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1.

Association of dietary folate and vitamin B-12 intake with genome-wide DNA methylation in blood: a large-scale epigenome-wide association analysis in 5841 individuals.

Mandaviya PR, Joehanes R, Brody J, Castillo-Fernandez JE, Dekkers KF, Do AN, Graff M, Hänninen IK, Tanaka T, de Jonge EAL, Kiefte-de Jong JC, Absher DM, Aslibekyan S, de Rijke YB, Fornage M, Hernandez DG, Hurme MA, Ikram MA, Jacques PF, Justice AE, Kiel DP, Lemaitre RN, Mendelson MM, Mikkilä V, Moore AZ, Pallister T, Raitakari OT, Schalkwijk CG, Sha J, Slagboom EPE, Smith CE, Stehouwer CDA, Tsai PC, Uitterlinden AG, van der Kallen CJH, van Heemst D, Arnett DK, Bandinelli S, Bell JT, Heijmans BT, Lehtimäki T, Levy D, North KE, Sotoodehnia N, van Greevenbroek MMJ, van Meurs JBJ, Heil SG.

Am J Clin Nutr. 2019 Aug 1;110(2):437-450. doi: 10.1093/ajcn/nqz031.

PMID:
31165884
2.

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.

van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernández I, van Eijk KR, Stringa N, Chen JA, Zettergren A, Andlauer TFM, Diez-Fairen M, Simon-Sanchez J, Lleó A, Zetterberg H, Nygaard M, Blauwendraat C, Savage JE, Mengel-From J, Moreno-Grau S, Wagner M, Fortea J, Keogh MJ, Blennow K, Skoog I, Friese MA, Pletnikova O, Zulaica M, Lage C, de Rojas I, Riedel-Heller S, Illán-Gala I, Wei W, Jeune B, Orellana A, Then Bergh F, Wang X, Hulsman M, Beker N, Tesi N, Morris CM, Indakoetxea B, Collij LE, Scherer M, Morenas-Rodríguez E, Ironside JW, van Berckel BNM, Alcolea D, Wiendl H, Strickland SL, Pastor P, Rodríguez Rodríguez E; DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank); EADB (Alzheimer Disease European DNA biobank); IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium); IPDGC (The International Parkinson Disease Genomics Consortium); RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia); Netherlands Brain Bank (NBB), Boeve BF, Petersen RC, Ferman TJ, van Gerpen JA, Reinders MJT, Uitti RJ, Tárraga L, Maier W, Dols-Icardo O, Kawalia A, Dalmasso MC, Boada M, Zettl UK, van Schoor NM, Beekman M, Allen M, Masliah E, de Munain AL, Pantelyat A, Wszolek ZK, Ross OA, Dickson DW, Graff-Radford NR, Knopman D, Rademakers R, Lemstra AW, Pijnenburg YAL, Scheltens P, Gasser T, Chinnery PF, Hemmer B, Huisman MA, Troncoso J, Moreno F, Nohr EA, Sørensen TIA, Heutink P, Sánchez-Juan P, Posthuma D; GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, Clarimón J, Christensen K, Ertekin-Taner N, Scholz SW, Ramirez A, Ruiz A, Slagboom E, van der Flier WM, Holstege H.

Acta Neuropathol. 2019 Aug;138(2):237-250. doi: 10.1007/s00401-019-02026-8. Epub 2019 May 27.

3.

Annotating Transcriptional Effects of Genetic Variants in Disease-Relevant Tissue: Transcriptome-Wide Allelic Imbalance in Osteoarthritic Cartilage.

den Hollander W, Pulyakhina I, Boer C, Bomer N, van der Breggen R, Arindrarto W, Couthino de Almeida R, Lakenberg N, Sentner T, Laros JFJ, 't Hoen PAC, Slagboom EPE, Nelissen RGHH, van Meurs J, Ramos YFM, Meulenbelt I.

Arthritis Rheumatol. 2019 Apr;71(4):561-570. doi: 10.1002/art.40748. Epub 2019 Feb 23.

4.

Sex Differences in Genetic Associations With Longevity.

