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Items: 1 to 50 of 323

1.

Biotransformation of the Mycotoxin Enniatin B1 by CYP P450 3A4 and Potential for Drug-Drug Interactions.

Ivanova L, Denisov IG, Grinkova YV, Sligar SG, Fæste CK.

Metabolites. 2019 Jul 27;9(8). pii: E158. doi: 10.3390/metabo9080158.

2.

PIP2 Influences the Conformational Dynamics of Membrane-Bound KRAS4b.

McLean MA, Stephen AG, Sligar SG.

Biochemistry. 2019 Aug 1. doi: 10.1021/acs.biochem.9b00395. [Epub ahead of print]

PMID:
31339036
3.

Nanodiscs as a New Tool to Examine Lipid-Protein Interactions.

Denisov IG, Schuler MA, Sligar SG.

Methods Mol Biol. 2019;2003:645-671. doi: 10.1007/978-1-4939-9512-7_25.

PMID:
31218635
4.

Correction to "Allosteric Interactions in Human Cytochrome P450 CYP3A4: The Role of Phenylalanine 213".

Denisov IG, Grinkova YV, Nandigrami P, Shekhar M, Tajkhorshid E, Sligar SG.

Biochemistry. 2019 Jun 18;58(24):2796. doi: 10.1021/acs.biochem.9b00438. Epub 2019 Jun 6. No abstract available.

PMID:
31181900
5.

Allosteric Interactions in Human Cytochrome P450 CYP3A4: The Role of Phenylalanine 213.

Denisov IG, Grinkova YV, Nandigrami P, Shekhar M, Tajkhorshid E, Sligar SG.

Biochemistry. 2019 Mar 12;58(10):1411-1422. doi: 10.1021/acs.biochem.8b01268. Epub 2019 Feb 28. Erratum in: Biochemistry. 2019 Jun 18;58(24):2796.

PMID:
30785734
6.

Influence of Transmembrane Helix Mutations on Cytochrome P450-Membrane Interactions and Function.

Mustafa G, Nandekar PP, Camp TJ, Bruce NJ, Gregory MC, Sligar SG, Wade RC.

Biophys J. 2019 Feb 5;116(3):419-432. doi: 10.1016/j.bpj.2018.12.014. Epub 2019 Jan 3.

7.

Cytochrome b5 enhances androgen synthesis by rapidly reducing the CYP17A1 oxy-complex in the lyase step.

Duggal R, Denisov IG, Sligar SG.

FEBS Lett. 2018 Jul;592(13):2282-2288. doi: 10.1002/1873-3468.13153. Epub 2018 Jun 21.

8.

Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone.

Mak PJ, Duggal R, Denisov IG, Gregory MC, Sligar SG, Kincaid JR.

J Am Chem Soc. 2018 Jun 13;140(23):7324-7331. doi: 10.1021/jacs.8b03901. Epub 2018 Jun 5.

9.

Nanodiscs: A Controlled Bilayer Surface for the Study of Membrane Proteins.

McLean MA, Gregory MC, Sligar SG.

Annu Rev Biophys. 2018 Mar 1. doi: 10.1146/annurev-biophys-070816-033620. [Epub ahead of print]

PMID:
29494254
10.

Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202.

Gregory MC, Mak PJ, Khatri Y, Kincaid JR, Sligar SG.

Biochemistry. 2018 Feb 6;57(5):764-771. doi: 10.1021/acs.biochem.7b01067. Epub 2018 Jan 24.

11.

Drug-Drug Interactions between Atorvastatin and Dronedarone Mediated by Monomeric CYP3A4.

Denisov IG, Baylon JL, Grinkova YV, Tajkhorshid E, Sligar SG.

Biochemistry. 2018 Feb 6;57(5):805-816. doi: 10.1021/acs.biochem.7b01012. Epub 2017 Dec 14.

12.

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.

Guo Z, Sevrioukova IF, Denisov IG, Zhang X, Chiu TL, Thomas DG, Hanse EA, Cuellar RAD, Grinkova YV, Langenfeld VW, Swedien DS, Stamschror JD, Alvarez J, Luna F, Galván A, Bae YK, Wulfkuhle JD, Gallagher RI, Petricoin EF Rd, Norris B, Flory CM, Schumacher RJ, O'Sullivan MG, Cao Q, Chu H, Lipscomb JD, Atkins WM, Gupta K, Kelekar A, Blair IA, Capdevila JH, Falck JR, Sligar SG, Poulos TL, Georg GI, Ambrose E, Potter DA.

