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Items: 1 to 50 of 112

1.

Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells.

Tornillo G, Knowlson C, Kendrick H, Cooke J, Mirza H, Aurrekoetxea-Rodríguez I, Vivanco MDM, Buckley NE, Grigoriadis A, Smalley MJ.

Cell Rep. 2018 Dec 26;25(13):3674-3692.e10. doi: 10.1016/j.celrep.2018.11.103.

2.

Work-life balance versus responsibility to patients.

Smalley M.

Vet Rec. 2018 Dec 8;183(22):699. doi: 10.1136/vr.k5144. No abstract available.

PMID:
30523193
3.

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth.

Pearson HB, Li J, Meniel VS, Fennell CM, Waring P, Montgomery KG, Rebello RJ, Macpherson AA, Koushyar S, Furic L, Cullinane C, Clarkson RW, Smalley MJ, Simpson KJ, Phesse TJ, Shepherd PR, Humbert PO, Sansom OJ, Phillips WA.

Cancer Discov. 2018 Jun;8(6):764-779. doi: 10.1158/2159-8290.CD-17-0867. Epub 2018 Mar 26.

PMID:
29581176
4.

NanoVelcro rare-cell assays for detection and characterization of circulating tumor cells.

Jan YJ, Chen JF, Zhu Y, Lu YT, Chen SH, Chung H, Smalley M, Huang YW, Dong J, Chen LC, Yu HH, Tomlinson JS, Hou S, Agopian VG, Posadas EM, Tseng HR.

Adv Drug Deliv Rev. 2018 Feb 1;125:78-93. doi: 10.1016/j.addr.2018.03.006. Epub 2018 Mar 15. Review.

5.

See One, Do One, Teach One: A Practical Course on Methods in Mammary Gland Biology.

Jechlinger M, Kendrick H, Smalley M, Vivanco MD.

J Mammary Gland Biol Neoplasia. 2017 Dec;22(4):215-219. doi: 10.1007/s10911-017-9387-6. Epub 2018 Feb 14. No abstract available.

PMID:
29446000
6.

Cancer Immunotherapy and Personalized Medicine: Emerging Technologies and Biomarker-Based Approaches.

Maciejko L, Smalley M, Goldman A.

J Mol Biomark Diagn. 2017 Sep;8(5). pii: 350. doi: 10.4172/2155-9929.1000350. Epub 2017 Jun 28.

7.

PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression.

Chiang K, Zielinska AE, Shaaban AM, Sanchez-Bailon MP, Jarrold J, Clarke TL, Zhang J, Francis A, Jones LJ, Smith S, Barbash O, Guccione E, Farnie G, Smalley MJ, Davies CC.

Cell Rep. 2017 Dec 19;21(12):3498-3513. doi: 10.1016/j.celrep.2017.11.096.

8.

PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis.

Jefferies MT, Cox AC, Shorning BY, Meniel V, Griffiths D, Kynaston HG, Smalley MJ, Clarke AR.

J Pathol. 2017 Dec;243(4):442-456. doi: 10.1002/path.4977. Epub 2017 Nov 14.

9.

The receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis.

Soady KJ, Tornillo G, Kendrick H, Meniel V, Olijnyk-Dallis D, Morris JS, Stein T, Gusterson BA, Isacke CM, Smalley MJ.

Development. 2017 Oct 15;144(20):3777-3788. doi: 10.1242/dev.149120. Epub 2017 Sep 4.

10.

Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids.

Jardé T, Lloyd-Lewis B, Thomas M, Kendrick H, Melchor L, Bougaret L, Watson PD, Ewan K, Smalley MJ, Dale TC.

Nat Commun. 2016 Oct 26;7:13207. doi: 10.1038/ncomms13207.

11.

The use of everolimus in the treatment of neurocognitive problems in tuberous sclerosis (TRON): study protocol for a randomised controlled trial.

