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Items: 42

1.

Defining the binding interface of Amyloid Precursor Protein (APP) and Contactin3 (CNTN3) by site-directed mutagenesis.

Peng X, Williams J, Smallwood PM, Nathans J.

PLoS One. 2019 Jul 18;14(7):e0219384. doi: 10.1371/journal.pone.0219384. eCollection 2019.

2.

Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development.

Cho C, Wang Y, Smallwood PM, Williams J, Nathans J.

Elife. 2019 Jun 21;8. pii: e47300. doi: 10.7554/eLife.47300.

3.

Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers.

Cho C, Wang Y, Smallwood PM, Williams J, Nathans J.

Elife. 2019 May 8;8. pii: e45542. doi: 10.7554/eLife.45542.

4.

Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance.

Wang Y, Cho C, Williams J, Smallwood PM, Zhang C, Junge HJ, Nathans J.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11827-E11836. doi: 10.1073/pnas.1813217115. Epub 2018 Nov 26. Erratum in: Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3934.

5.

Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions.

Peng X, Emiliani F, Smallwood PM, Rattner A, Lei H, Sabbagh MF, Nathans J.

Elife. 2018 Oct 22;7. pii: e40982. doi: 10.7554/eLife.40982.

6.

Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation.

Cho C, Smallwood PM, Nathans J.

Neuron. 2017 Aug 30;95(5):1221-1225. doi: 10.1016/j.neuron.2017.08.032. No abstract available.

7.

Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation.

Cho C, Smallwood PM, Nathans J.

Neuron. 2017 Aug 30;95(5):1056-1073.e5. doi: 10.1016/j.neuron.2017.07.031. Epub 2017 Aug 10. Erratum in: Neuron. 2017 Aug 30;95(5):1221-1225.

8.

Intramembrane Proteolysis of Astrotactins.

Chang H, Smallwood PM, Williams J, Nathans J.

J Biol Chem. 2017 Feb 24;292(8):3506-3516. doi: 10.1074/jbc.M116.768077. Epub 2017 Jan 18.

9.

Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina.

Zhou Y, Williams J, Smallwood PM, Nathans J.

PLoS One. 2015 Dec 2;10(12):e0143650. doi: 10.1371/journal.pone.0143650. eCollection 2015.

10.

The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation.

Chang H, Smallwood PM, Williams J, Nathans J.

Dev Biol. 2016 Jan 1;409(1):181-193. doi: 10.1016/j.ydbio.2015.10.027. Epub 2015 Nov 10.

11.

Identification of Astrotactin2 as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles.

Chang H, Cahill H, Smallwood PM, Wang Y, Nathans J.

PLoS Genet. 2015 Sep 29;11(9):e1005532. doi: 10.1371/journal.pgen.1005532. eCollection 2015.

12.

Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance.

Hua ZL, Chang H, Wang Y, Smallwood PM, Nathans J.

Development. 2014 Oct;141(20):3944-54. doi: 10.1242/dev.110189.

13.

Canonical WNT signaling components in vascular development and barrier formation.

Zhou Y, Wang Y, Tischfield M, Williams J, Smallwood PM, Rattner A, Taketo MM, Nathans J.

J Clin Invest. 2014 Sep;124(9):3825-46. doi: 10.1172/JCI76431. Epub 2014 Aug 1.

14.

Cellular resolution maps of X chromosome inactivation: implications for neural development, function, and disease.

Wu H, Luo J, Yu H, Rattner A, Mo A, Wang Y, Smallwood PM, Erlanger B, Wheelan SJ, Nathans J.

Neuron. 2014 Jan 8;81(1):103-19. doi: 10.1016/j.neuron.2013.10.051.

15.

Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons.

Hua ZL, Smallwood PM, Nathans J.

Elife. 2013 Dec 17;2:e01482. doi: 10.7554/eLife.01482.

16.

Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis.

Rattner A, Yu H, Williams J, Smallwood PM, Nathans J.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3830-9. doi: 10.1073/pnas.1315509110. Epub 2013 Sep 16.

17.

Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity.

Wang Y, Rattner A, Zhou Y, Williams J, Smallwood PM, Nathans J.

Cell. 2012 Dec 7;151(6):1332-44. doi: 10.1016/j.cell.2012.10.042.

18.

Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes.

Yu H, Smallwood PM, Wang Y, Vidaltamayo R, Reed R, Nathans J.

Development. 2010 Nov;137(21):3707-17. doi: 10.1242/dev.052001.

19.

New mouse lines for the analysis of neuronal morphology using CreER(T)/loxP-directed sparse labeling.

Badea TC, Hua ZL, Smallwood PM, Williams J, Rotolo T, Ye X, Nathans J.

PLoS One. 2009 Nov 16;4(11):e7859. doi: 10.1371/journal.pone.0007859.

20.

Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization.

Ye X, Wang Y, Cahill H, Yu M, Badea TC, Smallwood PM, Peachey NS, Nathans J.

