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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 5
2004 8
2005 10
2006 7
2007 4
2008 6
2009 3
2010 4
2011 4
2012 5
2013 6
2014 11
2015 9
2016 8
2017 8
2018 7
2019 6
2020 8
2021 10
2022 8
2023 15
2024 6

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147 results

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Page 1
SLC11A2: a promising biomarker and therapeutic target in ovarian cancer.
Tian L, Li X, Lai H, Sun T, Li X, Wu L, Wu C, Yao S, Ren Y, He S, Yang G. Tian L, et al. Sci Rep. 2023 Jan 20;13(1):1132. doi: 10.1038/s41598-022-26789-5. Sci Rep. 2023. PMID: 36670142 Free PMC article.
The aim of this study was to investigate the effectiveness of SLC11A2 as a therapeutic target and marker for ovarian cancer. Expression data of SLC11A2 were obtained from public databases. ...Serum SLC11A2 may help improve the detection rate of ovarian cancer …
The aim of this study was to investigate the effectiveness of SLC11A2 as a therapeutic target and marker for ovarian cancer. Expressi …
Regulation of Iron-Ion Transporter SLC11A2 by Three Identical miRNAs.
Sugino Y, Uchiyama R, Shibasaki C, Kugawa F. Sugino Y, et al. Biol Pharm Bull. 2022;45(9):1291-1299. doi: 10.1248/bpb.b22-00214. Biol Pharm Bull. 2022. PMID: 36047197 Free article.
Here, we searched for microRNAs (miRNAs) in silico that could interact with SLC11A2 mRNA, a solute carrier (SLC) iron-ion transporter, and investigated their effects on SLC11A2 gene expression using the cultured human colon carcinoma cell line, Caco-2. ...We then ex …
Here, we searched for microRNAs (miRNAs) in silico that could interact with SLC11A2 mRNA, a solute carrier (SLC) iron-ion transporter …
Copper metabolism in cell death and autophagy.
Xue Q, Kang R, Klionsky DJ, Tang D, Liu J, Chen X. Xue Q, et al. Autophagy. 2023 Aug;19(8):2175-2195. doi: 10.1080/15548627.2023.2200554. Epub 2023 Apr 16. Autophagy. 2023. PMID: 37055935 Free PMC article. Review.
This knowledge may help in the design of future clinical tools to improve cancer diagnosis and treatment.Abbreviations: ACSL4, acyl-CoA synthetase long chain family member 4; AIFM1/AIF, apoptosis inducing factor mitochondria associated 1; AIFM2, apoptosis inducing factor mitochon …
This knowledge may help in the design of future clinical tools to improve cancer diagnosis and treatment.Abbreviations: ACSL4, acyl-CoA synt …
DOES SLC11A2 GENE MUTATION ASSOCIATE WITH IRON-REFRACTORY IRON-DEFICIENCY ANEMIA AFTER BARIATRIC SURGERY?
Piatto VB, Ferdinando DLT, Funes HLX. Piatto VB, et al. Arq Bras Cir Dig. 2022 Jun 17;35:e1645. doi: 10.1590/0102-672020210002e1645. eCollection 2022. Arq Bras Cir Dig. 2022. PMID: 35730874 Free PMC article.
This study aimed to investigate the association of both mutations 1285G-C and 1246C-T, in the SLC11A2 gene, and the etiopathogenesis of anemia refractory to iron supplementation in patients undergoing bariatric surgery using Roux-en-Y gastric bypass (RYGB). ...CONCLUSION: …
This study aimed to investigate the association of both mutations 1285G-C and 1246C-T, in the SLC11A2 gene, and the etiopathogenesis …
Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver.
Gunshin H, Fujiwara Y, Custodio AO, Direnzo C, Robine S, Andrews NC. Gunshin H, et al. J Clin Invest. 2005 May;115(5):1258-66. doi: 10.1172/JCI24356. Epub 2005 Apr 21. J Clin Invest. 2005. PMID: 15849611 Free PMC article.
We found that fetal Slc11a2 is not needed for materno-fetal iron transfer but that Slc11a2 activity is essential for intestinal non-heme iron absorption after birth. ...However, inactivation of murine Hfe ameliorates the phenotype of animals lacking Slc11a2.. …
We found that fetal Slc11a2 is not needed for materno-fetal iron transfer but that Slc11a2 activity is essential for intestina …
Microglial-specific knockdown of iron import gene, Slc11a2, blunts LPS-induced neuroinflammatory responses in a sex-specific manner.