Zeng Y, Nie C, Min J, Chen H, Liu X, Ye R, Chen Z, Bai C, Xie E, Yin Z, Lv Y, Lu J, Li J, Ni T, Bolund L, Land KC, Yashin A, O'Rand AM, Sun L, Yang Z, Tao W, Gurinovich A, Franceschi C, Xie J, Gu J, Hou Y, Liu X, Xu X, Robine JM, Deelen J, Sebastiani P, Slagboom E, Perls T, Hauser E, Gottschalk W, Tan Q, Christensen K, Shi X, Lutz M, Tian XL, Yang H, Vaupel J.

JAMA Netw Open. 2018 Aug;1(4):e181670. doi: 10.1001/jamanetworkopen.2018.1670. Epub 2018 Aug 24.

5.

Facial Wrinkles in Europeans: A Genome-Wide Association Study.

Hamer MA, Pardo LM, Jacobs LC, Deelen J, Uitterlinden AG, Slagboom E, van Heemst D, Uh HW, Beekman M, Kayser M, Liu F, Gunn DA, Nijsten T.

J Invest Dermatol. 2018 Aug;138(8):1877-1880. doi: 10.1016/j.jid.2017.12.037. Epub 2018 Mar 16. No abstract available.

6.

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.

Jiang X, O'Reilly PF, Aschard H, Hsu YH, Richards JB, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, Kestenbaum B, Zheng J, Luan J, Sofianopoulou E, Streeten EA, Albanes D, Lutsey PL, Yao L, Tang W, Econs MJ, Wallaschofski H, Völzke H, Zhou A, Power C, McCarthy MI, Michos ED, Boerwinkle E, Weinstein SJ, Freedman ND, Huang WY, Van Schoor NM, van der Velde N, Groot LCPGM, Enneman A, Cupples LA, Booth SL, Vasan RS, Liu CT, Zhou Y, Ripatti S, Ohlsson C, Vandenput L, Lorentzon M, Eriksson JG, Shea MK, Houston DK, Kritchevsky SB, Liu Y, Lohman KK, Ferrucci L, Peacock M, Gieger C, Beekman M, Slagboom E, Deelen J, Heemst DV, Kleber ME, März W, de Boer IH, Wood AC, Rotter JI, Rich SS, Robinson-Cohen C, den Heijer M, Jarvelin MR, Cavadino A, Joshi PK, Wilson JF, Hayward C, Lind L, Michaëlsson K, Trompet S, Zillikens MC, Uitterlinden AG, Rivadeneira F, Broer L, Zgaga L, Campbell H, Theodoratou E, Farrington SM, Timofeeva M, Dunlop MG, Valdes AM, Tikkanen E, Lehtimäki T, Lyytikäinen LP, Kähönen M, Raitakari OT, Mikkilä V, Ikram MA, Sattar N, Jukema JW, Wareham NJ, Langenberg C, Forouhi NG, Gundersen TE, Khaw KT, Butterworth AS, Danesh J, Spector T, Wang TJ, Hyppönen E, Kraft P, Kiel DP.

Nat Commun. 2018 Jan 17;9(1):260. doi: 10.1038/s41467-017-02662-2.

7.

Zinc-Induced Metallothionein in Centenarian Offspring From a Large European Population: The MARK-AGE Project.

Giacconi R, Costarelli L, Piacenza F, Basso A, Bürkle A, Moreno-Villanueva M, Grune T, Weber D, Stuetz W, Gonos ES, Schön C, Grubeck-Loebenstein B, Sikora E, Toussaint O, Debacq-Chainiaux F, Franceschi C, Hervonen A, Slagboom E, Ciccarone F, Zampieri M, Caiafa P, Jansen E, Dollé MET, Breusing N, Mocchegiani E, Malavolta M.

J Gerontol A Biol Sci Med Sci. 2018 May 9;73(6):745-753. doi: 10.1093/gerona/glx192.

PMID:
29045571
8.

Correction: The complex genetics of gait speed: genome-wide meta-analysis approach.

