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Items: 1 to 50 of 57

1.

Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells.

Tornillo G, Knowlson C, Kendrick H, Cooke J, Mirza H, Aurrekoetxea-Rodríguez I, Vivanco MDM, Buckley NE, Grigoriadis A, Smalley MJ.

Cell Rep. 2018 Dec 26;25(13):3674-3692.e10. doi: 10.1016/j.celrep.2018.11.103.

2.

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth.

Pearson HB, Li J, Meniel VS, Fennell CM, Waring P, Montgomery KG, Rebello RJ, Macpherson AA, Koushyar S, Furic L, Cullinane C, Clarkson RW, Smalley MJ, Simpson KJ, Phesse TJ, Shepherd PR, Humbert PO, Sansom OJ, Phillips WA.

Cancer Discov. 2018 Jun;8(6):764-779. doi: 10.1158/2159-8290.CD-17-0867. Epub 2018 Mar 26.

PMID:
29581176
3.

PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression.

Chiang K, Zielinska AE, Shaaban AM, Sanchez-Bailon MP, Jarrold J, Clarke TL, Zhang J, Francis A, Jones LJ, Smith S, Barbash O, Guccione E, Farnie G, Smalley MJ, Davies CC.

Cell Rep. 2017 Dec 19;21(12):3498-3513. doi: 10.1016/j.celrep.2017.11.096.

4.

PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis.

Jefferies MT, Cox AC, Shorning BY, Meniel V, Griffiths D, Kynaston HG, Smalley MJ, Clarke AR.

J Pathol. 2017 Dec;243(4):442-456. doi: 10.1002/path.4977. Epub 2017 Nov 14.

5.

The receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis.

Soady KJ, Tornillo G, Kendrick H, Meniel V, Olijnyk-Dallis D, Morris JS, Stein T, Gusterson BA, Isacke CM, Smalley MJ.

Development. 2017 Oct 15;144(20):3777-3788. doi: 10.1242/dev.149120. Epub 2017 Sep 4.

6.

Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids.

Jardé T, Lloyd-Lewis B, Thomas M, Kendrick H, Melchor L, Bougaret L, Watson PD, Ewan K, Smalley MJ, Dale TC.

Nat Commun. 2016 Oct 26;7:13207. doi: 10.1038/ncomms13207.

7.

Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression.

Estrada MF, Rebelo SP, Davies EJ, Pinto MT, Pereira H, Santo VE, Smalley MJ, Barry ST, Gualda EJ, Alves PM, Anderson E, Brito C.

Biomaterials. 2016 Feb;78:50-61. doi: 10.1016/j.biomaterials.2015.11.030. Epub 2015 Nov 19.

8.

Runx2 contributes to the regenerative potential of the mammary epithelium.

Ferrari N, Riggio AI, Mason S, McDonald L, King A, Higgins T, Rosewell I, Neil JC, Smalley MJ, Sansom OJ, Morris J, Cameron ER, Blyth K.

Sci Rep. 2015 Oct 22;5:15658. doi: 10.1038/srep15658.

9.

Overview of Genetically Engineered Mouse Models of Breast Cancer Used in Translational Biology and Drug Development.

Greenow KR, Smalley MJ.

Curr Protoc Pharmacol. 2015 Sep 1;70:14.36.1-14. doi: 10.1002/0471141755.ph1436s70. Review.

PMID:
26331886
10.

ERrrr…where are the progenitors? Hormone receptors and mammary cell heterogeneity.

Tornillo G, Smalley MJ.

J Mammary Gland Biol Neoplasia. 2015 Jun;20(1-2):63-73. doi: 10.1007/s10911-015-9336-1. Epub 2015 Jul 21. Review.

11.

Mouse mammary stem cells express prognostic markers for triple-negative breast cancer.

Soady KJ, Kendrick H, Gao Q, Tutt A, Zvelebil M, Ordonez LD, Quist J, Tan DW, Isacke CM, Grigoriadis A, Smalley MJ.

Breast Cancer Res. 2015 Mar 4;17:31. doi: 10.1186/s13058-015-0539-6.

12.

Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.

Iglesias JM, Cairney CJ, Ferrier RK, McDonald L, Soady K, Kendrick H, Pringle MA, Morgan RO, Martin F, Smalley MJ, Blyth K, Stein T.

PLoS One. 2015 Mar 24;10(3):e0119718. doi: 10.1371/journal.pone.0119718. eCollection 2015.

