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Items: 31


Long-term consequences of early postnatal lead exposure on hippocampal synaptic activity in adult mice.

Tena A, Peru E, Martinetti LE, Cano JC, Loyola Baltazar CD, Wagler AE, Skouta R, Fenelon K.

Brain Behav. 2019 Aug;9(8):e01307. doi: 10.1002/brb3.1307. Epub 2019 Jul 3.


Green barley mitigates cytotoxicity in human lymphocytes undergoing aggressive oxidative stress, via activation of both the Lyn/PI3K/Akt and MAPK/ERK pathways.

Ruiz-Medina BE, Lerma D, Hwang M, Ross JA, Skouta R, Aguilera RJ, Kirken RA, Varela-Ramirez A, Robles-Escajeda E.

Sci Rep. 2019 Apr 12;9(1):6005. doi: 10.1038/s41598-019-42228-4.


Virucidal and Synergistic Activity of Polyphenol-Rich Extracts of Seaweeds against Measles Virus.

Morán-Santibañez K, Peña-Hernández MA, Cruz-Suárez LE, Ricque-Marie D, Skouta R, Vasquez AH, Rodríguez-Padilla C, Trejo-Avila LM.

Viruses. 2018 Aug 30;10(9). pii: E465. doi: 10.3390/v10090465.


Induction of apoptosis via proteasome inhibition in leukemia/lymphoma cells by two potent piperidones.

Contreras L, Calderon RI, Varela-Ramirez A, Zhang HY, Quan Y, Das U, Dimmock JR, Skouta R, Aguilera RJ.

Cell Oncol (Dordr). 2018 Dec;41(6):623-636. doi: 10.1007/s13402-018-0397-1. Epub 2018 Aug 7.


Assessing the Antioxidant Properties of Larrea tridentata Extract as a Potential Molecular Therapy against Oxidative Stress.

Skouta R, Morán-Santibañez K, Valenzuela CA, Vasquez AH, Fenelon K.

Molecules. 2018 Jul 23;23(7). pii: E1826. doi: 10.3390/molecules23071826.


Development of Thiophene Compounds as Potent Chemotherapies for the Treatment of Cutaneous Leishmaniasis Caused by Leishmania major.

Rodriguez F, Iniguez E, Pena Contreras G, Ahmed H, Costa TEMM, Skouta R, Maldonado RA.

Molecules. 2018 Jul 4;23(7). pii: E1626. doi: 10.3390/molecules23071626.


Neuroprotective effect of antioxidant compounds.

Skouta R.

Neural Regen Res. 2016 Apr;11(4):566-7. doi: 10.4103/1673-5374.180738. No abstract available.


Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis.

Shimada K, Skouta R, Kaplan A, Yang WS, Hayano M, Dixon SJ, Brown LM, Valenzuela CA, Wolpaw AJ, Stockwell BR.

Nat Chem Biol. 2016 Jul;12(7):497-503. doi: 10.1038/nchembio.2079. Epub 2016 May 9.


ER Protein Processing Under Oxidative Stress: Implications and Prevention.

Khalil MF, Valenzuela C, Sisniega D, Skouta R, Narayan M.

Cell Biochem Biophys. 2016 Jun;74(2):213-20. doi: 10.1007/s12013-016-0726-9. Epub 2016 Mar 17.


Novel arylalkylamine compounds exhibits potent selective antiparasitic activity against Leishmania major.

Iniguez EA, Perez A, Maldonado RA, Skouta R.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5315-20. doi: 10.1016/j.bmcl.2015.09.041. Epub 2015 Sep 22.


The neuroprotective role of ferrostatin-1 under rotenone-induced oxidative stress in dopaminergic neuroblastoma cells.

Kabiraj P, Valenzuela CA, Marin JE, Ramirez DA, Mendez L, Hwang MS, Varela-Ramirez A, Fenelon K, Narayan M, Skouta R.

Protein J. 2015 Oct;34(5):349-58. doi: 10.1007/s10930-015-9629-7.


Synchronized renal tubular cell death involves ferroptosis.

Linkermann A, Skouta R, Himmerkus N, Mulay SR, Dewitz C, De Zen F, Prokai A, Zuchtriegel G, Krombach F, Welz PS, Weinlich R, Vanden Berghe T, Vandenabeele P, Pasparakis M, Bleich M, Weinberg JM, Reichel CA, Bräsen JH, Kunzendorf U, Anders HJ, Stockwell BR, Green DR, Krautwald S.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16836-41. doi: 10.1073/pnas.1415518111. Epub 2014 Nov 10.


Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis.

Dixon SJ, Patel DN, Welsch M, Skouta R, Lee ED, Hayano M, Thomas AG, Gleason CE, Tatonetti NP, Slusher BS, Stockwell BR.

