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Items: 47

1.

Food hypersensitivity-induced chronic gastrointestinal inflammation in a non-human primate model of diet-induced obesity.

Mustafa T, Li Q, Kelly LE, Gibbon A, Ryan I, Roffey K, Simonds S, Cowley MA, Sleeman MW.

PLoS One. 2019 Apr 4;14(4):e0214621. doi: 10.1371/journal.pone.0214621. eCollection 2019.

2.

A function-blocking PAR4 antibody is markedly antithrombotic in the face of a hyperreactive PAR4 variant.

French SL, Thalmann C, Bray PF, Macdonald LE, Murphy AJ, Sleeman MW, Hamilton JR.

Blood Adv. 2018 Jun 12;2(11):1283-1293. doi: 10.1182/bloodadvances.2017015552.

3.

CD8+ T cells in beige adipogenesis and energy homeostasis.

Moysidou M, Karaliota S, Kodela E, Salagianni M, Koutmani Y, Katsouda A, Kodella K, Tsakanikas P, Ourailidou S, Andreakos E, Kostomitsopoulos N, Skokos D, Chatzigeorgiou A, Chung KJ, Bornstein S, Sleeman MW, Chavakis T, Karalis KP.

JCI Insight. 2018 Mar 8;3(5). pii: 95456. doi: 10.1172/jci.insight.95456.

4.

Deletion of hepatic carbohydrate response element binding protein (ChREBP) impairs glucose homeostasis and hepatic insulin sensitivity in mice.

Jois T, Chen W, Howard V, Harvey R, Youngs K, Thalmann C, Saha P, Chan L, Cowley MA, Sleeman MW.

Mol Metab. 2017 Nov;6(11):1381-1394. doi: 10.1016/j.molmet.2017.07.006. Epub 2017 Jul 18.

5.

The regulation and role of carbohydrate response element-binding protein in metabolic homeostasis and disease.

Jois T, Sleeman MW.

J Neuroendocrinol. 2017 Oct;29(10). doi: 10.1111/jne.12473. Review.

PMID:
28370553
6.

The Ghrelin/GOAT System Regulates Obesity-Induced Inflammation in Male Mice.

Harvey RE, Howard VG, Lemus MB, Jois T, Andrews ZB, Sleeman MW.

Endocrinology. 2017 Jul 1;158(7):2179-2189. doi: 10.1210/en.2016-1832.

7.

Dietary Macronutrient Composition Directs ChREBP Isoform Expression and Glucose Metabolism in Mice.

Jois T, Howard V, Youngs K, Cowley MA, Sleeman MW.

PLoS One. 2016 Dec 19;11(12):e0168797. doi: 10.1371/journal.pone.0168797. eCollection 2016.

8.

Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL.

Hu X, Sleeman MW, Miyashita K, Linton MF, Allan CM, He C, Larsson M, Tu Y, Sandoval NP, Jung RS, Mapar A, Machida T, Murakami M, Nakajima K, Ploug M, Fong LG, Young SG, Beigneux AP.

J Lipid Res. 2017 Jan;58(1):208-215. doi: 10.1194/jlr.M072462. Epub 2016 Nov 15.

9.

Ghrelin-related peptides do not modulate vasodilator nitric oxide production or superoxide levels in mouse systemic arteries.

Ku JM, Sleeman MW, Sobey CG, Andrews ZB, Miller AA.

Clin Exp Pharmacol Physiol. 2016 Apr;43(4):468-75. doi: 10.1111/1440-1681.12548.

PMID:
26800483
10.

Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance.

Sun YB, Qu X, Howard V, Dai L, Jiang X, Ren Y, Fu P, Puelles VG, Nikolic-Paterson DJ, Caruana G, Bertram JF, Sleeman MW, Li J.

Kidney Int. 2015 Aug;88(2):286-98. doi: 10.1038/ki.2015.121. Epub 2015 May 6.

PMID:
25945408
11.

Ghrelin-related peptides exert protective effects in the cerebral circulation of male mice through a nonclassical ghrelin receptor(s).

Ku JM, Andrews ZB, Barsby T, Reichenbach A, Lemus MB, Drummond GR, Sleeman MW, Spencer SJ, Sobey CG, Miller AA.

