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Items: 1 to 50 of 108

1.

Molecular insight into a new low affinity xylan binding module from the xylanolytic gut symbiont Roseburia intestinalis.

Leth ML, Ejby M, Madland E, Kitaoku Y, Slotboom DJ, Guskov A, Aachmann FL, Abou Hachem M.

FEBS J. 2019 Nov 6. doi: 10.1111/febs.15117. [Epub ahead of print]

PMID:
31693302
2.

A one-gate elevator mechanism for the human neutral amino acid transporter ASCT2.

Garaeva AA, Guskov A, Slotboom DJ, Paulino C.

Nat Commun. 2019 Jul 31;10(1):3427. doi: 10.1038/s41467-019-11363-x.

3.

Binding and transport of D-aspartate by the glutamate transporter homolog GltTk.

Arkhipova V, Trinco G, Ettema TW, Jensen S, Slotboom DJ, Guskov A.

Elife. 2019 Apr 10;8. pii: e45286. doi: 10.7554/eLife.45286.

4.

Two binding proteins of the ABC transporter that confers growth of Bifidobacterium animalis subsp. lactis ATCC27673 on β-mannan possess distinct manno-oligosaccharide-binding profiles.

Ejby M, Guskov A, Pichler MJ, Zanten GC, Schoof E, Saburi W, Slotboom DJ, Abou Hachem M.

Mol Microbiol. 2019 Jul;112(1):114-130. doi: 10.1111/mmi.14257. Epub 2019 Apr 25.

PMID:
30947380
5.

Epidural and Non-epidural Analgesia in Patients Undergoing Open Pancreatectomy: a Retrospective Cohort Study.

Groen JV, Slotboom DEF, Vuyk J, Martini CH, Dahan A, Vahrmeijer AL, Bonsing BA, Mieog JSD.

J Gastrointest Surg. 2019 Feb 26. doi: 10.1007/s11605-019-04136-w. [Epub ahead of print]

PMID:
30809780
6.

Models to determine the kinetic mechanisms of ion-coupled transporters.

Lolkema JS, Slotboom DJ.

J Gen Physiol. 2019 Mar 4;151(3):369-380. doi: 10.1085/jgp.201812055. Epub 2019 Jan 10.

7.

ECF-Type ATP-Binding Cassette Transporters.

Rempel S, Stanek WK, Slotboom DJ.

Annu Rev Biochem. 2019 Jun 20;88:551-576. doi: 10.1146/annurev-biochem-013118-111705. Epub 2019 Nov 28.

PMID:
30485755
8.

Cysteine-mediated decyanation of vitamin B12 by the predicted membrane transporter BtuM.

Rempel S, Colucci E, de Gier JW, Guskov A, Slotboom DJ.

Nat Commun. 2018 Aug 2;9(1):3038. doi: 10.1038/s41467-018-05441-9.

9.

Cryo-EM structure of the human neutral amino acid transporter ASCT2.

Garaeva AA, Oostergetel GT, Gati C, Guskov A, Paulino C, Slotboom DJ.

Nat Struct Mol Biol. 2018 Jun;25(6):515-521. doi: 10.1038/s41594-018-0076-y. Epub 2018 Jun 5.

PMID:
29872227
10.

Functional and structural characterization of an ECF-type ABC transporter for vitamin B12.

Santos JA, Rempel S, Mous ST, Pereira CT, Ter Beek J, de Gier JW, Guskov A, Slotboom DJ.

Elife. 2018 May 29;7. pii: e35828. doi: 10.7554/eLife.35828.

11.

The tunable pReX expression vector enables optimizing the T7-based production of membrane and secretory proteins in E. coli.

Kuipers G, Karyolaimos A, Zhang Z, Ismail N, Trinco G, Vikström D, Slotboom DJ, de Gier JW.

Microb Cell Fact. 2017 Dec 16;16(1):226. doi: 10.1186/s12934-017-0840-4.

12.

PnuT uses a facilitated diffusion mechanism for thiamine uptake.

Jaehme M, Singh R, Garaeva AA, Duurkens RH, Slotboom DJ.

J Gen Physiol. 2018 Jan 2;150(1):41-50. doi: 10.1085/jgp.201711850. Epub 2017 Dec 4.

