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Items: 14

1.

ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition.

Skrypek N, Bruneel K, Vandewalle C, De Smedt E, Soen B, Loret N, Taminau J, Goossens S, Vandamme N, Berx G.

Epigenetics Chromatin. 2018 Nov 16;11(1):70. doi: 10.1186/s13072-018-0239-4.

2.

TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727.

Drubay V, Skrypek N, Cordiez L, Vasseur R, Schulz C, Boukrout N, Duchêne B, Coppin L, Van Seuningen I, Jonckheere N.

Cancers (Basel). 2018 Jul 31;10(8). pii: E254. doi: 10.3390/cancers10080254.

3.

Epithelial-to-Mesenchymal Transition: Epigenetic Reprogramming Driving Cellular Plasticity.

Skrypek N, Goossens S, De Smedt E, Vandamme N, Berx G.

Trends Genet. 2017 Dec;33(12):943-959. doi: 10.1016/j.tig.2017.08.004. Epub 2017 Sep 14. Review.

PMID:
28919019
4.

Tissue Factor Induced by Epithelial-Mesenchymal Transition Triggers a Procoagulant State That Drives Metastasis of Circulating Tumor Cells.

Bourcy M, Suarez-Carmona M, Lambert J, Francart ME, Schroeder H, Delierneux C, Skrypek N, Thompson EW, Jérusalem G, Berx G, Thiry M, Blacher S, Hollier BG, Noël A, Oury C, Polette M, Gilles C.

Cancer Res. 2016 Jul 15;76(14):4270-82. doi: 10.1158/0008-5472.CAN-15-2263. Epub 2016 May 24.

5.

The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2.

Scott CL, Soen B, Martens L, Skrypek N, Saelens W, Taminau J, Blancke G, Van Isterdael G, Huylebroeck D, Haigh J, Saeys Y, Guilliams M, Lambrecht BN, Berx G.

J Exp Med. 2016 May 30;213(6):897-911. doi: 10.1084/jem.20151715. Epub 2016 May 16.

6.

The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-κB and RalB signaling pathways.

Vasseur R, Skrypek N, Duchêne B, Renaud F, Martínez-Maqueda D, Vincent A, Porchet N, Van Seuningen I, Jonckheere N.

Biochim Biophys Acta. 2015 Dec;1849(12):1375-84. doi: 10.1016/j.bbagrm.2015.10.014. Epub 2015 Oct 22.

PMID:
26477488
7.
8.

Overexpression of chemokine receptor CXCR2 and ligand CXCL7 in liver metastases from colon cancer is correlated to shorter disease-free and overall survival.

Desurmont T, Skrypek N, Duhamel A, Jonckheere N, Millet G, Leteurtre E, Gosset P, Duchene B, Ramdane N, Hebbar M, Van Seuningen I, Pruvot FR, Huet G, Truant S.

Cancer Sci. 2015 Mar;106(3):262-9. doi: 10.1111/cas.12603. Epub 2015 Mar 5.

9.

Mucins and tumor resistance to chemotherapeutic drugs.

Jonckheere N, Skrypek N, Van Seuningen I.

Biochim Biophys Acta. 2014 Aug;1846(1):142-51. doi: 10.1016/j.bbcan.2014.04.008. Epub 2014 Apr 29. Review.

PMID:
24785432
10.

Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis.

Touil Y, Igoudjil W, Corvaisier M, Dessein AF, Vandomme J, Monté D, Stechly L, Skrypek N, Langlois C, Grard G, Millet G, Leteurtre E, Dumont P, Truant S, Pruvot FR, Hebbar M, Fan F, Ellis LM, Formstecher P, Van Seuningen I, Gespach C, Polakowska R, Huet G.

Clin Cancer Res. 2014 Feb 15;20(4):837-46. doi: 10.1158/1078-0432.CCR-13-1854. Epub 2013 Dec 9.

11.

Membrane-bound mucin modular domains: from structure to function.

Jonckheere N, Skrypek N, Frénois F, Van Seuningen I.

Biochimie. 2013 Jun;95(6):1077-86. doi: 10.1016/j.biochi.2012.11.005. Epub 2012 Nov 20. Review.

12.

The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family.

Skrypek N, Duchêne B, Hebbar M, Leteurtre E, van Seuningen I, Jonckheere N.

Oncogene. 2013 Mar 28;32(13):1714-23. doi: 10.1038/onc.2012.179. Epub 2012 May 14.

13.

The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways.

Jonckheere N, Skrypek N, Merlin J, Dessein AF, Dumont P, Leteurtre E, Harris A, Desseyn JL, Susini C, Frénois F, Van Seuningen I.

PLoS One. 2012;7(2):e32232. doi: 10.1371/journal.pone.0032232. Epub 2012 Feb 29.

14.

Mucins and pancreatic cancer.

Jonckheere N, Skrypek N, Van Seuningen I.

Cancers (Basel). 2010 Oct 25;2(4):1794-812. doi: 10.3390/cancers2041794.

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