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SLC13A4 Might Serve as a Prognostic Biomarker and be Correlated with Immune Infiltration into Head and Neck Squamous Cell Carcinoma.
Yang ML, Zhang JH, Li S, Zhu R, Wang L. Yang ML, et al. Pathol Oncol Res. 2021 Nov 10;27:1609967. doi: 10.3389/pore.2021.1609967. eCollection 2021. Pathol Oncol Res. 2021. PMID: 34840533 Free PMC article.
The CIBERSORT database was used to analyze the correlation between SLC13A4 expression and the infiltration of immune cells. SLC13A4 enrichment analysis was carried out by GSEA. ...The SLC13A4 high expression group was mainly enriched in metabolic pathways. .. …
The CIBERSORT database was used to analyze the correlation between SLC13A4 expression and the infiltration of immune cells. SLC13A …
Genome-wide transcriptomic analysis of the forebrain of postnatal Slc13a4(+/-) mice.
Harvey TJ, Davila RA, Vidovic D, Sharmin S, Piper M, Simmons DG. Harvey TJ, et al. BMC Res Notes. 2021 Jul 13;14(1):269. doi: 10.1186/s13104-021-05687-5. BMC Res Notes. 2021. PMID: 34256843 Free PMC article.
We have previously shown expression levels for the sulfate transporter Slc13a4 to be elevated during postnatal development, and that sulfate accumulation in the brains of Slc13a4(+/-) mice is reduced, suggesting a role for this transporter during this critical windo …
We have previously shown expression levels for the sulfate transporter Slc13a4 to be elevated during postnatal development, and that …
Perineuronal net abnormalities in Slc13a4(+/-) mice are rescued by postnatal administration of N-acetylcysteine.
Sharmin S, Pradhan J, Zhang Z, Bellingham M, Simmons D, Piper M. Sharmin S, et al. Exp Neurol. 2021 Aug;342:113734. doi: 10.1016/j.expneurol.2021.113734. Epub 2021 May 1. Exp Neurol. 2021. PMID: 33945789
Here, we sought to investigate aberrant PNN formation as a potential mechanism contributing to the functional deficits displayed by Slc13a4(+/-) mice. Following social interactions, we reveal reduced neuronal activation in the somatosensory cortex of Slc13a4(+/-) mi …
Here, we sought to investigate aberrant PNN formation as a potential mechanism contributing to the functional deficits displayed by Slc13 …
Sodium-sulfate/carboxylate cotransporters (SLC13).
Markovich D. Markovich D. Curr Top Membr. 2012;70:239-56. doi: 10.1016/B978-0-12-394316-3.00007-7. Curr Top Membr. 2012. PMID: 23177988 Review.
Members of this gene family (in ascending order) are: SLC13A1 (NaS1), SLC13A2 (NaC1), SLC13A3 (NaC3), SLC13A4 (NaS2) and SLC13A5 (NaC2). SLC13 proteins encode plasma membrane polypeptides with 8-13 putative transmembrane domains, and are expressed in a variety of tissues. …
Members of this gene family (in ascending order) are: SLC13A1 (NaS1), SLC13A2 (NaC1), SLC13A3 (NaC3), SLC13A4 (NaS2) and SLC13A5 (NaC …
Molecular analysis of the human SLC13A4 sulfate transporter gene promoter.
Jefferis J, Rakoczy J, Simmons DG, Dawson PA. Jefferis J, et al. Biochem Biophys Res Commun. 2013 Mar 29;433(1):79-83. doi: 10.1016/j.bbrc.2013.02.061. Epub 2013 Feb 26. Biochem Biophys Res Commun. 2013. PMID: 23485456
The human solute linked carrier (SLC) 13A4 gene is primarily expressed in the placenta where it is proposed to mediate the transport of nutrient sulfate from mother to fetus. The molecular mechanisms involved in the regulation of SLC13A4 expression remain unknown. To inves …
The human solute linked carrier (SLC) 13A4 gene is primarily expressed in the placenta where it is proposed to mediate the transport of nutr …
Molecular analysis of sequence and splice variants of the human SLC13A4 sulfate transporter.
Zhang Z, Aung ZT, Simmons DG, Dawson PA. Zhang Z, et al. Mol Genet Metab. 2017 May;121(1):35-42. doi: 10.1016/j.ymgme.2017.03.010. Epub 2017 Apr 1. Mol Genet Metab. 2017. PMID: 28385533
In mice, targeted disruption of placental Slc13a4 leads to severe and lethal fetal phenotypes, however the involvement of SLC13A4 in human development is unknown. ...SLC13A4 mRNA variant 1 has three additional nucleotides CAG compared to SLC13A4 mRNA v …
In mice, targeted disruption of placental Slc13a4 leads to severe and lethal fetal phenotypes, however the involvement of SLC13A4 …
Postnatal N-acetylcysteine administration rescues impaired social behaviors and neurogenesis in Slc13a4 haploinsufficient mice.
Zhang Z, Dawson PA, Piper M, Simmons DG. Zhang Z, et al. EBioMedicine. 2019 May;43:435-446. doi: 10.1016/j.ebiom.2019.03.081. Epub 2019 Apr 5. EBioMedicine. 2019. PMID: 30956169 Free PMC article.
Immunohistochemistry examined neurogenesis within the stem cells niches. FINDINGS: The sulfate transporter Slc13a4 plays a critical role in postnatal brain development. Slc13a4 haploinsufficiency results in significant behavioral phenotypes in adult mice, notably im …
Immunohistochemistry examined neurogenesis within the stem cells niches. FINDINGS: The sulfate transporter Slc13a4 plays a critical r …
Role of sodium dependent SLC13 transporter inhibitors in various metabolic disorders.
Akhtar MJ, Khan SA, Kumar B, Chawla P, Bhatia R, Singh K. Akhtar MJ, et al. Mol Cell Biochem. 2023 Aug;478(8):1669-1687. doi: 10.1007/s11010-022-04618-7. Epub 2022 Dec 10. Mol Cell Biochem. 2023. PMID: 36495372 Review.
The sodium dependent SLC13 family transporters comprise of five genes SLC13A1, SLC13A2 (NaDC1), SLC13A3 (NaDC3), SLC13A4 and SLC13A5 (NaCT). Among them, NaDC1, NaDC3 and NaCT are sodium dependent transporters belonging to family of dicarboxylates (succinate, malate, alpha- …
The sodium dependent SLC13 family transporters comprise of five genes SLC13A1, SLC13A2 (NaDC1), SLC13A3 (NaDC3), SLC13A4 and SLC13A5 …
Structure, organization and tissue expression of the pig SLC13A1 and SLC13A4 sulfate transporter genes.
Barnes SK, Eiby YA, Lee S, Lingwood BE, Dawson PA. Barnes SK, et al. Biochem Biophys Rep. 2017 Apr 13;10:215-223. doi: 10.1016/j.bbrep.2017.04.005. eCollection 2017 Jul. Biochem Biophys Rep. 2017. PMID: 28955749 Free PMC article.
In this study, we determined the tissue distribution of pig SLC13A1 and SLC13A4 mRNA, and compared the gene, cDNA and protein sequences of the pig, human and mouse homologues. ...The pig SLC13A4 protein contains 626 amino acids that share 91% and 90% identity with h …
In this study, we determined the tissue distribution of pig SLC13A1 and SLC13A4 mRNA, and compared the gene, cDNA and protein sequenc …
22 results