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Items: 8

1.

The metabolic drug-drug interaction profile of Dabrafenib: in vitro investigations and quantitative extrapolation of the P450-mediated DDI risk.

Lawrence SK, Nguyen D, Bowen C, Richards-Peterson L, Skordos KW.

Drug Metab Dispos. 2014 Jul;42(7):1180-90. doi: 10.1124/dmd.114.057778. Epub 2014 Apr 18.

PMID:
24748562
2.

Inhibition of Polo-like kinase 1 prevents the growth of metastatic breast cancer cells in the brain.

Qian Y, Hua E, Bisht K, Woditschka S, Skordos KW, Liewehr DJ, Steinberg SM, Brogi E, Akram MM, Killian JK, Edelman DC, Pineda M, Scurci S, Degenhardt YY, Laquerre S, Lampkin TA, Meltzer PS, Camphausen K, Steeg PS, Palmieri D.

Clin Exp Metastasis. 2011 Dec;28(8):899-908. doi: 10.1007/s10585-011-9421-9. Epub 2011 Sep 21.

PMID:
21953073
3.

Utilizing drug-drug interaction prediction tools during drug development: enhanced decision making based on clinical risk.

Shardlow CE, Generaux GT, MacLauchlin CC, Pons N, Skordos KW, Bloomer JC.

Drug Metab Dispos. 2011 Nov;39(11):2076-84. doi: 10.1124/dmd.111.039214. Epub 2011 Aug 10.

PMID:
21832001
4.

The conduct of in vitro studies to address time-dependent inhibition of drug-metabolizing enzymes: a perspective of the pharmaceutical research and manufacturers of America.

Grimm SW, Einolf HJ, Hall SD, He K, Lim HK, Ling KH, Lu C, Nomeir AA, Seibert E, Skordos KW, Tonn GR, Van Horn R, Wang RW, Wong YN, Yang TJ, Obach RS.

Drug Metab Dispos. 2009 Jul;37(7):1355-70. doi: 10.1124/dmd.109.026716. Epub 2009 Apr 9.

PMID:
19359406
5.

Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase.

Kartha JS, Skordos KW, Sun H, Hall C, Easterwood LM, Reilly CA, Johnson EF, Yost GS.

Biochemistry. 2008 Sep 16;47(37):9756-70. doi: 10.1021/bi8005658. Epub 2008 Aug 22.

6.

Identification of phase I metabolites of 3-methylindole produced by pig liver microsomes.

Diaz GJ, Skordos KW, Yost GS, Squires EJ.

Drug Metab Dispos. 1999 Oct;27(10):1150-6.

PMID:
10497141
7.

Thioether adducts of a new imine reactive intermediate of the pneumotoxin 3-methylindole.

Skordos KW, Laycock JD, Yost GS.

Chem Res Toxicol. 1998 Nov;11(11):1326-31.

PMID:
9815193
8.

Evidence supporting the formation of 2,3-epoxy-3-methylindoline: a reactive intermediate of the pneumotoxin 3-methylindole.

Skordos KW, Skiles GL, Laycock JD, Lanza DL, Yost GS.

Chem Res Toxicol. 1998 Jul;11(7):741-9.

PMID:
9671536

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