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Items: 36

1.

Using [2H]water to quantify the contribution of de novo palmitate synthesis in plasma: enabling back-to-back studies.

Previs SF, Herath K, Nawrocki AR, Rodriguez CG, Slipetz D, Singh SB, Kang L, Bhat G, Roddy TP, Conarello S, Terebetski J, Erion MD, Kelley DE.

Am J Physiol Endocrinol Metab. 2018 Jul 1;315(1):E63-E71. doi: 10.1152/ajpendo.00010.2017. Epub 2018 Jan 2.

2.

Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor.

Elwood F, Witter DJ, Piesvaux J, Kraybill B, Bays N, Alpert C, Goldenblatt P, Qu Y, Ivanovska I, Lee HH, Chiu CS, Tang H, Scott ME, Deshmukh SV, Zielstorff M, Byford A, Chakravarthy K, Dorosh L, Rivkin A, Klappenbach J, Pan BS, Kariv I, Dinsmore C, Slipetz D, Dandliker PJ.

J Pharmacol Exp Ther. 2017 May;361(2):229-244. doi: 10.1124/jpet.116.239723. Epub 2017 Feb 13.

PMID:
28193636
3.

Quantifying rates of glucose production in vivo following an intraperitoneal tracer bolus.

Wang SP, Zhou D, Yao Z, Satapati S, Chen Y, Daurio NA, Petrov A, Shen X, Metzger D, Yin W, Nawrocki AR, Eiermann GJ, Hwa J, Fancourt C, Miller C, Herath K, Roddy TP, Slipetz D, Erion MD, Previs SF, Kelley DE.

Am J Physiol Endocrinol Metab. 2016 Dec 1;311(6):E911-E921. doi: 10.1152/ajpendo.00182.2016. Epub 2016 Sep 20.

4.

A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized (3)He MRI.

Thomas AC, Potts EN, Chen BT, Slipetz DM, Foster WM, Driehuys B.

NMR Biomed. 2015 Sep;28(9):1185. doi: 10.1002/nbm.3365. Epub 2015 Jul 15. No abstract available.

PMID:
26174861
5.

Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers.

Wang IM, Zhang B, Yang X, Zhu J, Stepaniants S, Zhang C, Meng Q, Peters M, He Y, Ni C, Slipetz D, Crackower MA, Houshyar H, Tan CM, Asante-Appiah E, O'Neill G, Luo MJ, Thieringer R, Yuan J, Chiu CS, Lum PY, Lamb J, Boie Y, Wilkinson HA, Schadt EE, Dai H, Roberts C.

Mol Syst Biol. 2012 Jul 17;8:594. doi: 10.1038/msb.2012.24.

6.

Effects of corticosteroid treatment on airway inflammation, mechanics, and hyperpolarized ³He magnetic resonance imaging in an allergic mouse model.

Thomas AC, Kaushik SS, Nouls J, Potts EN, Slipetz DM, Foster WM, Driehuys B.

J Appl Physiol (1985). 2012 May;112(9):1437-44. doi: 10.1152/japplphysiol.01293.2011. Epub 2012 Jan 12. Retraction in: J Appl Physiol (1985). 2015 Jun 15;118(12):1561.

7.

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.

Gallant M, Beaulieu C, Berthelette C, Colucci J, Crackower MA, Dalton C, Denis D, Ducharme Y, Friesen RW, Guay D, Gervais FG, Hamel M, Houle R, Krawczyk CM, Kosjek B, Lau S, Leblanc Y, Lee EE, Levesque JF, Mellon C, Molinaro C, Mullet W, O'Neill GP, O'Shea P, Sawyer N, Sillaots S, Simard D, Slipetz D, Stocco R, Sørensen D, Truong VL, Wong E, Wu J, Zaghdane H, Wang Z.

Bioorg Med Chem Lett. 2011 Jan 1;21(1):288-93. doi: 10.1016/j.bmcl.2010.11.015. Epub 2010 Nov 5.

PMID:
21106375
8.

ANKRD13C acts as a molecular chaperone for G protein-coupled receptors.

Parent A, Roy SJ, Iorio-Morin C, Lépine MC, Labrecque P, Gallant MA, Slipetz D, Parent JL.

J Biol Chem. 2010 Dec 24;285(52):40838-51. doi: 10.1074/jbc.M110.142257. Epub 2010 Oct 19.

9.

Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells) antagonist.

Gervais FG, Sawyer N, Stocco R, Hamel M, Krawczyk C, Sillaots S, Denis D, Wong E, Wang Z, Gallant M, Abraham WM, Slipetz D, Crackower MA, O'Neill GP.

Mol Pharmacol. 2011 Jan;79(1):69-76. doi: 10.1124/mol.110.068585. Epub 2010 Oct 13.

PMID:
20943773
10.

Genetic and pharmacological evaluation of cathepsin s in a mouse model of asthma.

