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Items: 39

1.

A CRISPR Activation Screen Identifies Genes That Protect against Zika Virus Infection.

Dukhovny A, Lamkiewicz K, Chen Q, Fricke M, Jabrane-Ferrat N, Marz M, Jung JU, Sklan EH.

J Virol. 2019 Jul 30;93(16). pii: e00211-19. doi: 10.1128/JVI.00211-19. Print 2019 Aug 15.

PMID:
31142663
2.

Striatin is a novel modulator of cell adhesion.

Lahav-Ariel L, Caspi M, Nadar-Ponniah PT, Zelikson N, Hofmann I, Hanson KK, Franke WW, Sklan EH, Avraham KB, Rosin-Arbesfeld R.

FASEB J. 2019 Apr;33(4):4729-4740. doi: 10.1096/fj.201801882R. Epub 2018 Dec 28.

PMID:
30592649
3.

The antiviral protein Viperin suppresses T7 promoter dependent RNA synthesis-possible implications for its antiviral activity.

Dukhovny A, Shlomai A, Sklan EH.

Sci Rep. 2018 May 25;8(1):8100. doi: 10.1038/s41598-018-26516-z.

4.

Characterization of hepatitis B and delta coinfection in Israel.

Shirazi R, Ram D, Rakovsky A, Bucris E, Gozlan Y, Lustig Y, Shaked-Mishan P, Picard O, Shemer-Avni Y, Ben-Zvi H, Halutz O, Lurie Y, Veizman E, Carlebach M, Braun M, Naftaly MC, Shlomai A, Safadi R, Mendelson E, Sklan EH, Ben-Ari Z, Mor O.

BMC Infect Dis. 2018 Feb 27;18(1):97. doi: 10.1186/s12879-018-3008-x.

5.

TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing.

Seo GJ, Kim C, Shin WJ, Sklan EH, Eoh H, Jung JU.

Nat Commun. 2018 Feb 9;9(1):613. doi: 10.1038/s41467-018-02936-3.

6.

Live cell imaging and analysis of lipid droplets biogenesis in hepatatis C virus infected cells.

Nevo-Yassaf I, Lovelle M, Nahmias Y, Hirschberg K, Sklan EH.

Methods. 2017 Aug 15;127:30-36. doi: 10.1016/j.ymeth.2017.05.010. Epub 2017 May 17.

PMID:
28526563
7.

Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection.

Levy G, Habib N, Guzzardi MA, Kitsberg D, Bomze D, Ezra E, Uygun BE, Uygun K, Trippler M, Schlaak JF, Shibolet O, Sklan EH, Cohen M, Timm J, Friedman N, Nahmias Y.

Nat Chem Biol. 2016 Dec;12(12):1037-1045. doi: 10.1038/nchembio.2193. Epub 2016 Oct 10.

PMID:
27723751
8.

Detection of a Tumor Suppressor Gene Variant Predisposing to Colorectal Cancer in an 18th Century Hungarian Mummy.

Feldman M, Hershkovitz I, Sklan EH, Kahila Bar-Gal G, Pap I, Szikossy I, Rosin-Arbesfeld R.

PLoS One. 2016 Feb 10;11(2):e0147217. doi: 10.1371/journal.pone.0147217. eCollection 2016.

9.

Amino Terminal Region of Dengue Virus NS4A Cytosolic Domain Binds to Highly Curved Liposomes.

Hung YF, Schwarten M, Hoffmann S, Willbold D, Sklan EH, Koenig B.

Viruses. 2015 Jul 21;7(7):4119-30. doi: 10.3390/v7072812.

10.

The myelin proteolipid plasmolipin forms oligomers and induces liquid-ordered membranes in the Golgi complex.

Yaffe Y, Hugger I, Yassaf IN, Shepshelovitch J, Sklan EH, Elkabetz Y, Yeheskel A, Pasmanik-Chor M, Benzing C, Macmillan A, Gaus K, Eshed-Eisenbach Y, Peles E, Hirschberg K.

J Cell Sci. 2015 Jul 1;128(13):2293-302. doi: 10.1242/jcs.166249. Epub 2015 May 22.

11.

Dengue virus NS4A cytoplasmic domain binding to liposomes is sensitive to membrane curvature.

Hung YF, Schwarten M, Schünke S, Thiagarajan-Rosenkranz P, Hoffmann S, Sklan EH, Willbold D, Koenig BW.

Biochim Biophys Acta. 2015 May;1848(5):1119-26. doi: 10.1016/j.bbamem.2015.01.015. Epub 2015 Jan 30.

12.