Cell Chem Biol. 2017 Oct 19;24(10):1314. doi: 10.1016/j.chembiol.2017.09.012. No abstract available.

13.

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria.

Guo Z, Sevrioukova IF, Denisov IG, Zhang X, Chiu TL, Thomas DG, Hanse EA, Cuellar RAD, Grinkova YV, Langenfeld VW, Swedien DS, Stamschror JD, Alvarez J, Luna F, Galván A, Bae YK, Wulfkuhle JD, Gallagher RI, Petricoin EF Rd, Norris B, Flory CM, Schumacher RJ, O'Sullivan MG, Cao Q, Chu H, Lipscomb JD, Atkins WM, Gupta K, Kelekar A, Blair IA, Capdevila JH, Falck JR, Sligar SG, Poulos TL, Georg GI, Ambrose E, Potter DA.

Cell Chem Biol. 2017 Oct 19;24(10):1259-1275.e6. doi: 10.1016/j.chembiol.2017.08.009. Epub 2017 Sep 14. Erratum in: Cell Chem Biol. 2017 Oct 19;24(10):1314.

14.

Microfluidic platform for efficient Nanodisc assembly, membrane protein incorporation, and purification.

Wade JH, Jones JD, Lenov IL, Riordan CM, Sligar SG, Bailey RC.

Lab Chip. 2017 Aug 22;17(17):2951-2959. doi: 10.1039/c7lc00601b.

15.

Interaction of KRas4b with anionic membranes: A special role for PIP2.

Gregory MC, McLean MA, Sligar SG.

Biochem Biophys Res Commun. 2017 May 27;487(2):351-355. doi: 10.1016/j.bbrc.2017.04.063. Epub 2017 Apr 13.

16.

Conformational equilibria of light-activated rhodopsin in nanodiscs.

Van Eps N, Caro LN, Morizumi T, Kusnetzow AK, Szczepek M, Hofmann KP, Bayburt TH, Sligar SG, Ernst OP, Hubbell WL.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3268-E3275. doi: 10.1073/pnas.1620405114. Epub 2017 Apr 3.

17.

Alzheimer's Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station.

DiChiara T, DiNunno N, Clark J, Bu RL, Cline EN, Rollins MG, Gong Y, Brody DL, Sligar SG, Velasco PT, Viola KL, Klein WL.

Yale J Biol Med. 2017 Mar 29;90(1):45-61. eCollection 2017 Mar.

18.

Nanodiscs in Membrane Biochemistry and Biophysics.

Denisov IG, Sligar SG.

Chem Rev. 2017 Mar 22;117(6):4669-4713. doi: 10.1021/acs.chemrev.6b00690. Epub 2017 Feb 8. Review.

19.

The Charge Properties of Phospholipid Nanodiscs.

Her C, Filoti DI, McLean MA, Sligar SG, Alexander Ross JB, Steele H, Laue TM.

Biophys J. 2016 Sep 6;111(5):989-98. doi: 10.1016/j.bpj.2016.06.041.

20.

Phosphatidylinositol 4,5-Bisphosphate Modulates the Affinity of Talin-1 for Phospholipid Bilayers and Activates Its Autoinhibited Form.

Ye X, McLean MA, Sligar SG.

Biochemistry. 2016 Sep 13;55(36):5038-48. doi: 10.1021/acs.biochem.6b00497. Epub 2016 Aug 31.

21.

Evidence that cytochrome b5 acts as a redox donor in CYP17A1 mediated androgen synthesis.

Duggal R, Liu Y, Gregory MC, Denisov IG, Kincaid JR, Sligar SG.

Biochem Biophys Res Commun. 2016 Aug 19;477(2):202-8. doi: 10.1016/j.bbrc.2016.06.043. Epub 2016 Jun 10.

22.

Nanodiscs for structural and functional studies of membrane proteins.

Denisov IG, Sligar SG.

Nat Struct Mol Biol. 2016 Jun;23(6):481-6. doi: 10.1038/nsmb.3195. Epub 2016 Jun 7. Review.

PMID:
27273631
23.

Conformational equilibrium of talin is regulated by anionic lipids.

Ye X, McLean MA, Sligar SG.

Biochim Biophys Acta. 2016 Aug;1858(8):1833-40. doi: 10.1016/j.bbamem.2016.05.005. Epub 2016 May 6.

24.

Trimerization of the HIV Transmembrane Domain in Lipid Bilayers Modulates Broadly Neutralizing Antibody Binding.