Deschamps K, Cromlish W, Weicker S, Lamontagne S, Huszar SL, Gauthier JY, Mudgett JS, Guimond A, Romand R, Frossard N, Percival MD, Slipetz D, Tan CM.

Am J Respir Cell Mol Biol. 2011 Jul;45(1):81-7. doi: 10.1165/rcmb.2009-0392OC. Epub 2010 Sep 20.

PMID:
20855652
11.

Discovery of potent and selective DP1 receptor antagonists in the azaindole series.

Leblanc Y, Roy P, Dufresne C, Lachance N, Wang Z, O'Neill G, Greig G, Denis D, Mathieu MC, Slipetz D, Sawyer N, Tsou N.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2125-8. doi: 10.1016/j.bmcl.2009.03.010. Epub 2009 Mar 9.

PMID:
19307115
12.

A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI.

Thomas AC, Potts EN, Chen BT, Slipetz DM, Foster WM, Driehuys B.

NMR Biomed. 2009 Jun;22(5):502-15. doi: 10.1002/nbm.1362. Erratum in: NMR Biomed. 2015 Sep;28(9):1185.

13.

Adenovirus IL-13-induced airway disease in mice: a corticosteroid-resistant model of severe asthma.

Therien AG, Bernier V, Weicker S, Tawa P, Falgueyret JP, Mathieu MC, Honsberger J, Pomerleau V, Robichaud A, Stocco R, Dufresne L, Houshyar H, Lafleur J, Ramachandran C, O'Neill GP, Slipetz D, Tan CM.

Am J Respir Cell Mol Biol. 2008 Jul;39(1):26-35. doi: 10.1165/rcmb.2007-0240OC. Epub 2008 Feb 7.

PMID:
18258919
14.

Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).

Sturino CF, O'Neill G, Lachance N, Boyd M, Berthelette C, Labelle M, Li L, Roy B, Scheigetz J, Tsou N, Aubin Y, Bateman KP, Chauret N, Day SH, Lévesque JF, Seto C, Silva JH, Trimble LA, Carriere MC, Denis D, Greig G, Kargman S, Lamontagne S, Mathieu MC, Sawyer N, Slipetz D, Abraham WM, Jones T, McAuliffe M, Piechuta H, Nicoll-Griffith DA, Wang Z, Zamboni R, Young RN, Metters KM.

J Med Chem. 2007 Feb 22;50(4):794-806.

PMID:
17300164
15.

Differential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2.

Gallant MA, Slipetz D, Hamelin E, Rochdi MD, Talbot S, de Brum-Fernandes AJ, Parent JL.

Eur J Pharmacol. 2007 Feb 28;557(2-3):115-23. Epub 2006 Dec 5.

PMID:
17207480
16.

Comparison between two classes of selective EP(3) antagonists and their biological activities.

Belley M, Chan CC, Gareau Y, Gallant M, Juteau H, Houde K, Lachance N, Labelle M, Sawyer N, Tremblay N, Lamontagne S, Carrière MC, Denis D, Greig GM, Slipetz D, Gordon R, Chauret N, Li C, Zamboni RJ, Metters KM.

Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. Epub 2006 Aug 22.

PMID:
16931013
17.

Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I.

Bernier V, Stocco R, Bogusky MJ, Joyce JG, Parachoniak C, Grenier K, Arget M, Mathieu MC, O'Neill GP, Slipetz D, Crackower MA, Tan CM, Therien AG.

J Biol Chem. 2006 Aug 25;281(34):24704-12. Epub 2006 Jun 20.

18.

Identification of an indole series of prostaglandin D2 receptor antagonists.

Sturino CF, Lachance N, Boyd M, Berthelette C, Labelle M, Li L, Roy B, Scheigetz J, Tsou N, Brideau C, Cauchon E, Carriere MC, Denis D, Greig G, Kargman S, Lamontagne S, Mathieu MC, Sawyer N, Slipetz D, O'Neill G, Wang Z, Zamboni R, Metters KM, Young RN.

Bioorg Med Chem Lett. 2006 Jun 1;16(11):3043-8. Epub 2006 Mar 10.

PMID:
16529930
19.

Gob-5 is not essential for mucus overproduction in preclinical murine models of allergic asthma.

Robichaud A, Tuck SA, Kargman S, Tam J, Wong E, Abramovitz M, Mortimer JR, Burston HE, Masson P, Hirota J, Slipetz D, Kennedy B, O'Neill G, Xanthoudakis S.

Am J Respir Cell Mol Biol. 2005 Sep;33(3):303-14. Epub 2005 Jun 9. Erratum in: Am J Respir Cell Mol Biol. 2006 Mar;34(3):383. Mortimer, James [corrected to Mortimer, James R].

PMID:
15947424
20.

Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP(3) antagonists.

Belley M, Gallant M, Roy B, Houde K, Lachance N, Labelle M, Trimble LA, Chauret N, Li C, Sawyer N, Tremblay N, Lamontagne S, Carrière MC, Denis D, Greig GM, Slipetz D, Metters KM, Gordon R, Chan CC, Zamboni RJ.