13.

Whole-exome DNA sequence analysis of Brca2- and Trp53-deficient mouse mammary gland tumours.

Francis JC, Melchor L, Campbell J, Kendrick H, Wei W, Armisen-Garrido J, Assiotis I, Chen L, Kozarewa I, Fenwick K, Swain A, Smalley MJ, Lord CJ, Ashworth A.

J Pathol. 2015 Jun;236(2):186-200. doi: 10.1002/path.4517. Epub 2015 Apr 2.

PMID:
25692405
14.

Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models.

Melchor L, Molyneux G, Mackay A, Magnay FA, Atienza M, Kendrick H, Nava-Rodrigues D, López-García MÁ, Milanezi F, Greenow K, Robertson D, Palacios J, Reis-Filho JS, Smalley MJ.

J Pathol. 2014 Jun;233(2):124-37. doi: 10.1002/path.4345.

PMID:
24615332
15.

Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup.

Cowley M, Garfield AS, Madon-Simon M, Charalambous M, Clarkson RW, Smalley MJ, Kendrick H, Isles AR, Parry AJ, Carney S, Oakey RJ, Heisler LK, Moorwood K, Wolf JB, Ward A.

PLoS Biol. 2014 Feb 25;12(2):e1001799. doi: 10.1371/journal.pbio.1001799. eCollection 2014 Feb.

16.

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K, Brown NJ, Bryant HE, Bundred NJ, Burchell JM, Campbell AM, Carroll JS, Clarke RB, Coles CE, Cook GJ, Cox A, Curtin NJ, Dekker LV, Silva Idos S, Duffy SW, Easton DF, Eccles DM, Edwards DR, Edwards J, Evans D, Fenlon DF, Flanagan JM, Foster C, Gallagher WM, Garcia-Closas M, Gee JM, Gescher AJ, Goh V, Groves AM, Harvey AJ, Harvie M, Hennessy BT, Hiscox S, Holen I, Howell SJ, Howell A, Hubbard G, Hulbert-Williams N, Hunter MS, Jasani B, Jones LJ, Key TJ, Kirwan CC, Kong A, Kunkler IH, Langdon SP, Leach MO, Mann DJ, Marshall JF, Martin L, Martin SG, Macdougall JE, Miles DW, Miller WR, Morris JR, Moss SM, Mullan P, Natrajan R, O'Connor JP, O'Connor R, Palmieri C, Pharoah PD, Rakha EA, Reed E, Robinson SP, Sahai E, Saxton JM, Schmid P, Smalley MJ, Speirs V, Stein R, Stingl J, Streuli CH, Tutt AN, Velikova G, Walker RA, Watson CJ, Williams KJ, Young LS, Thompson AM.

Breast Cancer Res. 2013 Oct 1;15(5):R92. doi: 10.1186/bcr3493. Review.

17.

Aurora A kinase regulates mammary epithelial cell fate by determining mitotic spindle orientation in a Notch-dependent manner.

Regan JL, Sourisseau T, Soady K, Kendrick H, McCarthy A, Tang C, Brennan K, Linardopoulos S, White DE, Smalley MJ.

Cell Rep. 2013 Jul 11;4(1):110-23. doi: 10.1016/j.celrep.2013.05.044. Epub 2013 Jun 27.

18.

Embryonic mammary signature subsets are activated in Brca1-/- and basal-like breast cancers.

Zvelebil M, Oliemuller E, Gao Q, Wansbury O, Mackay A, Kendrick H, Smalley MJ, Reis-Filho JS, Howard BA.

Breast Cancer Res. 2013 Mar 18;15(2):R25. doi: 10.1186/bcr3403.

19.

Who do they think they are? Wnt-responsive cells reveal their family trees.

Ordonez L, Smalley MJ.

Breast Cancer Res. 2012 Dec 10;14(6):327. doi: 10.1186/bcr3351.

20.

Protein tyrosine phosphatase 1B restrains mammary alveologenesis and secretory differentiation.

Milani ES, Brinkhaus H, Dueggeli R, Klebba I, Mueller U, Stadler M, Kohler H, Smalley MJ, Bentires-Alj M.

Development. 2013 Jan 1;140(1):117-25. doi: 10.1242/dev.082941. Epub 2012 Nov 15.

21.

Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis.

Hopkins S, Linderoth E, Hantschel O, Suarez-Henriques P, Pilia G, Kendrick H, Smalley MJ, Superti-Furga G, Ferby I.

