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Items: 25

1.

UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy.

Shorrock HK, van der Hoorn D, Boyd PJ, Llavero Hurtado M, Lamont DJ, Wirth B, Sleigh JN, Schiavo G, Wishart TM, Groen EJN, Gillingwater TH.

Brain. 2018 Oct 1;141(10):2878-2894. doi: 10.1093/brain/awy237.

2.

Plexin-Semaphorin Signaling Modifies Neuromuscular Defects in a Drosophila Model of Peripheral Neuropathy.

Grice SJ, Sleigh JN, Zameel Cader M.

Front Mol Neurosci. 2018 Feb 22;11:55. doi: 10.3389/fnmol.2018.00055. eCollection 2018.

3.

Antisense oligonucleotides and other genetic therapies made simple.

Rossor AM, Reilly MM, Sleigh JN.

Pract Neurol. 2018 Apr;18(2):126-131. doi: 10.1136/practneurol-2017-001764. Epub 2018 Feb 17. Review.

PMID:
29455156
4.

Aligned electrospun fibers for neural patterning.

Soliman E, Bianchi F, Sleigh JN, George JH, Cader MZ, Cui Z, Ye H.

Biotechnol Lett. 2018 Mar;40(3):601-607. doi: 10.1007/s10529-017-2494-z. Epub 2018 Jan 8.

5.

Motor Neuron Gene Therapy: Lessons from Spinal Muscular Atrophy for Amyotrophic Lateral Sclerosis.

Tosolini AP, Sleigh JN.

Front Mol Neurosci. 2017 Dec 7;10:405. doi: 10.3389/fnmol.2017.00405. eCollection 2017. Review.

6.

Engineered method for directional growth of muscle sheets on electrospun fibers.

Soliman E, Bianchi F, Sleigh JN, George JH, Cader MZ, Cui Z, Ye H.

J Biomed Mater Res A. 2018 May;106(5):1165-1176. doi: 10.1002/jbm.a.36312. Epub 2018 Jan 9.

PMID:
29266766
7.

Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular homeostasis.

Sleigh JN, Gómez-Martín A, Wei N, Bai G, Yang XL, Schiavo G.

Sci Rep. 2017 Aug 23;7(1):9216. doi: 10.1038/s41598-017-10005-w.

8.

Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations.

Sleigh JN, Dawes JM, West SJ, Wei N, Spaulding EL, Gómez-Martín A, Zhang Q, Burgess RW, Cader MZ, Talbot K, Yang XL, Bennett DL, Schiavo G.

Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3324-E3333. doi: 10.1073/pnas.1614557114. Epub 2017 Mar 28.

9.

Methodological advances in imaging intravital axonal transport.

Sleigh JN, Vagnoni A, Twelvetrees AE, Schiavo G.

F1000Res. 2017 Mar 1;6:200. doi: 10.12688/f1000research.10433.1. eCollection 2017. Review.

10.

Systemic peptide-mediated oligonucleotide therapy improves long-term survival in spinal muscular atrophy.

Hammond SM, Hazell G, Shabanpoor F, Saleh AF, Bowerman M, Sleigh JN, Meijboom KE, Zhou H, Muntoni F, Talbot K, Gait MJ, Wood MJ.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10962-7. doi: 10.1073/pnas.1605731113. Epub 2016 Sep 12.

11.

Synaptic Deficits at Neuromuscular Junctions in Two Mouse Models of Charcot-Marie-Tooth Type 2d.

Spaulding EL, Sleigh JN, Morelli KH, Pinter MJ, Burgess RW, Seburn KL.

J Neurosci. 2016 Mar 16;36(11):3254-67. doi: 10.1523/JNEUROSCI.1762-15.2016.

12.

A simple, step-by-step dissection protocol for the rapid isolation of mouse dorsal root ganglia.

Sleigh JN, Weir GA, Schiavo G.

BMC Res Notes. 2016 Feb 11;9:82. doi: 10.1186/s13104-016-1915-8.

13.

Vascular Defects and Spinal Cord Hypoxia in Spinal Muscular Atrophy.

Somers E, Lees RD, Hoban K, Sleigh JN, Zhou H, Muntoni F, Talbot K, Gillingwater TH, Parson SH.

Ann Neurol. 2016 Feb;79(2):217-30. doi: 10.1002/ana.24549. Epub 2016 Jan 13.

