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Items: 27


Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction.

Borg DJ, Yap FYT, Keshvari S, Simmons DG, Gallo LA, Fotheringham AK, Zhuang A, Slattery RM, Hasnain SZ, Coughlan MT, Kantharidis P, Forbes JM.

Islets. 2018 Jan 2;10(1):10-24. doi: 10.1080/19382014.2017.1405189. Epub 2017 Dec 22.


A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis.

Hebbandi Nanjundappa R, Ronchi F, Wang J, Clemente-Casares X, Yamanouchi J, Sokke Umeshappa C, Yang Y, Blanco J, Bassolas-Molina H, Salas A, Khan H, Slattery RM, Wyss M, Mooser C, Macpherson AJ, Sycuro LK, Serra P, McKay DM, McCoy KD, Santamaria P.

Cell. 2017 Oct 19;171(3):655-667.e17. doi: 10.1016/j.cell.2017.09.022.


The NF-κB transcription factor RelA is required for the tolerogenic function of Foxp3(+) regulatory T cells.

Messina N, Fulford T, O'Reilly L, Loh WX, Motyer JM, Ellis D, McLean C, Naeem H, Lin A, Gugasyan R, Slattery RM, Grumont RJ, Gerondakis S.

J Autoimmun. 2016 Jun;70:52-62. doi: 10.1016/j.jaut.2016.03.017. Epub 2016 Apr 7.


Perforin facilitates beta cell killing and regulates autoreactive CD8+ T-cell responses to antigen in mouse models of type 1 diabetes.

Trivedi P, Graham KL, Krishnamurthy B, Fynch S, Slattery RM, Kay TW, Thomas HE.

Immunol Cell Biol. 2016 Apr;94(4):334-41. doi: 10.1038/icb.2015.89. Epub 2015 Oct 8.


Advances in our understanding of the pathophysiology of Type 1 diabetes: lessons from the NOD mouse.

Jayasimhan A, Mansour KP, Slattery RM.

Clin Sci (Lond). 2014 Jan 1;126(1):1-18. doi: 10.1042/CS20120627. Review.


The CD19 signalling molecule is elevated in NOD mice and controls type 1 diabetes development.

Ziegler AI, Le Page MA, Maxwell MJ, Stolp J, Guo H, Jayasimhan A, Hibbs ML, Santamaria P, Miller JF, Plebanski M, Silveira PA, Slattery RM.

Diabetologia. 2013 Dec;56(12):2659-68. doi: 10.1007/s00125-013-3038-2. Epub 2013 Sep 8.


Dendritic cell-dependent in vivo generation of autoregulatory T cells by antidiabetogenic MHC class II.

Tsai S, Serra P, Clemente-Casares X, Slattery RM, Santamaria P.

J Immunol. 2013 Jul 1;191(1):70-82. doi: 10.4049/jimmunol.1300168. Epub 2013 Jun 5.


Antidiabetogenic MHC class II promotes the differentiation of MHC-promiscuous autoreactive T cells into FOXP3+ regulatory T cells.

Tsai S, Serra P, Clemente-Casares X, Yamanouchi J, Thiessen S, Slattery RM, Elliott JF, Santamaria P.

Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3471-6. doi: 10.1073/pnas.1211391110. Epub 2013 Feb 11.


Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression.

Graham KL, Krishnamurthy B, Fynch S, Ayala-Perez R, Slattery RM, Santamaria P, Thomas HE, Kay TW.

Eur J Immunol. 2012 Jul;42(7):1717-22. doi: 10.1002/eji.201242435. Epub 2012 Jun 12.


Advanced glycation end products are direct modulators of β-cell function.

Coughlan MT, Yap FY, Tong DC, Andrikopoulos S, Gasser A, Thallas-Bonke V, Webster DE, Miyazaki J, Kay TW, Slattery RM, Kaye DM, Drew BG, Kingwell BA, Fourlanos S, Groop PH, Harrison LC, Knip M, Forbes JM.

