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Items: 1 to 50 of 121

1.

Staphylococcal Plasmids, Transposable and Integrative Elements.

Firth N, Jensen SO, Kwong SM, Skurray RA, Ramsay JP.

Microbiol Spectr. 2018 Nov;6(6). doi: 10.1128/microbiolspec.GPP3-0030-2018. Review.

PMID:
30547857
2.

Dynamic Filament Formation by a Divergent Bacterial Actin-Like ParM Protein.

Brzoska AJ, Jensen SO, Barton DA, Davies DS, Overall RL, Skurray RA, Firth N.

PLoS One. 2016 Jun 16;11(6):e0156944. doi: 10.1371/journal.pone.0156944. eCollection 2016.

3.

Mechanism of staphylococcal multiresistance plasmid replication origin assembly by the RepA protein.

Schumacher MA, Tonthat NK, Kwong SM, Chinnam NB, Liu MA, Skurray RA, Firth N.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9121-6. doi: 10.1073/pnas.1406065111. Epub 2014 Jun 9.

4.

Genetic requirements for replication initiation of the staphylococcal multiresistance plasmid pSK41.

Liu MA, Kwong SM, Pon CK, Skurray RA, Firth N.

Microbiology. 2012 Jun;158(Pt 6):1456-67. doi: 10.1099/mic.0.057620-0. Epub 2012 Mar 22.

PMID:
22442303
5.

Major families of multiresistant plasmids from geographically and epidemiologically diverse staphylococci.

Shearer JE, Wireman J, Hostetler J, Forberger H, Borman J, Gill J, Sanchez S, Mankin A, Lamarre J, Lindsay JA, Bayles K, Nicholson A, O'Brien F, Jensen SO, Firth N, Skurray RA, Summers AO.

G3 (Bethesda). 2011 Dec;1(7):581-91. doi: 10.1534/g3.111.000760. Epub 2011 Dec 1.

6.

A single acidic residue can guide binding site selection but does not govern QacR cationic-drug affinity.

Peters KM, Brooks BE, Schumacher MA, Skurray RA, Brennan RG, Brown MH.

PLoS One. 2011 Jan 17;6(1):e15974. doi: 10.1371/journal.pone.0015974.

7.

Analysis of the prototypical Staphylococcus aureus multiresistance plasmid pSK1.

Jensen SO, Apisiridej S, Kwong SM, Yang YH, Skurray RA, Firth N.

Plasmid. 2010 Nov;64(3):135-42. doi: 10.1016/j.plasmid.2010.06.001. Epub 2010 Jun 12.

PMID:
20547176
8.

Structure and filament dynamics of the pSK41 actin-like ParM protein: implications for plasmid DNA segregation.

Popp D, Xu W, Narita A, Brzoska AJ, Skurray RA, Firth N, Ghoshdastider U, MaƩda Y, Robinson RC, Schumacher MA.

J Biol Chem. 2010 Mar 26;285(13):10130-40. doi: 10.1074/jbc.M109.071613. Epub 2010 Jan 27. Erratum in: J Biol Chem. 2010 Jun 4;285(23):18122. Goshdastider, Umesh [corrected to Ghoshdastider, Umesh].

9.

Biochemical characterization of the multidrug regulator QacR distinguishes residues that are crucial to multidrug binding and induction of qacA transcription.

Peters KM, Sharbeen G, Theis T, Skurray RA, Brown MH.

Biochemistry. 2009 Oct 20;48(41):9794-800. doi: 10.1021/bi901102h.

PMID:
19761200
10.

The Staphylococcus aureus pSK41 plasmid-encoded ArtA protein is a master regulator of plasmid transmission genes and contains a RHH motif used in alternate DNA-binding modes.

Ni L, Jensen SO, Ky Tonthat N, Berg T, Kwong SM, Guan FH, Brown MH, Skurray RA, Firth N, Schumacher MA.

Nucleic Acids Res. 2009 Nov;37(20):6970-83. doi: 10.1093/nar/gkp756. Epub 2009 Sep 16.

11.

Optimized production and analysis of the staphylococcal multidrug efflux protein QacA.

Hassan KA, Xu Z, Watkins RE, Brennan RG, Skurray RA, Brown MH.

Protein Expr Purif. 2009 Apr;64(2):118-24. doi: 10.1016/j.pep.2008.11.009. Epub 2008 Dec 6.