PMID:
26506088
14.

In vivo imaging of axonal transport in murine motor and sensory neurons.

Gibbs KL, Kalmar B, Sleigh JN, Greensmith L, Schiavo G.

J Neurosci Methods. 2016 Jan 15;257:26-33. doi: 10.1016/j.jneumeth.2015.09.018. Epub 2015 Sep 28.

15.

Dominant, toxic gain-of-function mutations in gars lead to non-cell autonomous neuropathology.

Grice SJ, Sleigh JN, Motley WW, Liu JL, Burgess RW, Talbot K, Cader MZ.

Hum Mol Genet. 2015 Aug 1;24(15):4397-406. doi: 10.1093/hmg/ddv176. Epub 2015 May 13.

16.

Morphological analysis of neuromuscular junction development and degeneration in rodent lumbrical muscles.

Sleigh JN, Burgess RW, Gillingwater TH, Cader MZ.

J Neurosci Methods. 2014 Apr 30;227:159-65. doi: 10.1016/j.jneumeth.2014.02.005. Epub 2014 Feb 14.

17.

Neuromuscular junction maturation defects precede impaired lower motor neuron connectivity in Charcot-Marie-Tooth type 2D mice.

Sleigh JN, Grice SJ, Burgess RW, Talbot K, Cader MZ.

Hum Mol Genet. 2014 May 15;23(10):2639-50. doi: 10.1093/hmg/ddt659. Epub 2013 Dec 23.

18.

Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice.

Turner BJ, Alfazema N, Sheean RK, Sleigh JN, Davies KE, Horne MK, Talbot K.

Neurobiol Aging. 2014 Apr;35(4):906-15. doi: 10.1016/j.neurobiolaging.2013.09.030. Epub 2013 Oct 24.

19.

Chondrolectin affects cell survival and neuronal outgrowth in in vitro and in vivo models of spinal muscular atrophy.

Sleigh JN, Barreiro-Iglesias A, Oliver PL, Biba A, Becker T, Davies KE, Becker CG, Talbot K.

Hum Mol Genet. 2014 Feb 15;23(4):855-69. doi: 10.1093/hmg/ddt477. Epub 2013 Sep 25.

PMID:
24067532
20.

Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease.

Bogdanik LP, Sleigh JN, Tian C, Samuels ME, Bedard K, Seburn KL, Burgess RW.

Dis Model Mech. 2013 May;6(3):780-92. doi: 10.1242/dmm.010942. Epub 2013 Mar 8.

21.

Spinal muscular atrophy at the crossroads of basic science and therapy.

Sleigh JN, Grice SJ, Davies KE, Talbot K.

Neuromuscul Disord. 2013 Jan;23(1):96. doi: 10.1016/j.nmd.2012.08.008. Epub 2012 Sep 13. No abstract available.

PMID:
22981697
22.

Invertebrate models of spinal muscular atrophy: insights into mechanisms and potential therapeutics.

Grice SJ, Sleigh JN, Liu JL, Sattelle DB.

Bioessays. 2011 Dec;33(12):956-65. doi: 10.1002/bies.201100082. Epub 2011 Oct 18. Review.

PMID:
22009672
23.

The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy.

Sleigh JN, Gillingwater TH, Talbot K.

Dis Model Mech. 2011 Jul;4(4):457-67. doi: 10.1242/dmm.007245. Review.

24.

Conserved genes act as modifiers of invertebrate SMN loss of function defects.

Dimitriadi M, Sleigh JN, Walker A, Chang HC, Sen A, Kalloo G, Harris J, Barsby T, Walsh MB, Satterlee JS, Li C, Van Vactor D, Artavanis-Tsakonas S, Hart AC.

PLoS Genet. 2010 Oct 28;6(10):e1001172. doi: 10.1371/journal.pgen.1001172.

25.

A novel Caenorhabditis elegans allele, smn-1(cb131), mimicking a mild form of spinal muscular atrophy, provides a convenient drug screening platform highlighting new and pre-approved compounds.

Sleigh JN, Buckingham SD, Esmaeili B, Viswanathan M, Cuppen E, Westlund BM, Sattelle DB.

Hum Mol Genet. 2011 Jan 15;20(2):245-60. doi: 10.1093/hmg/ddq459. Epub 2010 Oct 20.

PMID:
20962036

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