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Items: 1 to 50 of 61

1.

Physiological Regulation of Drug Metabolism and Transport: Pregnancy, Microbiome, Inflammation, Infection, and Fasting.

Morgan ET, Dempsey JL, Mimche SM, Lamb TJ, Kulkarni S, Cui JY, Jeong H, Slitt AL.

Drug Metab Dispos. 2018 May;46(5):503-513. doi: 10.1124/dmd.117.079905. Epub 2018 Mar 7.

2.

Thymoquinone ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways.

Karandrea S, Yin H, Liang X, Slitt AL, Heart EA.

PLoS One. 2017 Sep 26;12(9):e0185374. doi: 10.1371/journal.pone.0185374. eCollection 2017.

3.

Hepatic Lipid Accumulation and Nrf2 Expression following Perinatal and Peripubertal Exposure to Bisphenol A in a Mouse Model of Nonalcoholic Liver Disease.

Shimpi PC, More VR, Paranjpe M, Donepudi AC, Goodrich JM, Dolinoy DC, Rubin B, Slitt AL.

Environ Health Perspect. 2017 Aug 4;125(8):087005. doi: 10.1289/EHP664.

4.

Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation in vitro.

DaSilva NA, Nahar PP, Ma H, Eid A, Wei Z, Meschwitz S, Zawia NH, Slitt AL, Seeram NP.

Nutr Neurosci. 2019 Mar;22(3):185-195. doi: 10.1080/1028415X.2017.1360558. Epub 2017 Aug 7.

PMID:
28784051
5.

Effects of a Standardized Phenolic-Enriched Maple Syrup Extract on β-Amyloid Aggregation, Neuroinflammation in Microglial and Neuronal Cells, and β-Amyloid Induced Neurotoxicity in Caenorhabditis elegans.

Ma H, DaSilva NA, Liu W, Nahar PP, Wei Z, Liu Y, Pham PT, Crews R, Vattem DA, Slitt AL, Shaikh ZA, Seeram NP.

Neurochem Res. 2016 Nov;41(11):2836-2847. Epub 2016 Jul 14.

6.

Correlation between Conjugated Bisphenol A Concentrations and Efflux Transporter Expression in Human Fetal Livers.

Moscovitz JE, Nahar MS, Shalat SL, Slitt AL, Dolinoy DC, Aleksunes LM.

Drug Metab Dispos. 2016 Jul;44(7):1061-5. doi: 10.1124/dmd.115.068668. Epub 2016 Feb 5.

7.

Hepatic Transporter Expression in Metabolic Syndrome: Phenotype, Serum Metabolic Hormones, and Transcription Factor Expression.

Donepudi AC, Cheng Q, Lu ZJ, Cherrington NJ, Slitt AL.

Drug Metab Dispos. 2016 Apr;44(4):518-26. doi: 10.1124/dmd.115.066779. Epub 2016 Feb 4.

8.

Bisphenol A sulfonation is impaired in metabolic and liver disease.

Yalcin EB, Kulkarni SR, Slitt AL, King R.

Toxicol Appl Pharmacol. 2016 Feb 1;292:75-84. doi: 10.1016/j.taap.2015.12.009. Epub 2015 Dec 19.

9.

PFOS induces adipogenesis and glucose uptake in association with activation of Nrf2 signaling pathway.

Xu J, Shimpi P, Armstrong L, Salter D, Slitt AL.

Toxicol Appl Pharmacol. 2016 Jan 1;290:21-30. doi: 10.1016/j.taap.2015.11.002. Epub 2015 Nov 5.

10.

Anti-Inflammatory Effects of Novel Standardized Solid Lipid Curcumin Formulations.

Nahar PP, Slitt AL, Seeram NP.

J Med Food. 2015 Jul;18(7):786-92. doi: 10.1089/jmf.2014.0053. Epub 2014 Dec 9.

11.

Deficiency in Nrf2 transcription factor decreases adipose tissue mass and hepatic lipid accumulation in leptin-deficient mice.

Xu J, Donepudi AC, More VR, Kulkarni SR, Li L, Guo L, Yan B, Chatterjee T, Weintraub N, Slitt AL.

Obesity (Silver Spring). 2015 Feb;23(2):335-44. doi: 10.1002/oby.20929. Epub 2014 Nov 29.

12.

Differential Fmo3 gene expression in various liver injury models involving hepatic oxidative stress in mice.

