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Items: 1 to 50 of 103

1.

Runx1 promotes murine erythroid progenitor proliferation and inhibits differentiation by preventing Pu.1 downregulation.

Willcockson MA, Taylor SJ, Ghosh S, Healton SE, Wheat JC, Wilson TJ, Steidl U, Skoultchi AI.

Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17841-17847. doi: 10.1073/pnas.1901122116. Epub 2019 Aug 20.

PMID:
31431533
2.

ISWI ATPase Smarca5 Regulates Differentiation of Thymocytes Undergoing β-Selection.

Zikmund T, Kokavec J, Turkova T, Savvulidi F, Paszekova H, Vodenkova S, Sedlacek R, Skoultchi AI, Stopka T.

J Immunol. 2019 Jun 15;202(12):3434-3446. doi: 10.4049/jimmunol.1801684. Epub 2019 May 8.

PMID:
31068388
3.

Bidirectional Analysis of Cryba4-Crybb1 Nascent Transcription and Nuclear Accumulation of Crybb3 mRNAs in Lens Fibers.

Limi S, Zhao Y, Guo P, Lopez-Jones M, Zheng D, Singer RH, Skoultchi AI, Cvekl A.

Invest Ophthalmol Vis Sci. 2019 Jan 2;60(1):234-244. doi: 10.1167/iovs.18-25921.

4.

Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process.

Limi S, Senecal A, Coleman R, Lopez-Jones M, Guo P, Polumbo C, Singer RH, Skoultchi AI, Cvekl A.

J Biol Chem. 2018 Aug 24;293(34):13176-13190. doi: 10.1074/jbc.RA118.001927. Epub 2018 Jun 29.

5.

Emerging roles of linker histones in regulating chromatin structure and function.

Fyodorov DV, Zhou BR, Skoultchi AI, Bai Y.

Nat Rev Mol Cell Biol. 2018 Mar;19(3):192-206. doi: 10.1038/nrm.2017.94. Epub 2017 Oct 11. Review.

6.

Regulatory functions and chromatin loading dynamics of linker histone H1 during endoreplication in Drosophila.

Andreyeva EN, Bernardo TJ, Kolesnikova TD, Lu X, Yarinich LA, Bartholdy BA, Guo X, Posukh OV, Healton S, Willcockson MA, Pindyurin AV, Zhimulev IF, Skoultchi AI, Fyodorov DV.

Genes Dev. 2017 Mar 15;31(6):603-616. doi: 10.1101/gad.295717.116.

7.

The ISWI ATPase Smarca5 (Snf2h) Is Required for Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells.

Kokavec J, Zikmund T, Savvulidi F, Kulvait V, Edelmann W, Skoultchi AI, Stopka T.

Stem Cells. 2017 Jun;35(6):1614-1623. doi: 10.1002/stem.2604. Epub 2017 Apr 15.

8.

BEN domain protein Elba2 can functionally substitute for linker histone H1 in Drosophila in vivo.

Xu N, Lu X, Kavi H, Emelyanov AV, Bernardo TJ, Vershilova E, Skoultchi AI, Fyodorov DV.

Sci Rep. 2016 Sep 30;6:34354. doi: 10.1038/srep34354.

9.

Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation.

He S, Limi S, McGreal RS, Xie Q, Brennan LA, Kantorow WL, Kokavec J, Majumdar R, Hou H Jr, Edelmann W, Liu W, Ashery-Padan R, Zavadil J, Kantorow M, Skoultchi AI, Stopka T, Cvekl A.

Development. 2016 Jun 1;143(11):1937-47. doi: 10.1242/dev.135285.

10.

Independent Biological and Biochemical Functions for Individual Structural Domains of Drosophila Linker Histone H1.

Kavi H, Emelyanov AV, Fyodorov DV, Skoultchi AI.

J Biol Chem. 2016 Jul 15;291(29):15143-55. doi: 10.1074/jbc.M116.730705. Epub 2016 May 18.

11.

Local compartment changes and regulatory landscape alterations in histone H1-depleted cells.

Geeven G, Zhu Y, Kim BJ, Bartholdy BA, Yang SM, Macfarlan TS, Gifford WD, Pfaff SL, Verstegen MJ, Pinto H, Vermunt MW, Creyghton MP, Wijchers PJ, Stamatoyannopoulos JA, Skoultchi AI, de Laat W.

