Smedsrød B.

Comp Hepatol. 2004 Aug 12;3(1):4.

46.

The liver sinusoidal endothelial cell hyaluronan receptor and its homolog, stabilin-1 - Their roles (known and unknown) in endocytosis.

McCourt PA, Hansen B, Svistuonov D, Johansson S, Longati P, Schledzewski K, Kzhyshkowska J, Goerdt S, Johansson S, Smedsrød B.

Comp Hepatol. 2004 Jan 14;3 Suppl 1:S24. No abstract available.

47.

Clearance function of scavenger endothelial cells.

Smedsrød B.

Comp Hepatol. 2004 Jan 14;3 Suppl 1:S22. No abstract available.

48.

Lack of recognition of Nepsilon-(carboxymethyl)lysine by the mouse liver reticulo-endothelial system: implications for pathophysiology.

Svistounov DN, Berg TJ, McCourt PA, Zykova SN, Elvevold KH, Nagai R, Horiuchi S, Smedsrod BH.

Biochem Biophys Res Commun. 2003 Oct 3;309(4):786-91.

PMID:
13679041
49.

Structure and liver cell expression pattern of the HFE gene in the rat.

Holmström P, Dzikaite V, Hultcrantz R, Melefors O, Eckes K, Stål P, Kinnman N, Smedsrød B, Gåfvels M, Eggertsen G.

J Hepatol. 2003 Sep;39(3):308-14.

PMID:
12927914
50.

Lipoteichoic acid is a potent inducer of cytokine production in rat and human Kupffer cells in vitro.

Øverland G, Morath S, Yndestad A, Hartung T, Thiemermann C, Foster SJ, Smedsrød B, Mathisen Ø, Aukrust P, Aasen AO, Wang JE.

Surg Infect (Larchmt). 2003 Summer;4(2):181-91.

PMID:
12906718

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