Reichart TM, Baksh MM, Rhee JK, Fiedler JD, Sligar SG, Finn MG, Zwick MB, Dawson PE.

Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2688-92. doi: 10.1002/anie.201508421. Epub 2016 Jan 22.

25.

The use of isomeric testosterone dimers to explore allosteric effects in substrate binding to cytochrome P450 CYP3A4.

Denisov IG, Mak PJ, Grinkova YV, Bastien D, Bérubé G, Sligar SG, Kincaid JR.

J Inorg Biochem. 2016 May;158:77-85. doi: 10.1016/j.jinorgbio.2015.12.019. Epub 2015 Dec 31.

26.

Unveiling the crucial intermediates in androgen production.

Mak PJ, Gregory MC, Denisov IG, Sligar SG, Kincaid JR.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15856-61. doi: 10.1073/pnas.1519376113. Epub 2015 Dec 14.

27.

Small-angle scattering determination of the shape and localization of human cytochrome P450 embedded in a phospholipid nanodisc environment.

Skar-Gislinge N, Kynde SA, Denisov IG, Ye X, Lenov I, Sligar SG, Arleth L.

Acta Crystallogr D Biol Crystallogr. 2015 Dec 1;71(Pt 12):2412-21. doi: 10.1107/S1399004715018702. Epub 2015 Nov 26.

28.

Metalloproteins: The long and the short of it.

Denisov IG, Sligar SG.

Nat Chem. 2015 Sep;7(9):687-8. doi: 10.1038/nchem.2335. No abstract available.

PMID:
26291938
29.

Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers.

Wilcox KC, Marunde MR, Das A, Velasco PT, Kuhns BD, Marty MT, Jiang H, Luan CH, Sligar SG, Klein WL.

PLoS One. 2015 Apr 30;10(4):e0125263. doi: 10.1371/journal.pone.0125263. eCollection 2015.

30.

Nanodiscs as a Modular Platform for Multimodal MR-Optical Imaging.

Carney CE, Lenov IL, Baker CJ, MacRenaris KW, Eckermann AL, Sligar SG, Meade TJ.

Bioconjug Chem. 2015 May 20;26(5):899-905. doi: 10.1021/acs.bioconjchem.5b00107. Epub 2015 Apr 9.

31.

Mechanism of drug-drug interactions mediated by human cytochrome P450 CYP3A4 monomer.

Denisov IG, Grinkova YV, Baylon JL, Tajkhorshid E, Sligar SG.

Biochemistry. 2015 Apr 7;54(13):2227-39. doi: 10.1021/acs.biochem.5b00079. Epub 2015 Mar 25.

32.

Kinetic solvent isotope effect in steady-state turnover by CYP19A1 suggests involvement of Compound 1 for both hydroxylation and aromatization steps.

Khatri Y, Luthra A, Duggal R, Sligar SG.

FEBS Lett. 2014 Aug 25;588(17):3117-22. doi: 10.1016/j.febslet.2014.06.050. Epub 2014 Jul 2.

33.

Resonance Raman spectroscopy of the oxygenated intermediates of human CYP19A1 implicates a compound i intermediate in the final lyase step.

Mak PJ, Luthra A, Sligar SG, Kincaid JR.

J Am Chem Soc. 2014 Apr 2;136(13):4825-8. doi: 10.1021/ja500054c. Epub 2014 Mar 25.

34.

Interpretation and deconvolution of nanodisc native mass spectra.

Marty MT, Zhang H, Cui W, Gross ML, Sligar SG.

J Am Soc Mass Spectrom. 2014 Feb;25(2):269-77. doi: 10.1007/s13361-013-0782-y. Epub 2013 Dec 19.

35.

Resonance Raman spectroscopy reveals that substrate structure selectively impacts the heme-bound diatomic ligands of CYP17.

Mak PJ, Gregory MC, Sligar SG, Kincaid JR.

Biochemistry. 2014 Jan 14;53(1):90-100. doi: 10.1021/bi4014424. Epub 2013 Dec 20.

36.

Assembly of an activated rhodopsin-transducin complex in nanoscale lipid bilayers.

D'Antona AM, Xie G, Sligar SG, Oprian DD.

Biochemistry. 2014 Jan 14;53(1):127-34. doi: 10.1021/bi4012995. Epub 2013 Dec 20.

37.

Active site proton delivery and the lyase activity of human CYP17A1.

Khatri Y, Gregory MC, Grinkova YV, Denisov IG, Sligar SG.

