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Mycobacterium ulcerans toxin, mycolactone may enhance host-seeking and oviposition behaviour by Aedes aegypti (L.) (Diptera: Culicidae).

Sanders ML, Jordan HR, Serewis-Pond C, Zheng L, Benbow ME, Small PL, Tomberlin JK.

Environ Microbiol. 2017 May;19(5):1750-1760. doi: 10.1111/1462-2920.13629. Epub 2017 Jan 25.


Functional Diversity as a New Framework for Understanding the Ecology of an Emerging Generalist Pathogen.

Morris A, Guégan JF, Benbow ME, Williamson H, Small PL, Quaye C, Boakye D, Merritt RW, Gozlan RE.

Ecohealth. 2016 Sep;13(3):570-581. Epub 2016 Jun 29.


Comparative Sigma Factor-mRNA Levels in Mycobacterium marinum under Stress Conditions and during Host Infection.

Pettersson BM, Das S, Behra PR, Jordan HR, Ramesh M, Mallick A, Root KM, Cheramie MN, de la Cruz Melara I, Small PL, Dasgupta S, Ennis DG, Kirsebom LA.

PLoS One. 2015 Oct 7;10(10):e0139823. doi: 10.1371/journal.pone.0139823. eCollection 2015.


Mycobacterium ulcerans fails to infect through skin abrasions in a guinea pig infection model: implications for transmission.

Williamson HR, Mosi L, Donnell R, Aqqad M, Merritt RW, Small PL.

PLoS Negl Trop Dis. 2014 Apr 10;8(4):e2770. doi: 10.1371/journal.pntd.0002770. eCollection 2014 Apr.


Identifying the Achilles' heel of multi-host pathogens: The concept of keystone "host" species illustrated by Mycobacterium ulcerans transmission.

Roche B, Benbow ME, Merritt R, Kimbirauskas R, McIntosh M, Small PL, Williamson H, Guégan JF.

Environ Res Lett. 2013;8(4):045009.


Aquatic macroinvertebrate assemblages of Ghana, West Africa: understanding the ecology of a neglected tropical disease.

Eric Benbow M, Kimbirauskas R, McIntosh MD, Williamson H, Quaye C, Boakye D, Small PL, Merritt RW.

Ecohealth. 2014 Jun;11(2):168-83. doi: 10.1007/s10393-013-0886-7. Epub 2013 Dec 4.


Mycobacterium ulcerans causes minimal pathogenesis and colonization in medaka (Oryzias latipes): an experimental fish model of disease transmission.

Mosi L, Mutoji NK, Basile FA, Donnell R, Jackson KL, Spangenberg T, Kishi Y, Ennis DG, Small PL.

Microbes Infect. 2012 Aug;14(9):719-29. doi: 10.1016/j.micinf.2012.02.009. Epub 2012 Mar 14.


Detection of Mycobacterium ulcerans in the environment predicts prevalence of Buruli ulcer in Benin.

Williamson HR, Benbow ME, Campbell LP, Johnson CR, Sopoh G, Barogui Y, Merritt RW, Small PL.

PLoS Negl Trop Dis. 2012 Jan;6(1):e1506. doi: 10.1371/journal.pntd.0001506. Epub 2012 Jan 31.


Ecology and transmission of Buruli ulcer disease: a systematic review.

Merritt RW, Walker ED, Small PL, Wallace JR, Johnson PD, Benbow ME, Boakye DA.

PLoS Negl Trop Dis. 2010 Dec 14;4(12):e911. doi: 10.1371/journal.pntd.0000911. Review.


Mycobacterium liflandii outbreak in a research colony of Xenopus (Silurana) tropicalis frogs.

Fremont-Rahl JJ, Ek C, Williamson HR, Small PL, Fox JG, Muthupalani S.

Vet Pathol. 2011 Jul;48(4):856-67. doi: 10.1177/0300985810388520. Epub 2010 Nov 29.


Antioxidants protect keratinocytes against M. ulcerans mycolactone cytotoxicity.

Grönberg A, Zettergren L, Bergh K, Ståhle M, Heilborn J, Angeby K, Small PL, Akuffo H, Britton S.

PLoS One. 2010 Nov 4;5(11):e13839. doi: 10.1371/journal.pone.0013839.


A Mycobacterium ulcerans toxin, mycolactone, induces apoptosis in primary human keratinocytes and in HaCaT cells.

Bozzo C, Tiberio R, Graziola F, Pertusi G, Valente G, Colombo E, Small PL, Leigheb G.

Microbes Infect. 2010 Dec;12(14-15):1258-63. doi: 10.1016/j.micinf.2010.08.005. Epub 2010 Aug 25.


Interaction of Mycobacterium ulcerans with mosquito species: implications for transmission and trophic relationships.

Wallace JR, Gordon MC, Hartsell L, Mosi L, Benbow ME, Merritt RW, Small PL.

