β-Elemene induced ferroptosis via TFEB-mediated GPX4 degradation in EGFR wide-type non-small cell lung cancer.
Zhao LP, Wang HJ, Hu D, Hu JH, Guan ZR, Yu LH, Jiang YP, Tang XQ, Zhou ZH, Xie T, Lou JS.
Zhao LP, et al.
J Adv Res. 2023 Sep 7:S2090-1232(23)00234-5. doi: 10.1016/j.jare.2023.08.018. Online ahead of print.
J Adv Res. 2023.
PMID: 37689240
Free article.
RESULTS: beta-ELE can bind to TFEB, notably activate TFEB, lysosome and transcriptional increase on downstream gene GLA, MCOLN1, SLC26A11 involved in lysosome activity in EGFR wild-type NSCLC cells. beta-ELE increased GPX4 ubiquitination and lysosomal localization, with th …
RESULTS: beta-ELE can bind to TFEB, notably activate TFEB, lysosome and transcriptional increase on downstream gene GLA, MCOLN1, SLC26A11 …