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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 1
1992 35
1993 104
1994 94
1995 131
1996 144
1997 164
1998 140
1999 162
2000 154
2001 190
2002 164
2003 160
2004 166
2005 153
2006 99
2007 100
2008 114
2009 149
2010 139
2011 136
2012 154
2013 194
2014 183
2015 180
2016 129
2017 158
2018 143
2019 142
2020 126
2021 123
2022 56
2023 43
2024 9

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3,914 results

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Page 1
Fatty Acid Induced Hypermethylation in the Slc2a4 Gene in Visceral Adipose Tissue Is Associated to Insulin-Resistance and Obesity.
Britsemmer JH, Krause C, Taege N, Geißler C, Lopez-Alcantara N, Schmidtke L, Naujack AM, Wagner J, Wolter S, Mann O, Kirchner H. Britsemmer JH, et al. Int J Mol Sci. 2023 Mar 29;24(7):6417. doi: 10.3390/ijms24076417. Int J Mol Sci. 2023. PMID: 37047391 Free PMC article.
DNL in VAT is regulated through ChREBP activity and glucose uptake through Glut4 (encoded by Slc2a4). Slc2a4 expression, ChREBP activity, and DNL are decreased in obesity, the underlying cause however remains unidentified. We hypothesize that increased DNA methylati …
DNL in VAT is regulated through ChREBP activity and glucose uptake through Glut4 (encoded by Slc2a4). Slc2a4 expression, ChREB …
miR-335-5p aggravates type 2 diabetes by inhibiting SLC2A4 expression.
Li G, Zhang L. Li G, et al. Biochem Biophys Res Commun. 2021 Jun 18;558:71-78. doi: 10.1016/j.bbrc.2021.04.011. Epub 2021 Apr 23. Biochem Biophys Res Commun. 2021. PMID: 33901926
The relationship between miR-335-5p and SLC2A4 was investigated using a luciferase assay. The role of the miR-335-5p-SLC2A4 axis was detected by CCK8, BrdU, and caspase-3 assays in pancreatic cells treated with 25 mM glucose. Increased miR-335-5p and decreased SL …
The relationship between miR-335-5p and SLC2A4 was investigated using a luciferase assay. The role of the miR-335-5p-SLC2A4 ax …
ATM loss disrupts the autophagy-lysosomal pathway.
Cheng A, Tse KH, Chow HM, Gan Y, Song X, Ma F, Qian YXY, She W, Herrup K. Cheng A, et al. Autophagy. 2021 Aug;17(8):1998-2010. doi: 10.1080/15548627.2020.1805860. Epub 2020 Aug 14. Autophagy. 2021. PMID: 32757690 Free PMC article.
We attributed this change to an unexpected physical interaction between ATM and the retrograde transport motor protein, dynein. As a consequence, SLC2A4/GLUT4 (solute carrier family 4 [facilitated glucose transporter], member 4) translocation to the plasma membrane was inh …
We attributed this change to an unexpected physical interaction between ATM and the retrograde transport motor protein, dynein. As a consequ …
Estradiol stimulates adipogenesis and Slc2a4/GLUT4 expression via ESR1-mediated activation of CEBPA.
Fatima LA, Campello RS, Barreto-Andrade JN, Passarelli M, Santos RS, Clegg DJ, Machado UF. Fatima LA, et al. Mol Cell Endocrinol. 2019 Dec 1;498:110447. doi: 10.1016/j.mce.2019.05.006. Epub 2019 May 14. Mol Cell Endocrinol. 2019. PMID: 31100494
The CCAAT/enhancer-binding protein alpha (CEBPA) enhances the expression of the Slc2a4 gene and GLUT4 protein, which are markers of adipocyte differentiation/glucose disposal. ...Our results suggest that E2 (10 nM) has a positive effect on 3T3-L1 adipocyte differentiation …
The CCAAT/enhancer-binding protein alpha (CEBPA) enhances the expression of the Slc2a4 gene and GLUT4 protein, which are markers of a …
Estrogen Receptor 1 (ESR1) Enhances Slc2a4/GLUT4 Expression by a SP1 Cooperative Mechanism.
Barreto-Andrade JN, de Fátima LA, Campello RS, Guedes JAC, de Freitas HS, Machado MMOUF. Barreto-Andrade JN, et al. Int J Med Sci. 2018 Aug 10;15(12):1320-1328. doi: 10.7150/ijms.26774. eCollection 2018. Int J Med Sci. 2018. PMID: 30275758 Free PMC article.