Phosphatidylinositol 4,5-bisphosphate is an HCV NS5A ligand and mediates replication of the viral genome.

Cho NJ, Lee C, Pang PS, Pham EA, Fram B, Nguyen K, Xiong A, Sklan EH, Elazar M, Koytak ES, Kersten C, Kanazawa KK, Frank CW, Glenn JS.

Gastroenterology. 2015 Mar;148(3):616-25. doi: 10.1053/j.gastro.2014.11.043. Epub 2014 Dec 2.

13.

The interaction between the hepatitis C proteins NS4B and NS5A is involved in viral replication.

David N, Yaffe Y, Hagoel L, Elazar M, Glenn JS, Hirschberg K, Sklan EH.

Virology. 2015 Jan 15;475:139-49. doi: 10.1016/j.virol.2014.10.021. Epub 2014 Dec 2.

14.

Competing targets of microRNA-608 affect anxiety and hypertension.

Hanin G, Shenhar-Tsarfaty S, Yayon N, Yau YH, Bennett ER, Sklan EH, Rao DC, Rankinen T, Bouchard C, Geifman-Shochat S, Shifman S, Greenberg DS, Soreq H.

Hum Mol Genet. 2014 Sep 1;23(17):4569-80. doi: 10.1093/hmg/ddu170. Epub 2014 Apr 9. Erratum in: Hum Mol Genet. 2014 Dec 15;23(24):6694. Hoe, Yau Yin [corrected to Yau, Yin Hoe].

15.

An N-terminal amphipathic helix in dengue virus nonstructural protein 4A mediates oligomerization and is essential for replication.

Stern O, Hung YF, Valdau O, Yaffe Y, Harris E, Hoffmann S, Willbold D, Sklan EH.

J Virol. 2013 Apr;87(7):4080-5. doi: 10.1128/JVI.01900-12. Epub 2013 Jan 16.

16.

The metabolic regulator PGC-1α links hepatitis C virus infection to hepatic insulin resistance.

Shlomai A, Rechtman MM, Burdelova EO, Zilberberg A, Hoffman S, Solar I, Fishman S, Halpern Z, Sklan EH.

J Hepatol. 2012 Oct;57(4):867-73. doi: 10.1016/j.jhep.2012.06.021. Epub 2012 Jun 23.

PMID:
22732512
17.

Role for TBC1D20 and Rab1 in hepatitis C virus replication via interaction with lipid droplet-bound nonstructural protein 5A.

Nevo-Yassaf I, Yaffe Y, Asher M, Ravid O, Eizenberg S, Henis YI, Nahmias Y, Hirschberg K, Sklan EH.

J Virol. 2012 Jun;86(12):6491-502. doi: 10.1128/JVI.00496-12. Epub 2012 Apr 4.

18.

Human immunodeficiency virus type 1 envelope proteins traffic toward virion assembly sites via a TBC1D20/Rab1-regulated pathway.

Nachmias D, Sklan EH, Ehrlich M, Bacharach E.

Retrovirology. 2012 Jan 19;9:7. doi: 10.1186/1742-4690-9-7.

19.

The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein.

Lee C, Ma H, Hang JQ, Leveque V, Sklan EH, Elazar M, Klumpp K, Glenn JS.

Virology. 2011 May 25;414(1):10-8. doi: 10.1016/j.virol.2011.03.026. Epub 2011 Apr 22.

20.

HCV NS4B: From Obscurity to Central Stage.

Sklan EH, Glenn JS.

In: Tan SL, editor. Hepatitis C Viruses: Genomes and Molecular Biology. Norfolk (UK): Horizon Bioscience; 2006. Chapter 8.

21.

Role for ADP ribosylation factor 1 in the regulation of hepatitis C virus replication.

Matto M, Sklan EH, David N, Melamed-Book N, Casanova JE, Glenn JS, Aroeti B.

J Virol. 2011 Jan;85(2):946-56. doi: 10.1128/JVI.00753-10. Epub 2010 Nov 10.

22.

Mechanisms of HCV survival in the host.

Sklan EH, Charuworn P, Pang PS, Glenn JS.

Nat Rev Gastroenterol Hepatol. 2009 Apr;6(4):217-27. doi: 10.1038/nrgastro.2009.32. Review.

PMID:
19347013
23.

Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis.

Einav S, Gerber D, Bryson PD, Sklan EH, Elazar M, Maerkl SJ, Glenn JS, Quake SR.

Nat Biotechnol. 2008 Sep;26(9):1019-27. doi: 10.1038/nbt.1490.

24.

Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility.

Mor I, Sklan EH, Podoly E, Pick M, Kirschner M, Yogev L, Bar-Sheshet Itach S, Schreiber L, Geyer B, Mor T, Grisaru D, Soreq H.

