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Early Detection and Preventive Intervention in Schizophrenia: From Fantasy to Reality.

Lieberman JA, Small SA, Girgis RR.

Am J Psychiatry. 2019 Oct 1;176(10):794-810. doi: 10.1176/appi.ajp.2019.19080865.


Cerebrospinal fluid amyloid levels are associated with delayed memory retention in cognitively normal biomarker-negative older adults.

Yeung LK, Hale C, Last BS, Andrews H, Sloan RP, Honig LS, Small SA, Brickman AM.

Neurobiol Aging. 2019 Aug 15;84:90-97. doi: 10.1016/j.neurobiolaging.2019.08.010. [Epub ahead of print]


Unilateral Focused Ultrasound-Induced Blood-Brain Barrier Opening Reduces Phosphorylated Tau from The rTg4510 Mouse Model.

Karakatsani ME, Kugelman T, Ji R, Murillo M, Wang S, Niimi Y, Small SA, Duff KE, Konofagou EE.

Theranostics. 2019 Jul 13;9(18):5396-5411. doi: 10.7150/thno.28717. eCollection 2019.


A Network Explanation of Alzheimer's Regional Vulnerability.

Small SA, Swanson LW.

Cold Spring Harb Symp Quant Biol. 2018;83:193-200. doi: 10.1101/sqb.2018.83.036889. Epub 2019 Jan 14.


An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney.

Rush BM, Small SA, Stolz DB, Tan RJ.

J Vis Exp. 2018 Nov 1;(141). doi: 10.3791/58162.


An Alzheimer's Disease-Linked Loss-of-Function CLN5 Variant Impairs Cathepsin D Maturation, Consistent with a Retromer Trafficking Defect.

Qureshi YH, Patel VM, Berman DE, Kothiya MJ, Neufeld JL, Vardarajan B, Tang M, Reyes-Dumeyer D, Lantigua R, Medrano M, Jiménez-Velázquez IJ, Small SA, Reitz C.

Mol Cell Biol. 2018 Sep 28;38(20). pii: e00011-18. doi: 10.1128/MCB.00011-18. Print 2018 Oct 15.


Cholera toxin inhibits SNX27-retromer-mediated delivery of cargo proteins to the plasma membrane.

Singh V, Yang J, Yin J, Cole R, Tse M, Berman DE, Small SA, Petsko G, Donowitz M.

J Cell Sci. 2018 Aug 17;131(16). pii: jcs218610. doi: 10.1242/jcs.218610.


Temporal lobe epilepsy lateralization using retrospective cerebral blood volume MRI.

Feng X, Hamberger MJ, Sigmon HC, Guo J, Small SA, Provenzano FA.

Neuroimage Clin. 2018 May 10;19:911-917. doi: 10.1016/j.nicl.2018.05.012. eCollection 2018.


Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein.

Young JE, Fong LK, Frankowski H, Petsko GA, Small SA, Goldstein LSB.

Stem Cell Reports. 2018 Mar 13;10(3):1046-1058. doi: 10.1016/j.stemcr.2018.01.031. Epub 2018 Mar 1.


Glutamate Dehydrogenase-Deficient Mice Display Schizophrenia-Like Behavioral Abnormalities and CA1-Specific Hippocampal Dysfunction.

Lander SS, Khan U, Lewandowski N, Chakraborty D, Provenzano FA, Mingote S, Chornyy S, Frigerio F, Maechler P, Kaphzan H, Small SA, Rayport S, Gaisler-Salomon I.

Schizophr Bull. 2019 Jan 1;45(1):127-137. doi: 10.1093/schbul/sby011.


Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures.

Miranda AM, Lasiecka ZM, Xu Y, Neufeld J, Shahriar S, Simoes S, Chan RB, Oliveira TG, Small SA, Di Paolo G.

Nat Commun. 2018 Jan 18;9(1):291. doi: 10.1038/s41467-017-02533-w.


Hippocampal dysfunction in the pathophysiology of schizophrenia: a selective review and hypothesis for early detection and intervention.