13.

Single-molecule visualization of conformational changes and substrate transport in the vitamin B12 ABC importer BtuCD-F.

Goudsmits JMH, Slotboom DJ, van Oijen AM.

Nat Commun. 2017 Nov 21;8(1):1652. doi: 10.1038/s41467-017-01815-7.

14.

The structural basis of proton driven zinc transport by ZntB.

Gati C, Stetsenko A, Slotboom DJ, Scheres SHW, Guskov A.

Nat Commun. 2017 Nov 3;8(1):1313. doi: 10.1038/s41467-017-01483-7.

15.

Analysis of the quality of crystallographic data and the limitations of structural models.

Arkhipova V, Guskov A, Slotboom DJ.

J Gen Physiol. 2017 Dec 4;149(12):1091-1103. doi: 10.1085/jgp.201711852. Epub 2017 Oct 31. Review.

16.

Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine.

Monjas L, Swier LJYM, Setyawati I, Slotboom DJ, Hirsch AKH.

ChemMedChem. 2017 Oct 20;12(20):1693-1696. doi: 10.1002/cmdc.201700440. Epub 2017 Oct 6.

17.

Single-Molecule Fluorescence Studies of Membrane Transporters Using Total Internal Reflection Microscopy.

Goudsmits JMH, van Oijen AM, Slotboom DJ.

Methods Enzymol. 2017;594:101-121. doi: 10.1016/bs.mie.2017.05.009. Epub 2017 Jul 18.

PMID:
28779837
18.

Targeted Diazotransfer Reagents Enable Selective Modification of Proteins with Azides.

Lohse J, Swier LJYM, Oudshoorn RC, Médard G, Kuster B, Slotboom DJ, Witte MD.

Bioconjug Chem. 2017 Apr 19;28(4):913-917. doi: 10.1021/acs.bioconjchem.7b00110. Epub 2017 Apr 5.

19.

Insight into the complete substrate-binding pocket of ThiT by chemical and genetic mutations.

Swier LJYM, Monjas L, Reeßing F, Oudshoorn RC, Aisyah, Primke T, Bakker MM, van Olst E, Ritschel T, Faustino I, Marrink SJ, Hirsch AKH, Slotboom DJ.

Medchemcomm. 2017 Mar 31;8(5):1121-1130. doi: 10.1039/c7md00079k. eCollection 2017 May 1.

20.

Isolation and characterization of the E. coli membrane protein production strain Mutant56(DE3).

Baumgarten T, Schlegel S, Wagner S, Löw M, Eriksson J, Bonde I, Herrgård MJ, Heipieper HJ, Nørholm MH, Slotboom DJ, de Gier JW.

Sci Rep. 2017 Mar 24;7:45089. doi: 10.1038/srep45089.

21.

Tailoring Escherichia coli for the l-Rhamnose PBAD Promoter-Based Production of Membrane and Secretory Proteins.

Hjelm A, Karyolaimos A, Zhang Z, Rujas E, Vikström D, Slotboom DJ, de Gier JW.

ACS Synth Biol. 2017 Jun 16;6(6):985-994. doi: 10.1021/acssynbio.6b00321. Epub 2017 Mar 3.

PMID:
28226208
22.

Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk.

Guskov A, Jensen S, Faustino I, Marrink SJ, Slotboom DJ.

Nat Commun. 2016 Nov 10;7:13420. doi: 10.1038/ncomms13420.

23.

Structure and elevator mechanism of the Na+-citrate transporter CitS.

Lolkema JS, Slotboom DJ.

Curr Opin Struct Biol. 2017 Aug;45:1-9. doi: 10.1016/j.sbi.2016.10.004. Epub 2016 Oct 21. Review.

PMID:
27776291
24.

An ATP Binding Cassette Transporter Mediates the Uptake of α-(1,6)-Linked Dietary Oligosaccharides in Bifidobacterium and Correlates with Competitive Growth on These Substrates.

Ejby M, Fredslund F, Andersen JM, Vujičić Žagar A, Henriksen JR, Andersen TL, Svensson B, Slotboom DJ, Abou Hachem M.

J Biol Chem. 2016 Sep 16;291(38):20220-31. doi: 10.1074/jbc.M116.746529. Epub 2016 Aug 8.