Ben-Avraham D, Karasik D, Verghese J, Lunetta KL, Smith JA, Eicher JD, Vered R, Deelen J, Arnold AM, Buchman AS, Tanaka T, Faul JD, Nethander M, Fornage M, Adams HH, Matteini AM, Callisaya ML, Smith AV, Yu L, De Jager PL, Evans DA, Gudnason V, Hofman A, Pattie A, Corley J, Launer LJ, Knopman DS, Parimi N, Turner ST, Bandinelli S, Beekman M, Gutman D, Sharvit L, Mooijaart SP, Liewald DC, Houwing-Duistermaat JJ, Ohlsson C, Moed M, Verlinden VJ, Mellström D, van der Geest JN, Karlsson M, Hernandez D, McWhirter R, Liu Y, Thomson R, Tranah GJ, Uitterlinden AG, Weir DR, Zhao W, Starr JM, Johnson AD, Ikram MA, Bennett DA, Cummings SR, Deary IJ, Harris TB, Kardia SLR, Mosley TH, Srikanth VK, Windham BG, Newman AB, Walston JD, Davies G, Evans DS, Slagboom EP, Ferrucci L, Kiel DP, Murabito JM, Atzmon G.

Aging (Albany NY). 2017 Jul;9(7):1844-1846. doi: 10.18632/aging.101260. Epub 2017 Jul 7. No abstract available.

9.

Automated quantification of metabolites in blood-derived samples by NMR.

Verhoeven A, Slagboom E, Wuhrer M, Giera M, Mayboroda OA.

Anal Chim Acta. 2017 Jul 11;976:52-62. doi: 10.1016/j.aca.2017.04.013. Epub 2017 Apr 13.

10.

Secondary phenotype analysis in ascertained family designs: application to the Leiden longevity study.

Tissier R, Tsonaka R, Mooijaart SP, Slagboom E, Houwing-Duistermaat JJ.

Stat Med. 2017 Jun 30;36(14):2288-2301. doi: 10.1002/sim.7281. Epub 2017 Mar 16.

11.

The complex genetics of gait speed: genome-wide meta-analysis approach.

Ben-Avraham D, Karasik D, Verghese J, Lunetta KL, Smith JA, Eicher JD, Vered R, Deelen J, Arnold AM, Buchman AS, Tanaka T, Faul JD, Nethander M, Fornage M, Adams HH, Matteini AM, Callisaya ML, Smith AV, Yu L, De Jager PL, Evans DA, Gudnason V, Hofman A, Pattie A, Corley J, Launer LJ, Knopman DS, Parimi N, Turner ST, Bandinelli S, Beekman M, Gutman D, Sharvit L, Mooijaart SP, Liewald DC, Houwing-Duistermaat JJ, Ohlsson C, Moed M, Verlinden VJ, Mellström D, van der Geest JN, Karlsson M, Hernandez D, McWhirter R, Liu Y, Thomson R, Tranah GJ, Uitterlinden AG, Weir DR, Zhao W, Starr JM, Johnson AD, Ikram MA, Bennett DA, Cummings SR, Deary IJ, Harris TB, Kardia SL, Mosley TH, Srikanth VK, Windham BG, Newman AB, Walston JD, Davies G, Evans DS, Slagboom EP, Ferrucci L, Kiel DP, Murabito JM, Atzmon G.

Aging (Albany NY). 2017 Jan 10;9(1):209-246. doi: 10.18632/aging.101151. Erratum in: Aging (Albany NY). 2017 Jul 7;9(7):1844-1846.

12.

Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis.

Castaño-Betancourt MC, Evans DS, Ramos YF, Boer CG, Metrustry S, Liu Y, den Hollander W, van Rooij J, Kraus VB, Yau MS, Mitchell BD, Muir K, Hofman A, Doherty M, Doherty S, Zhang W, Kraaij R, Rivadeneira F, Barrett-Connor E, Maciewicz RA, Arden N, Nelissen RG, Kloppenburg M, Jordan JM, Nevitt MC, Slagboom EP, Hart DJ, Lafeber F, Styrkarsdottir U, Zeggini E, Evangelou E, Spector TD, Uitterlinden AG, Lane NE, Meulenbelt I, Valdes AM, van Meurs JB.

PLoS Genet. 2016 Oct 4;12(10):e1006260. doi: 10.1371/journal.pgen.1006260. eCollection 2016 Oct.

13.

Maternal and child cytokine relationship in early life is not altered by cytokine gene polymorphisms.

Djuardi Y, Supali T, Wibowo H, Heijmans BT, Deelen J, Slagboom EP, Houwing-Duistermaat JJ, Sartono E, Yazdanbakhsh M.

Genes Immun. 2016 Dec;17(7):380-385. doi: 10.1038/gene.2016.35. Epub 2016 Sep 1.