Volk Robertson K, Schleh MW, Harrison FE, Hasty AH. Volk Robertson K, et al. Brain Behav Immun. 2024 Feb;116:370-384. doi: 10.1016/j.bbi.2023.12.020. Epub 2023 Dec 22. Brain Behav Immun. 2024. PMID: 38141840
These studies aimed to determine the effect of knocking down microglial iron import gene Slc11a2 on the inflammatory response in vivo. We generated a novel model of tamoxifen-inducible, microglial-specific Slc11a2 knockdown using Cx3cr1(Cre-ERT2) mice. ...Control ma …
These studies aimed to determine the effect of knocking down microglial iron import gene Slc11a2 on the inflammatory response in vivo …
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis.
Bell S, Rigas AS, Magnusson MK, Ferkingstad E, Allara E, Bjornsdottir G, Ramond A, Sørensen E, Halldorsson GH, Paul DS, Burgdorf KS, Eggertsson HP, Howson JMM, Thørner LW, Kristmundsdottir S, Astle WJ, Erikstrup C, Sigurdsson JK, Vuckovic D, Dinh KM, Tragante V, Surendran P, Pedersen OB, Vidarsson B, Jiang T, Paarup HM, Onundarson PT, Akbari P, Nielsen KR, Lund SH, Juliusson K, Magnusson MI, Frigge ML, Oddsson A, Olafsson I, Kaptoge S, Hjalgrim H, Runarsson G, Wood AM, Jonsdottir I, Hansen TF, Sigurdardottir O, Stefansson H, Rye D; DBDS Genomic Consortium; Peters JE, Westergaard D, Holm H, Soranzo N, Banasik K, Thorleifsson G, Ouwehand WH, Thorsteinsdottir U, Roberts DJ, Sulem P, Butterworth AS, Gudbjartsson DF, Danesh J, Brunak S, Di Angelantonio E, Ullum H, Stefansson K. Bell S, et al. Commun Biol. 2021 Feb 3;4(1):156. doi: 10.1038/s42003-020-01575-z. Commun Biol. 2021. PMID: 33536631 Free PMC article. Review.
We found 62 independent sequence variants associating with iron homeostasis parameters at 56 loci, including 46 novel loci. Variants at DUOX2, F5, SLC11A2 and TMPRSS6 associate with iron deficiency anemia, while variants at TF, HFE, TFR2 and TMPRSS6 associate with iron ove …
We found 62 independent sequence variants associating with iron homeostasis parameters at 56 loci, including 46 novel loci. Variants at DUOX …
The Associations between Metalloestrogens, GSTP1, and SLC11A2 Polymorphism and the Risk of Endometrial Cancer.
Michalczyk K, Kapczuk P, Witczak G, Bosiacki M, Kurzawski M, Chlubek D, Cymbaluk-Płoska A. Michalczyk K, et al. Nutrients. 2022 Jul 27;14(15):3079. doi: 10.3390/nu14153079. Nutrients. 2022. PMID: 35893933 Free PMC article.
This study aimed to investigate total blood trace elements levels and evaluate the distribution of selected genotypes in GSTP1 and SLC11A2 genes. METHODS: This retrospective case-control analysis was carried out in peripheral blood samples of 110 women with endometrial can …
This study aimed to investigate total blood trace elements levels and evaluate the distribution of selected genotypes in GSTP1 and SLC11A …
BMP4, SGSH, and SLC11A2 are Predicted to Be Biomarkers of Aging Associated with Programmed Cell Death.
Kubat Oktem E. Kubat Oktem E. J Mol Neurosci. 2023 Oct;73(9-10):713-723. doi: 10.1007/s12031-023-02148-5. Epub 2023 Aug 26. J Mol Neurosci. 2023. PMID: 37632651
The diagnostic utility of the biomarkers was tested using a logistic regression-based prediction model. Three genes, namely BMP4, SGSH, and SLC11A2, were found to be aging biomarkers associated with PCD. Finally, a multifactorial regulatory network with interacting protein …
The diagnostic utility of the biomarkers was tested using a logistic regression-based prediction model. Three genes, namely BMP4, SGSH, and …
Inhibitors of Human Divalent Metal Transporters DMT1 (SLC11A2) and ZIP8 (SLC39A8) from a GDB-17 Fragment Library.
Pujol-Giménez J, Poirier M, Bühlmann S, Schuppisser C, Bhardwaj R, Awale M, Visini R, Javor S, Hediger MA, Reymond JL. Pujol-Giménez J, et al. ChemMedChem. 2021 Nov 5;16(21):3306-3314. doi: 10.1002/cmdc.202100467. Epub 2021 Aug 31. ChemMedChem. 2021. PMID: 34309203 Free PMC article.
Here we searched for inhibitors of divalent metal transporters in a library of 1,676 commercially available 3D-shaped fragment-like molecules from the generated database GDB-17, which lists all possible organic molecules up to 17 atoms of C, N, O, S and halogen following simple c …
Here we searched for inhibitors of divalent metal transporters in a library of 1,676 commercially available 3D-shaped fragment-like molecule …
147 results