Endocrinology. 2015 Jan;156(1):280-90. doi: 10.1210/en.2014-1415.

12.

Starving for ghrelin.

Sleeman MW, Spanswick DC.

Cell Metab. 2014 Jul 1;20(1):1-2. doi: 10.1016/j.cmet.2014.06.006.

13.

Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle.

Koh HJ, Toyoda T, Didesch MM, Lee MY, Sleeman MW, Kulkarni RN, Musi N, Hirshman MF, Goodyear LJ.

Nat Commun. 2013;4:1871. doi: 10.1038/ncomms2851.

14.

Ghrelin receptor expression and colocalization with anterior pituitary hormones using a GHSR-GFP mouse line.

Reichenbach A, Steyn FJ, Sleeman MW, Andrews ZB.

Endocrinology. 2012 Nov;153(11):5452-66. doi: 10.1210/en.2012-1622. Epub 2012 Sep 7.

PMID:
22962259
15.

Mouse ghrelin-O-acyltransferase (GOAT) plays a critical role in bile acid reabsorption.

Kang K, Schmahl J, Lee JM, Garcia K, Patil K, Chen A, Keene M, Murphy A, Sleeman MW.

FASEB J. 2012 Jan;26(1):259-71. doi: 10.1096/fj.11-191460. Epub 2011 Sep 29.

PMID:
21965605
16.

Reduced locomotor responses to cocaine in ghrelin-deficient mice.

Abizaid A, Mineur YS, Roth RH, Elsworth JD, Sleeman MW, Picciotto MR, Horvath TL.

Neuroscience. 2011 Sep 29;192:500-6. doi: 10.1016/j.neuroscience.2011.06.001. Epub 2011 Jun 12.

PMID:
21699961
17.

Physiological role of ghrelin as revealed by the ghrelin and GOAT knockout mice.

Kang K, Zmuda E, Sleeman MW.

Peptides. 2011 Nov;32(11):2236-41. doi: 10.1016/j.peptides.2011.04.028. Epub 2011 May 10. Review.

PMID:
21600256
18.

Melanocortin signaling in the CNS directly regulates circulating cholesterol.

Perez-Tilve D, Hofmann SM, Basford J, Nogueiras R, Pfluger PT, Patterson JT, Grant E, Wilson-Perez HE, Granholm NA, Arnold M, Trevaskis JL, Butler AA, Davidson WS, Woods SC, Benoit SC, Sleeman MW, DiMarchi RD, Hui DY, Tschöp MH.

Nat Neurosci. 2010 Jul;13(7):877-82. doi: 10.1038/nn.2569. Epub 2010 Jun 6.

19.

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.

Zhao TJ, Liang G, Li RL, Xie X, Sleeman MW, Murphy AJ, Valenzuela DM, Yancopoulos GD, Goldstein JL, Brown MS.

Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7467-72. doi: 10.1073/pnas.1002271107. Epub 2010 Mar 15.

20.

Analysis of knockout mice suggests a role for VGF in the control of fat storage and energy expenditure.

Watson E, Fargali S, Okamoto H, Sadahiro M, Gordon RE, Chakraborty T, Sleeman MW, Salton SR.

BMC Physiol. 2009 Oct 28;9:19. doi: 10.1186/1472-6793-9-19.

21.

Reduced anticipatory locomotor responses to scheduled meals in ghrelin receptor deficient mice.

Blum ID, Patterson Z, Khazall R, Lamont EW, Sleeman MW, Horvath TL, Abizaid A.

Neuroscience. 2009 Dec 1;164(2):351-9. doi: 10.1016/j.neuroscience.2009.08.009. Epub 2009 Aug 8.

22.

Increased fear- and stress-related anxiety-like behavior in mice lacking tuberoinfundibular peptide of 39 residues.

Fegley DB, Holmes A, Riordan T, Faber CA, Weiss JR, Ma S, Batkai S, Pacher P, Dobolyi A, Murphy A, Sleeman MW, Usdin TB.

Genes Brain Behav. 2008 Nov;7(8):933-42. doi: 10.1111/j.1601-183X.2008.00432.x. Epub 2008 Sep 17.

23.

Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin.

