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Items: 1 to 50 of 56

1.

NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains.

Lhoumaud P, Badri S, Rodriguez-Hernaez J, Sakellaropoulos T, Sethia G, Kloetgen A, Cornwell M, Bhattacharyya S, Ay F, Bonneau R, Tsirigos A, Skok JA.

Nat Commun. 2019 Oct 24;10(1):4843. doi: 10.1038/s41467-019-12811-4.

2.

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage.

Wong JB, Hewitt SL, Heltemes-Harris LM, Mandal M, Johnson K, Rajewsky K, Koralov SB, Clark MR, Farrar MA, Skok JA.

Nat Commun. 2019 Oct 18;10(1):4768. doi: 10.1038/s41467-019-12824-z.

3.

Impaired Expression of Rearranged Immunoglobulin Genes and Premature p53 Activation Block B Cell Development in BMI1 Null Mice.

Cantor DJ, King B, Blumenberg L, DiMauro T, Aifantis I, Koralov SB, Skok JA, David G.

Cell Rep. 2019 Jan 2;26(1):108-118.e4. doi: 10.1016/j.celrep.2018.12.030.

4.

Analysis of 3D genomic interactions identifies candidate host genes that transposable elements potentially regulate.

Raviram R, Rocha PP, Luo VM, Swanzey E, Miraldi ER, Chuong EB, Feschotte C, Bonneau R, Skok JA.

Genome Biol. 2018 Dec 13;19(1):216. doi: 10.1186/s13059-018-1598-7.

5.

Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development.

Issuree PD, Day K, Au C, Raviram R, Zappile P, Skok JA, Xue HH, Myers RM, Littman DR.

Nat Commun. 2018 Sep 5;9(1):3594. doi: 10.1038/s41467-018-05834-w.

6.

Capturing the Onset of PRC2-Mediated Repressive Domain Formation.

Oksuz O, Narendra V, Lee CH, Descostes N, LeRoy G, Raviram R, Blumenberg L, Karch K, Rocha PP, Garcia BA, Skok JA, Reinberg D.

Mol Cell. 2018 Jun 21;70(6):1149-1162.e5. doi: 10.1016/j.molcel.2018.05.023.

7.

Enhancer talk.

Snetkova V, Skok JA.

Epigenomics. 2018 Apr 1;10(4):483-498. doi: 10.2217/epi-2017-0157. Epub 2018 Mar 27. Review.

8.

Control of B-1a cell development by instructive BCR signaling.

Kreslavsky T, Wong JB, Fischer M, Skok JA, Busslinger M.

Curr Opin Immunol. 2018 Apr;51:24-31. doi: 10.1016/j.coi.2018.01.001. Epub 2018 Feb 3. Review.

9.

Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2.

Modrek AS, Golub D, Khan T, Bready D, Prado J, Bowman C, Deng J, Zhang G, Rocha PP, Raviram R, Lazaris C, Stafford JM, LeRoy G, Kader M, Dhaliwal J, Bayin NS, Frenster JD, Serrano J, Chiriboga L, Baitalmal R, Nanjangud G, Chi AS, Golfinos JG, Wang J, Karajannis MA, Bonneau RA, Reinberg D, Tsirigos A, Zagzag D, Snuderl M, Skok JA, Neubert TA, Placantonakis DG.

Cell Rep. 2017 Oct 31;21(5):1267-1280. doi: 10.1016/j.celrep.2017.10.009.

10.

The Conserved ATM Kinase RAG2-S365 Phosphorylation Site Limits Cleavage Events in Individual Cells Independent of Any Repair Defect.

Hewitt SL, Wong JB, Lee JH, Nishana M, Chen H, Coussens M, Arnal SM, Blumenberg LM, Roth DB, Paull TT, Skok JA.

Cell Rep. 2017 Oct 24;21(4):979-993. doi: 10.1016/j.celrep.2017.09.084.

11.

Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development.

Campos-Sanchez E, Deleyto-Seldas N, Dominguez V, Carrillo-de-Santa-Pau E, Ura K, Rocha PP, Kim J, Aljoufi A, Esteve-Codina A, Dabad M, Gut M, Heyn H, Kaneda Y, Nimura K, Skok JA, Martinez-Frias ML, Cobaleda C.

Cell Rep. 2017 May 23;19(8):1586-1601. doi: 10.1016/j.celrep.2017.04.069.

12.

miRNAs Are Essential for the Regulation of the PI3K/AKT/FOXO Pathway and Receptor Editing during B Cell Maturation.