Dev Cell. 2012 Sep 11;23(3):547-59. doi: 10.1016/j.devcel.2012.08.001.

22.

Slugging their way to immortality: driving mammary epithelial cells into a stem cell-like state.

Soady K, Smalley MJ.

Breast Cancer Res. 2012 Sep 10;14(5):319. doi: 10.1186/bcr3188.

23.

Isolation of mouse mammary epithelial subpopulations: a comparison of leading methods.

Smalley MJ, Kendrick H, Sheridan JM, Regan JL, Prater MD, Lindeman GJ, Watson CJ, Visvader JE, Stingl J.

J Mammary Gland Biol Neoplasia. 2012 Jun;17(2):91-7. doi: 10.1007/s10911-012-9257-1. Epub 2012 May 30. Review.

PMID:
22644112
24.

Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer.

Gastaldi S, Sassi F, Accornero P, Torti D, Galimi F, Migliardi G, Molyneux G, Perera T, Comoglio PM, Boccaccio C, Smalley MJ, Bertotti A, Trusolino L.

Oncogene. 2013 Mar 14;32(11):1428-40. doi: 10.1038/onc.2012.154. Epub 2012 May 7.

25.

Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment.

Wansbury O, Mackay A, Kogata N, Mitsopoulos C, Kendrick H, Davidson K, Ruhrberg C, Reis-Filho JS, Smalley MJ, Zvelebil M, Howard BA.

Breast Cancer Res. 2011 Aug 11;13(4):R79. doi: 10.1186/bcr2928.

26.

c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer.

Regan JL, Kendrick H, Magnay FA, Vafaizadeh V, Groner B, Smalley MJ.

Oncogene. 2012 Feb 16;31(7):869-83. doi: 10.1038/onc.2011.289. Epub 2011 Jul 18.

PMID:
21765473
27.

The cell of origin of BRCA1 mutation-associated breast cancer: a cautionary tale of gene expression profiling.

Molyneux G, Smalley MJ.

J Mammary Gland Biol Neoplasia. 2011 Apr;16(1):51-5. doi: 10.1007/s10911-011-9202-8. Epub 2011 Feb 19. Review.

PMID:
21336547
28.

Methods in Mammary Gland Development and Cancer: the second ENDBC meeting--intravital imaging, genomics, modeling and metastasis.

Stingl J, Smalley MJ, Glukhova MA, Bentires-Alj M.

Breast Cancer Res. 2010;12(5):311. doi: 10.1186/bcr2630. Epub 2010 Sep 9.

29.

BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells.

Molyneux G, Geyer FC, Magnay FA, McCarthy A, Kendrick H, Natrajan R, Mackay A, Grigoriadis A, Tutt A, Ashworth A, Reis-Filho JS, Smalley MJ.

Cell Stem Cell. 2010 Sep 3;7(3):403-17. doi: 10.1016/j.stem.2010.07.010.

30.

Isolation, culture and analysis of mouse mammary epithelial cells.

Smalley MJ.

Methods Mol Biol. 2010;633:139-70. doi: 10.1007/978-1-59745-019-5_11.

PMID:
20204626
31.

Separating stem cells by flow cytometry: reducing variability for solid tissues.

Alexander CM, Puchalski J, Klos KS, Badders N, Ailles L, Kim CF, Dirks P, Smalley MJ.

Cell Stem Cell. 2009 Dec 4;5(6):579-83. doi: 10.1016/j.stem.2009.11.008.

32.

A tissue reconstitution model to study cancer cell-intrinsic and -extrinsic factors in mammary tumourigenesis.

Evers B, Speksnijder EN, Schut E, Ciampricotti M, Smalley MJ, Derksen PW, Jonkers J, de Visser KE.

J Pathol. 2010 Jan;220(1):34-44. doi: 10.1002/path.2655.

PMID:
19927317
33.

TSC-22D1 isoforms have opposing roles in mammary epithelial cell survival.

Huser CA, Pringle MA, Heath VJ, Bell AK, Kendrick H, Smalley MJ, Crighton D, Ryan KM, Gusterson BA, Stein T.

Cell Death Differ. 2010 Feb;17(2):304-15. doi: 10.1038/cdd.2009.126. Epub 2009 Sep 11.

34.

Identification of differentially expressed sense and antisense transcript pairs in breast epithelial tissues.

Grigoriadis A, Oliver GR, Tanney A, Kendrick H, Smalley MJ, Jat P, Neville AM.