Genome Biol. 2015 Dec 23;16:289. doi: 10.1186/s13059-015-0857-0.

12.

A genetic screen and transcript profiling reveal a shared regulatory program for Drosophila linker histone H1 and chromatin remodeler CHD1.

Kavi H, Lu X, Xu N, Bartholdy BA, Vershilova E, Skoultchi AI, Fyodorov DV.

G3 (Bethesda). 2015 Jan 27;5(4):677-87. doi: 10.1534/g3.115.016709.

13.

Drosophila linker histone H1 coordinates STAT-dependent organization of heterochromatin and suppresses tumorigenesis caused by hyperactive JAK-STAT signaling.

Xu N, Emelyanov AV, Fyodorov DV, Skoultchi AI.

Epigenetics Chromatin. 2014 Jul 28;7:16. doi: 10.1186/1756-8935-7-16. eCollection 2014.

14.

Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation.

Alvarez-Saavedra M, De Repentigny Y, Lagali PS, Raghu Ram EV, Yan K, Hashem E, Ivanochko D, Huh MS, Yang D, Mears AJ, Todd MA, Corcoran CP, Bassett EA, Tokarew NJ, Kokavec J, Majumder R, Ioshikhes I, Wallace VA, Kothary R, Meshorer E, Stopka T, Skoultchi AI, Picketts DJ.

Nat Commun. 2014 Jun 20;5:4181. doi: 10.1038/ncomms5181.

15.

The role of H1 linker histone subtypes in preserving the fidelity of elaboration of mesendodermal and neuroectodermal lineages during embryonic development.

Nguyen GD, Gokhan S, Molero AE, Yang SM, Kim BJ, Skoultchi AI, Mehler MF.

PLoS One. 2014 May 6;9(5):e96858. doi: 10.1371/journal.pone.0096858. eCollection 2014.

16.

Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina.

Popova EY, Grigoryev SA, Fan Y, Skoultchi AI, Zhang SS, Barnstable CJ.

J Biol Chem. 2013 Jun 14;288(24):17895-907. doi: 10.1074/jbc.M113.452144. Epub 2013 May 3.

17.

Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9.

Lu X, Wontakal SN, Kavi H, Kim BJ, Guzzardo PM, Emelyanov AV, Xu N, Hannon GJ, Zavadil J, Fyodorov DV, Skoultchi AI.

Science. 2013 Apr 5;340(6128):78-81. doi: 10.1126/science.1234654.

18.

H1 linker histone promotes epigenetic silencing by regulating both DNA methylation and histone H3 methylation.

Yang SM, Kim BJ, Norwood Toro L, Skoultchi AI.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1708-13. doi: 10.1073/pnas.1213266110. Epub 2013 Jan 9.

19.

A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation.

Wontakal SN, Guo X, Smith C, MacCarthy T, Bresnick EH, Bergman A, Snyder MP, Weissman SM, Zheng D, Skoultchi AI.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3832-7. doi: 10.1073/pnas.1121019109. Epub 2012 Feb 22.

20.

Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-β-catenin signaling pathway.

Nishiyama M, Skoultchi AI, Nakayama KI.

Mol Cell Biol. 2012 Jan;32(2):501-12. doi: 10.1128/MCB.06409-11. Epub 2011 Nov 14.

21.

A large gene network in immature erythroid cells is controlled by the myeloid and B cell transcriptional regulator PU.1.

Wontakal SN, Guo X, Will B, Shi M, Raha D, Mahajan MC, Weissman S, Snyder M, Steidl U, Zheng D, Skoultchi AI.

PLoS Genet. 2011 Jun;7(6):e1001392. doi: 10.1371/journal.pgen.1001392. Epub 2011 Jun 9.

22.

The rhox homeobox gene cluster is imprinted and selectively targeted for regulation by histone h1 and DNA methylation.

Maclean JA, Bettegowda A, Kim BJ, Lou CH, Yang SM, Bhardwaj A, Shanker S, Hu Z, Fan Y, Eckardt S, McLaughlin KJ, Skoultchi AI, Wilkinson MF.