Lieberman JA, Girgis RR, Brucato G, Moore H, Provenzano F, Kegeles L, Javitt D, Kantrowitz J, Wall MM, Corcoran CM, Schobel SA, Small SA.

Mol Psychiatry. 2018 Aug;23(8):1764-1772. doi: 10.1038/mp.2017.249. Epub 2018 Jan 9. Review.


Maturation of bone-conduction transcranial and forehead attenuation using a measure of sound pressure in the ear canal.

Mackey AR, Hodgetts WE, Small SA.

Int J Audiol. 2018 Apr;57(4):283-290. doi: 10.1080/14992027.2017.1410585. Epub 2017 Dec 14.


Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology.

Nuriel T, Angulo SL, Khan U, Ashok A, Chen Q, Figueroa HY, Emrani S, Liu L, Herman M, Barrett G, Savage V, Buitrago L, Cepeda-Prado E, Fung C, Goldberg E, Gross SS, Hussaini SA, Moreno H, Small SA, Duff KE.

Nat Commun. 2017 Nov 13;8(1):1464. doi: 10.1038/s41467-017-01444-0.


In vivo detection and automatic analysis of GABA in the mouse brain with MEGA-PRESS at 9.4 T.

Guo J, Gang Z, Sun Y, Laine A, Small SA, Rothman DL.

NMR Biomed. 2018 Jan;31(1). doi: 10.1002/nbm.3837. Epub 2017 Nov 3.


Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer's Disease.

Small SA, Simoes-Spassov S, Mayeux R, Petsko GA.

Trends Neurosci. 2017 Oct;40(10):592-602. doi: 10.1016/j.tins.2017.08.003. Review.


The Effect of Signal to Noise Ratio on Cortical Auditory-Evoked Potentials Elicited to Speech Stimuli in Infants and Adults With Normal Hearing.

Small SA, Sharma M, Bradford M, Mandikal Vasuki PR.

Ear Hear. 2018 Mar/Apr;39(2):305-317. doi: 10.1097/AUD.0000000000000487.


Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit.

Angulo SL, Orman R, Neymotin SA, Liu L, Buitrago L, Cepeda-Prado E, Stefanov D, Lytton WW, Stewart M, Small SA, Duff KE, Moreno H.

Neurobiol Dis. 2017 Dec;108:261-276. doi: 10.1016/j.nbd.2017.08.015. Epub 2017 Aug 30.


The ModRey: An Episodic Memory Test for Nonclinical and Preclinical Populations.

Hale C, Last BS, Meier IB, Yeung LK, Budge M, Sloan RP, Small SA, Brickman AM.

Assessment. 2019 Sep;26(6):1154-1161. doi: 10.1177/1073191117723113. Epub 2017 Aug 11.


Maturation of Mechanical Impedance of the Skin-Covered Skull: Implications for Soft Band Bone-Anchored Hearing Systems Fitted in Infants and Young Children.

Mackey AR, Hodgetts WE, Scott D, Small SA.

Ear Hear. 2016 Jul-Aug;37(4):e210-23. doi: 10.1097/AUD.0000000000000272.


Elicitation of the Acoustic Change Complex to Long-Duration Speech Stimuli in Four-Month-Old Infants.

Chen KH, Small SA.

Int J Otolaryngol. 2015;2015:562030. doi: 10.1155/2015/562030. Epub 2015 Dec 22.


Physiological Measures and Their Potential for the Assessment of Pediatric Hearing Needs.

Small SA.

Am J Audiol. 2015 Jun;24(2):113-6. doi: 10.1044/2015_AJA-14-0070.


Retromer in Alzheimer disease, Parkinson disease and other neurological disorders.

Small SA, Petsko GA.

Nat Rev Neurosci. 2015 Mar;16(3):126-32. doi: 10.1038/nrn3896. Epub 2015 Feb 11. Review.


Anhedonia in the psychosis risk syndrome: associations with social impairment and basal orbitofrontal cortical activity.

