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Items: 12


Human monocytes and macrophages regulate immune tolerance via integrin αvβ8-mediated TGFβ activation.

Kelly A, Gunaltay S, McEntee CP, Shuttleworth EE, Smedley C, Houston SA, Fenton TM, Levison S, Mann ER, Travis MA.

J Exp Med. 2018 Nov 5;215(11):2725-2736. doi: 10.1084/jem.20171491. Epub 2018 Oct 24.


Sustainable Syntheses of (-)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site.

Smedley CJ, Stanley PA, Qazzaz ME, Prota AE, Olieric N, Collins H, Eastman H, Barrow AS, Lim KH, Kam TS, Smith BJ, Duivenvoorden HM, Parker BS, Bradshaw TD, Steinmetz MO, Moses JE.

Sci Rep. 2018 Jul 13;8(1):10617. doi: 10.1038/s41598-018-28880-2.


1-Bromoethene-1-sulfonyl fluoride (BESF) is another good connective hub for SuFEx click chemistry.

Smedley CJ, Giel MC, Molino A, Barrow AS, Wilson DJD, Moses JE.

Chem Commun (Camb). 2018 Jun 8;54(47):6020-6023. doi: 10.1039/c8cc03400a.


Intestinal mucin activates human dendritic cells and IL-8 production in a glycan-specific manner.

Melo-Gonzalez F, Fenton TM, Forss C, Smedley C, Goenka A, MacDonald AS, Thornton DJ, Travis MA.

J Biol Chem. 2018 Jun 1;293(22):8543-8553. doi: 10.1074/jbc.M117.789305. Epub 2018 Mar 26.


Increased glomerular filtration rate and impaired contractile function of mesangial cells in TRPC6 knockout mice.

Li W, Ding Y, Smedley C, Wang Y, Chaudhari S, Birnbaumer L, Ma R.

Sci Rep. 2017 Jun 23;7(1):4145. doi: 10.1038/s41598-017-04067-z.


Sulfur-Fluoride Exchange (SuFEx)-Mediated Synthesis of Sterically Hindered and Electron-Deficient Secondary and Tertiary Amides via Acyl Fluoride Intermediates.

Smedley CJ, Barrow AS, Spiteri C, Giel MC, Sharma P, Moses JE.

Chemistry. 2017 Jul 26;23(42):9990-9995. doi: 10.1002/chem.201701552.


Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8.

Fenton TM, Kelly A, Shuttleworth EE, Smedley C, Atakilit A, Powrie F, Campbell S, Nishimura SL, Sheppard D, Levison S, Worthington JJ, Lehtinen MJ, Travis MA.

Mucosal Immunol. 2017 May;10(3):624-634. doi: 10.1038/mi.2016.94. Epub 2016 Oct 26.


A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-β.

Ucar O, Li K, Dvornikov D, Kreutz C, Timmer J, Matt S, Brenner L, Smedley C, Travis MA, Hofmann TG, Klingmüller U, Kyewski B.

Cell Rep. 2016 Oct 4;17(2):448-457. doi: 10.1016/j.celrep.2016.09.027.


Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation.

Worthington JJ, Kelly A, Smedley C, Bauché D, Campbell S, Marie JC, Travis MA.

Immunity. 2015 May 19;42(5):903-15. doi: 10.1016/j.immuni.2015.04.012. Epub 2015 May 12.


Structure Activity Relationships of αv Integrin Antagonists for Pulmonary Fibrosis by Variation in Aryl Substituents.

Adams J, Anderson EC, Blackham EE, Chiu YW, Clarke T, Eccles N, Gill LA, Haye JJ, Haywood HT, Hoenig CR, Kausas M, Le J, Russell HL, Smedley C, Tipping WJ, Tongue T, Wood CC, Yeung J, Rowedder JE, Fray MJ, McInally T, Macdonald SJ.

ACS Med Chem Lett. 2014 Sep 19;5(11):1207-12. doi: 10.1021/ml5002079. eCollection 2014 Nov 13.


Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity.

Worthington JJ, Klementowicz JE, Rahman S, Czajkowska BI, Smedley C, Waldmann H, Sparwasser T, Grencis RK, Travis MA.

PLoS Pathog. 2013;9(10):e1003675. doi: 10.1371/journal.ppat.1003675. Epub 2013 Oct 3.


Strontium-90 and cesium-137 in total diet samples--a comparative study of data.

Roecklein PD, Smedley CE, Simpson RE.

Radiol Health Data Rep. 1970 Feb;11(2):47-64. No abstract available.


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