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Items: 38


Structures of TOG1 and TOG2 from the human microtubule dynamics regulator CLASP1.

Leano JB, Slep KC.

PLoS One. 2019 Jul 19;14(7):e0219823. doi: 10.1371/journal.pone.0219823. eCollection 2019.


Cytoskeletal cryptography: structure and mechanism of an eraser.

Slep KC.

Nat Struct Mol Biol. 2019 Jul;26(7):532-534. doi: 10.1038/s41594-019-0266-2. No abstract available.


Mapping multivalency in the CLIP-170-EB1 microtubule plus-end complex.

Chen Y, Wang P, Slep KC.

J Biol Chem. 2019 Jan 18;294(3):918-931. doi: 10.1074/jbc.RA118.006125. Epub 2018 Nov 19.


Asterless is a Polo-like kinase 4 substrate that both activates and inhibits kinase activity depending on its phosphorylation state.

Boese CJ, Nye J, Buster DW, McLamarrah TA, Byrnes AE, Slep KC, Rusan NM, Rogers GC.

Mol Biol Cell. 2018 Nov 15;29(23):2874-2886. doi: 10.1091/mbc.E18-07-0445. Epub 2018 Sep 26.


A Cytoskeletal Symphony: Owed to TOG.

Slep KC.

Dev Cell. 2018 Jul 2;46(1):5-7. doi: 10.1016/j.devcel.2018.06.010.


An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly.

McLamarrah TA, Buster DW, Galletta BJ, Boese CJ, Ryniawec JM, Hollingsworth NA, Byrnes AE, Brownlee CW, Slep KC, Rusan NM, Rogers GC.

J Cell Biol. 2018 Apr 2;217(4):1217-1231. doi: 10.1083/jcb.201605106. Epub 2018 Mar 1.


Control of microtubule dynamics using an optogenetic microtubule plus end-F-actin cross-linker.

Adikes RC, Hallett RA, Saway BF, Kuhlman B, Slep KC.

J Cell Biol. 2018 Feb 5;217(2):779-793. doi: 10.1083/jcb.201705190. Epub 2017 Dec 19.


Stu2 uses a 15-nm parallel coiled coil for kinetochore localization and concomitant regulation of the mitotic spindle.

Haase KP, Fox JC, Byrnes AE, Adikes RC, Speed SK, Haase J, Friedman B, Cook DM, Bloom K, Rusan NM, Slep KC.

Mol Biol Cell. 2018 Feb 1;29(3):285-294. doi: 10.1091/mbc.E17-01-0057. Epub 2017 Nov 29.


Structure of the ACF7 EF-Hand-GAR Module and Delineation of Microtubule Binding Determinants.

Lane TR, Fuchs E, Slep KC.

Structure. 2017 Jul 5;25(7):1130-1138.e6. doi: 10.1016/j.str.2017.05.006. Epub 2017 Jun 8.


TOG-tubulin binding specificity promotes microtubule dynamics and mitotic spindle formation.

Byrnes AE, Slep KC.

J Cell Biol. 2017 Jun 5;216(6):1641-1657. doi: 10.1083/jcb.201610090. Epub 2017 May 16.


A microtubule dynamics reconstitutional convention.

Slep KC.

J Cell Biol. 2016 Nov 7;215(3):305-307.


A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4.

Galletta BJ, Fagerstrom CJ, Schoborg TA, McLamarrah TA, Ryniawec JM, Buster DW, Slep KC, Rogers GC, Rusan NM.

Nat Commun. 2016 Aug 25;7:12476. doi: 10.1038/ncomms12476.


The Secret of Centriole Length: Keep a LID on It.

Slep KC.

Dev Cell. 2016 May 23;37(4):293-295. doi: 10.1016/j.devcel.2016.05.008.


Newly Characterized Region of CP190 Associates with Microtubules and Mediates Proper Spindle Morphology in Drosophila Stem Cells.

Plevock KM, Galletta BJ, Slep KC, Rusan NM.

PLoS One. 2015 Dec 9;10(12):e0144174. doi: 10.1371/journal.pone.0144174. eCollection 2015.


Crescerin uses a TOG domain array to regulate microtubules in the primary cilium.

Das A, Dickinson DJ, Wood CC, Goldstein B, Slep KC.

Mol Biol Cell. 2015 Nov 15;26(23):4248-64. doi: 10.1091/mbc.E15-08-0603. Epub 2015 Sep 16.


Drosophila melanogaster mini spindles TOG3 utilizes unique structural elements to promote domain stability and maintain a TOG1- and TOG2-like tubulin-binding surface.

Howard AE, Fox JC, Slep KC.

J Biol Chem. 2015 Apr 17;290(16):10149-62. doi: 10.1074/jbc.M114.633826. Epub 2015 Feb 26.


Two Polo-like kinase 4 binding domains in Asterless perform distinct roles in regulating kinase stability.

Klebba JE, Galletta BJ, Nye J, Plevock KM, Buster DW, Hollingsworth NA, Slep KC, Rusan NM, Rogers GC.

J Cell Biol. 2015 Feb 16;208(4):401-14. doi: 10.1083/jcb.201410105.