Bioorg Med Chem Lett. 2005 Feb 1;15(3):527-30.

PMID:
15664806
21.

Benzimidazoles as new potent and selective DP antagonists for the treatment of allergic rhinitis.

Beaulieu C, Wang Z, Denis D, Greig G, Lamontagne S, O'Neill G, Slipetz D, Wang J.

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3195-9.

PMID:
15149674
22.

Structure-activity relationship of triaryl propionic acid analogues on the human EP3 prostanoid receptor.

Gallant M, Belley M, Carrière MC, Chateauneuf A, Denis D, Lachance N, Lamontagne S, Metters KM, Sawyer N, Slipetz D, Truchon JF, Labelle M.

Bioorg Med Chem Lett. 2003 Nov 3;13(21):3813-6.

PMID:
14552786
23.

Discovery of a potent and selective agonist of the prostaglandin EP4 receptor.

Billot X, Chateauneuf A, Chauret N, Denis D, Greig G, Mathieu MC, Metters KM, Slipetz DM, Young RN.

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1129-32.

PMID:
12643927
24.

Structure-activity relationship of biaryl acylsulfonamide analogues on the human EP(3) prostanoid receptor.

Gallant M, Carrière MC, Chateauneuf A, Denis D, Gareau Y, Godbout C, Greig G, Juteau H, Lachance N, Lacombe P, Lamontagne S, Metters KM, Rochette C, Ruel R, Slipetz D, Sawyer N, Tremblay N, Labelle M.

Bioorg Med Chem Lett. 2002 Sep 16;12(18):2583-6.

PMID:
12182865
25.

Sequestration and phosphorylation of the prostaglandin E2 EP4 receptor: dependence on the C-terminal tail.

Slipetz D, Buchanan S, Mackereth C, Brewer N, Pellow V, Hao C, Adam M, Abramovitz M, Metters KM.

Biochem Pharmacol. 2001 Oct 15;62(8):997-1012.

PMID:
11597569
26.

Prostaglandin receptor EP(4) mediates the bone anabolic effects of PGE(2).

Machwate M, Harada S, Leu CT, Seedor G, Labelle M, Gallant M, Hutchins S, Lachance N, Sawyer N, Slipetz D, Metters KM, Rodan SB, Young R, Rodan GA.

Mol Pharmacol. 2001 Jul;60(1):36-41. Erratum in: Mol Pharmacol. 2003 Jul;64(1):192.

PMID:
11408598
27.

Characterization of the cloned guinea pig leukotriene B4 receptor: comparison to its human orthologue.

Boie Y, Stocco R, Sawyer N, Greig GM, Kargman S, Slipetz DM, O'Neill GP, Shimizu T, Yokomizo T, Metters KM, Abramovitz M.

Eur J Pharmacol. 1999 Sep 10;380(2-3):203-13.

PMID:
10513580
28.

Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes.

Boie Y, Stocco R, Sawyer N, Slipetz DM, Ungrin MD, Neuschäfer-Rube F, Püschel GP, Metters KM, Abramovitz M.

Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41.

PMID:
9537820
29.

Molecular cloning and characterization of the human prostanoid DP receptor.

Boie Y, Sawyer N, Slipetz DM, Metters KM, Abramovitz M.

J Biol Chem. 1995 Aug 11;270(32):18910-6.

30.

Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase.

Slipetz DM, O'Neill GP, Favreau L, Dufresne C, Gallant M, Gareau Y, Guay D, Labelle M, Metters KM.

Mol Pharmacol. 1995 Aug;48(2):352-61.

PMID:
7651369
31.

Cloning and expression of a cDNA for the human prostanoid IP receptor.

Boie Y, Rushmore TH, Darmon-Goodwin A, Grygorczyk R, Slipetz DM, Metters KM, Abramovitz M.

J Biol Chem. 1994 Apr 22;269(16):12173-8.

32.

Cloning and expression of a cDNA for the human prostanoid FP receptor.

Abramovitz M, Boie Y, Nguyen T, Rushmore TH, Bayne MA, Metters KM, Slipetz DM, Grygorczyk R.

J Biol Chem. 1994 Jan 28;269(4):2632-6.

33.

Photoaffinity labelling and radiation inactivation of the leukotriene B4 receptor in human myeloid cells.

Slipetz DM, Scoggan KA, Nicholson DW, Metters KM.

Eur J Pharmacol. 1993 Jan 15;244(2):161-73.

PMID:
8381743
34.

Congenital deficiency of a 20-kDa subunit of mitochondrial complex I in fibroblasts.

Slipetz DM, Goodyer PR, Rozen R.

Am J Hum Genet. 1991 Jun;48(6):1121-6.

35.

Deficiency of complex III of the mitochondrial respiratory chain in a patient with facioscapulohumeral disease.

Slipetz DM, Aprille JR, Goodyer PR, Rozen R.

Am J Hum Genet. 1991 Mar;48(3):502-10.

36.

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