BMC Genomics. 2009 Jul 17;10:324. doi: 10.1186/1471-2164-10-324.

35.

Pregnancy in the mature adult mouse does not alter the proportion of mammary epithelial stem/progenitor cells.

Britt KL, Kendrick H, Regan JL, Molyneux G, Magnay FA, Ashworth A, Smalley MJ.

Breast Cancer Res. 2009;11(2):R20. doi: 10.1186/bcr2245. Epub 2009 Apr 23.

36.

Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate.

Kendrick H, Regan JL, Magnay FA, Grigoriadis A, Mitsopoulos C, Zvelebil M, Smalley MJ.

BMC Genomics. 2008 Dec 8;9:591. doi: 10.1186/1471-2164-9-591.

37.

Highway to heaven: mammary gland development and differentiation.

Melchor L, Smalley MJ.

Breast Cancer Res. 2008;10(5):305. doi: 10.1186/bcr2147. Epub 2008 Oct 6.

38.

The future of mammary stem cell biology: the power of in vivo transplants.

Lindeman GJ, Visvader JE, Smalley MJ, Eaves CJ.

Breast Cancer Res. 2008;10(3):402; author reply 403. doi: 10.1186/bcr1986. Epub 2008 May 29. No abstract available.

39.

BRCA1 and stem cells: tumour typecasting.

Smalley MJ, Reis-Filho JS, Ashworth A.

Nat Cell Biol. 2008 Apr;10(4):377-9. doi: 10.1038/ncb0408-377.

PMID:
18379596
40.

Regulator of G-protein signalling 2 mRNA is differentially expressed in mammary epithelial subpopulations and over-expressed in the majority of breast cancers.

Smalley MJ, Iravani M, Leao M, Grigoriadis A, Kendrick H, Dexter T, Fenwick K, Regan JL, Britt K, McDonald S, Lord CJ, Mackay A, Ashworth A.

Breast Cancer Res. 2007;9(6):R85.

41.

Mammary stem cells and breast cancer.

Molyneux G, Regan J, Smalley MJ.

Cell Mol Life Sci. 2007 Dec;64(24):3248-60. Review.

PMID:
17955177
42.

Alpha-6 integrin is necessary for the tumourigenicity of a stem cell-like subpopulation within the MCF7 breast cancer cell line.

Cariati M, Naderi A, Brown JP, Smalley MJ, Pinder SE, Caldas C, Purushotham AD.

Int J Cancer. 2008 Jan 15;122(2):298-304.

43.

Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland.

Sleeman KE, Kendrick H, Robertson D, Isacke CM, Ashworth A, Smalley MJ.

J Cell Biol. 2007 Jan 1;176(1):19-26. Epub 2006 Dec 26.

44.

CD24 staining of mouse mammary gland cells defines luminal epithelial, myoepithelial/basal and non-epithelial cells.

Sleeman KE, Kendrick H, Ashworth A, Isacke CM, Smalley MJ.

Breast Cancer Res. 2006;8(1):R7. Epub 2005 Dec 12.

45.

An improved definition of mouse mammary epithelial side population cells.

Smalley MJ, Titley I, Ashworth A.

Cytotherapy. 2005;7(6):497-508.

PMID:
16306012
46.

Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta.

Smalley MJ, Signoret N, Robertson D, Tilley A, Hann A, Ewan K, Ding Y, Paterson H, Dale TC.

J Cell Sci. 2005 Nov 15;118(Pt 22):5279-89. Epub 2005 Nov 1.

47.

The mammary gland "side population": a putative stem/progenitor cell marker?

Smalley MJ, Clarke RB.

J Mammary Gland Biol Neoplasia. 2005 Jan;10(1):37-47. Review.

PMID:
15886885
48.
49.

Functional and molecular characterisation of mammary side population cells.

Alvi AJ, Clayton H, Joshi C, Enver T, Ashworth A, Vivanco Md, Dale TC, Smalley MJ.

Breast Cancer Res. 2003;5(1):R1-8. Epub 2002 Oct 14.

50.

Identification of the Axin and Frat binding region of glycogen synthase kinase-3.

Fraser E, Young N, Dajani R, Franca-Koh J, Ryves J, Williams RS, Yeo M, Webster MT, Richardson C, Smalley MJ, Pearl LH, Harwood A, Dale TC.

J Biol Chem. 2002 Jan 18;277(3):2176-85. Epub 2001 Nov 13.

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