25.

Structural insight in the toppling mechanism of an energy-coupling factor transporter.

Swier LJ, Guskov A, Slotboom DJ.

Nat Commun. 2016 Mar 30;7:11072. doi: 10.1038/ncomms11072.

26.

Pnu Transporters: Ain't They SWEET?

Jaehme M, Guskov A, Slotboom DJ.

Trends Biochem Sci. 2016 Feb;41(2):117-118. doi: 10.1016/j.tibs.2015.11.013. Epub 2015 Dec 13. No abstract available.

PMID:
26692123
27.

Relative Rates of Amino Acid Import via the ABC Transporter GlnPQ Determine the Growth Performance of Lactococcus lactis.

Fulyani F, Schuurman-Wolters GK, Slotboom DJ, Poolman B.

J Bacteriol. 2015 Nov 9;198(3):477-85. doi: 10.1128/JB.00685-15. Print 2016 Feb 1.

28.

High-level production of membrane proteins in E. coli BL21(DE3) by omitting the inducer IPTG.

Zhang Z, Kuipers G, Niemiec Ł, Baumgarten T, Slotboom DJ, de Gier JW, Hjelm A.

Microb Cell Fact. 2015 Sep 16;14:142. doi: 10.1186/s12934-015-0328-z.

29.

Structure, function, evolution, and application of bacterial Pnu-type vitamin transporters.

Jaehme M, Slotboom DJ.

Biol Chem. 2015 Sep;396(9-10):955-66. doi: 10.1515/hsz-2015-0113. Review.

30.

Competition between Different S-Components for the Shared Energy Coupling Factor Module in Energy Coupling Factor Transporters.

Majsnerowska M, Ter Beek J, Stanek WK, Duurkens RH, Slotboom DJ.

Biochemistry. 2015 Aug 11;54(31):4763-6. doi: 10.1021/acs.biochem.5b00609. Epub 2015 Jul 30.

PMID:
26217920
31.

The Hill analysis and co-ion-driven transporter kinetics.

Lolkema JS, Slotboom DJ.

J Gen Physiol. 2015 Jun;145(6):565-74. doi: 10.1085/jgp.201411332. Review.

32.

Low Affinity and Slow Na+ Binding Precedes High Affinity Aspartate Binding in the Secondary-active Transporter GltPh.

Hänelt I, Jensen S, Wunnicke D, Slotboom DJ.

J Biol Chem. 2015 Jun 26;290(26):15962-72. doi: 10.1074/jbc.M115.656876. Epub 2015 Apr 28.

33.

The twisted relation between Pnu and SWEET transporters.

Jaehme M, Guskov A, Slotboom DJ.

Trends Biochem Sci. 2015 Apr;40(4):183-8. doi: 10.1016/j.tibs.2015.02.002. Epub 2015 Mar 7. Review.

PMID:
25757400
34.

Structure-based design of potent small-molecule binders to the S-component of the ECF transporter for thiamine.

Swier LJ, Monjas L, Guskov A, de Voogd AR, Erkens GB, Slotboom DJ, Hirsch AK.

Chembiochem. 2015 Mar 23;16(5):819-26. doi: 10.1002/cbic.201402673. Epub 2015 Feb 12.

PMID:
25676607
35.

Crystal structure of the vitamin B3 transporter PnuC, a full-length SWEET homolog.

Jaehme M, Guskov A, Slotboom DJ.

Nat Struct Mol Biol. 2014 Nov;21(11):1013-5. doi: 10.1038/nsmb.2909. Epub 2014 Oct 7.

PMID:
25291599
36.

Diversity of membrane transport proteins for vitamins in bacteria and archaea.

Jaehme M, Slotboom DJ.

Biochim Biophys Acta. 2015 Mar;1850(3):565-76. doi: 10.1016/j.bbagen.2014.05.006. Epub 2014 May 13. Review.

PMID:
24836521
37.

Structural diversity of ABC transporters.

ter Beek J, Guskov A, Slotboom DJ.

J Gen Physiol. 2014 Apr;143(4):419-35. doi: 10.1085/jgp.201411164. Epub 2014 Mar 17. Review.

38.

Structural and mechanistic insights into prokaryotic energy-coupling factor transporters.

Slotboom DJ.