14.

Survival analysis with delayed entry in selected families with application to human longevity.

Rodríguez-Girondo M, Deelen J, Slagboom EP, Houwing-Duistermaat JJ.

Stat Methods Med Res. 2018 Mar;27(3):933-954. doi: 10.1177/0962280216648356. Epub 2016 May 13.

15.

Novel loci and pathways significantly associated with longevity.

Zeng Y, Nie C, Min J, Liu X, Li M, Chen H, Xu H, Wang M, Ni T, Li Y, Yan H, Zhang JP, Song C, Chi LQ, Wang HM, Dong J, Zheng GY, Lin L, Qian F, Qi Y, Liu X, Cao H, Wang Y, Zhang L, Li Z, Zhou Y, Wang Y, Lu J, Li J, Qi M, Bolund L, Yashin A, Land KC, Gregory S, Yang Z, Gottschalk W, Tao W, Wang J, Wang J, Xu X, Bae H, Nygaard M, Christiansen L, Christensen K, Franceschi C, Lutz MW, Gu J, Tan Q, Perls T, Sebastiani P, Deelen J, Slagboom E, Hauser E, Xu H, Tian XL, Yang H, Vaupel JW.

Sci Rep. 2016 Feb 25;6:21243. doi: 10.1038/srep21243.

16.

Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age.

Akintola AA, van den Berg A, van Buchem MA, Jansen SW, Slagboom EP, Westendorp RG, van der Grond J, van Heemst D.

Front Aging Neurosci. 2015 May 28;7:92. doi: 10.3389/fnagi.2015.00092. eCollection 2015.

17.

Genetically determined prospect to become long-lived is associated with less abdominal fat and in particular less abdominal visceral fat in men.

Sala ML, Röell B, van der Bijl N, van der Grond J, de Craen AJ, Slagboom EP, van der Geest R, de Roos A, Kroft LJ.

Age Ageing. 2015 Jul;44(4):713-7. doi: 10.1093/ageing/afv063. Epub 2015 May 16.

PMID:
25983277
18.

Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism.

Germain M, Chasman DI, de Haan H, Tang W, Lindström S, Weng LC, de Andrade M, de Visser MC, Wiggins KL, Suchon P, Saut N, Smadja DM, Le Gal G, van Hylckama Vlieg A, Di Narzo A, Hao K, Nelson CP, Rocanin-Arjo A, Folkersen L, Monajemi R, Rose LM, Brody JA, Slagboom E, Aïssi D, Gagnon F, Deleuze JF, Deloukas P, Tzourio C, Dartigues JF, Berr C, Taylor KD, Civelek M, Eriksson P; Cardiogenics Consortium, Psaty BM, Houwing-Duitermaat J, Goodall AH, Cambien F, Kraft P, Amouyel P, Samani NJ, Basu S, Ridker PM, Rosendaal FR, Kabrhel C, Folsom AR, Heit J, Reitsma PH, Trégouët DA, Smith NL, Morange PE.

Am J Hum Genet. 2015 Apr 2;96(4):532-42. doi: 10.1016/j.ajhg.2015.01.019. Epub 2015 Mar 12.

19.

Mobster: accurate detection of mobile element insertions in next generation sequencing data.

Thung DT, de Ligt J, Vissers LE, Steehouwer M, Kroon M, de Vries P, Slagboom EP, Ye K, Veltman JA, Hehir-Kwa JY.

Genome Biol. 2014;15(10):488.

20.

An alternative approach to multiple testing for methylation QTL mapping reduces the proportion of falsely identified CpGs.

Luijk R, Goeman JJ, Slagboom EP, Heijmans BT, van Zwet EW.

Bioinformatics. 2015 Feb 1;31(3):340-5. doi: 10.1093/bioinformatics/btu654. Epub 2014 Oct 4.

PMID:
25282645
21.

Latent infection with cytomegalovirus is associated with poor memory CD4 responses to influenza A core proteins in the elderly.

Derhovanessian E, Maier AB, Hähnel K, McElhaney JE, Slagboom EP, Pawelec G.

J Immunol. 2014 Oct 1;193(7):3624-31. doi: 10.4049/jimmunol.1303361. Epub 2014 Sep 3.

22.

Relationship between genome and epigenome--challenges and requirements for future research.