J Cell Mol Med. 2008 Apr;12(2):479-95. doi: 10.1111/j.1582-4934.2008.00231.x. Epub 2008 Jan 11.

25.

The nucleotide binding motif of hepatitis C virus NS4B can mediate cellular transformation and tumor formation without Ha-ras co-transfection.

Einav S, Sklan EH, Moon HM, Gehrig E, Liu P, Hao Y, Lowe AW, Glenn JS.

Hepatology. 2008 Mar;47(3):827-35.

PMID:
18081150
26.

TBC1D20 is a Rab1 GTPase-activating protein that mediates hepatitis C virus replication.

Sklan EH, Serrano RL, Einav S, Pfeffer SR, Lambright DG, Glenn JS.

J Biol Chem. 2007 Dec 14;282(50):36354-61. Epub 2007 Sep 27.

27.

A Rab-GAP TBC domain protein binds hepatitis C virus NS5A and mediates viral replication.

Sklan EH, Staschke K, Oakes TM, Elazar M, Winters M, Aroeti B, Danieli T, Glenn JS.

J Virol. 2007 Oct;81(20):11096-105. Epub 2007 Aug 8.

28.

The Power of silence: application of small interfering RNAs to gastrointestinal diseases.

Sklan EH, Glenn JS.

Gastroenterology. 2007 Jun;132(7):2291-5. Review. No abstract available.

PMID:
17570202
29.

Acetylcholinesterase/C terminal binding protein interactions modify Ikaros functions, causing T lymphopenia.

Perry C, Pick M, Podoly E, Gilboa-Geffen A, Zimmerman G, Sklan EH, Ben-Shaul Y, Diamant S, Soreq H.

Leukemia. 2007 Jul;21(7):1472-80. Epub 2007 May 3.

PMID:
17476278
30.

Acetylcholinesterase modulates stress-induced motor responses through catalytic and noncatalytic properties.

Sklan EH, Berson A, Birikh KR, Gutnick A, Shahar O, Shoham S, Soreq H.

Biol Psychiatry. 2006 Oct 1;60(7):741-51. Epub 2006 Aug 14.

PMID:
16904653
31.

RACK1 has the nerve to act: structure meets function in the nervous system.

Sklan EH, Podoly E, Soreq H.

Prog Neurobiol. 2006 Feb;78(2):117-34. Epub 2006 Feb 2. Review.

PMID:
16457939
32.

Hydrolytic and nonenzymatic functions of acetylcholinesterase comodulate hemopoietic stress responses.

Grisaru D, Pick M, Perry C, Sklan EH, Almog R, Goldberg I, Naparstek E, Lessing JB, Soreq H, Deutsch V.

J Immunol. 2006 Jan 1;176(1):27-35.

33.

Memory deficits correlating with acetylcholinesterase splice shift and amyloid burden in doubly transgenic mice.

Rees TM, Berson A, Sklan EH, Younkin L, Younkin S, Brimijoin S, Soreq H.

Curr Alzheimer Res. 2005 Jul;2(3):291-300.

PMID:
15974894
34.

CREB regulates AChE-R-induced proliferation of human glioblastoma cells.

Perry C, Sklan EH, Soreq H.

Neoplasia. 2004 May-Jun;6(3):279-86.

35.

Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study.

Sklan EH, Lowenthal A, Korner M, Ritov Y, Landers DM, Rankinen T, Bouchard C, Leon AS, Rice T, Rao DC, Wilmore JH, Skinner JS, Soreq H.

Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5512-7. Epub 2004 Apr 1.

36.

Stress-induced alternative splicing of acetylcholinesterase results in enhanced fear memory and long-term potentiation.

Nijholt I, Farchi N, Kye M, Sklan EH, Shoham S, Verbeure B, Owen D, Hochner B, Spiess J, Soreq H, Blank T.

Mol Psychiatry. 2004 Feb;9(2):174-83.

PMID:
14581933
37.

Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior.

Birikh KR, Sklan EH, Shoham S, Soreq H.

Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):283-8. Epub 2002 Dec 30.

38.

Complex regulation of acetylcholinesterase gene expression in human brain tumors.

Perry C, Sklan EH, Birikh K, Shapira M, Trejo L, Eldor A, Soreq H.

Oncogene. 2002 Dec 5;21(55):8428-41.

39.

Inhibition of murine AIDS (MAIDS) development in C57BL/6J mice by tyrphostin AG-1387.

Sklan EH, Gazit A, Priel E.

Virology. 2000 Dec 5;278(1):95-102.

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