Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 42

1.

Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes.

Indorato RL, Talapatra SK, Lin F, Haider S, Mackay SP, Kozielski F, Skoufias DA.

Mol Cancer Ther. 2019 Dec;18(12):2394-2406. doi: 10.1158/1535-7163.MCT-19-0154. Epub 2019 Sep 5.

PMID:
31488701
2.

Structure of an H1-Bound 6-Nucleosome Array Reveals an Untwisted Two-Start Chromatin Fiber Conformation.

Garcia-Saez I, Menoni H, Boopathi R, Shukla MS, Soueidan L, Noirclerc-Savoye M, Le Roy A, Skoufias DA, Bednar J, Hamiche A, Angelov D, Petosa C, Dimitrov S.

Mol Cell. 2018 Dec 6;72(5):902-915.e7. doi: 10.1016/j.molcel.2018.09.027. Epub 2018 Nov 1.

3.

Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1.

Bednar J, Garcia-Saez I, Boopathi R, Cutter AR, Papai G, Reymer A, Syed SH, Lone IN, Tonchev O, Crucifix C, Menoni H, Papin C, Skoufias DA, Kurumizaka H, Lavery R, Hamiche A, Hayes JJ, Schultz P, Angelov D, Petosa C, Dimitrov S.

Mol Cell. 2017 Jun 1;66(5):729. doi: 10.1016/j.molcel.2017.05.018. No abstract available.

4.

Structure and Dynamics of a 197 bp Nucleosome in Complex with Linker Histone H1.

Bednar J, Garcia-Saez I, Boopathi R, Cutter AR, Papai G, Reymer A, Syed SH, Lone IN, Tonchev O, Crucifix C, Menoni H, Papin C, Skoufias DA, Kurumizaka H, Lavery R, Hamiche A, Hayes JJ, Schultz P, Angelov D, Petosa C, Dimitrov S.

Mol Cell. 2017 May 4;66(3):384-397.e8. doi: 10.1016/j.molcel.2017.04.012. Erratum in: Mol Cell. 2017 Jun 1;66(5):729.

5.

The Flexible Ends of CENP-A Nucleosome Are Required for Mitotic Fidelity.

Roulland Y, Ouararhni K, Naidenov M, Ramos L, Shuaib M, Syed SH, Lone IN, Boopathi R, Fontaine E, Papai G, Tachiwana H, Gautier T, Skoufias D, Padmanabhan K, Bednar J, Kurumizaka H, Schultz P, Angelov D, Hamiche A, Dimitrov S.

Mol Cell. 2016 Aug 18;63(4):674-685. doi: 10.1016/j.molcel.2016.06.023. Epub 2016 Aug 4.

6.

Self protein-protein interactions are involved in TPPP/p25 mediated microtubule bundling.

DeBonis S, Neumann E, Skoufias DA.

Sci Rep. 2015 Aug 20;5:13242. doi: 10.1038/srep13242.

7.

IPP51, a chalcone acting as a microtubule inhibitor with in vivo antitumor activity against bladder carcinoma.

Martel-Frachet V, Keramidas M, Nurisso A, DeBonis S, Rome C, Coll JL, Boumendjel A, Skoufias DA, Ronot X.

Oncotarget. 2015 Jun 10;6(16):14669-86.

8.

STLC-resistant cell lines as tools to classify chemically divergent Eg5 targeting agents according to their mode of action and target specificity.

Indorato RL, DeBonis S, Kozielski F, Garcia-Saez I, Skoufias DA.

Biochem Pharmacol. 2013 Nov 15;86(10):1441-51. doi: 10.1016/j.bcp.2013.09.003. Epub 2013 Sep 13.

PMID:
24041742
9.

Phosphorylation of the CENP-A amino-terminus in mitotic centromeric chromatin is required for kinetochore function.

Goutte-Gattat D, Shuaib M, Ouararhni K, Gautier T, Skoufias DA, Hamiche A, Dimitrov S.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8579-84. doi: 10.1073/pnas.1302955110. Epub 2013 May 8.

10.

