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Items: 33


Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes.

Yeo L, Woodwyk A, Sood S, Lorenc A, Eichmann M, Pujol-Autonell I, Melchiotti R, Skowera A, Fidanis E, Dolton GM, Tungatt K, Sewell AK, Heck S, Saxena A, Beam CA, Peakman M.

J Clin Invest. 2018 Aug 1;128(8):3460-3474. doi: 10.1172/JCI120555. Epub 2018 Jul 16.


Combinatorial detection of autoreactive CD8+ T cells with HLA-A2 multimers: a multi-centre study by the Immunology of Diabetes Society T Cell Workshop.

James EA, Abreu JRF, McGinty JW, Odegard JM, Fillié YE, Hocter CN, Culina S, Ladell K, Price DA, Alkanani A, Rihanek M, Fitzgerald-Miller L, Skowera A, Speake C, Gottlieb P, Davidson HW, Wong FS, Roep B, Mallone R; Immunology of Diabetes Society T Cell Workshop Committee.

Diabetologia. 2018 Mar;61(3):658-670. doi: 10.1007/s00125-017-4508-8. Epub 2017 Dec 1.


Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies.

Clement M, Pearson JA, Gras S, van den Berg HA, Lissina A, Llewellyn-Lacey S, Willis MD, Dockree T, McLaren JE, Ekeruche-Makinde J, Gostick E, Robertson NP, Rossjohn J, Burrows SR, Price DA, Wong FS, Peakman M, Skowera A, Wooldridge L.

Sci Rep. 2016 Oct 17;6:35332. doi: 10.1038/srep35332.


Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.

Cole DK, Bulek AM, Dolton G, Schauenberg AJ, Szomolay B, Rittase W, Trimby A, Jothikumar P, Fuller A, Skowera A, Rossjohn J, Zhu C, Miles JJ, Peakman M, Wooldridge L, Rizkallah PJ, Sewell AK.

J Clin Invest. 2016 Sep 1;126(9):3626. doi: 10.1172/JCI89919. Epub 2016 Aug 15. No abstract available.


Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.

Cole DK, Bulek AM, Dolton G, Schauenberg AJ, Szomolay B, Rittase W, Trimby A, Jothikumar P, Fuller A, Skowera A, Rossjohn J, Zhu C, Miles JJ, Peakman M, Wooldridge L, Rizkallah PJ, Sewell AK.

J Clin Invest. 2016 Jun 1;126(6):2191-204. doi: 10.1172/JCI85679. Epub 2016 May 16. Erratum in: J Clin Invest. 2016 Sep 1;126(9):3626.


β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure.

Skowera A, Ladell K, McLaren JE, Dolton G, Matthews KK, Gostick E, Kronenberg-Versteeg D, Eichmann M, Knight RR, Heck S, Powrie J, Bingley PJ, Dayan CM, Miles JJ, Sewell AK, Price DA, Peakman M.

Diabetes. 2015 Mar;64(3):916-925. doi: 10.2337/db14-0332. Epub 2014 Sep 23.


A distinct immunogenic region of glutamic acid decarboxylase 65 is naturally processed and presented by human islet cells to cytotoxic CD8 T cells.

Knight RR, Dolton G, Kronenberg-Versteeg D, Eichmann M, Zhao M, Huang GC, Beck K, Cole DK, Sewell AK, Skowera A, Peakman M.

Clin Exp Immunol. 2015 Jan;179(1):100-7. doi: 10.1111/cei.12436.


Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells.

Dolton G, Lissina A, Skowera A, Ladell K, Tungatt K, Jones E, Kronenberg-Versteeg D, Akpovwa H, Pentier JM, Holland CJ, Godkin AJ, Cole DK, Neller MA, Miles JJ, Price DA, Peakman M, Sewell AK.

Clin Exp Immunol. 2014 Jul;177(1):47-63. doi: 10.1111/cei.12339.


Effector-memory T cells develop in islets and report islet pathology in type 1 diabetes.

Chee J, Ko HJ, Skowera A, Jhala G, Catterall T, Graham KL, Sutherland RM, Thomas HE, Lew AM, Peakman M, Kay TW, Krishnamurthy B.