Mol Cell Biol. 2011 Mar;31(6):1275-87. doi: 10.1128/MCB.00734-10. Epub 2011 Jan 18.

23.

Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep.

Funato H, Sato M, Sinton CM, Gautron L, Williams SC, Skach A, Elmquist JK, Skoultchi AI, Yanagisawa M.

Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18155-60. doi: 10.1073/pnas.1012764107. Epub 2010 Oct 4.

24.

GATA-1 directly regulates p21 gene expression during erythroid differentiation.

Papetti M, Wontakal SN, Stopka T, Skoultchi AI.

Cell Cycle. 2010 May 15;9(10):1972-80. Epub 2010 May 15.

25.

Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination.

Eskeland R, Leeb M, Grimes GR, Kress C, Boyle S, Sproul D, Gilbert N, Fan Y, Skoultchi AI, Wutz A, Bickmore WA.

Mol Cell. 2010 May 14;38(3):452-64. doi: 10.1016/j.molcel.2010.02.032.

26.

PU.1 directly regulates cdk6 gene expression, linking the cell proliferation and differentiation programs in erythroid cells.

Choe KS, Ujhelly O, Wontakal SN, Skoultchi AI.

J Biol Chem. 2010 Jan 29;285(5):3044-52. doi: 10.1074/jbc.M109.077727. Epub 2009 Dec 2.

27.

PU.1 activation relieves GATA-1-mediated repression of Cebpa and Cbfb during leukemia differentiation.

Burda P, Curik N, Kokavec J, Basova P, Mikulenkova D, Skoultchi AI, Zavadil J, Stopka T.

Mol Cancer Res. 2009 Oct;7(10):1693-703. doi: 10.1158/1541-7786.MCR-09-0031. Epub 2009 Oct 13.

28.

Nuclear localization of ISWI ATPase Smarca5 (Snf2h) in mouse.

Vargova J, Vargova K, Skoultchi AI, Stopka T.

Front Biosci (Elite Ed). 2009 Jun 1;1:553-9.

29.

Linker histone H1 is essential for Drosophila development, the establishment of pericentric heterochromatin, and a normal polytene chromosome structure.

Lu X, Wontakal SN, Emelyanov AV, Morcillo P, Konev AY, Fyodorov DV, Skoultchi AI.

Genes Dev. 2009 Feb 15;23(4):452-65. doi: 10.1101/gad.1749309. Epub 2009 Feb 4.

30.

CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis.

Nishiyama M, Oshikawa K, Tsukada Y, Nakagawa T, Iemura S, Natsume T, Fan Y, Kikuchi A, Skoultchi AI, Nakayama KI.

Nat Cell Biol. 2009 Feb;11(2):172-82. doi: 10.1038/ncb1831. Epub 2009 Jan 18.

31.

Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3' regulatory region of the immunoglobulin heavy chain locus.

Giambra V, Volpi S, Emelyanov AV, Pflugh D, Bothwell AL, Norio P, Fan Y, Ju Z, Skoultchi AI, Hardy RR, Frezza D, Birshtein BK.

Mol Cell Biol. 2008 Oct;28(19):6123-33. doi: 10.1128/MCB.00233-08. Epub 2008 Jul 21.

32.
33.

Global chromatin compaction limits the strength of the DNA damage response.

Murga M, Jaco I, Fan Y, Soria R, Martinez-Pastor B, Cuadrado M, Yang SM, Blasco MA, Skoultchi AI, Fernandez-Capetillo O.

J Cell Biol. 2007 Sep 24;178(7):1101-8.

34.

Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndrome.

Long JM, LaPorte P, Merscher S, Funke B, Saint-Jore B, Puech A, Kucherlapati R, Morrow BE, Skoultchi AI, Wynshaw-Boris A.

Neurogenetics. 2006 Nov;7(4):247-57. Epub 2006 Aug 10.

PMID:
16900388
35.

Regulation of alphaA-crystallin via Pax6, c-Maf, CREB and a broad domain of lens-specific chromatin.

Yang Y, Stopka T, Golestaneh N, Wang Y, Wu K, Li A, Chauhan BK, Gao CY, Cveklová K, Duncan MK, Pestell RG, Chepelinsky AB, Skoultchi AI, Cvekl A.