Randell E, McNamara R, Davies DM, Owen-Jones E, Kirby N, Angel L, Drew C, Cannings-John R, Smalley M, Saxena A, McDermott E, Stockwell L, de Vries PJ, Hood K, Sampson JR.

Trials. 2016 Aug 11;17:398. doi: 10.1186/s13063-016-1446-6.

12.

Essential role of HDAC6 in the regulation of PD-L1 in melanoma.

M L, P PV, T K, M P, E S, J P, K V W, C L, F C, S D, M SKS, M M, A K, J PI, A S, E S, J W, E M S, A V.

Mol Oncol. 2016 May;10(5):735-750. doi: 10.1016/j.molonc.2015.12.012. Epub 2016 Jan 6.

13.

Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression.

Estrada MF, Rebelo SP, Davies EJ, Pinto MT, Pereira H, Santo VE, Smalley MJ, Barry ST, Gualda EJ, Alves PM, Anderson E, Brito C.

Biomaterials. 2016 Feb;78:50-61. doi: 10.1016/j.biomaterials.2015.11.030. Epub 2015 Nov 19.

14.

Runx2 contributes to the regenerative potential of the mammary epithelium.

Ferrari N, Riggio AI, Mason S, McDonald L, King A, Higgins T, Rosewell I, Neil JC, Smalley MJ, Sansom OJ, Morris J, Cameron ER, Blyth K.

Sci Rep. 2015 Oct 22;5:15658. doi: 10.1038/srep15658.

15.

Overview of Genetically Engineered Mouse Models of Breast Cancer Used in Translational Biology and Drug Development.

Greenow KR, Smalley MJ.

Curr Protoc Pharmacol. 2015 Sep 1;70:14.36.1-14. doi: 10.1002/0471141755.ph1436s70. Review.

PMID:
26331886
16.

ERrrr…where are the progenitors? Hormone receptors and mammary cell heterogeneity.

Tornillo G, Smalley MJ.

J Mammary Gland Biol Neoplasia. 2015 Jun;20(1-2):63-73. doi: 10.1007/s10911-015-9336-1. Epub 2015 Jul 21. Review.

17.

Peri-operative management of heparin-induced thrombocytopenia syndrome in a patient with a suspected gynecologic malignancy.

Burger BM, Burger A, Cromwell C, Crispens M, Fields A, Smalley ML, Boulay RM, Thomas MB, Martino MA.

Semin Oncol. 2015 Jun;42(3):e25-31. doi: 10.1053/j.seminoncol.2015.02.018. Epub 2015 Feb 14. No abstract available.

PMID:
25965371
18.

Mouse mammary stem cells express prognostic markers for triple-negative breast cancer.

Soady KJ, Kendrick H, Gao Q, Tutt A, Zvelebil M, Ordonez LD, Quist J, Tan DW, Isacke CM, Grigoriadis A, Smalley MJ.

Breast Cancer Res. 2015 Mar 4;17:31. doi: 10.1186/s13058-015-0539-6.

19.

Genome Sequence of Magnetospirillum magnetotacticum Strain MS-1.

Smalley MD, Marinov GK, Bertani LE, DeSalvo G.

Genome Announc. 2015 Apr 2;3(2). pii: e00233-15. doi: 10.1128/genomeA.00233-15.

20.

Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.

Iglesias JM, Cairney CJ, Ferrier RK, McDonald L, Soady K, Kendrick H, Pringle MA, Morgan RO, Martin F, Smalley MJ, Blyth K, Stein T.

PLoS One. 2015 Mar 24;10(3):e0119718. doi: 10.1371/journal.pone.0119718. eCollection 2015.

21.

Whole-exome DNA sequence analysis of Brca2- and Trp53-deficient mouse mammary gland tumours.

Francis JC, Melchor L, Campbell J, Kendrick H, Wei W, Armisen-Garrido J, Assiotis I, Chen L, Kozarewa I, Fenwick K, Swain A, Smalley MJ, Lord CJ, Ashworth A.