Elife. 2014 May 20;3:e02523. doi: 10.7554/eLife.02523.


Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models.

Skouta R, Dixon SJ, Wang J, Dunn DE, Orman M, Shimada K, Rosenberg PA, Lo DC, Weinberg JM, Linkermann A, Stockwell BR.

J Am Chem Soc. 2014 Mar 26;136(12):4551-6. doi: 10.1021/ja411006a. Epub 2014 Mar 14.


Regulation of ferroptotic cancer cell death by GPX4.

Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR.

Cell. 2014 Jan 16;156(1-2):317-331. doi: 10.1016/j.cell.2013.12.010.


Probing the conductance superposition law in single-molecule circuits with parallel paths.

Vazquez H, Skouta R, Schneebeli S, Kamenetska M, Breslow R, Venkataraman L, Hybertsen MS.

Nat Nanotechnol. 2012 Oct;7(10):663-7. doi: 10.1038/nnano.2012.147. Epub 2012 Sep 2.


Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death.

Skouta R, Hayano M, Shimada K, Stockwell BR.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5707-13. doi: 10.1016/j.bmcl.2012.06.077. Epub 2012 Jun 30.


Ferroptosis: an iron-dependent form of nonapoptotic cell death.

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR.

Cell. 2012 May 25;149(5):1060-72. doi: 10.1016/j.cell.2012.03.042.


Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay.

Herman AG, Hayano M, Poyurovsky MV, Shimada K, Skouta R, Prives C, Stockwell BR.

Cancer Discov. 2011 Sep;1(4):312-25. doi: 10.1158/2159-8290.CD-11-0104. Epub 2011 Jul 28.


Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency.

Yang WS, Shimada K, Delva D, Patel M, Ode E, Skouta R, Stockwell BR.

ACS Med Chem Lett. 2012 Jan 12;3(1):35-38. Epub 2011 Oct 31.


Modulatory profiling identifies mechanisms of small molecule-induced cell death.

Wolpaw AJ, Shimada K, Skouta R, Welsch ME, Akavia UD, Pe'er D, Shaik F, Bulinski JC, Stockwell BR.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):E771-80. doi: 10.1073/pnas.1106149108. Epub 2011 Sep 6.


In situ formation of highly conducting covalent Au-C contacts for single-molecule junctions.

Cheng ZL, Skouta R, Vazquez H, Widawsky JR, Schneebeli S, Chen W, Hybertsen MS, Breslow R, Venkataraman L.

Nat Nanotechnol. 2011 May 8;6(6):353-7. doi: 10.1038/nnano.2011.66.


Single-molecule conductance through multiple π-π-stacked benzene rings determined with direct electrode-to-benzene ring connections.

Schneebeli ST, Kamenetska M, Cheng Z, Skouta R, Friesner RA, Venkataraman L, Breslow R.

J Am Chem Soc. 2011 Feb 23;133(7):2136-9. doi: 10.1021/ja111320n. Epub 2011 Jan 25.


The electrical properties of biphenylenes.

Schneebeli S, Kamenetska M, Foss F, Vazquez H, Skouta R, Hybertsen M, Venkataraman L, Breslow R.

Org Lett. 2010 Sep 17;12(18):4114-7. doi: 10.1021/ol1017036.


Dendrimers in solution can have their remote catalytic groups folded back into the core: enantioselective transaminations by dendritic enzyme mimics-II.

Wei S, Wang J, Venhuizen S, Skouta R, Breslow R.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5543-6. doi: 10.1016/j.bmcl.2009.08.061. Epub 2009 Aug 21.


Palladium-catalyzed 1,4-addition of terminal alkynes to unsaturated carbonyl compounds promoted by electron-rich ligands.

Zhou L, Chen L, Skouta R, Jiang HF, Li CJ.

Org Biomol Chem. 2008 Aug 21;6(16):2969-77. doi: 10.1039/b805946m. Epub 2008 Jun 24.


Efficient synthesis and astonishing supramolecular architectures of several symmetric macrolactams.

Baillargeon P, Bernard S, Gauthier D, Skouta R, Dory YL.

Chemistry. 2007;13(33):9223-35.


Gold(I)-catalyzed annulation of salicylaldehydes and aryl acetylenes as an expedient route to isoflavanones.

Skouta R, Li CJ.

Angew Chem Int Ed Engl. 2007;46(7):1117-9. No abstract available.


Micrometer-sized hexagonal tubes self-assembled by a cyclic peptide in a liquid crystal.

Leclair S, Baillargeon P, Skouta R, Gauthier D, Zhao Y, Dory YL.

Angew Chem Int Ed Engl. 2004 Jan 3;43(3):349-53. No abstract available.


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