Rudraiah S, Moscovitz JE, Donepudi AC, Campion SN, Slitt AL, Aleksunes LM, Manautou JE.

Toxicology. 2014 Nov 5;325:85-95. doi: 10.1016/j.tox.2014.08.013. Epub 2014 Sep 2.

13.

Keap1-knockdown decreases fasting-induced fatty liver via altered lipid metabolism and decreased fatty acid mobilization from adipose tissue.

Xu J, Donepudi AC, Moscovitz JE, Slitt AL.

PLoS One. 2013 Nov 4;8(11):e79841. doi: 10.1371/journal.pone.0079841. eCollection 2013.

14.

Effect of caloric restriction and AMPK activation on hepatic nuclear receptor, biotransformation enzyme, and transporter expression in lean and obese mice.

Kulkarni SR, Xu J, Donepudi AC, Wei W, Slitt AL.

Pharm Res. 2013 Sep;30(9):2232-47. doi: 10.1007/s11095-013-1140-2. Epub 2013 Aug 16.

15.

Caloric restriction-mediated induction of lipid metabolism gene expression in liver is enhanced by Keap1-knockdown.

Kulkarni SR, Armstrong LE, Slitt AL.

Pharm Res. 2013 Sep;30(9):2221-31. doi: 10.1007/s11095-013-1138-9. Epub 2013 Jul 25.

16.

Downregulation of sulfotransferase expression and activity in diseased human livers.

Yalcin EB, More V, Neira KL, Lu ZJ, Cherrington NJ, Slitt AL, King RS.

Drug Metab Dispos. 2013 Sep;41(9):1642-50. doi: 10.1124/dmd.113.050930. Epub 2013 Jun 17.

17.

Fasting induces nuclear factor E2-related factor 2 and ATP-binding Cassette transporters via protein kinase A and Sirtuin-1 in mouse and human.

Kulkarni SR, Donepudi AC, Xu J, Wei W, Cheng QC, Driscoll MV, Johnson DA, Johnson JA, Li X, Slitt AL.

Antioxid Redox Signal. 2014 Jan 1;20(1):15-30. doi: 10.1089/ars.2012.5082. Epub 2013 Jul 31.

18.

Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding.

More VR, Xu J, Shimpi PC, Belgrave C, Luyendyk JP, Yamamoto M, Slitt AL.

Free Radic Biol Med. 2013 Aug;61:85-94. doi: 10.1016/j.freeradbiomed.2013.03.007. Epub 2013 Mar 16.

19.

Alcohol cirrhosis alters nuclear receptor and drug transporter expression in human liver.

More VR, Cheng Q, Donepudi AC, Buckley DB, Lu ZJ, Cherrington NJ, Slitt AL.

Drug Metab Dispos. 2013 May;41(5):1148-55. doi: 10.1124/dmd.112.049676. Epub 2013 Mar 5.

20.

Effects of developmental deltamethrin exposure on white adipose tissue gene expression.

Armstrong LE, Driscoll MV, Donepudi AC, Xu J, Baker A, Aleksunes LM, Richardson JR, Slitt AL.

J Biochem Mol Toxicol. 2013 Feb;27(2):165-71. doi: 10.1002/jbt.21477. Epub 2013 Feb 11. Erratum in: J Biochem Mol Toxicol. 2013 Apr;27(4):251-2.

21.

Pregnancy represses induction of efflux transporters in livers of type I diabetic mice.

Aleksunes LM, Xu J, Lin E, Wen X, Goedken MJ, Slitt AL.

Pharm Res. 2013 Sep;30(9):2209-20. doi: 10.1007/s11095-013-0981-z. Epub 2013 Jan 15.

22.

Altered UDP-glucuronosyltransferase and sulfotransferase expression and function during progressive stages of human nonalcoholic fatty liver disease.

Hardwick RN, Ferreira DW, More VR, Lake AD, Lu Z, Manautou JE, Slitt AL, Cherrington NJ.

Drug Metab Dispos. 2013 Mar;41(3):554-61. doi: 10.1124/dmd.112.048439. Epub 2012 Dec 7.

23.

Regulation of hepatic phase II metabolism in pregnant mice.

Wen X, Donepudi AC, Thomas PE, Slitt AL, King RS, Aleksunes LM.

J Pharmacol Exp Ther. 2013 Jan;344(1):244-52. doi: 10.1124/jpet.112.199034. Epub 2012 Oct 10.