Coffre M, Benhamou D, Rieß D, Blumenberg L, Snetkova V, Hines MJ, Chakraborty T, Bajwa S, Jensen K, Chong MMW, Getu L, Silverman GJ, Blelloch R, Littman DR, Calado D, Melamed D, Skok JA, Rajewsky K, Koralov SB.

Cell Rep. 2016 Nov 22;17(9):2271-2285. doi: 10.1016/j.celrep.2016.11.006.

13.

MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis.

Aranda-Orgilles B, Saldaña-Meyer R, Wang E, Trompouki E, Fassl A, Lau S, Mullenders J, Rocha PP, Raviram R, Guillamot M, Sánchez-Díaz M, Wang K, Kayembe C, Zhang N, Amoasii L, Choudhuri A, Skok JA, Schober M, Reinberg D, Sicinski P, Schrewe H, Tsirigos A, Zon LI, Aifantis I.

Cell Stem Cell. 2016 Dec 1;19(6):784-799. doi: 10.1016/j.stem.2016.08.004. Epub 2016 Aug 25.

14.

Identification of multi-loci hubs from 4C-seq demonstrates the functional importance of simultaneous interactions.

Jiang T, Raviram R, Snetkova V, Rocha PP, Proudhon C, Badri S, Bonneau R, Skok JA, Kluger Y.

Nucleic Acids Res. 2016 Oct 14;44(18):8714-8725. Epub 2016 Jul 20.

15.

A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination.

Rocha PP, Raviram R, Fu Y, Kim J, Luo VM, Aljoufi A, Swanzey E, Pasquarella A, Balestrini A, Miraldi ER, Bonneau R, Petrini J, Schotta G, Skok JA.

Cell Rep. 2016 Jun 28;16(1):48-55. doi: 10.1016/j.celrep.2016.05.073. Epub 2016 Jun 16.

16.

Active and Inactive Enhancers Cooperate to Exert Localized and Long-Range Control of Gene Regulation.

Proudhon C, Snetkova V, Raviram R, Lobry C, Badri S, Jiang T, Hao B, Trimarchi T, Kluger Y, Aifantis I, Bonneau R, Skok JA.

Cell Rep. 2016 Jun 7;15(10):2159-2169. doi: 10.1016/j.celrep.2016.04.087. Epub 2016 May 26.

17.

CRISPR-dCas9 and sgRNA scaffolds enable dual-colour live imaging of satellite sequences and repeat-enriched individual loci.

Fu Y, Rocha PP, Luo VM, Raviram R, Deng Y, Mazzoni EO, Skok JA.

Nat Commun. 2016 May 25;7:11707. doi: 10.1038/ncomms11707.

18.

4C-ker: A Method to Reproducibly Identify Genome-Wide Interactions Captured by 4C-Seq Experiments.

Raviram R, Rocha PP, Müller CL, Miraldi ER, Badri S, Fu Y, Swanzey E, Proudhon C, Snetkova V, Bonneau R, Skok JA.

PLoS Comput Biol. 2016 Mar 3;12(3):e1004780. doi: 10.1371/journal.pcbi.1004780. eCollection 2016 Mar.

19.

Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombination.

Thomas-Claudepierre AS, Robert I, Rocha PP, Raviram R, Schiavo E, Heyer V, Bonneau R, Luo VM, Reddy JK, Borggrefe T, Skok JA, Reina-San-Martin B.

J Exp Med. 2016 Mar 7;213(3):303-12. doi: 10.1084/jem.20141967. Epub 2016 Feb 22.

20.

RAG Off-Target Activity Is in the Loop.

Blumenberg L, Skok JA.

Trends Mol Med. 2015 Dec;21(12):733-735. doi: 10.1016/j.molmed.2015.10.007. Epub 2015 Nov 18.

21.

Long-Range Regulation of V(D)J Recombination.

Proudhon C, Hao B, Raviram R, Chaumeil J, Skok JA.

Adv Immunol. 2015;128:123-82. doi: 10.1016/bs.ai.2015.07.003. Epub 2015 Aug 20. Review.

22.

Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms.

Mullenders J, Aranda-Orgilles B, Lhoumaud P, Keller M, Pae J, Wang K, Kayembe C, Rocha PP, Raviram R, Gong Y, Premsrirut PK, Tsirigos A, Bonneau R, Skok JA, Cimmino L, Hoehn D, Aifantis I.