Cell. 2009 Oct 16;139(2):285-98. doi: 10.1016/j.cell.2009.07.047. Erratum in: Cell. 2010 Apr 2;141(1):191.

21.

Genetically-directed, cell type-specific sparse labeling for the analysis of neuronal morphology.

Rotolo T, Smallwood PM, Williams J, Nathans J.

PLoS One. 2008;3(12):e4099. doi: 10.1371/journal.pone.0004099. Epub 2008 Dec 31.

22.

An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus.

Liu C, Wang Y, Smallwood PM, Nathans J.

J Neurosci. 2008 May 28;28(22):5641-53. doi: 10.1523/JNEUROSCI.1056-08.2008.

23.

Mutational analysis of Norrin-Frizzled4 recognition.

Smallwood PM, Williams J, Xu Q, Leahy DJ, Nathans J.

J Biol Chem. 2007 Feb 9;282(6):4057-68. Epub 2006 Dec 6.

24.

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair.

Xu Q, Wang Y, Dabdoub A, Smallwood PM, Williams J, Woods C, Kelley MW, Jiang L, Tasman W, Zhang K, Nathans J.

Cell. 2004 Mar 19;116(6):883-95.

25.

Proximal and distal sequences control UV cone pigment gene expression in transgenic zebrafish.

Luo W, Williams J, Smallwood PM, Touchman JW, Roman LM, Nathans J.

J Biol Chem. 2004 Apr 30;279(18):19286-93. Epub 2004 Feb 13.

26.

Genetically engineered mice with an additional class of cone photoreceptors: implications for the evolution of color vision.

Smallwood PM, Olveczky BP, Williams GL, Jacobs GH, Reese BE, Meister M, Nathans J.

Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11706-11. Epub 2003 Sep 19.

27.

Frizzled-3 is required for the development of major fiber tracts in the rostral CNS.

Wang Y, Thekdi N, Smallwood PM, Macke JP, Nathans J.

J Neurosci. 2002 Oct 1;22(19):8563-73.

28.

Role of a locus control region in the mutually exclusive expression of human red and green cone pigment genes.

Smallwood PM, Wang Y, Nathans J.

Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):1008-11. Epub 2002 Jan 2.

29.

A photoreceptor-specific cadherin is essential for the structural integrity of the outer segment and for photoreceptor survival.

Rattner A, Smallwood PM, Williams J, Cooke C, Savchenko A, Lyubarsky A, Pugh EN, Nathans J.

Neuron. 2001 Dec 6;32(5):775-86.

31.

Biochemical defects in ABCR protein variants associated with human retinopathies.

Sun H, Smallwood PM, Nathans J.

Nat Genet. 2000 Oct;26(2):242-6.

PMID:
11017087
32.
33.

Mutually exclusive expression of human red and green visual pigment-reporter transgenes occurs at high frequency in murine cone photoreceptors.

Wang Y, Smallwood PM, Cowan M, Blesh D, Lawler A, Nathans J.

Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5251-6.

34.

A new secreted protein that binds to Wnt proteins and inhibits their activities.

Hsieh JC, Kodjabachian L, Rebbert ML, Rattner A, Smallwood PM, Samos CH, Nusse R, Dawid IB, Nathans J.

Nature. 1999 Apr 1;398(6726):431-6.

PMID:
10201374
35.

Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein.

Hsieh JC, Rattner A, Smallwood PM, Nathans J.

Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3546-51.

36.

Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C.

Sherman PM, Sun H, Macke JP, Williams J, Smallwood PM, Nathans J.

Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11639-44.

37.

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.

Rattner A, Hsieh JC, Smallwood PM, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J.

Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2859-63.

38.

Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J.

Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9850-7.

39.

Mutation in the gene encoding the stimulatory G protein of adenylate cyclase in Albright's hereditary osteodystrophy.

Patten JL, Johns DR, Valle D, Eil C, Gruppuso PA, Steele G, Smallwood PM, Levine MA.

N Engl J Med. 1990 May 17;322(20):1412-9.

40.

Molecular cloning of beta 3 subunit, a third form of the G protein beta-subunit polypeptide.

Levine MA, Smallwood PM, Moen PT Jr, Helman LJ, Ahn TG.

Proc Natl Acad Sci U S A. 1990 Mar;87(6):2329-33.

41.

Influence of thyroid hormone status on expression of genes encoding G protein subunits in the rat heart.

Levine MA, Feldman AM, Robishaw JD, Ladenson PW, Ahn TG, Moroney JF, Smallwood PM.

J Biol Chem. 1990 Feb 25;265(6):3553-60.

42.

Genetic deficiency of the alpha subunit of the guanine nucleotide-binding protein Gs as the molecular basis for Albright hereditary osteodystrophy.

Levine MA, Ahn TG, Klupt SF, Kaufman KD, Smallwood PM, Bourne HR, Sullivan KA, Van Dop C.

Proc Natl Acad Sci U S A. 1988 Jan;85(2):617-21.

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