Structural basis of cytotoxicity mediated by the type III secretion toxin ExoU from Pseudomonas aeruginosa.

Gendrin C, Contreras-Martel C, Bouillot S, Elsen S, Lemaire D, Skoufias DA, Huber P, Attree I, Dessen A.

PLoS Pathog. 2012;8(4):e1002637. doi: 10.1371/journal.ppat.1002637. Epub 2012 Apr 5.

11.

Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors.

Nagarajan S, Skoufias DA, Kozielski F, Pae AN.

J Med Chem. 2012 Mar 22;55(6):2561-73. doi: 10.1021/jm201290v. Epub 2012 Mar 1.

PMID:
22309208
12.

Elucidating the functionality of kinesins: an overview of small molecule inhibitors.

Good JA, Skoufias DA, Kozielski F.

Semin Cell Dev Biol. 2011 Dec;22(9):935-45. doi: 10.1016/j.semcdb.2011.09.023. Epub 2011 Oct 6. Review.

PMID:
22001111
13.

Is there a "G spot" in sister chromatid cohesion resolution?

Skoufias DA.

Cell Cycle. 2011 Sep 1;10(17):2835. Epub 2011 Sep 1. No abstract available.

PMID:
21869602
14.

Structural characterization of HBXIP: the protein that interacts with the anti-apoptotic protein survivin and the oncogenic viral protein HBx.

Garcia-Saez I, Lacroix FB, Blot D, Gabel F, Skoufias DA.

J Mol Biol. 2011 Jan 14;405(2):331-40. doi: 10.1016/j.jmb.2010.10.046. Epub 2010 Nov 6.

PMID:
21059355
15.

Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor.

Tcherniuk S, Skoufias DA, Labriere C, Rath O, Gueritte F, Guillou C, Kozielski F.

Angew Chem Int Ed Engl. 2010 Oct 25;49(44):8228-31. doi: 10.1002/anie.201003254. No abstract available.

PMID:
20857469
16.

Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in tumor derived cell lines.

Tcherniuk S, van Lis R, Kozielski F, Skoufias DA.

Biochem Pharmacol. 2010 Mar 15;79(6):864-72. doi: 10.1016/j.bcp.2009.11.001. Epub 2009 Nov 6.

PMID:
19896928
17.

SMC5 and MMS21 are required for chromosome cohesion and mitotic progression.

Behlke-Steinert S, Touat-Todeschini L, Skoufias DA, Margolis RL.

Cell Cycle. 2009 Jul 15;8(14):2211-8. Epub 2009 Jul 8.

PMID:
19502785
18.

Molecular distinctions between Aurora A and B: a single residue change transforms Aurora A into correctly localized and functional Aurora B.

Hans F, Skoufias DA, Dimitrov S, Margolis RL.

Mol Biol Cell. 2009 Aug;20(15):3491-502. doi: 10.1091/mbc.E09-05-0370. Epub 2009 Jun 3.

19.

Synthesis and antiproliferative evaluation of pyrazolo[1,5-a]-1,3,5-triazine myoseverin derivatives.

Popowycz F, Schneider C, Debonis S, Skoufias DA, Kozielski F, Galmarini CM, Joseph B.

Bioorg Med Chem. 2009 May 1;17(9):3471-8. doi: 10.1016/j.bmc.2009.03.007. Epub 2009 Mar 10.

PMID:
19349183
20.

Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.

Debonis S, Skoufias DA, Indorato RL, Liger F, Marquet B, Laggner C, Joseph B, Kozielski F.

J Med Chem. 2008 Mar 13;51(5):1115-25. doi: 10.1021/jm070606z. Epub 2008 Feb 12.

PMID:
18266314
21.

Proteome analysis of apoptosis signaling by S-trityl-L-cysteine, a potent reversible inhibitor of human mitotic kinesin Eg5.

Kozielski F, Skoufias DA, Indorato RL, Saoudi Y, Jungblut PR, Hustoft HK, Strozynski M, Thiede B.

Proteomics. 2008 Jan;8(2):289-300. doi: 10.1002/pmic.200700534.

PMID:
18186019
22.