Almouzni G, Altucci L, Amati B, Ashley N, Baulcombe D, Beaujean N, Bock C, Bongcam-Rudloff E, Bousquet J, Braun S, Bressac-de Paillerets B, Bussemakers M, Clarke L, Conesa A, Estivill X, Fazeli A, Grgurević N, Gut I, Heijmans BT, Hermouet S, Houwing-Duistermaat J, Iacobucci I, Ilaš J, Kandimalla R, Krauss-Etschmann S, Lasko P, Lehmann S, Lindroth A, Majdič G, Marcotte E, Martinelli G, Martinet N, Meyer E, Miceli C, Mills K, Moreno-Villanueva M, Morvan G, Nickel D, Niesler B, Nowacki M, Nowak J, Ossowski S, Pelizzola M, Pochet R, Potočnik U, Radwanska M, Raes J, Rattray M, Robinson MD, Roelen B, Sauer S, Schinzer D, Slagboom E, Spector T, Stunnenberg HG, Tiligada E, Torres-Padilla ME, Tsonaka R, Van Soom A, Vidaković M, Widschwendter M.

BMC Genomics. 2014 Jun 18;15:487. doi: 10.1186/1471-2164-15-487.

23.

Integrating metabolomics profiling measurements across multiple biobanks.

Dane AD, Hendriks MM, Reijmers TH, Harms AC, Troost J, Vreeken RJ, Boomsma DI, van Duijn CM, Slagboom EP, Hankemeier T.

Anal Chem. 2014 May 6;86(9):4110-4. doi: 10.1021/ac404191a. Epub 2014 Apr 16.

PMID:
24650176
24.

Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis.

Valdes AM, Meulenbelt I, Chassaing E, Arden NK, Bierma-Zeinstra S, Hart D, Hofman A, Karsdal M, Kloppenburg M, Kroon HM, Slagboom EP, Spector TD, Uitterlinden AG, van Meurs JB, Bay-Jensen AC.

Osteoarthritis Cartilage. 2014 May;22(5):683-9. doi: 10.1016/j.joca.2014.02.007. Epub 2014 Feb 25.

25.

The Genome of the Netherlands: design, and project goals.

Boomsma DI, Wijmenga C, Slagboom EP, Swertz MA, Karssen LC, Abdellaoui A, Ye K, Guryev V, Vermaat M, van Dijk F, Francioli LC, Hottenga JJ, Laros JF, Li Q, Li Y, Cao H, Chen R, Du Y, Li N, Cao S, van Setten J, Menelaou A, Pulit SL, Hehir-Kwa JY, Beekman M, Elbers CC, Byelas H, de Craen AJ, Deelen P, Dijkstra M, den Dunnen JT, de Knijff P, Houwing-Duistermaat J, Koval V, Estrada K, Hofman A, Kanterakis A, Enckevort Dv, Mai H, Kattenberg M, van Leeuwen EM, Neerincx PB, Oostra B, Rivadeneira F, Suchiman EH, Uitterlinden AG, Willemsen G, Wolffenbuttel BH, Wang J, de Bakker PI, van Ommen GJ, van Duijn CM.

Eur J Hum Genet. 2014 Feb;22(2):221-7. doi: 10.1038/ejhg.2013.118. Epub 2013 May 29.

26.

Role of hormones in cartilage and joint metabolism: understanding an unhealthy metabolic phenotype in osteoarthritis.

Bay-Jensen AC, Slagboom E, Chen-An P, Alexandersen P, Qvist P, Christiansen C, Meulenbelt I, Karsdal MA.

Menopause. 2013 May;20(5):578-86. doi: 10.1097/GME.0b013e3182745993. Review.

PMID:
23615651
27.

Lipidomics of familial longevity.

Gonzalez-Covarrubias V, Beekman M, Uh HW, Dane A, Troost J, Paliukhovich I, van der Kloet FM, Houwing-Duistermaat J, Vreeken RJ, Hankemeier T, Slagboom EP.

Aging Cell. 2013 Jun;12(3):426-34. doi: 10.1111/acel.12064. Epub 2013 Apr 2.

28.

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.