J Pathol. 2015 Jun;236(2):186-200. doi: 10.1002/path.4517. Epub 2015 Apr 2.

PMID:
25692405
22.

Three-dimensional models of cancer for pharmacology and cancer cell biology: capturing tumor complexity in vitro/ex vivo.

Hickman JA, Graeser R, de Hoogt R, Vidic S, Brito C, Gutekunst M, van der Kuip H; IMI PREDECT Consortium.

Biotechnol J. 2014 Sep;9(9):1115-28. doi: 10.1002/biot.201300492. Review.

PMID:
25174503
23.

Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models.

Melchor L, Molyneux G, Mackay A, Magnay FA, Atienza M, Kendrick H, Nava-Rodrigues D, López-García MÁ, Milanezi F, Greenow K, Robertson D, Palacios J, Reis-Filho JS, Smalley MJ.

J Pathol. 2014 Jun;233(2):124-37. doi: 10.1002/path.4345.

PMID:
24615332
24.

Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup.

Cowley M, Garfield AS, Madon-Simon M, Charalambous M, Clarkson RW, Smalley MJ, Kendrick H, Isles AR, Parry AJ, Carney S, Oakey RJ, Heisler LK, Moorwood K, Wolf JB, Ward A.

PLoS Biol. 2014 Feb 25;12(2):e1001799. doi: 10.1371/journal.pbio.1001799. eCollection 2014 Feb.

25.

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K, Brown NJ, Bryant HE, Bundred NJ, Burchell JM, Campbell AM, Carroll JS, Clarke RB, Coles CE, Cook GJ, Cox A, Curtin NJ, Dekker LV, Silva Idos S, Duffy SW, Easton DF, Eccles DM, Edwards DR, Edwards J, Evans D, Fenlon DF, Flanagan JM, Foster C, Gallagher WM, Garcia-Closas M, Gee JM, Gescher AJ, Goh V, Groves AM, Harvey AJ, Harvie M, Hennessy BT, Hiscox S, Holen I, Howell SJ, Howell A, Hubbard G, Hulbert-Williams N, Hunter MS, Jasani B, Jones LJ, Key TJ, Kirwan CC, Kong A, Kunkler IH, Langdon SP, Leach MO, Mann DJ, Marshall JF, Martin L, Martin SG, Macdougall JE, Miles DW, Miller WR, Morris JR, Moss SM, Mullan P, Natrajan R, O'Connor JP, O'Connor R, Palmieri C, Pharoah PD, Rakha EA, Reed E, Robinson SP, Sahai E, Saxton JM, Schmid P, Smalley MJ, Speirs V, Stein R, Stingl J, Streuli CH, Tutt AN, Velikova G, Walker RA, Watson CJ, Williams KJ, Young LS, Thompson AM.

Breast Cancer Res. 2013 Oct 1;15(5):R92. doi: 10.1186/bcr3493. Review.

26.

Feasibility of Energy Dispersive X-Ray Fluorescence Determination of Gold in Soft Tissue for Clinical Applications.

Magaña IB, Adhikari P, Smalley MC, Eklund S, O'Neal DP.

Anal Methods. 2013 Jun 21;5(12):3148-3151.

27.

Aurora A kinase regulates mammary epithelial cell fate by determining mitotic spindle orientation in a Notch-dependent manner.

Regan JL, Sourisseau T, Soady K, Kendrick H, McCarthy A, Tang C, Brennan K, Linardopoulos S, White DE, Smalley MJ.

Cell Rep. 2013 Jul 11;4(1):110-23. doi: 10.1016/j.celrep.2013.05.044. Epub 2013 Jun 27.

28.

Embryonic mammary signature subsets are activated in Brca1-/- and basal-like breast cancers.

Zvelebil M, Oliemuller E, Gao Q, Wansbury O, Mackay A, Kendrick H, Smalley MJ, Reis-Filho JS, Howard BA.