Appl Environ Microbiol. 2010 Sep;76(18):6215-22. doi: 10.1128/AEM.00340-10. Epub 2010 Jul 30.


Detection of Mycolactone A/B in Mycobacterium ulcerans-Infected Human Tissue.

Sarfo FS, Phillips RO, Rangers B, Mahrous EA, Lee RE, Tarelli E, Asiedu KB, Small PL, Wansbrough-Jones MH.

PLoS Negl Trop Dis. 2010 Jan 5;4(1):e577. doi: 10.1371/journal.pntd.0000577.


Heterogeneity in the stereochemistry of mycolactones isolated from M. marinum: toxins produced by fresh vs. saltwater fish pathogens.

Kim HJ, Jackson KL, Kishi Y, Williamson HR, Mosi L, Small PL.

Chem Commun (Camb). 2009 Dec 21;(47):7402-4. doi: 10.1039/b917014f. Epub 2009 Oct 26.


Mycolactone inhibits monocyte cytokine production by a posttranscriptional mechanism.

Simmonds RE, Lali FV, Smallie T, Small PL, Foxwell BM.

J Immunol. 2009 Feb 15;182(4):2194-202. doi: 10.4049/jimmunol.0802294.


Limited repair and structural damages displayed by skeletal muscles loaded with mycolactone.

Houngbédji GM, Côté CH, Small PL, Frenette J.

Microbes Infect. 2009 Feb;11(2):238-44. doi: 10.1016/j.micinf.2008.11.016. Epub 2008 Dec 16.


Synthesis and structure of mycolactone E isolated from frog mycobacterium.

Aubry S, Lee RE, Mahrous EA, Small PL, Beachboard D, Kishi Y.

Org Lett. 2008 Dec 4;10(23):5385-8. doi: 10.1021/ol802233f.


Persistent association of Mycobacterium ulcerans with West African predaceous insects of the family belostomatidae.

Mosi L, Williamson H, Wallace JR, Merritt RW, Small PL.

Appl Environ Microbiol. 2008 Nov;74(22):7036-42. doi: 10.1128/AEM.01234-08. Epub 2008 Oct 3.


Identification of three cytotoxic early proteins of mycobacteriophage L5 leading to growth inhibition in Mycobacterium smegmatis.

Rybniker J, Plum G, Robinson N, Small PL, Hartmann P.

Microbiology. 2008 Aug;154(Pt 8):2304-2314. doi: 10.1099/mic.0.2008/017004-0.


A Landscape-based model for predicting Mycobacterium ulcerans infection (Buruli Ulcer disease) presence in Benin, West Africa.

Wagner T, Benbow ME, Burns M, Johnson RC, Merritt RW, Qi J, Small PL.

Ecohealth. 2008 Mar;5(1):69-79. doi: 10.1007/s10393-007-0148-7. Epub 2008 Feb 8.


Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.

Stinear TP, Seemann T, Harrison PF, Jenkin GA, Davies JK, Johnson PD, Abdellah Z, Arrowsmith C, Chillingworth T, Churcher C, Clarke K, Cronin A, Davis P, Goodhead I, Holroyd N, Jagels K, Lord A, Moule S, Mungall K, Norbertczak H, Quail MA, Rabbinowitsch E, Walker D, White B, Whitehead S, Small PL, Brosch R, Ramakrishnan L, Fischbach MA, Parkhill J, Cole ST.

Genome Res. 2008 May;18(5):729-41. doi: 10.1101/gr.075069.107. Epub 2008 Apr 10.


Distribution of Mycobacterium ulcerans in buruli ulcer endemic and non-endemic aquatic sites in Ghana.

Williamson HR, Benbow ME, Nguyen KD, Beachboard DC, Kimbirauskas RK, McIntosh MD, Quaye C, Ampadu EO, Boakye D, Merritt RW, Small PL.

PLoS Negl Trop Dis. 2008 Mar 26;2(3):e205. doi: 10.1371/journal.pntd.0000205.


First cultivation and characterization of Mycobacterium ulcerans from the environment.

Portaels F, Meyers WM, Ablordey A, Castro AG, Chemlal K, de Rijk P, Elsen P, Fissette K, Fraga AG, Lee R, Mahrous E, Small PL, Stragier P, Torrado E, Van Aerde A, Silva MT, Pedrosa J.

PLoS Negl Trop Dis. 2008 Mar 26;2(3):e178. doi: 10.1371/journal.pntd.0000178.


Mycolactone is responsible for the painlessness of Mycobacterium ulcerans infection (buruli ulcer) in a murine study.

En J, Goto M, Nakanaga K, Higashi M, Ishii N, Saito H, Yonezawa S, Hamada H, Small PL.

Infect Immun. 2008 May;76(5):2002-7. doi: 10.1128/IAI.01588-07. Epub 2008 Mar 3.


Mycolactone-mediated inhibition of tumor necrosis factor production by macrophages infected with Mycobacterium ulcerans has implications for the control of infection.