J Exp Med. 2015 Oct 19;212(11):1833-50. doi: 10.1084/jem.20151323. Epub 2015 Oct 5.

23.

Breaking TADs: insights into hierarchical genome organization.

Rocha PP, Raviram R, Bonneau R, Skok JA.

Epigenomics. 2015;7(4):523-6. doi: 10.2217/epi.15.25. Review. No abstract available.

24.

CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation.

Narendra V, Rocha PP, An D, Raviram R, Skok JA, Mazzoni EO, Reinberg D.

Science. 2015 Feb 27;347(6225):1017-21. doi: 10.1126/science.1262088.

25.

VH replacement in primary immunoglobulin repertoire diversification.

Sun A, Novobrantseva TI, Coffre M, Hewitt SL, Jensen K, Skok JA, Rajewsky K, Koralov SB.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E458-66. doi: 10.1073/pnas.1418001112. Epub 2015 Jan 21.

26.

Taking a break from the lab: can it really be done?

Skok JA.

Trends Cell Biol. 2014 Dec;24(12):725-6. doi: 10.1016/j.tcb.2014.09.002. Epub 2014 Nov 24.

27.

Interpreting 4C-Seq data: how far can we go?

Raviram R, Rocha PP, Bonneau R, Skok JA.

Epigenomics. 2014;6(5):455-7. doi: 10.2217/epi.14.47. No abstract available.

28.

β-Catenin induces T-cell transformation by promoting genomic instability.

Dose M, Emmanuel AO, Chaumeil J, Zhang J, Sun T, Germar K, Aghajani K, Davis EM, Keerthivasan S, Bredemeyer AL, Sleckman BP, Rosen ST, Skok JA, Le Beau MM, Georgopoulos K, Gounari F.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):391-6. doi: 10.1073/pnas.1315752111. Epub 2013 Dec 26.

29.

A new take on v(d)j recombination: transcription driven nuclear and chromatin reorganization in rag-mediated cleavage.

Chaumeil J, Skok JA.

Front Immunol. 2013 Dec 6;4:423. doi: 10.3389/fimmu.2013.00423. Review.

30.

Molecular biology. Finding the right partner in a 3D genome.

Rocha PP, Chaumeil J, Skok JA.

Science. 2013 Dec 13;342(6164):1333-4. doi: 10.1126/science.1246106. No abstract available.

31.

Response to Casellas et al.

Rocha PP, Micsinai M, Kluger Y, Skok JA.

Mol Cell. 2013 Aug 8;51(3):277-8. doi: 10.1016/j.molcel.2013.07.019. No abstract available.

32.

The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage.

Chaumeil J, Micsinai M, Ntziachristos P, Roth DB, Aifantis I, Kluger Y, Deriano L, Skok JA.

Nat Commun. 2013;4:2231. doi: 10.1038/ncomms3231.

33.

The origin of recurrent translocations in recombining lymphocytes: a balance between break frequency and nuclear proximity.

Rocha PP, Skok JA.

Curr Opin Cell Biol. 2013 Jun;25(3):365-71. doi: 10.1016/j.ceb.2013.02.007. Epub 2013 Mar 13. Review.

34.

Higher-order looping and nuclear organization of Tcra facilitate targeted rag cleavage and regulated rearrangement in recombination centers.

Chaumeil J, Micsinai M, Ntziachristos P, Deriano L, Wang JM, Ji Y, Nora EP, Rodesch MJ, Jeddeloh JA, Aifantis I, Kluger Y, Schatz DG, Skok JA.

Cell Rep. 2013 Feb 21;3(2):359-70. doi: 10.1016/j.celrep.2013.01.024. Epub 2013 Feb 14.

35.

Combined immunofluorescence and DNA FISH on 3D-preserved interphase nuclei to study changes in 3D nuclear organization.

Chaumeil J, Micsinai M, Skok JA.

J Vis Exp. 2013 Feb 3;(72):e50087. doi: 10.3791/50087.

36.

Close proximity to Igh is a contributing factor to AID-mediated translocations.

Rocha PP, Micsinai M, Kim JR, Hewitt SL, Souza PP, Trimarchi T, Strino F, Parisi F, Kluger Y, Skok JA.

Mol Cell. 2012 Sep 28;47(6):873-85. doi: 10.1016/j.molcel.2012.06.036. Epub 2012 Aug 2.

37.

IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle.

Johnson K, Chaumeil J, Micsinai M, Wang JM, Ramsey LB, Baracho GV, Rickert RC, Strino F, Kluger Y, Farrar MA, Skok JA.