Nat Rev Microbiol. 2014 Feb;12(2):79-87. doi: 10.1038/nrmicro3175. Epub 2013 Dec 23.

PMID:
24362466
39.

Structural basis for arabinoxylo-oligosaccharide capture by the probiotic Bifidobacterium animalis subsp. lactis Bl-04.

Ejby M, Fredslund F, Vujicic-Zagar A, Svensson B, Slotboom DJ, Abou Hachem M.

Mol Microbiol. 2013 Dec;90(5):1100-12. doi: 10.1111/mmi.12419. Epub 2013 Oct 31.

40.

Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters.

Erkens GB, Hänelt I, Goudsmits JM, Slotboom DJ, van Oijen AM.

Nature. 2013 Oct 3;502(7469):119-23. doi: 10.1038/nature12538.

PMID:
24091978
41.

Crystal structure of a substrate-free aspartate transporter.

Jensen S, Guskov A, Rempel S, Hänelt I, Slotboom DJ.

Nat Struct Mol Biol. 2013 Oct;20(10):1224-6. doi: 10.1038/nsmb.2663. Epub 2013 Sep 8.

PMID:
24013209
42.

Functional diversity of tandem substrate-binding domains in ABC transporters from pathogenic bacteria.

Fulyani F, Schuurman-Wolters GK, Zagar AV, Guskov A, Slotboom DJ, Poolman B.

Structure. 2013 Oct 8;21(10):1879-88. doi: 10.1016/j.str.2013.07.020. Epub 2013 Aug 29.

43.

Flipping the sidedness of disulfide bond formation.

Slotboom DJ.

J Mol Biol. 2013 Sep 23;425(18):3265-7. doi: 10.1016/j.jmb.2013.07.005. Epub 2013 Jul 12. No abstract available.

44.

Substrate-induced conformational changes in the S-component ThiT from an energy coupling factor transporter.

Majsnerowska M, Hänelt I, Wunnicke D, Schäfer LV, Steinhoff HJ, Slotboom DJ.

Structure. 2013 May 7;21(5):861-7. doi: 10.1016/j.str.2013.03.007. Epub 2013 Apr 18.

45.

Conformational heterogeneity of the aspartate transporter Glt(Ph).

Hänelt I, Wunnicke D, Bordignon E, Steinhoff HJ, Slotboom DJ.

Nat Struct Mol Biol. 2013 Feb;20(2):210-4. doi: 10.1038/nsmb.2471. Epub 2013 Jan 20.

PMID:
23334291
46.

Genomic distribution of the small multidrug resistance protein EmrE over 29 Escherichia coli strains reveals two forms of the protein.

Kolbusz MA, Slotboom DJ, Lolkema JS.

FEBS J. 2013 Jan;280(1):244-55. doi: 10.1111/febs.12065. Epub 2012 Dec 11.

47.

Role of individual positive charges in the membrane orientation and activity of transporters of the small multidrug resistance family.

Kolbusz MA, Slotboom DJ, Lolkema JS.

Biochemistry. 2012 Nov 6;51(44):8867-76. doi: 10.1021/bi300854c. Epub 2012 Oct 23.

PMID:
23043311
48.

Structure and mode of peptide binding of pheromone receptor PrgZ.

Berntsson RP, Schuurman-Wolters GK, Dunny G, Slotboom DJ, Poolman B.

J Biol Chem. 2012 Oct 26;287(44):37165-70. doi: 10.1074/jbc.M112.386334. Epub 2012 Sep 4.

49.

Structural divergence of paralogous S components from ECF-type ABC transporters.

Berntsson RP, ter Beek J, Majsnerowska M, Duurkens RH, Puri P, Poolman B, Slotboom DJ.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):13990-5. doi: 10.1073/pnas.1203219109. Epub 2012 Aug 13.

50.

Optimizing membrane protein overexpression in the Escherichia coli strain Lemo21(DE3).

Schlegel S, Löfblom J, Lee C, Hjelm A, Klepsch M, Strous M, Drew D, Slotboom DJ, de Gier JW.

J Mol Biol. 2012 Nov 2;423(4):648-59. doi: 10.1016/j.jmb.2012.07.019. Epub 2012 Jul 31.

PMID:
22858868

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