Porcu E, Medici M, Pistis G, Volpato CB, Wilson SG, Cappola AR, Bos SD, Deelen J, den Heijer M, Freathy RM, Lahti J, Liu C, Lopez LM, Nolte IM, O'Connell JR, Tanaka T, Trompet S, Arnold A, Bandinelli S, Beekman M, Böhringer S, Brown SJ, Buckley BM, Camaschella C, de Craen AJ, Davies G, de Visser MC, Ford I, Forsen T, Frayling TM, Fugazzola L, Gögele M, Hattersley AT, Hermus AR, Hofman A, Houwing-Duistermaat JJ, Jensen RA, Kajantie E, Kloppenburg M, Lim EM, Masciullo C, Mariotti S, Minelli C, Mitchell BD, Nagaraja R, Netea-Maier RT, Palotie A, Persani L, Piras MG, Psaty BM, Räikkönen K, Richards JB, Rivadeneira F, Sala C, Sabra MM, Sattar N, Shields BM, Soranzo N, Starr JM, Stott DJ, Sweep FC, Usala G, van der Klauw MM, van Heemst D, van Mullem A, Vermeulen SH, Visser WE, Walsh JP, Westendorp RG, Widen E, Zhai G, Cucca F, Deary IJ, Eriksson JG, Ferrucci L, Fox CS, Jukema JW, Kiemeney LA, Pramstaller PP, Schlessinger D, Shuldiner AR, Slagboom EP, Uitterlinden AG, Vaidya B, Visser TJ, Wolffenbuttel BH, Meulenbelt I, Rotter JI, Spector TD, Hicks AA, Toniolo D, Sanna S, Peeters RP, Naitza S.

PLoS Genet. 2013;9(2):e1003266. doi: 10.1371/journal.pgen.1003266. Epub 2013 Feb 7.

29.

Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people.

Derhovanessian E, Maier AB, Hähnel K, Zelba H, de Craen AJ, Roelofs H, Slagboom EP, Westendorp RG, Pawelec G.

Age (Dordr). 2013 Aug;35(4):1387-99. doi: 10.1007/s11357-012-9425-7. Epub 2012 Jun 4.

30.

Distinguishing between longevity and buffered-deleterious genotypes for exceptional human longevity: the case of the MTP gene.

Huffman DM, Deelen J, Ye K, Bergman A, Slagboom EP, Barzilai N, Atzmon G.

J Gerontol A Biol Sci Med Sci. 2012 Nov;67(11):1153-60. doi: 10.1093/gerona/gls103. Epub 2012 Apr 10.

31.

Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes.

Webb BT, Guo AY, Maher BS, Zhao Z, van den Oord EJ, Kendler KS, Riley BP, Gillespie NA, Prescott CA, Middeldorp CM, Willemsen G, de Geus EJ, Hottenga JJ, Boomsma DI, Slagboom EP, Wray NR, Montgomery GW, Martin NG, Wright MJ, Heath AC, Madden PA, Gelernter J, Knowles JA, Hamilton SP, Weissman MM, Fyer AJ, Huezo-Diaz P, McGuffin P, Farmer A, Craig IW, Lewis C, Sham P, Crowe RR, Flint J, Hettema JM.

Eur J Hum Genet. 2012 Oct;20(10):1078-84. doi: 10.1038/ejhg.2012.47. Epub 2012 Apr 4.

32.

Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data.

Brandys MK, Slof-Op't Landt MC, van Elburg AA, Ophoff R, Verduijn W, Meulenbelt I, Middeldorp CM, Boomsma DI, van Furth EF, Slagboom E, Kas MJ, Adan RA.

Psychiatr Genet. 2012 Jun;22(3):130-6. doi: 10.1097/YPG.0b013e328351859e.

PMID:
22366815
33.

Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans.

Derhovanessian E, Maier AB, Hähnel K, Beck R, de Craen AJ, Slagboom EP, Westendorp RG, Pawelec G.

J Gen Virol. 2011 Dec;92(Pt 12):2746-56. doi: 10.1099/vir.0.036004-0. Epub 2011 Aug 3.

PMID:
21813708
34.

ADHD in Dutch adults: heritability and linkage study.

Saviouk V, Hottenga JJ, Slagboom EP, Distel MA, de Geus EJ, Willemsen G, Boomsma DI.

Am J Med Genet B Neuropsychiatr Genet. 2011 Apr;156B(3):352-62. doi: 10.1002/ajmg.b.31170. Epub 2011 Feb 3.