J Immunol. 2012 Jun 15;188(12):6084-92. doi: 10.4049/jimmunol.1200368. Epub 2012 May 11.

38.

The role of CTCF in regulating V(D)J recombination.

Chaumeil J, Skok JA.

Curr Opin Immunol. 2012 Apr;24(2):153-9. doi: 10.1016/j.coi.2012.01.003. Epub 2012 Mar 15. Review.

39.

Equal opportunity for all.

Chaumeil J, Skok JA.

EMBO J. 2012 Apr 4;31(7):1627-9. doi: 10.1038/emboj.2012.64. Epub 2012 Mar 13. No abstract available.

40.

A multifunctional element in the mouse Igκ locus that specifies repertoire and Ig loci subnuclear location.

Xiang Y, Zhou X, Hewitt SL, Skok JA, Garrard WT.

J Immunol. 2011 May 1;186(9):5356-66. doi: 10.4049/jimmunol.1003794. Epub 2011 Mar 25.

41.

RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation.

Collins A, Hewitt SL, Chaumeil J, Sellars M, Micsinai M, Allinne J, Parisi F, Nora EP, Bolland DJ, Corcoran AE, Kluger Y, Bosselut R, Ellmeier W, Chong MM, Littman DR, Skok JA.

Immunity. 2011 Mar 25;34(3):303-14. doi: 10.1016/j.immuni.2011.03.004.

42.

The RAG2 C terminus suppresses genomic instability and lymphomagenesis.

Deriano L, Chaumeil J, Coussens M, Multani A, Chou Y, Alekseyenko AV, Chang S, Skok JA, Roth DB.

Nature. 2011 Mar 3;471(7336):119-23. doi: 10.1038/nature09755.

43.

It takes two: communication between homologous alleles preserves genomic stability during V(D)J recombination.

Brandt VL, Hewitt SL, Skok JA.

Nucleus. 2010 Jan-Feb;1(1):23-9. doi: 10.4161/nucl.1.1.10595.

44.

Epigenetic regulation of V(D)J recombination.

Johnson K, Chaumeil J, Skok JA.

Essays Biochem. 2010 Sep 20;48(1):221-43. doi: 10.1042/bse0480221. Review.

PMID:
20822496
45.

Chromosome dynamics and the regulation of V(D)J recombination.

Hewitt SL, Chaumeil J, Skok JA.

Immunol Rev. 2010 Sep;237(1):43-54. doi: 10.1111/j.1600-065X.2010.00931.x. Review.

PMID:
20727028
46.

V(D)J recombination: a paradigm for studying chromosome interactions in mammalian cells.

Skok JA.

Epigenomics. 2010 Apr;2(2):175-7. doi: 10.2217/epi.10.10. No abstract available.

47.

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.

Hewitt SL, Yin B, Ji Y, Chaumeil J, Marszalek K, Tenthorey J, Salvagiotto G, Steinel N, Ramsey LB, Ghysdael J, Farrar MA, Sleckman BP, Schatz DG, Busslinger M, Bassing CH, Skok JA.

Nat Immunol. 2009 Jun;10(6):655-64. doi: 10.1038/ni.1735. Erratum in: Nat Immunol. 2009 Jun;10(6). doi: 10.1038/ni.1735. Nat Immunol. 2009 Sep;10(9):1034. Nat Immunol. 2010 Mar;11(4):355-6.

48.

Silencing and nuclear repositioning of the lambda5 gene locus at the pre-B cell stage requires Aiolos and OBF-1.

Karnowski A, Cao C, Matthias G, Carotta S, Corcoran LM, Martensson IL, Skok JA, Matthias P.

PLoS One. 2008;3(10):e3568. doi: 10.1371/journal.pone.0003568. Epub 2008 Oct 30.

49.

Association between the Igk and Igh immunoglobulin loci mediated by the 3' Igk enhancer induces 'decontraction' of the Igh locus in pre-B cells.

Hewitt SL, Farmer D, Marszalek K, Cadera E, Liang HE, Xu Y, Schlissel MS, Skok JA.

Nat Immunol. 2008 Apr;9(4):396-404. doi: 10.1038/ni1567. Epub 2008 Feb 24.

50.

Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling.

Johnson K, Hashimshony T, Sawai CM, Pongubala JM, Skok JA, Aifantis I, Singh H.

Immunity. 2008 Mar;28(3):335-45. doi: 10.1016/j.immuni.2007.12.019. Epub 2008 Feb 14.

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