PMID:
19073264
12.

Analysis of the pSK1 replicon, a prototype from the staphylococcal multiresistance plasmid family.

Kwong SM, Lim R, Lebard RJ, Skurray RA, Firth N.

Microbiology. 2008 Oct;154(Pt 10):3084-94. doi: 10.1099/mic.0.2008/017418-0.

PMID:
18832314
13.

Functional analyses reveal an important role for tyrosine residues in the staphylococcal multidrug efflux protein QacA.

Wu J, Hassan KA, Skurray RA, Brown MH.

BMC Microbiol. 2008 Sep 16;8:147. doi: 10.1186/1471-2180-8-147.

14.

QacR-cation recognition is mediated by a redundancy of residues capable of charge neutralization.

Peters KM, Schuman JT, Skurray RA, Brown MH, Brennan RG, Schumacher MA.

Biochemistry. 2008 Aug 5;47(31):8122-9. doi: 10.1021/bi8008246. Epub 2008 Jul 11.

15.

A multimer resolution system contributes to segregational stability of the prototypical staphylococcal conjugative multiresistance plasmid pSK41.

LeBard RJ, Jensen SO, Arnaiz IA, Skurray RA, Firth N.

FEMS Microbiol Lett. 2008 Jul;284(1):58-67. doi: 10.1111/j.1574-6968.2008.01190.x. Epub 2008 May 17.

16.

Analysis of tryptophan residues in the staphylococcal multidrug transporter QacA reveals long-distance functional associations of residues on opposite sides of the membrane.

Hassan KA, Souhani T, Skurray RA, Brown MH.

J Bacteriol. 2008 Apr;190(7):2441-9. doi: 10.1128/JB.01864-07. Epub 2008 Jan 25.

17.

Segrosome structure revealed by a complex of ParR with centromere DNA.

Schumacher MA, Glover TC, Brzoska AJ, Jensen SO, Dunham TD, Skurray RA, Firth N.

Nature. 2007 Dec 20;450(7173):1268-71.

PMID:
18097417
18.
19.
20.

Active export proteins mediating drug resistance in staphylococci.

Hassan KA, Skurray RA, Brown MH.

J Mol Microbiol Biotechnol. 2007;12(3-4):180-96. Review.

PMID:
17587867
21.

Glycine-rich transmembrane helix 10 in the staphylococcal tetracycline transporter TetA(K) lines a solvent-accessible channel.

Hassan KA, Robinson KL, Smith AN, Gibson JH, Skurray RA, Brown MH.

Biochemistry. 2006 Dec 26;45(51):15661-9. Epub 2006 Dec 6.

PMID:
17176088
22.

Mobile elements in the evolution and spread of multiple-drug resistance in staphylococci.

Firth N, Skurray RA.

Drug Resist Updat. 1998 Mar;1(1):49-58.

PMID:
17092796
23.

Functional effects of intramembranous proline substitutions in the staphylococcal multidrug transporter QacA.

Hassan KA, Galea M, Wu J, Mitchell BA, Skurray RA, Brown MH.

FEMS Microbiol Lett. 2006 Oct;263(1):76-85.

24.

Microbial drug efflux proteins of the major facilitator superfamily.

Saidijam M, Benedetti G, Ren Q, Xu Z, Hoyle CJ, Palmer SL, Ward A, Bettaney KE, Szakonyi G, Meuller J, Morrison S, Pos MK, Butaye P, Walravens K, Langton K, Herbert RB, Skurray RA, Paulsen IT, O'reilly J, Rutherford NG, Brown MH, Bill RM, Henderson PJ.

Curr Drug Targets. 2006 Jul;7(7):793-811. Review.

PMID:
16842212
25.

Low-level resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein 1 in vitro associated with qacA gene carriage is independent of multidrug efflux pump activity.

Bayer AS, Kupferwasser LI, Brown MH, Skurray RA, Grkovic S, Jones T, Mukhopadhay K, Yeaman MR.

Antimicrob Agents Chemother. 2006 Jul;50(7):2448-54.

27.

Role of transmembrane segment 10 in efflux mediated by the staphylococcal multidrug transport protein QacA.

Xu Z, O'Rourke BA, Skurray RA, Brown MH.

J Biol Chem. 2006 Jan 13;281(2):792-9. Epub 2005 Nov 9.

29.
30.
31.