Screening for inhibitors of microtubule-associated motor proteins.

Kozielski F, DeBonis S, Skoufias DA.

Methods Mol Med. 2007;137:189-207.

PMID:
18085231
23.

Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed.

Skoufias DA, Indorato RL, Lacroix F, Panopoulos A, Margolis RL.

J Cell Biol. 2007 Nov 19;179(4):671-85.

24.

New chemical tools for investigating human mitotic kinesin Eg5.

Klein E, DeBonis S, Thiede B, Skoufias DA, Kozielski F, Lebeau L.

Bioorg Med Chem. 2007 Oct 1;15(19):6474-88. Epub 2007 Jun 10.

PMID:
17587586
25.

S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.

Skoufias DA, DeBonis S, Saoudi Y, Lebeau L, Crevel I, Cross R, Wade RH, Hackney D, Kozielski F.

J Biol Chem. 2006 Jun 30;281(26):17559-69. Epub 2006 Feb 28.

26.

A small C-terminal sequence of Aurora B is responsible for localization and function.

Scrittori L, Skoufias DA, Hans F, Gerson V, Sassone-Corsi P, Dimitrov S, Margolis RL.

Mol Biol Cell. 2005 Jan;16(1):292-305. Epub 2004 Oct 27.

27.

Distinct dynamics of Aurora B and Survivin during mitosis.

Delacour-Larose M, Molla A, Skoufias DA, Margolis RL, Dimitrov S.

Cell Cycle. 2004 Nov;3(11):1418-26. Epub 2004 Nov 3.

PMID:
15483398
28.

Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase.

Skoufias DA, Lacroix FB, Andreassen PR, Wilson L, Margolis RL.

Mol Cell. 2004 Sep 24;15(6):977-90.

29.

In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities.

DeBonis S, Skoufias DA, Lebeau L, Lopez R, Robin G, Margolis RL, Wade RH, Kozielski F.

Mol Cancer Ther. 2004 Sep;3(9):1079-90.

30.

Analysis of the spindle-assembly checkpoint in HeLa cells.

Andreassen PR, Skoufias DA, Margolis RL.

Methods Mol Biol. 2004;281:213-25.

PMID:
15220532
31.

Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.

DeBonis S, Simorre JP, Crevel I, Lebeau L, Skoufias DA, Blangy A, Ebel C, Gans P, Cross R, Hackney DD, Wade RH, Kozielski F.

Biochemistry. 2003 Jan 21;42(2):338-49.

PMID:
12525161
32.

Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints.

Skoufias DA, Andreassen PR, Lacroix FB, Wilson L, Margolis RL.

Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4492-7. Epub 2001 Mar 27.

33.

Human survivin is a kinetochore-associated passenger protein.

Skoufias DA, Mollinari C, Lacroix FB, Margolis RL.

J Cell Biol. 2000 Dec 25;151(7):1575-82.

34.

Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions.

Chantalat L, Skoufias DA, Kleman JP, Jung B, Dideberg O, Margolis RL.

Mol Cell. 2000 Jul;6(1):183-9.

35.
36.

The carboxyl-terminal domain of kinesin heavy chain is important for membrane binding.

Skoufias DA, Cole DG, Wedaman KP, Scholey JM.

J Biol Chem. 1994 Jan 14;269(2):1477-85.

37.

Cytoplasmic microtubule-based motor proteins.

Skoufias DA, Scholey JM.

Curr Opin Cell Biol. 1993 Feb;5(1):95-104. Review.

PMID:
8448036
38.

Isolation of a sea urchin egg kinesin-related protein using peptide antibodies.

Cole DG, Cande WZ, Baskin RJ, Skoufias DA, Hogan CJ, Scholey JM.

J Cell Sci. 1992 Feb;101 ( Pt 2):291-301.

41.

Disruption of the Golgi apparatus with brefeldin A does not destabilize the associated detyrosinated microtubule network.

Burgess TL, Skoufias DA, Wilson L.

Cell Motil Cytoskeleton. 1991;20(4):289-300.

PMID:
1802418
42.

Supplemental Content

Loading ...
Support Center