J Immunol. 2014 Jan 15;192(2):572-80. doi: 10.4049/jimmunol.1302100. Epub 2013 Dec 11.


Genetically engineered human islets protected from CD8-mediated autoimmune destruction in vivo.

Zaldumbide A, Alkemade G, Carlotti F, Nikolic T, Abreu JR, Engelse MA, Skowera A, de Koning EJ, Peakman M, Roep BO, Hoeben RC, Wiertz EJ.

Mol Ther. 2013 Aug;21(8):1592-601. doi: 10.1038/mt.2013.105. Epub 2013 May 21.


Clinical-grade multipotent adult progenitor cells durably control pathogenic T cell responses in human models of transplantation and autoimmunity.

Reading JL, Yang JH, Sabbah S, Skowera A, Knight RR, Pinxteren J, Vaes B, Allsopp T, Ting AE, Busch S, Raber A, Deans R, Tree TI.

J Immunol. 2013 May 1;190(9):4542-52. doi: 10.4049/jimmunol.1202710. Epub 2013 Apr 1.


Peptide length determines the outcome of TCR/peptide-MHCI engagement.

Ekeruche-Makinde J, Miles JJ, van den Berg HA, Skowera A, Cole DK, Dolton G, Schauenburg AJ, Tan MP, Pentier JM, Llewellyn-Lacey S, Miles KM, Bulek AM, Clement M, Williams T, Trimby A, Bailey M, Rizkallah P, Rossjohn J, Peakman M, Price DA, Burrows SR, Sewell AK, Wooldridge L.

Blood. 2013 Feb 14;121(7):1112-23. doi: 10.1182/blood-2012-06-437202. Epub 2012 Dec 18.


Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity.

Knight RR, Kronenberg D, Zhao M, Huang GC, Eichmann M, Bulek A, Wooldridge L, Cole DK, Sewell AK, Peakman M, Skowera A.

Diabetes. 2013 Jan;62(1):205-13. doi: 10.2337/db12-0315. Epub 2012 Aug 30.


Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation.

Chu CC, Ali N, Karagiannis P, Di Meglio P, Skowera A, Napolitano L, Barinaga G, Grys K, Sharif-Paghaleh E, Karagiannis SN, Peakman M, Lombardi G, Nestle FO.

J Exp Med. 2012 May 7;209(5):935-45. doi: 10.1084/jem.20112583. Epub 2012 Apr 30.


Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill β-cells.

Kronenberg D, Knight RR, Estorninho M, Ellis RJ, Kester MG, de Ru A, Eichmann M, Huang GC, Powrie J, Dayan CM, Skowera A, van Veelen PA, Peakman M.

Diabetes. 2012 Jul;61(7):1752-9. doi: 10.2337/db11-1520. Epub 2012 Apr 20.


Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.

Bulek AM, Cole DK, Skowera A, Dolton G, Gras S, Madura F, Fuller A, Miles JJ, Gostick E, Price DA, Drijfhout JW, Knight RR, Huang GC, Lissin N, Molloy PE, Wooldridge L, Jakobsen BK, Rossjohn J, Peakman M, Rizkallah PJ, Sewell AK.

Nat Immunol. 2012 Jan 15;13(3):283-9. doi: 10.1038/ni.2206.


A single autoimmune T cell receptor recognizes more than a million different peptides.

Wooldridge L, Ekeruche-Makinde J, van den Berg HA, Skowera A, Miles JJ, Tan MP, Dolton G, Clement M, Llewellyn-Lacey S, Price DA, Peakman M, Sewell AK.

J Biol Chem. 2012 Jan 6;287(2):1168-77. doi: 10.1074/jbc.M111.289488. Epub 2011 Nov 18.


Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition.

Cole DK, Edwards ES, Wynn KK, Clement M, Miles JJ, Ladell K, Ekeruche J, Gostick E, Adams KJ, Skowera A, Peakman M, Wooldridge L, Price DA, Sewell AK.

J Immunol. 2010 Aug 15;185(4):2600-10. doi: 10.4049/jimmunol.1000629. Epub 2010 Jul 16.


Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression.

Tree TI, Lawson J, Edwards H, Skowera A, Arif S, Roep BO, Peakman M.