PMID:
21294247
35.

C-reactive protein and glucose regulation in familial longevity.

Rozing MP, Mooijaart SP, Beekman M, Wijsman CA, Maier AB, Bartke A, Westendorp RG, Slagboom EP, van Heemst D.

Age (Dordr). 2011 Dec;33(4):623-30. doi: 10.1007/s11357-011-9206-8. Epub 2011 Jan 19.

36.

Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis.

Kerkhof HJ, Doherty M, Arden NK, Abramson SB, Attur M, Bos SD, Cooper C, Dennison EM, Doherty SA, Evangelou E, Hart DJ, Hofman A, Javaid K, Kerna I, Kisand K, Kloppenburg M, Krasnokutsky S, Maciewicz RA, Meulenbelt I, Muir KR, Rivadeneira F, Samuels J, Sezgin M, Slagboom E, Smith AJ, Spector TD, Tamm A, Tamm A, Uitterlinden AG, Wheeler M, Zhai G, Zhang W, van Meurs JB, Valdes AM.

Osteoarthritis Cartilage. 2011 Mar;19(3):265-71. doi: 10.1016/j.joca.2010.12.003. Epub 2010 Dec 10. Review.

37.

Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis.

Kerkhof HJ, Meulenbelt I, Carr A, Gonzalez A, Hart D, Hofman A, Kloppenburg M, Lane NE, Loughlin J, Nevitt MC, Pols HA, Rivadeneira F, Slagboom EP, Spector TD, Stolk L, Tsezou A, Uitterlinden AG, Valdes AM, van Meurs JB.

BMC Med Genet. 2010 Nov 16;11:164. doi: 10.1186/1471-2350-11-164.

38.

Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium.

Kerkhof HJ, Meulenbelt I, Akune T, Arden NK, Aromaa A, Bierma-Zeinstra SM, Carr A, Cooper C, Dai J, Doherty M, Doherty SA, Felson D, Gonzalez A, Gordon A, Harilainen A, Hart DJ, Hauksson VB, Heliovaara M, Hofman A, Ikegawa S, Ingvarsson T, Jiang Q, Jonsson H, Jonsdottir I, Kawaguchi H, Kloppenburg M, Kujala UM, Lane NE, Leino-Arjas P, Lohmander LS, Luyten FP, Malizos KN, Nakajima M, Nevitt MC, Pols HA, Rivadeneira F, Shi D, Slagboom E, Spector TD, Stefansson K, Sudo A, Tamm A, Tamm AE, Tsezou A, Uchida A, Uitterlinden AG, Wilkinson JM, Yoshimura N, Valdes AM, van Meurs JB.

Osteoarthritis Cartilage. 2011 Mar;19(3):254-64. doi: 10.1016/j.joca.2010.10.027. Epub 2010 Nov 6.

39.

Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study.

Lu Y, Feskens EJ, Boer JM, Imholz S, Verschuren WM, Wijmenga C, Vaarhorst A, Slagboom E, Müller M, Dollé ME.

Atherosclerosis. 2010 Nov;213(1):200-5. doi: 10.1016/j.atherosclerosis.2010.08.053. Epub 2010 Aug 19.

PMID:
20832063
40.

No or only population-specific effect of PON1 on human longevity: a comprehensive meta-analysis.

Caliebe A, Kleindorp R, Blanché H, Christiansen L, Puca AA, Rea IM, Slagboom E, Flachsbart F, Christensen K, Rimbach G, Schreiber S, Nebel A.

Ageing Res Rev. 2010 Jul;9(3):238-44. doi: 10.1016/j.arr.2010.03.003. Epub 2010 Apr 1. Review.

PMID:
20362697
41.

A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22.

Kerkhof HJ, Lories RJ, Meulenbelt I, Jonsdottir I, Valdes AM, Arp P, Ingvarsson T, Jhamai M, Jonsson H, Stolk L, Thorleifsson G, Zhai G, Zhang F, Zhu Y, van der Breggen R, Carr A, Doherty M, Doherty S, Felson DT, Gonzalez A, Halldorsson BV, Hart DJ, Hauksson VB, Hofman A, Ioannidis JP, Kloppenburg M, Lane NE, Loughlin J, Luyten FP, Nevitt MC, Parimi N, Pols HA, Rivadeneira F, Slagboom EP, Styrkársdóttir U, Tsezou A, van de Putte T, Zmuda J, Spector TD, Stefansson K, Uitterlinden AG, van Meurs JB.