Torrado E, Adusumilli S, Fraga AG, Small PL, Castro AG, Pedrosa J.

Infect Immun. 2007 Aug;75(8):3979-88. Epub 2007 May 21.


Newly identified Mycobacterium species in a Xenopus laevis colony.

Godfrey D, Williamson H, Silverman J, Small PL.

Comp Med. 2007 Feb;57(1):97-104.


Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer.

Stinear TP, Seemann T, Pidot S, Frigui W, Reysset G, Garnier T, Meurice G, Simon D, Bouchier C, Ma L, Tichit M, Porter JL, Ryan J, Johnson PD, Davies JK, Jenkin GA, Small PL, Jones LM, Tekaia F, Laval F, Daffé M, Parkhill J, Cole ST.

Genome Res. 2007 Feb;17(2):192-200. Epub 2007 Jan 8.


Globally distributed mycobacterial fish pathogens produce a novel plasmid-encoded toxic macrolide, mycolactone F.

Ranger BS, Mahrous EA, Mosi L, Adusumilli S, Lee RE, Colorni A, Rhodes M, Small PL.

Infect Immun. 2006 Nov;74(11):6037-45. Epub 2006 Aug 21.


Mycobacterium ulcerans toxic macrolide, mycolactone modulates the host immune response and cellular location of M. ulcerans in vitro and in vivo.

Adusumilli S, Mve-Obiang A, Sparer T, Meyers W, Hayman J, Small PL.

Cell Microbiol. 2005 Sep;7(9):1295-304.


Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin.

Coutanceau E, Marsollier L, Brosch R, Perret E, Goossens P, Tanguy M, Cole ST, Small PL, Demangel C.

Cell Microbiol. 2005 Aug;7(8):1187-96.


Colonization of the salivary glands of Naucoris cimicoides by Mycobacterium ulcerans requires host plasmatocytes and a macrolide toxin, mycolactone.

Marsollier L, Aubry J, Coutanceau E, André JP, Small PL, Milon G, Legras P, Guadagnini S, Carbonnelle B, Cole ST.

Cell Microbiol. 2005 Jul;7(7):935-43.


A newly discovered mycobacterial pathogen isolated from laboratory colonies of Xenopus species with lethal infections produces a novel form of mycolactone, the Mycobacterium ulcerans macrolide toxin.

Mve-Obiang A, Lee RE, Umstot ES, Trott KA, Grammer TC, Parker JM, Ranger BS, Grainger R, Mahrous EA, Small PL.

Infect Immun. 2005 Jun;73(6):3307-12.


Buruli ulcer (M. ulcerans infection): new insights, new hope for disease control.

Johnson PD, Stinear T, Small PL, Pluschke G, Merritt RW, Portaels F, Huygen K, Hayman JA, Asiedu K.

PLoS Med. 2005 Apr;2(4):e108. Epub 2005 Apr 26. No abstract available. Erratum in: PLoS Med. 2005 May;2(5):e173.


Structure determination of mycolactone C via total synthesis.

Judd TC, Bischoff A, Kishi Y, Adusumilli S, Small PL.

Org Lett. 2004 Dec 23;6(26):4901-4.


Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.

Stinear TP, Mve-Obiang A, Small PL, Frigui W, Pryor MJ, Brosch R, Jenkin GA, Johnson PD, Davies JK, Lee RE, Adusumilli S, Garnier T, Haydock SF, Leadlay PF, Cole ST.

Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1345-9. Epub 2004 Jan 21.


Analysis of Mycobacterium species for the presence of a macrolide toxin, mycolactone.

Daniel AK, Lee RE, Portaels F, Small PL.

Infect Immun. 2004 Jan;72(1):123-32.


Mycolactones and Mycobacterium ulcerans disease.

van der Werf TS, Stinear T, Stienstra Y, van der Graaf WT, Small PL.

Lancet. 2003 Sep 27;362(9389):1062-4. Review.


Suspension cultivation of Mycobacterium ulcerans for the production of mycolactones.

Cadapan LD, Arslanian RL, Carney JR, Zavala SM, Small PL, Licari P.

FEMS Microbiol Lett. 2001 Dec 18;205(2):385-9.


Staining of cellular mitochondria with LDS-751.

Snyder DS, Small PL.

J Immunol Methods. 2001 Nov 1;257(1-2):35-40.


Mycobacterium ulcerans cytotoxicity in an adipose cell model.

Dobos KM, Small PL, Deslauriers M, Quinn FD, King CH.

Infect Immun. 2001 Nov;69(11):7182-6.


Complete structure of the mycolactones.

Fidanze S, Song F, Szlosek-Pinaud M, Small PL, Kishi Y.

J Am Chem Soc. 2001 Oct 17;123(41):10117-8. No abstract available.


Stereochemistry of the core structure of the mycolactones.

Benowitz AB, Fidanze S, Small PL, Kishi Y.

J Am Chem Soc. 2001 May 30;123(21):5128-9. No abstract available.


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