Diabetes. 2011 Oct;60(10):2523-32. doi: 10.2337/db10-1033. Epub 2011 Sep 12.


An indirect role for NK cells in a CD4(+) T-cell-dependent mouse model of type I diabetes.

Angstetra E, Graham KL, Zhao Y, Irvin AE, Elkerbout L, Santamaria P, Slattery RM, Kay TW, Thomas HE.

Immunol Cell Biol. 2012 Feb;90(2):243-7. doi: 10.1038/icb.2011.16. Epub 2011 Mar 8.


Congenic analysis of the NKT cell control gene Nkt2 implicates the peroxisomal protein Pxmp4.

Fletcher JM, Jordan MA, Snelgrove SL, Slattery RM, Dufour FD, Kyparissoudis K, Besra GS, Godfrey DI, Baxter AG.

J Immunol. 2008 Sep 1;181(5):3400-12.


Functional interaction of AIRE with PIAS1 in transcriptional regulation.

Ilmarinen T, Kangas H, Kytömaa T, Eskelin P, Saharinen J, Seeler JS, Tanhuanpää K, Chan FY, Slattery RM, Alakurtti K, Palvimo JJ, Ulmanen I.

Mol Immunol. 2008 Apr;45(7):1847-62.


Beta cells cannot directly prime diabetogenic CD8 T cells in nonobese diabetic mice.

de Jersey J, Snelgrove SL, Palmer SE, Teteris SA, Mullbacher A, Miller JF, Slattery RM.

Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1295-300. Epub 2007 Jan 17.


MHC class II molecules play a role in the selection of autoreactive class I-restricted CD8 T cells that are essential contributors to type 1 diabetes development in nonobese diabetic mice.

Serreze DV, Holl TM, Marron MP, Graser RT, Johnson EA, Choisy-Rossi C, Slattery RM, Lieberman SM, DiLorenzo TP.

J Immunol. 2004 Jan 15;172(2):871-9.


Beta cell MHC class I is a late requirement for diabetes.

Hamilton-Williams EE, Palmer SE, Charlton B, Slattery RM.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6688-93. Epub 2003 May 15.


B lymphocytes not required for progression from insulitis to diabetes in non-obese diabetic mice.

Charlton B, Zhang MD, Slattery RM.

Immunol Cell Biol. 2001 Dec;79(6):597-601.


Transgenic rescue implicates beta2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice.

Hamilton-Williams EE, Serreze DV, Charlton B, Johnson EA, Marron MP, Mullbacher A, Slattery RM.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11533-8. Erratum in: Proc Natl Acad Sci U S A 2001 Nov 6;98(23):13472.


Th1 unresponsiveness can be infectious for unrelated antigens.

Charlton B, Fathman CG, Slattery RM.

Immunol Cell Biol. 1998 Apr;76(2):173-8.


Prevention of Th2-mediated murine allergic airways disease by soluble antigen administration in the neonate.

Hogan SP, Foster PS, Charlton B, Slattery RM.

Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2441-5.


Failure of a protective major histocompatibility complex class II molecule to delete autoreactive T cells in autoimmune diabetes.

Slattery RM, Miller JF, Heath WR, Charlton B.

Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10808-10.


Bone marrow transplantation prevents autoimmune diabetes in nonobese diabetic mice.

Georgiou HM, Slattery RM, Charlton B.

Transplant Proc. 1993 Oct;25(5):2896-7. No abstract available.


Intercellular adhesion molecule (ICAM-1) inhibition can induce tolerance in vivo.

Charlton B, Guymer RH, Slattery RM, Mandel TE.

Immunol Cell Biol. 1991 Apr;69 ( Pt 2):89-93.


Prevention of diabetes in non-obese diabetic I-Ak transgenic mice.

Slattery RM, Kjer-Nielsen L, Allison J, Charlton B, Mandel TE, Miller JF.

Nature. 1990 Jun 21;345(6277):724-6.


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