Slc2a4 and Sp1 mRNAs (RT-qPCR), total GLUT4 and nuclear ESR1, ESR2 and SP1 proteins (Western blotting), SP1 binding activity into Slc2a4 promoter (EMSA), and nuclear complexation of SP1/ESR1 (immunoprecipitation) were analyzed. ...PPT also increased the nuclear cont …
Slc2a4 and Sp1 mRNAs (RT-qPCR), total GLUT4 and nuclear ESR1, ESR2 and SP1 proteins (Western blotting), SP1 binding activity into …
Glucocorticoid Receptor Alpha Targets SLC2A4 to Regulate Protein Synthesis and Breakdown in Porcine Skeletal Muscle Cells.
Du XL, Xu WJ, Shi JL, Guo K, Guo CT, Zheng R, Jiang SW, Chai J. Du XL, et al. Biomolecules. 2021 May 12;11(5):721. doi: 10.3390/biom11050721. Biomolecules. 2021. PMID: 34065777 Free PMC article.
Additionally, we found a relationship between GRalpha and solute carrier family 2 member 4 (SLC2A4), SLC2A4 expression level increases when stress occurs, suggesting that increasing SLC2A4 expression can partially alleviate stress-induced damage, and we found …
Additionally, we found a relationship between GRalpha and solute carrier family 2 member 4 (SLC2A4), SLC2A4 expression level i …
Effects of short-term endurance and strength exercise in the molecular regulation of skeletal muscle in hyperinsulinemic and hyperglycemic Slc2a4(+/-) mice.
Muñoz VR, Botezelli JD, Gaspar RC, da Rocha AL, Vieira RFL, Crisol BM, Braga RR, Severino MB, Nakandakari SCBR, Antunes GC, Brunetto SQ, Ramos CD, Velloso LA, Simabuco FM, de Moura LP, da Silva ASR, Ropelle ER, Cintra DE, Pauli JR. Muñoz VR, et al. Cell Mol Life Sci. 2023 Apr 13;80(5):122. doi: 10.1007/s00018-023-04771-2. Cell Mol Life Sci. 2023. PMID: 37052684
METHODS: Slc2a4(+/-) mice were used, that performed 5 days of endurance or strength exercise training. ...Thus, the performance of both types of physical exercise proved to be a very effective way to mitigate the impacts of hyperglycemia and hyperinsulinemia in the Slc2 …
METHODS: Slc2a4(+/-) mice were used, that performed 5 days of endurance or strength exercise training. ...Thus, the performance of bo …
Identification of nuclear factor-kappaB sites in the Slc2a4 gene promoter.
Furuya DT, Neri EA, Poletto AC, Anhê GF, Freitas HS, Campello RS, Rebouças NA, Machado UF. Furuya DT, et al. Mol Cell Endocrinol. 2013 May 6;370(1-2):87-95. doi: 10.1016/j.mce.2013.01.019. Epub 2013 Feb 24. Mol Cell Endocrinol. 2013. PMID: 23462193 Free article.
Inflammatory NF-kappaB transcriptional factor has been proposed as a repressor of Slc2a4; although, the binding site(s) in Slc2a4 promoter and the direct repressor effect have never been reported yet. ...Chromatin immunoprecipitation assay using genomic DNA from adi …
Inflammatory NF-kappaB transcriptional factor has been proposed as a repressor of Slc2a4; although, the binding site(s) in Slc2a4 …
Reduced Slc2a4/GLUT4 expression in subcutaneous adipose tissue of monosodium glutamate obese mice is recovered after atorvastatin treatment.
Poletto AC, David-Silva A, Yamamoto AP, Machado UF, Furuya DT. Poletto AC, et al. Diabetol Metab Syndr. 2015 Mar 14;7:18. doi: 10.1186/s13098-015-0015-6. eCollection 2015. Diabetol Metab Syndr. 2015. PMID: 25834641 Free PMC article.
BACKGROUND: Decreased expression of glucose transporter protein GLUT4, encoded by the solute carrier 2A4 (Slc2a4) gene, is involved in obesity-induced insulin resistance. Local tissue inflammation, by nuclear factor-kappaB (NFkappaB)-mediated pathway, has been related to …
BACKGROUND: Decreased expression of glucose transporter protein GLUT4, encoded by the solute carrier 2A4 (Slc2a4) gene, is involved i …
3,914 results