Stable low-copy-number Staphylococcus aureus shuttle vectors.

Grkovic S, Brown MH, Hardie KM, Firth N, Skurray RA.

Microbiology. 2003 Mar;149(Pt 3):785-94.

PMID:
12634346
32.

Regulation of bacterial drug export systems.

Grkovic S, Brown MH, Skurray RA.

Microbiol Mol Biol Rev. 2002 Dec;66(4):671-701, table of contents. Review.

33.

Analysis and characterization of the IncFV plasmid pED208 transfer region.

Lu J, Manchak J, Klimke W, Davidson C, Firth N, Skurray RA, Frost LS.

Plasmid. 2002 Jul;48(1):24-37.

PMID:
12206753
34.

Structural basis for cooperative DNA binding by two dimers of the multidrug-binding protein QacR.

Schumacher MA, Miller MC, Grkovic S, Brown MH, Skurray RA, Brennan RG.

EMBO J. 2002 Mar 1;21(5):1210-8. Erratum in: EMBO J 2002 May 1;21(9):2301.

35.

Structural mechanisms of QacR induction and multidrug recognition.

Schumacher MA, Miller MC, Grkovic S, Brown MH, Skurray RA, Brennan RG.

Science. 2001 Dec 7;294(5549):2158-63.

36.

The staphylococcal QacR multidrug regulator binds a correctly spaced operator as a pair of dimers.

Grkovic S, Brown MH, Schumacher MA, Brennan RG, Skurray RA.

J Bacteriol. 2001 Dec;183(24):7102-9.

37.

Transcriptional regulation of multidrug efflux pumps in bacteria.

Grkovic S, Brown MH, Skurray RA.

Semin Cell Dev Biol. 2001 Jun;12(3):225-37. Review.

PMID:
11428915
38.

Staphylococcal multidrug efflux protein QacA.

Brown MH, Skurray RA.

J Mol Microbiol Biotechnol. 2001 Apr;3(2):163-70. Review.

PMID:
11321569
40.

In vitro resistance of Staphylococcus aureus to thrombin-induced platelet microbicidal protein is associated with alterations in cytoplasmic membrane fluidity.

Bayer AS, Prasad R, Chandra J, Koul A, Smriti M, Varma A, Skurray RA, Firth N, Brown MH, Koo SP, Yeaman MR.

Infect Immun. 2000 Jun;68(6):3548-53.

41.

Replication of staphylococcal multiresistance plasmids.

Firth N, Apisiridej S, Berg T, O'Rourke BA, Curnock S, Dyke KG, Skurray RA.

J Bacteriol. 2000 Apr;182(8):2170-8.

42.
43.

Plasmid-mediated resistance to thrombin-induced platelet microbicidal protein in staphylococci: role of the qacA locus.

Kupferwasser LI, Skurray RA, Brown MH, Firth N, Yeaman MR, Bayer AS.

Antimicrob Agents Chemother. 1999 Oct;43(10):2395-9.

44.

Nucleotide sequence of the F plasmid leading region.

Manwaring NP, Skurray RA, Firth N.

Plasmid. 1999 May;41(3):219-25.

PMID:
10366527
45.

Evolution of conjugative plasmids from gram-positive bacteria.

Firth N, Berg T, Skurray RA.

Mol Microbiol. 1999 Mar;31(5):1598-600. No abstract available.

46.

The multidrug efflux protein NorM is a prototype of a new family of transporters.

Brown MH, Paulsen IT, Skurray RA.

Mol Microbiol. 1999 Jan;31(1):394-5. No abstract available.

47.
48.

A retrospective molecular analysis of gentamicin resistance in Staphylococcus aureus strains from UK hospitals.

Wright CL, Byrne ME, Firth N, Skurray RA.

J Med Microbiol. 1998 Feb;47(2):173-8.

PMID:
9879961
49.

Complete nucleotide sequence of pSK41: evolution of staphylococcal conjugative multiresistance plasmids.

Berg T, Firth N, Apisiridej S, Hettiaratchi A, Leelaporn A, Skurray RA.

J Bacteriol. 1998 Sep;180(17):4350-9.

50.

QacR is a repressor protein that regulates expression of the Staphylococcus aureus multidrug efflux pump QacA.

Grkovic S, Brown MH, Roberts NJ, Paulsen IT, Skurray RA.

J Biol Chem. 1998 Jul 17;273(29):18665-73.

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