24.

Enhanced Nrf2 activity worsens insulin resistance, impairs lipid accumulation in adipose tissue, and increases hepatic steatosis in leptin-deficient mice.

Xu J, Kulkarni SR, Donepudi AC, More VR, Slitt AL.

Diabetes. 2012 Dec;61(12):3208-18. doi: 10.2337/db11-1716. Epub 2012 Aug 30.

25.

Severe diabetes and leptin resistance cause differential hepatic and renal transporter expression in mice.

More VR, Wen X, Thomas PE, Aleksunes LM, Slitt AL.

Comp Hepatol. 2012 Apr 23;11(1):1. doi: 10.1186/1476-5926-11-1.

26.

The traditional ayurvedic medicine, Eugenia jambolana (Jamun fruit), decreases liver inflammation, injury and fibrosis during cholestasis.

Donepudi AC, Aleksunes LM, Driscoll MV, Seeram NP, Slitt AL.

Liver Int. 2012 Apr;32(4):560-73. doi: 10.1111/j.1478-3231.2011.02724.x. Epub 2011 Dec 30.

27.

UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis.

Xu J, Kulkarni SR, Li L, Slitt AL.

Drug Metab Dispos. 2012 Feb;40(2):259-66. doi: 10.1124/dmd.111.039925. Epub 2011 Oct 26.

28.

Constitutive activation of nuclear factor-E2-related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte-specific deletion of Kelch-like ECH-associated protein 1.

Cheng Q, Taguchi K, Aleksunes LM, Manautou JE, Cherrington NJ, Yamamoto M, Slitt AL.

J Biochem Mol Toxicol. 2011 Sep-Oct;25(5):320-9. doi: 10.1002/jbt.20392. Epub 2011 May 2.

29.

Alteration of hepatic but not renal transporter expression in diet-induced obese mice.

More VR, Slitt AL.

Drug Metab Dispos. 2011 Jun;39(6):992-9. doi: 10.1124/dmd.110.037507. Epub 2011 Mar 23.

30.

The Nrf2 activator oltipraz also activates the constitutive androstane receptor.

Merrell MD, Jackson JP, Augustine LM, Fisher CD, Slitt AL, Maher JM, Huang W, Moore DD, Zhang Y, Klaassen CD, Cherrington NJ.

Drug Metab Dispos. 2008 Aug;36(8):1716-21. doi: 10.1124/dmd.108.020867. Epub 2008 May 12.

31.

Gender divergent expression of Nqo1 in Sprague Dawley and August Copenhagen x Irish rats.

Augustine LM, Fisher CD, Lickteig AJ, Aleksunes LM, Slitt AL, Cherrington NJ.

J Biochem Mol Toxicol. 2008 Mar-Apr;22(2):93-100. doi: 10.1002/jbt.20224.

PMID:
18418895
32.

Induction of drug metabolism enzymes and transporters by oltipraz in rats.

Merrell MD, Augustine LM, Slitt AL, Cherrington NJ.

J Biochem Mol Toxicol. 2008 Mar-Apr;22(2):128-35. doi: 10.1002/jbt.20225.

PMID:
18418891
33.

Drug-metabolizing enzyme and transporter expression in a mouse model of diabetes and obesity.

Cheng Q, Aleksunes LM, Manautou JE, Cherrington NJ, Scheffer GL, Yamasaki H, Slitt AL.

Mol Pharm. 2008 Jan-Feb;5(1):77-91. doi: 10.1021/mp700114j. Epub 2008 Jan 12.

PMID:
18189363
34.

Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis.

Beilke LD, Besselsen DG, Cheng Q, Kulkarni S, Slitt AL, Cherrington NJ.

Toxicol Sci. 2008 Mar;102(1):196-204. Epub 2007 Nov 20.

PMID:
18032408
35.

Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2.

Aleksunes LM, Slitt AL, Maher JM, Augustine LM, Goedken MJ, Chan JY, Cherrington NJ, Klaassen CD, Manautou JE.

Toxicol Appl Pharmacol. 2008 Jan 1;226(1):74-83. Epub 2007 Aug 31.

36.

Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway.

Maher JM, Dieter MZ, Aleksunes LM, Slitt AL, Guo G, Tanaka Y, Scheffer GL, Chan JY, Manautou JE, Chen Y, Dalton TP, Yamamoto M, Klaassen CD.