The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array.

Fox JC, Howard AE, Currie JD, Rogers SL, Slep KC.

Mol Biol Cell. 2014 Aug 15;25(16):2375-92. doi: 10.1091/mbc.E13-08-0501. Epub 2014 Jun 25.


The mechanism of dynein light chain LC8-mediated oligomerization of the Ana2 centriole duplication factor.

Slevin LK, Romes EM, Dandulakis MG, Slep KC.

J Biol Chem. 2014 Jul 25;289(30):20727-39. doi: 10.1074/jbc.M114.576041. Epub 2014 Jun 11.


The yeast dynein Dyn2-Pac11 complex is a dynein dimerization/processivity factor: structural and single-molecule characterization.

Rao L, Romes EM, Nicholas MP, Brenner S, Tripathy A, Gennerich A, Slep KC.

Mol Biol Cell. 2013 Aug;24(15):2362-77. doi: 10.1091/mbc.E13-03-0166. Epub 2013 Jun 12.


The structure of the plk4 cryptic polo box reveals two tandem polo boxes required for centriole duplication.

Slevin LK, Nye J, Pinkerton DC, Buster DW, Rogers GC, Slep KC.

Structure. 2012 Nov 7;20(11):1905-17. doi: 10.1016/j.str.2012.08.025. Epub 2012 Sep 20.


Structure of a yeast Dyn2-Nup159 complex and molecular basis for dynein light chain-nuclear pore interaction.

Romes EM, Tripathy A, Slep KC.

J Biol Chem. 2012 May 4;287(19):15862-73. doi: 10.1074/jbc.M111.336172. Epub 2012 Mar 12.


The microtubule lattice and plus-end association of Drosophila Mini spindles is spatially regulated to fine-tune microtubule dynamics.

Currie JD, Stewman S, Schimizzi G, Slep KC, Ma A, Rogers SL.

Mol Biol Cell. 2011 Nov;22(22):4343-61. doi: 10.1091/mbc.E11-06-0520. Epub 2011 Sep 30.


αβ-Tubulin and microtubule-binding assays.

Campbell JN, Slep KC.

Methods Mol Biol. 2011;777:87-97. doi: 10.1007/978-1-61779-252-6_6.


The spectraplakin Short stop is an actin-microtubule cross-linker that contributes to organization of the microtubule network.

Applewhite DA, Grode KD, Keller D, Zadeh AD, Slep KC, Rogers SL.

Mol Biol Cell. 2010 May 15;21(10):1714-24. doi: 10.1091/mbc.E10-01-0011. Epub 2010 Mar 24. Erratum in: Mol Biol Cell. 2010 Jun 15;21(12):2097. Zadeh, Alireza [corrected to Zadeh, Alireza Dehghani].


Structural and mechanistic insights into microtubule end-binding proteins.

Slep KC.

Curr Opin Cell Biol. 2010 Feb;22(1):88-95. doi: 10.1016/ Epub 2009 Dec 1. Review.


The role of TOG domains in microtubule plus end dynamics.

Slep KC.

Biochem Soc Trans. 2009 Oct;37(Pt 5):1002-6. doi: 10.1042/BST0371002. Review.


The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction.

Sawyer JK, Harris NJ, Slep KC, Gaul U, Peifer M.

J Cell Biol. 2009 Jul 13;186(1):57-73. doi: 10.1083/jcb.200904001.


Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation.

Slep KC, Kercher MA, Wieland T, Chen CK, Simon MI, Sigler PB.

Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6243-8. doi: 10.1073/pnas.0801569105. Epub 2008 Apr 23.


It takes more than two to tango: Dishevelled polymerization and Wnt signaling.

Roberts DM, Slep KC, Peifer M.

Nat Struct Mol Biol. 2007 Jun;14(6):463-5. No abstract available.


Structural determinants for EB1-mediated recruitment of APC and spectraplakins to the microtubule plus end.

Slep KC, Rogers SL, Elliott SL, Ohkura H, Kolodziej PA, Vale RD.

J Cell Biol. 2005 Feb 14;168(4):587-98. Epub 2005 Feb 7.


Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A.

Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB.

Nature. 2001 Feb 22;409(6823):1071-7.


Prediction and confirmation of a site critical for effector regulation of RGS domain activity.

Sowa ME, He W, Slep KC, Kercher MA, Lichtarge O, Wensel TG.

Nat Struct Biol. 2001 Mar;8(3):234-7.


Modules in the photoreceptor RGS9-1.Gbeta 5L GTPase-accelerating protein complex control effector coupling, GTPase acceleration, protein folding, and stability.

He W, Lu L, Zhang X, El-Hodiri HM, Chen CK, Slep KC, Simon MI, Jamrich M, Wensel TG.

J Biol Chem. 2000 Nov 24;275(47):37093-100.


Sst2 is a GTPase-activating protein for Gpa1: purification and characterization of a cognate RGS-Galpha protein pair in yeast.

Apanovitch DM, Slep KC, Sigler PB, Dohlman HG.

Biochemistry. 1998 Apr 7;37(14):4815-22.


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