Breast Cancer Res. 2013 Mar 18;15(2):R25. doi: 10.1186/bcr3403.

29.

Who do they think they are? Wnt-responsive cells reveal their family trees.

Ordonez L, Smalley MJ.

Breast Cancer Res. 2012 Dec 10;14(6):327. doi: 10.1186/bcr3351.

30.

Protein tyrosine phosphatase 1B restrains mammary alveologenesis and secretory differentiation.

Milani ES, Brinkhaus H, Dueggeli R, Klebba I, Mueller U, Stadler M, Kohler H, Smalley MJ, Bentires-Alj M.

Development. 2013 Jan 1;140(1):117-25. doi: 10.1242/dev.082941. Epub 2012 Nov 15.

31.

Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis.

Hopkins S, Linderoth E, Hantschel O, Suarez-Henriques P, Pilia G, Kendrick H, Smalley MJ, Superti-Furga G, Ferby I.

Dev Cell. 2012 Sep 11;23(3):547-59. doi: 10.1016/j.devcel.2012.08.001.

32.

Slugging their way to immortality: driving mammary epithelial cells into a stem cell-like state.

Soady K, Smalley MJ.

Breast Cancer Res. 2012 Sep 10;14(5):319. doi: 10.1186/bcr3188.

33.

Isolation of mouse mammary epithelial subpopulations: a comparison of leading methods.

Smalley MJ, Kendrick H, Sheridan JM, Regan JL, Prater MD, Lindeman GJ, Watson CJ, Visvader JE, Stingl J.

J Mammary Gland Biol Neoplasia. 2012 Jun;17(2):91-7. doi: 10.1007/s10911-012-9257-1. Epub 2012 May 30. Review.

PMID:
22644112
34.

Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer.

Gastaldi S, Sassi F, Accornero P, Torti D, Galimi F, Migliardi G, Molyneux G, Perera T, Comoglio PM, Boccaccio C, Smalley MJ, Bertotti A, Trusolino L.

Oncogene. 2013 Mar 14;32(11):1428-40. doi: 10.1038/onc.2012.154. Epub 2012 May 7.

35.

Breast cancer stem cells: obstacles to therapy.

Smalley M, Piggott L, Clarkson R.

Cancer Lett. 2013 Sep 10;338(1):57-62. doi: 10.1016/j.canlet.2012.04.023. Epub 2012 Apr 30. Review.

PMID:
22554712
36.

Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment.

Wansbury O, Mackay A, Kogata N, Mitsopoulos C, Kendrick H, Davidson K, Ruhrberg C, Reis-Filho JS, Smalley MJ, Zvelebil M, Howard BA.

Breast Cancer Res. 2011 Aug 11;13(4):R79. doi: 10.1186/bcr2928.

37.

The effects of testosterone on craniosynostotic calvarial cells: a test of the gene/environmental model of craniofacial anomalies.

Cray JJ Jr, Durham EL, Smalley MA, Finegold DN, Siegel MI, Losee JE, Mooney MP, Cooper GM.

Orthod Craniofac Res. 2011 Aug;14(3):149-55. doi: 10.1111/j.1601-6343.2011.01520.x. Epub 2011 Jul 14.

PMID:
21771269
38.

c-Kit is required for growth and survival of the cells of origin of Brca1-mutation-associated breast cancer.

Regan JL, Kendrick H, Magnay FA, Vafaizadeh V, Groner B, Smalley MJ.

Oncogene. 2012 Feb 16;31(7):869-83. doi: 10.1038/onc.2011.289. Epub 2011 Jul 18.

PMID:
21765473
39.

The cell of origin of BRCA1 mutation-associated breast cancer: a cautionary tale of gene expression profiling.

Molyneux G, Smalley MJ.

J Mammary Gland Biol Neoplasia. 2011 Apr;16(1):51-5. doi: 10.1007/s10911-011-9202-8. Epub 2011 Feb 19. Review.

PMID:
21336547
40.

Chiral interactions of histidine in a hydrated vermiculite clay.