López M, Lage R, Saha AK, Pérez-Tilve D, Vázquez MJ, Varela L, Sangiao-Alvarellos S, Tovar S, Raghay K, Rodríguez-Cuenca S, Deoliveira RM, Castañeda T, Datta R, Dong JZ, Culler M, Sleeman MW, Alvarez CV, Gallego R, Lelliott CJ, Carling D, Tschöp MH, Diéguez C, Vidal-Puig A.

Cell Metab. 2008 May;7(5):389-99. doi: 10.1016/j.cmet.2008.03.006.

24.

The CAMplexities of central ghrelin.

Sleeman MW, Latres E.

Cell Metab. 2008 May;7(5):361-2. doi: 10.1016/j.cmet.2008.04.009.

25.

The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome.

Raz R, Stricker S, Gazzerro E, Clor JL, Witte F, Nistala H, Zabski S, Pereira RC, Stadmeyer L, Wang X, Gowen L, Sleeman MW, Yancopoulos GD, Canalis E, Mundlos S, Valenzuela DM, Economides AN.

Development. 2008 May;135(9):1713-23. doi: 10.1242/dev.015149. Epub 2008 Mar 19.

26.

Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure.

Pfluger PT, Kirchner H, Günnel S, Schrott B, Perez-Tilve D, Fu S, Benoit SC, Horvath T, Joost HG, Wortley KE, Sleeman MW, Tschöp MH.

Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G610-8. Epub 2007 Nov 29.

27.

Peptide YY regulates bone turnover in rodents.

Wortley KE, Garcia K, Okamoto H, Thabet K, Anderson KD, Shen V, Herman JP, Valenzuela D, Yancopoulos GD, Tschöp MH, Murphy A, Sleeman MW.

Gastroenterology. 2007 Nov;133(5):1534-43. Epub 2007 Aug 15.

PMID:
17920065
28.

Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses.

Torres R, Croll SD, Vercollone J, Reinhardt J, Griffiths J, Zabski S, Anderson KD, Adams NC, Gowen L, Sleeman MW, Valenzuela DM, Wiegand SJ, Yancopoulos GD, Murphy AJ.

Pain. 2007 Aug;130(3):267-78. Epub 2007 Mar 26.

PMID:
17379411
29.

Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis.

Okamoto H, Latres E, Liu R, Thabet K, Murphy A, Valenzeula D, Yancopoulos GD, Stitt TN, Glass DJ, Sleeman MW.

Diabetes. 2007 May;56(5):1350-6. Epub 2007 Feb 15.

30.

Decreased hepatic futile cycling compensates for increased glucose disposal in the Pten heterodeficient mouse.

Xu J, Gowen L, Raphalides C, Hoyer KK, Weinger JG, Renard M, Troke JJ, Vaitheesyaran B, Lee WN, Saad MF, Sleeman MW, Teitell MA, Kurland IJ.

Diabetes. 2006 Dec;55(12):3372-80.

31.

Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite.

Abizaid A, Liu ZW, Andrews ZB, Shanabrough M, Borok E, Elsworth JD, Roth RH, Sleeman MW, Picciotto MR, Tschöp MH, Gao XB, Horvath TL.

J Clin Invest. 2006 Dec;116(12):3229-39. Epub 2006 Oct 19.

32.

Ghrelin controls hippocampal spine synapse density and memory performance.

Diano S, Farr SA, Benoit SC, McNay EC, da Silva I, Horvath B, Gaskin FS, Nonaka N, Jaeger LB, Banks WA, Morley JE, Pinto S, Sherwin RS, Xu L, Yamada KA, Sleeman MW, Tschöp MH, Horvath TL.

Nat Neurosci. 2006 Mar;9(3):381-8. Epub 2006 Feb 19.

PMID:
16491079
33.

Agouti-related protein-deficient mice display an age-related lean phenotype.

Wortley KE, Anderson KD, Yasenchak J, Murphy A, Valenzuela D, Diano S, Yancopoulos GD, Wiegand SJ, Sleeman MW.

Cell Metab. 2005 Dec;2(6):421-7.

34.

Absence of ghrelin protects against early-onset obesity.

Wortley KE, del Rincon JP, Murray JD, Garcia K, Iida K, Thorner MO, Sleeman MW.

