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Items: 13


High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage.

Slaymaker IM, Mesa P, Kellner MJ, Kannan S, Brignole E, Koob J, Feliciano PR, Stella S, Abudayyeh OO, Gootenberg JS, Strecker J, Montoya G, Zhang F.

Cell Rep. 2019 Mar 26;26(13):3741-3751.e5. doi: 10.1016/j.celrep.2019.02.094.


CRISPR-Cas9 Mediated DNA Unwinding Detected Using Site-Directed Spin Labeling.

Tangprasertchai NS, Di Felice R, Zhang X, Slaymaker IM, Vazquez Reyes C, Jiang W, Rohs R, Qin PZ.

ACS Chem Biol. 2017 Jun 16;12(6):1489-1493. doi: 10.1021/acschembio.6b01137. Epub 2017 May 3.


Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits.

Platt RJ, Zhou Y, Slaymaker IM, Shetty AS, Weisbach NR, Kim JA, Sharma J, Desai M, Sood S, Kempton HR, Crabtree GR, Feng G, Zhang F.

Cell Rep. 2017 Apr 11;19(2):335-350. doi: 10.1016/j.celrep.2017.03.052.


Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28.

Smargon AA, Cox DBT, Pyzocha NK, Zheng K, Slaymaker IM, Gootenberg JS, Abudayyeh OA, Essletzbichler P, Shmakov S, Makarova KS, Koonin EV, Zhang F.

Mol Cell. 2017 Feb 16;65(4):618-630.e7. doi: 10.1016/j.molcel.2016.12.023. Epub 2017 Jan 5.


C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector.

Abudayyeh OO, Gootenberg JS, Konermann S, Joung J, Slaymaker IM, Cox DB, Shmakov S, Makarova KS, Semenova E, Minakhin L, Severinov K, Regev A, Lander ES, Koonin EV, Zhang F.

Science. 2016 Aug 5;353(6299):aaf5573. doi: 10.1126/science.aaf5573. Epub 2016 Jun 2.


Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA.

Yamano T, Nishimasu H, Zetsche B, Hirano H, Slaymaker IM, Li Y, Fedorova I, Nakane T, Makarova KS, Koonin EV, Ishitani R, Zhang F, Nureki O.

Cell. 2016 May 5;165(4):949-62. doi: 10.1016/j.cell.2016.04.003. Epub 2016 Apr 21.


Rationally engineered Cas9 nucleases with improved specificity.

Slaymaker IM, Gao L, Zetsche B, Scott DA, Yan WX, Zhang F.

Science. 2016 Jan 1;351(6268):84-8. doi: 10.1126/science.aad5227. Epub 2015 Dec 1.


Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system.

Zetsche B, Gootenberg JS, Abudayyeh OO, Slaymaker IM, Makarova KS, Essletzbichler P, Volz SE, Joung J, van der Oost J, Regev A, Koonin EV, Zhang F.

Cell. 2015 Oct 22;163(3):759-71. doi: 10.1016/j.cell.2015.09.038. Epub 2015 Sep 25.


The 1.8-Å crystal structure of the N-terminal domain of an archaeal MCM as a right-handed filament.

Fu Y, Slaymaker IM, Wang J, Wang G, Chen XS.

J Mol Biol. 2014 Apr 3;426(7):1512-23. doi: 10.1016/j.jmb.2013.12.025. Epub 2013 Dec 27.


Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology.

Slaymaker IM, Fu Y, Toso DB, Ranatunga N, Brewster A, Forsburg SL, Zhou ZH, Chen XS.

Nucleic Acids Res. 2013 Mar 1;41(5):3446-56. doi: 10.1093/nar/gkt022. Epub 2013 Jan 29.


MCM structure and mechanics: what we have learned from archaeal MCM.

Slaymaker IM, Chen XS.

Subcell Biochem. 2012;62:89-111. doi: 10.1007/978-94-007-4572-8_6. Review.


Mutational analysis of an archaeal minichromosome maintenance protein exterior hairpin reveals critical residues for helicase activity and DNA binding.

Brewster AS, Slaymaker IM, Afif SA, Chen XS.

BMC Mol Biol. 2010 Aug 18;11:62. doi: 10.1186/1471-2199-11-62.


Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase.

Slaymaker IM, Bracey M, Mileni M, Garfunkle J, Cravatt BF, Boger DL, Stevens RC.

Bioorg Med Chem Lett. 2008 Nov 15;18(22):5847-50. doi: 10.1016/j.bmcl.2008.06.086. Epub 2008 Jun 28.

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