Fraser DG, Greenwell HC, Skipper NT, Smalley MV, Wilkinson MA, Demé B, Heenan RK.

Phys Chem Chem Phys. 2011 Jan 21;13(3):825-30. doi: 10.1039/c0cp01387k. Epub 2010 Oct 28.

PMID:
21031173
41.

Direct comparison of progenitor cells derived from adipose, muscle, and bone marrow from wild-type or craniosynostotic rabbits.

Cooper GM, Durham EL, Cray JJ Jr, Bykowski MR, DeCesare GE, Smalley MA, Mooney MP, Campbell PG, Losee JE.

Plast Reconstr Surg. 2011 Jan;127(1):88-97. doi: 10.1097/PRS.0b013e3181fad311.

42.

Methods in Mammary Gland Development and Cancer: the second ENDBC meeting--intravital imaging, genomics, modeling and metastasis.

Stingl J, Smalley MJ, Glukhova MA, Bentires-Alj M.

Breast Cancer Res. 2010;12(5):311. doi: 10.1186/bcr2630. Epub 2010 Sep 9.

43.

BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells.

Molyneux G, Geyer FC, Magnay FA, McCarthy A, Kendrick H, Natrajan R, Mackay A, Grigoriadis A, Tutt A, Ashworth A, Reis-Filho JS, Smalley MJ.

Cell Stem Cell. 2010 Sep 3;7(3):403-17. doi: 10.1016/j.stem.2010.07.010.

44.

BMP-4 response in wild-type and craniosynostotic rabbit bone cells.

Cooper GM, Lensie EL, Cray JJ Jr, Decesare GE, Smalley MA, Losee JE, Mooney MP.

Plast Reconstr Surg. 2010 May;125(5):1403-11. doi: 10.1097/PRS.0b013e3181d62ad4.

PMID:
20440160
45.

Isolation, culture and analysis of mouse mammary epithelial cells.

Smalley MJ.

Methods Mol Biol. 2010;633:139-70. doi: 10.1007/978-1-59745-019-5_11.

PMID:
20204626
46.

Separating stem cells by flow cytometry: reducing variability for solid tissues.

Alexander CM, Puchalski J, Klos KS, Badders N, Ailles L, Kim CF, Dirks P, Smalley MJ.

Cell Stem Cell. 2009 Dec 4;5(6):579-83. doi: 10.1016/j.stem.2009.11.008.

47.

A tissue reconstitution model to study cancer cell-intrinsic and -extrinsic factors in mammary tumourigenesis.

Evers B, Speksnijder EN, Schut E, Ciampricotti M, Smalley MJ, Derksen PW, Jonkers J, de Visser KE.

J Pathol. 2010 Jan;220(1):34-44. doi: 10.1002/path.2655.

PMID:
19927317
48.

Mixed model approaches for the identification of QTLs within a maize hybrid breeding program.

van Eeuwijk FA, Boer M, Totir LR, Bink M, Wright D, Winkler CR, Podlich D, Boldman K, Baumgarten A, Smalley M, Arbelbide M, ter Braak CJ, Cooper M.

Theor Appl Genet. 2010 Jan;120(2):429-40. doi: 10.1007/s00122-009-1205-0. Epub 2009 Nov 17.

49.

TSC-22D1 isoforms have opposing roles in mammary epithelial cell survival.

Huser CA, Pringle MA, Heath VJ, Bell AK, Kendrick H, Smalley MJ, Crighton D, Ryan KM, Gusterson BA, Stein T.

Cell Death Differ. 2010 Feb;17(2):304-15. doi: 10.1038/cdd.2009.126. Epub 2009 Sep 11.

50.

It's all in the details: methods in breast development and cancer.

Bentires-Alj M, Clarke RB, Jonkers J, Smalley M, Stein T.

Breast Cancer Res. 2009;11(4):305. doi: 10.1186/bcr2346. Epub 2009 Aug 14.

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