Biochem Biophys Res Commun. 2014 Jan 3;443(1):179-84. doi: 10.1016/j.bbrc.2013.11.094. Epub 2013 Dec 2.

38.

Kinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: evidence for a reactive peroxoanion intermediate.

Gregory MC, Denisov IG, Grinkova YV, Khatri Y, Sligar SG.

J Am Chem Soc. 2013 Nov 6;135(44):16245-7. doi: 10.1021/ja4086403. Epub 2013 Oct 29.

39.

Investigations of heme ligation and ligand switching in cytochromes p450 and p420.

Sun Y, Zeng W, Benabbas A, Ye X, Denisov I, Sligar SG, Du J, Dawson JH, Champion PM.

Biochemistry. 2013 Aug 27;52(34):5941-51. doi: 10.1021/bi400541v. Epub 2013 Aug 14.

40.

Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding.

Vishnivetskiy SA, Ostermaier MK, Singhal A, Panneels V, Homan KT, Glukhova A, Sligar SG, Tesmer JJ, Schertler GF, Standfuss J, Gurevich VV.

Cell Signal. 2013 Nov;25(11):2155-62. doi: 10.1016/j.cellsig.2013.07.009. Epub 2013 Jul 17.

41.

Nanodiscs as a therapeutic delivery agent: inhibition of respiratory syncytial virus infection in the lung.

Numata M, Grinkova YV, Mitchell JR, Chu HW, Sligar SG, Voelker DR.

Int J Nanomedicine. 2013;8:1417-27. doi: 10.2147/IJN.S39888. Epub 2013 Apr 15.

42.

Characterizing the membrane-bound state of cytochrome P450 3A4: structure, depth of insertion, and orientation.

Baylon JL, Lenov IL, Sligar SG, Tajkhorshid E.

J Am Chem Soc. 2013 Jun 12;135(23):8542-51. doi: 10.1021/ja4003525. Epub 2013 May 30.

43.

Differential hydrogen bonding in human CYP17 dictates hydroxylation versus lyase chemistry.

Gregory M, Mak PJ, Sligar SG, Kincaid JR.

Angew Chem Int Ed Engl. 2013 May 10;52(20):5342-5. doi: 10.1002/anie.201300760. Epub 2013 Apr 10. No abstract available.

44.

Nanodiscs in the studies of membrane-bound cytochrome P450 enzymes.

Luthra A, Gregory M, Grinkova YV, Denisov IG, Sligar SG.

Methods Mol Biol. 2013;987:115-27. doi: 10.1007/978-1-62703-321-3_10.

45.

Interfacing lipid bilayer nanodiscs and silicon photonic sensor arrays for multiplexed protein-lipid and protein-membrane protein interaction screening.

Sloan CD, Marty MT, Sligar SG, Bailey RC.

Anal Chem. 2013 Mar 5;85(5):2970-6. doi: 10.1021/ac3037359. Epub 2013 Feb 20.

46.

Nanodiscs as a new tool to examine lipid-protein interactions.

Schuler MA, Denisov IG, Sligar SG.

Methods Mol Biol. 2013;974:415-33. doi: 10.1007/978-1-62703-275-9_18. Review.

47.

Nanodisc-solubilized membrane protein library reflects the membrane proteome.

Marty MT, Wilcox KC, Klein WL, Sligar SG.

Anal Bioanal Chem. 2013 May;405(12):4009-16. doi: 10.1007/s00216-013-6790-8. Epub 2013 Feb 12.

48.

Oxidase uncoupling in heme monooxygenases: human cytochrome P450 CYP3A4 in Nanodiscs.

Grinkova YV, Denisov IG, McLean MA, Sligar SG.

Biochem Biophys Res Commun. 2013 Jan 25;430(4):1223-7. doi: 10.1016/j.bbrc.2012.12.072. Epub 2012 Dec 22.

49.

Native mass spectrometry characterization of intact nanodisc lipoprotein complexes.

Marty MT, Zhang H, Cui W, Blankenship RE, Gross ML, Sligar SG.

Anal Chem. 2012 Nov 6;84(21):8957-60. doi: 10.1021/ac302663f. Epub 2012 Oct 17.

50.

Nonlinear analyte concentration gradients for one-step kinetic analysis employing optical microring resonators.

Marty MT, Sloan CD, Bailey RC, Sligar SG.

Anal Chem. 2012 Jul 3;84(13):5556-64. doi: 10.1021/ac300478f. Epub 2012 Jun 22.

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