J Clin Invest. 2005 Dec;115(12):3573-8.

35.

Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity.

Harvey NL, Srinivasan RS, Dillard ME, Johnson NC, Witte MH, Boyd K, Sleeman MW, Oliver G.

Nat Genet. 2005 Oct;37(10):1072-81. Epub 2005 Sep 18.

PMID:
16170315
36.

Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5.

Macdonald LE, Wortley KE, Gowen LC, Anderson KD, Murray JD, Poueymirou WT, Simmons MV, Barber D, Valenzuela DM, Economides AN, Wiegand SJ, Yancopoulos GD, Sleeman MW, Murphy AJ.

Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2496-501. Epub 2005 Feb 7.

37.

Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity.

Sleeman MW, Wortley KE, Lai KM, Gowen LC, Kintner J, Kline WO, Garcia K, Stitt TN, Yancopoulos GD, Wiegand SJ, Glass DJ.

Nat Med. 2005 Feb;11(2):199-205. Epub 2005 Jan 16. Erratum in: Nat Med. 2005 Mar;11(3):353.

PMID:
15654325
38.

Ciliary neurotrophic factorAx15 alters energy homeostasis, decreases body weight, and improves metabolic control in diet-induced obese and UCP1-DTA mice.

Blüher S, Moschos S, Bullen J Jr, Kokkotou E, Maratos-Flier E, Wiegand SJ, Sleeman MW, Mantzoros CS.

Diabetes. 2004 Nov;53(11):2787-96. Erratum in: Diabetes. 2005 Jan;54(1):296. Sleemann, Mark W [corrected to Sleeman, Mark W].

39.

Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference.

Wortley KE, Anderson KD, Garcia K, Murray JD, Malinova L, Liu R, Moncrieffe M, Thabet K, Cox HJ, Yancopoulos GD, Wiegand SJ, Sleeman MW.

Proc Natl Acad Sci U S A. 2004 May 25;101(21):8227-32. Epub 2004 May 17.

40.

Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice.

Sleeman MW, Garcia K, Liu R, Murray JD, Malinova L, Moncrieffe M, Yancopoulos GD, Wiegand SJ.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14297-302. Epub 2003 Nov 10.

41.

Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity.

Lambert PD, Anderson KD, Sleeman MW, Wong V, Tan J, Hijarunguru A, Corcoran TL, Murray JD, Thabet KE, Yancopoulos GD, Wiegand SJ.

Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4652-7. Epub 2001 Mar 20.

42.

The ciliary neurotrophic factor and its receptor, CNTFR alpha.

Sleeman MW, Anderson KD, Lambert PD, Yancopoulos GD, Wiegand SJ.

Pharm Acta Helv. 2000 Mar;74(2-3):265-72. Review.

PMID:
10812968
43.

Association of acyl-CoA synthetase-1 with GLUT4-containing vesicles.

Sleeman MW, Donegan NP, Heller-Harrison R, Lane WS, Czech MP.

J Biol Chem. 1998 Feb 6;273(6):3132-5.

44.

Modulation of glucose transport by parathyroid hormone and insulin in UMR 106-01, a clonal rat osteogenic sarcoma cell line.

Thomas DM, Rogers SD, Sleeman MW, Pasquini GM, Bringhurst FR, Ng KW, Zajac JD, Best JD.

J Mol Endocrinol. 1995 Apr;14(2):263-75.

PMID:
7619214
45.

Retinoic acid stimulates glucose transporter expression in L6 muscle cells.

Sleeman MW, Zhou H, Rogers S, Ng KW, Best JD.

Mol Cell Endocrinol. 1995 Feb 27;108(1-2):161-7.

PMID:
7758830
46.

Effects of acute and chronic counterregulatory hormone infusions on glucose tolerance and insulin sensitivity in diabetic dogs.

Sleeman MW, Christopher MJ, Martin IK, Ward GM, Alford FP, Best JD.

Diabetes. 1992 Nov;41(11):1446-52.

PMID:
1397720
47.

Contrasting action of short- and long-term adrenaline infusion on dog skeletal muscle glucose metabolism.

Christopher MJ, Sleeman MW, Alford FP, Best JD.

Diabetologia. 1992 May;35(5):399-405.

PMID:
1387857

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