Hepatology. 2007 Nov;46(5):1597-610.

PMID:
17668877
37.

Efflux transporter expression and acetaminophen metabolite excretion are altered in rodent models of nonalcoholic fatty liver disease.

Lickteig AJ, Fisher CD, Augustine LM, Aleksunes LM, Besselsen DG, Slitt AL, Manautou JE, Cherrington NJ.

Drug Metab Dispos. 2007 Oct;35(10):1970-8. Epub 2007 Jul 19.

PMID:
17640958
38.

Induction of drug-metabolizing enzymes by garlic and allyl sulfide compounds via activation of constitutive androstane receptor and nuclear factor E2-related factor 2.

Fisher CD, Augustine LM, Maher JM, Nelson DM, Slitt AL, Klaassen CD, Lehman-McKeeman LD, Cherrington NJ.

Drug Metab Dispos. 2007 Jun;35(6):995-1000. Epub 2007 Mar 12.

PMID:
17353348
39.

Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis.

Aleksunes LM, Slitt AL, Maher JM, Dieter MZ, Knight TR, Goedken M, Cherrington NJ, Chan JY, Klaassen CD, Manautou JE.

Cell Stress Chaperones. 2006 Winter;11(4):356-63.

40.

Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen.

Moffit JS, Aleksunes LM, Kardas MJ, Slitt AL, Klaassen CD, Manautou JE.

Toxicology. 2007 Feb 12;230(2-3):197-206. Epub 2006 Nov 19.

41.
42.

Regulation of transporter expression in mouse liver, kidney, and intestine during extrahepatic cholestasis.

Slitt AL, Allen K, Morrone J, Aleksunes LM, Chen C, Maher JM, Manautou JE, Cherrington NJ, Klaassen CD.

Biochim Biophys Acta. 2007 Mar;1768(3):637-47. Epub 2006 Oct 26.

43.

Alterations in transporter expression in liver, kidney, and duodenum after targeted disruption of the transcription factor HNF1alpha.

Maher JM, Slitt AL, Callaghan TN, Cheng X, Cheung C, Gonzalez FJ, Klaassen CD.

Biochem Pharmacol. 2006 Aug 14;72(4):512-22. Epub 2006 Mar 30.

PMID:
16806085
44.

Induction of genes for metabolism and transport by trans-stilbene oxide in livers of Sprague-Dawley and Wistar-Kyoto rats.

Slitt AL, Cherrington NJ, Fisher CD, Negishi M, Klaassen CD.

Drug Metab Dispos. 2006 Jul;34(7):1190-7. Epub 2006 Apr 18.

PMID:
16621935
45.

trans-Stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors.

Slitt AL, Cherrington NJ, Dieter MZ, Aleksunes LM, Scheffer GL, Huang W, Moore DD, Klaassen CD.

Mol Pharmacol. 2006 May;69(5):1554-63. Epub 2006 Jan 31.

PMID:
16449384
46.

Early growth response factor-1 is critical for cholestatic liver injury.

Kim ND, Moon JO, Slitt AL, Copple BL.

Toxicol Sci. 2006 Apr;90(2):586-95. Epub 2006 Jan 19.

PMID:
16423862
47.

Tissue distribution and induction of the rat multidrug resistance-associated proteins 5 and 6.

Maher JM, Cherrington NJ, Slitt AL, Klaassen CD.

Life Sci. 2006 Apr 4;78(19):2219-25. Epub 2005 Nov 2.

PMID:
16260000
48.

Retinoid X receptor alpha Regulates the expression of glutathione s-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver.

Dai G, Chou N, He L, Gyamfi MA, Mendy AJ, Slitt AL, Klaassen CD, Wan YJ.

Mol Pharmacol. 2005 Dec;68(6):1590-6. Epub 2005 Sep 12.

PMID:
16157696
49.

Regulation of hepatic transporters by xenobiotic receptors.

Klaassen CD, Slitt AL.

Curr Drug Metab. 2005 Aug;6(4):309-28. Review.

PMID:
16101571
50.

Up-regulation of Mrp4 expression in kidney of Mrp2-deficient TR- rats.

Chen C, Slitt AL, Dieter MZ, Tanaka Y, Scheffer GL, Klaassen CD.

Biochem Pharmacol. 2005 Oct 1;70(7):1088-95.

PMID:
16099435

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