EMBO J. 2006 May 17;25(10):2107-18. Epub 2006 May 4.

36.

Role of linker histone in chromatin structure and function: H1 stoichiometry and nucleosome repeat length.

Woodcock CL, Skoultchi AI, Fan Y.

Chromosome Res. 2006;14(1):17-25. Review.

PMID:
16506093
37.

Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation.

Fan Y, Nikitina T, Zhao J, Fleury TJ, Bhattacharyya R, Bouhassira EE, Stein A, Woodcock CL, Skoultchi AI.

Cell. 2005 Dec 29;123(7):1199-212.

38.

PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure.

Stopka T, Amanatullah DF, Papetti M, Skoultchi AI.

EMBO J. 2005 Nov 2;24(21):3712-23. Epub 2005 Oct 13.

39.

MAPK-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival.

Yu YL, Chiang YJ, Chen YC, Papetti M, Juo CG, Skoultchi AI, Yen JJ.

J Biol Chem. 2005 Aug 19;280(33):29533-42. Epub 2005 Jun 20.

40.

Reductions in linker histone levels are tolerated in developing spermatocytes but cause changes in specific gene expression.

Lin Q, Inselman A, Han X, Xu H, Zhang W, Handel MA, Skoultchi AI.

J Biol Chem. 2004 May 28;279(22):23525-35. Epub 2004 Mar 23.

41.

Genetic analysis of H1 linker histone subtypes and their functions in mice.

Fan Y, Skoultchi AI.

Methods Enzymol. 2004;377:85-107. No abstract available.

PMID:
14979020
42.

The ISWI ATPase Snf2h is required for early mouse development.

Stopka T, Skoultchi AI.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14097-102. Epub 2003 Nov 14.

43.

PU.1 and pRB interact and cooperate to repress GATA-1 and block erythroid differentiation.

Rekhtman N, Choe KS, Matushansky I, Murray S, Stopka T, Skoultchi AI.

Mol Cell Biol. 2003 Nov;23(21):7460-74.

44.

Reversal of tumorigenicity and the block to differentiation in erythroleukemia cells by GATA-1.

Choe KS, Radparvar F, Matushansky I, Rekhtman N, Han X, Skoultchi AI.

Cancer Res. 2003 Oct 1;63(19):6363-9.

45.

Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks.

Konishi A, Shimizu S, Hirota J, Takao T, Fan Y, Matsuoka Y, Zhang L, Yoneda Y, Fujii Y, Skoultchi AI, Tsujimoto Y.

Cell. 2003 Sep 19;114(6):673-88.

46.

CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells.

Matushansky I, Radparvar F, Skoultchi AI.

Oncogene. 2003 Jul 3;22(27):4143-9.

PMID:
12833137
47.

H1 linker histones are essential for mouse development and affect nucleosome spacing in vivo.

Fan Y, Nikitina T, Morin-Kensicki EM, Zhao J, Magnuson TR, Woodcock CL, Skoultchi AI.

Mol Cell Biol. 2003 Jul;23(13):4559-72.

48.

Mammalian linker-histone subtypes differentially affect gene expression in vivo.

Alami R, Fan Y, Pack S, Sonbuchner TM, Besse A, Lin Q, Greally JM, Skoultchi AI, Bouhassira EE.

Proc Natl Acad Sci U S A. 2003 May 13;100(10):5920-5. Epub 2003 Apr 28.

49.

Mouse oocytes and early embryos express multiple histone H1 subtypes.

Fu G, Ghadam P, Sirotkin A, Khochbin S, Skoultchi AI, Clarke HJ.

Biol Reprod. 2003 May;68(5):1569-76. Epub 2002 Dec 11.

PMID:
12606334
50.

H1(0) histone and differentiation of dendritic cells. A molecular target for tumor-derived factors.

Gabrilovich DI, Cheng P, Fan Y, Yu B, Nikitina E, Sirotkin A, Shurin M, Oyama T, Adachi Y, Nadaf S, Carbone DP, Skoultchi AI.

J Leukoc Biol. 2002 Aug;72(2):285-96.

PMID:
12149419

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