Arthritis Rheum. 2010 Feb;62(2):499-510. doi: 10.1002/art.27184.

42.

A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium.

Zhai G, van Meurs JB, Livshits G, Meulenbelt I, Valdes AM, Soranzo N, Hart D, Zhang F, Kato BS, Richards JB, Williams FM, Inouye M, Kloppenburg M, Deloukas P, Slagboom E, Uitterlinden A, Spector TD.

J Med Genet. 2009 Sep;46(9):614-6. doi: 10.1136/jmg.2009.067314. Epub 2009 Jun 8.

43.

Human longevity and 11p15.5: a study in 1321 centenarians.

Lescai F, Blanché H, Nebel A, Beekman M, Sahbatou M, Flachsbart F, Slagboom E, Schreiber S, Sorbi S, Passarino G, Franceschi C.

Eur J Hum Genet. 2009 Nov;17(11):1515-9. doi: 10.1038/ejhg.2009.54. Epub 2009 Apr 15.

44.

Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations.

Meulenbelt I, Chapman K, Dieguez-Gonzalez R, Shi D, Tsezou A, Dai J, Malizos KN, Kloppenburg M, Carr A, Nakajima M, van der Breggen R, Lakenberg N, Gomez-Reino JJ, Jiang Q, Ikegawa S, Gonzalez A, Loughlin J, Slagboom EP.

Hum Mol Genet. 2009 Apr 15;18(8):1518-23. doi: 10.1093/hmg/ddp053. Epub 2009 Jan 30.

PMID:
19181678
45.

Genetics of osteoarthritis: early developmental clues to an old disease.

Slagboom E, Meulenbelt I.

Nat Clin Pract Rheumatol. 2008 Nov;4(11):563. doi: 10.1038/ncprheum0935. No abstract available.

PMID:
18971933
46.

Genome-wide association scan for five major dimensions of personality.

Terracciano A, Sanna S, Uda M, Deiana B, Usala G, Busonero F, Maschio A, Scally M, Patriciu N, Chen WM, Distel MA, Slagboom EP, Boomsma DI, Villafuerte S, Sliwerska E, Burmeister M, Amin N, Janssens AC, van Duijn CM, Schlessinger D, Abecasis GR, Costa PT Jr.

Mol Psychiatry. 2010 Jun;15(6):647-56. doi: 10.1038/mp.2008.113. Epub 2008 Oct 28.

47.

Progression of hand osteoarthritis over 2 years: a clinical and radiological follow-up study.

Botha-Scheepers S, Riyazi N, Watt I, Rosendaal FR, Slagboom E, Bellamy N, Breedveld FC, Kloppenburg M.

Ann Rheum Dis. 2009 Aug;68(8):1260-4. doi: 10.1136/ard.2008.087981. Epub 2008 Aug 26.

PMID:
18728047
48.

Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections.

Dieguez-Gonzalez R, Calaza M, Shi D, Meulenbelt I, Loughlin J, Tsezou A, Dai J, Malizos KN, Slagboom EP, Kloppenburg M, Chapman K, Jiang Q, Kremer D, Gomez-Reino JJ, Nakajima N, Ikegawa S, Gonzalez A.

Ann Rheum Dis. 2009 Jun;68(6):1017-21. doi: 10.1136/ard.2008.093641. Epub 2008 Jul 14.

PMID:
18625619
49.

Risk factors in familial osteoarthritis: the GARP sibling study.

Riyazi N, Rosendaal FR, Slagboom E, Kroon HM, Breedveld FC, Kloppenburg M.

Osteoarthritis Cartilage. 2008 Jun;16(6):654-9. doi: 10.1016/j.joca.2007.10.012. Epub 2008 Jan 15.

50.

Innate production of tumour necrosis factor alpha and interleukin 10 is associated with radiological progression of knee osteoarthritis.

Botha-Scheepers S, Watt I, Slagboom E, de Craen AJ, Meulenbelt I, Rosendaal FR, Breedveld FC, Huizinga TW, Kloppenburg M.

Ann Rheum Dis. 2008 Aug;67(8):1165-9. Epub 2007 Nov 20.

PMID:
18029383

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