Diabetes. 2010 Jun;59(6):1451-60. doi: 10.2337/db09-0503. Epub 2010 Mar 18.


Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers.

Lissina A, Ladell K, Skowera A, Clement M, Edwards E, Seggewiss R, van den Berg HA, Gostick E, Gallagher K, Jones E, Melenhorst JJ, Godkin AJ, Peakman M, Price DA, Sewell AK, Wooldridge L.

J Immunol Methods. 2009 Jan 1;340(1):11-24. doi: 10.1016/j.jim.2008.09.014. Epub 2008 Oct 16.


Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture.

Allen JS, Pang K, Skowera A, Ellis R, Rackham C, Lozanoska-Ochser B, Tree T, Leslie RD, Tremble JM, Dayan CM, Peakman M.

Diabetes. 2009 Jan;58(1):138-45. doi: 10.2337/db08-0964. Epub 2008 Oct 3.


CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.

Skowera A, Ellis RJ, Varela-Calviño R, Arif S, Huang GC, Van-Krinks C, Zaremba A, Rackham C, Allen JS, Tree TI, Zhao M, Dayan CM, Sewell AK, Unger WW, Drijfhout JW, Ossendorp F, Roep BO, Peakman M.

J Clin Invest. 2008 Oct;118(10):3390-402. doi: 10.1172/JCI35449. Erratum in: J Clin Invest. 2009 Sep;119(9):2844. Unger, Wendy [corrected to Unger, Wendy W].


Long-lasting T cell responses to biological warfare vaccines in human vaccinees.

Allen JS, Skowera A, Rubin GJ, Wessely S, Peakman M.

Clin Infect Dis. 2006 Jul 1;43(1):1-7. Epub 2006 May 23.


Immunological dysfunction, vaccination and Gulf War illness.

Peakman M, Skowera A, Hotopf M.

Philos Trans R Soc Lond B Biol Sci. 2006 Apr 29;361(1468):681-7.


Chronic fatigue syndrome: an update focusing on phenomenology and pathophysiology.

Cho HJ, Skowera A, Cleare A, Wessely S.

Curr Opin Psychiatry. 2006 Jan;19(1):67-73. Review.


Analysis of anthrax and plague biowarfare vaccine interactions with human monocyte-derived dendritic cells.

Skowera A, de Jong EC, Schuitemaker JH, Allen JS, Wessely SC, Griffiths G, Kapsenberg M, Peakman M.

J Immunol. 2005 Dec 1;175(11):7235-43.


Cellular immune activation in Gulf War veterans.

Skowera A, Hotopf M, Sawicka E, Varela-Calvino R, Unwin C, Nikolaou V, Hull L, Ismail K, David AS, Wessely SC, Peakman M.

J Clin Immunol. 2004 Jan;24(1):66-73.


High levels of type 2 cytokine-producing cells in chronic fatigue syndrome.

Skowera A, Cleare A, Blair D, Bevis L, Wessely SC, Peakman M.

Clin Exp Immunol. 2004 Feb;135(2):294-302.


Predictors of fatigue following the onset of infectious mononucleosis.

Candy B, Chalder T, Cleare AJ, Peakman A, Skowera A, Wessely S, Weinman J, Zuckerman M, Hotopf M.

Psychol Med. 2003 Jul;33(5):847-55.


Antinuclear autoantibodies (ANA) in Gulf War-related illness and chronic fatigue syndrome (CFS) patients.

Skowera A, Stewart E, Davis ET, Cleare AJ, Unwin C, Hull L, Ismail K, Hossain G, Wessely SC, Peakman M.

Clin Exp Immunol. 2002 Aug;129(2):354-8.


High prevalence of serum markers of coeliac disease in patients with chronic fatigue syndrome.

Skowera A, Peakman M, Cleare A, Davies E, Deale A, Wessely S.

J Clin Pathol. 2001 Apr;54(4):335-6. No abstract available.


[Treatment of wounds of the cervix uteri after coagulation, with a note on the use of organic glass].

Midak E, Skowera A.

Wiad Lek. 1965 Jun 15;18(12):995-7. Polish. No abstract available.


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