Cressman VL, Schobel SA, Steinfeld S, Ben-David S, Thompson JL, Small SA, Moore H, Corcoran CM.

NPJ Schizophr. 2015 Jul 15;1:15020. doi: 10.1038/npjschz.2015.20. eCollection 2015.


The use of pharmacological retromer chaperones in Alzheimer's disease and other endosomal-related disorders.

Berman DE, Ringe D, Petsko GA, Small SA.

Neurotherapeutics. 2015 Jan;12(1):12-8. doi: 10.1007/s13311-014-0321-y. Review.


Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults.

Brickman AM, Khan UA, Provenzano FA, Yeung LK, Suzuki W, Schroeter H, Wall M, Sloan RP, Small SA.

Nat Neurosci. 2014 Dec;17(12):1798-803. doi: 10.1038/nn.3850. Epub 2014 Oct 26.


Isolating pathogenic mechanisms embedded within the hippocampal circuit through regional vulnerability.

Small SA.

Neuron. 2014 Oct 1;84(1):32-39. doi: 10.1016/j.neuron.2014.08.030. Review.


Genetic variants in a 'cAMP element binding protein' (CREB)-dependent histone acetylation pathway influence memory performance in cognitively healthy elderly individuals.

Barral S, Reitz C, Small SA, Mayeux R.

Neurobiol Aging. 2014 Dec;35(12):2881.e7-2881.e10. doi: 10.1016/j.neurobiolaging.2014.06.024. Epub 2014 Jun 28.


Pharmacological chaperones in the age of proteomic pathology.

Small SA.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12274-5. doi: 10.1073/pnas.1413111111. Epub 2014 Aug 13. No abstract available.


An investigation into the clinical utility of ipsilateral/contralateral asymmetries in bone-conduction auditory steady-state responses.

Small SA, Love A.

Int J Audiol. 2014 Sep;53(9):604-12. doi: 10.3109/14992027.2014.906752. Epub 2014 May 6.


Interneuron precursor transplants in adult hippocampus reverse psychosis-relevant features in a mouse model of hippocampal disinhibition.

Gilani AI, Chohan MO, Inan M, Schobel SA, Chaudhury NH, Paskewitz S, Chuhma N, Glickstein S, Merker RJ, Xu Q, Small SA, Anderson SA, Ross ME, Moore H.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7450-5. doi: 10.1073/pnas.1316488111. Epub 2014 May 2.


Pharmacological chaperones stabilize retromer to limit APP processing.

Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA.

Nat Chem Biol. 2014 Jun;10(6):443-9. doi: 10.1038/nchembio.1508. Epub 2014 Apr 20.


Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease.

Morabito MV, Berman DE, Schneider RT, Zhang Y, Leibel RL, Small SA.

Neurobiol Dis. 2014 May;65:188-92. doi: 10.1016/j.nbd.2013.12.017. Epub 2014 Jan 14.


Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease.

Khan UA, Liu L, Provenzano FA, Berman DE, Profaci CP, Sloan R, Mayeux R, Duff KE, Small SA.

Nat Neurosci. 2014 Feb;17(2):304-11. doi: 10.1038/nn.3606. Epub 2013 Dec 22.


Effective masking levels for 500 and 2000 Hz bone conduction auditory steady state responses in infants and adults with normal hearing.

Small SA, Smyth A, Leon G.

Ear Hear. 2014 Jan-Feb;35(1):63-71. doi: 10.1097/AUD.0b013e31829f2657.


Cochlear implantation for a child with cochlear nerve deficiency: parental perspectives explored through narrative.

Kotjan H, Purves B, Small SA.

Int J Audiol. 2013 Nov;52(11):776-82. doi: 10.3109/14992027.2013.820000. Epub 2013 Aug 29.


Molecular mechanism for age-related memory loss: the histone-binding protein RbAp48.

Pavlopoulos E, Jones S, Kosmidis S, Close M, Kim C, Kovalerchik O, Small SA, Kandel ER.

Sci Transl Med. 2013 Aug 28;5(200):200ra115. doi: 10.1126/scitranslmed.3006373.


Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system.

Morel E, Chamoun Z, Lasiecka ZM, Chan RB, Williamson RL, Vetanovetz C, Dall'Armi C, Simoes S, Point Du Jour KS, McCabe BD, Small SA, Di Paolo G.

Nat Commun. 2013;4:2250. doi: 10.1038/ncomms3250.


Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver.

Schobel SA, Chaudhury NH, Khan UA, Paniagua B, Styner MA, Asllani I, Inbar BP, Corcoran CM, Lieberman JA, Moore H, Small SA.

Neuron. 2013 Apr 10;78(1):81-93. doi: 10.1016/j.neuron.2013.02.011.


RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk.

MacLeod DA, Rhinn H, Kuwahara T, Zolin A, Di Paolo G, McCabe BD, Marder KS, Honig LS, Clark LN, Small SA, Abeliovich A.

Neuron. 2013 Feb 6;77(3):425-39. doi: 10.1016/j.neuron.2012.11.033. Erratum in: Neuron. 2013 Mar 6;77(5):994. MacCabe, Brian D [corrected to McCabe, Brian D].


Regional vulnerability in Huntington's disease: fMRI-guided molecular analysis in patients and a mouse model of disease.

Lewandowski NM, Bordelon Y, Brickman AM, Angulo S, Khan U, Muraskin J, Griffith EY, Wasserman P, Menalled L, Vonsattel JP, Marder K, Small SA, Moreno H.

Neurobiol Dis. 2013 Apr;52:84-93. doi: 10.1016/j.nbd.2012.11.014. Epub 2012 Dec 4. Erratum in: Neurobiol Dis. 2013 Jun;54:115.


Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes.

Lane RF, St George-Hyslop P, Hempstead BL, Small SA, Strittmatter SM, Gandy S.

J Neurosci. 2012 Oct 10;32(41):14080-6. doi: 10.1523/JNEUROSCI.3359-12.2012. Review.


Does the ACC have potential as an index of early speech discrimination ability? A preliminary study in 4-month-old infants with normal hearing.

Small SA, Werker JF.

Ear Hear. 2012 Nov-Dec;33(6):e59-69. doi: 10.1097/AUD.0b013e31825f29be.


R6/2 Huntington's disease mice develop early and progressive abnormal brain metabolism and seizures.

Cepeda-Prado E, Popp S, Khan U, Stefanov D, Rodríguez J, Menalled LB, Dow-Edwards D, Small SA, Moreno H.

J Neurosci. 2012 May 9;32(19):6456-67. doi: 10.1523/JNEUROSCI.0388-12.2012.


Mechanisms of age-related cognitive change and targets for intervention: epigenetics.

Kosik KS, Rapp PR, Raz N, Small SA, Sweatt JD, Tsai LH.

J Gerontol A Biol Sci Med Sci. 2012 Jun;67(7):741-6. doi: 10.1093/gerona/gls110. Epub 2012 Apr 20. Review.


The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport.

Bhalla A, Vetanovetz CP, Morel E, Chamoun Z, Di Paolo G, Small SA.

Neurobiol Dis. 2012 Jul;47(1):126-34. doi: 10.1016/j.nbd.2012.03.030. Epub 2012 Apr 6.


Motor deficits correlate with resting state motor network connectivity in patients with brain tumours.

Otten ML, Mikell CB, Youngerman BE, Liston C, Sisti MB, Bruce JN, Small SA, McKhann GM 2nd.

Brain. 2012 Apr;135(Pt 4):1017-26. doi: 10.1093/brain/aws041. Epub 2012 Mar 8.


Activation of signaling pathways following localized delivery of systemically administered neurotrophic factors across the blood-brain barrier using focused ultrasound and microbubbles.

Baseri B, Choi JJ, Deffieux T, Samiotaki G, Tung YS, Olumolade O, Small SA, Morrison B, Konofagou EE.

Phys Med Biol. 2012 Apr 7;57(7):N65-81. doi: 10.1088/0031-9155/57/7/N65. Epub 2012 Mar 9.

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