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Items: 40


An Orthogonal and pH-Tunable Sensor-Selector for Muconic Acid Biosynthesis in Yeast.

Snoek T, Romero-Suarez D, Zhang J, Ambri F, Skjoedt ML, Sudarsan S, Jensen MK, Keasling JD.

ACS Synth Biol. 2018 Apr 20;7(4):995-1003. doi: 10.1021/acssynbio.7b00439. Epub 2018 Apr 5.


Design, Engineering, and Characterization of Prokaryotic Ligand-Binding Transcriptional Activators as Biosensors in Yeast.

Ambri F, Snoek T, Skjoedt ML, Jensen MK, Keasling JD.

Methods Mol Biol. 2018;1671:269-290. doi: 10.1007/978-1-4939-7295-1_17.


C-Reactive Protein Binds to Cholesterol Crystals and Co-Localizes with the Terminal Complement Complex in Human Atherosclerotic Plaques.

Pilely K, Fumagalli S, Rosbjerg A, Genster N, Skjoedt MO, Perego C, Ferrante AMR, De Simoni MG, Garred P.

Front Immunol. 2017 Aug 29;8:1040. doi: 10.3389/fimmu.2017.01040. eCollection 2017.


A novel antihuman C3d monoclonal antibody with specificity to the C3d complement split product.

Rasmussen KJ, Skjoedt MO, Vitved L, Skjoedt K, Palarasah Y.

J Immunol Methods. 2017 May;444:51-55. doi: 10.1016/j.jim.2017.02.002. Epub 2017 Feb 4.


Complementary Roles of the Classical and Lectin Complement Pathways in the Defense against Aspergillus fumigatus.

Rosbjerg A, Genster N, Pilely K, Skjoedt MO, Stahl GL, Garred P.

Front Immunol. 2016 Nov 3;7:473. eCollection 2016.


A journey through the lectin pathway of complement-MBL and beyond.

Garred P, Genster N, Pilely K, Bayarri-Olmos R, Rosbjerg A, Ma YJ, Skjoedt MO.

Immunol Rev. 2016 Nov;274(1):74-97. doi: 10.1111/imr.12468. Review.


Engineering prokaryotic transcriptional activators as metabolite biosensors in yeast.

Skjoedt ML, Snoek T, Kildegaard KR, Arsovska D, Eichenberger M, Goedecke TJ, Rajkumar AS, Zhang J, Kristensen M, Lehka BJ, Siedler S, Borodina I, Jensen MK, Keasling JD.

Nat Chem Biol. 2016 Nov;12(11):951-958. doi: 10.1038/nchembio.2177. Epub 2016 Sep 19.


Human mannose-binding lectin inhibitor prevents Shiga toxin-induced renal injury.

Ozaki M, Kang Y, Tan YS, Pavlov VI, Liu B, Boyle DC, Kushak RI, Skjoedt MO, Grabowski EF, Taira Y, Stahl GL.

Kidney Int. 2016 Oct;90(4):774-82. doi: 10.1016/j.kint.2016.05.011. Epub 2016 Jul 1.


The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation.

Kozarcanin H, Lood C, Munthe-Fog L, Sandholm K, Hamad OA, Bengtsson AA, Skjoedt MO, Huber-Lang M, Garred P, Ekdahl KN, Nilsson B.

J Thromb Haemost. 2016 Mar;14(3):531-45. doi: 10.1111/jth.13208. Epub 2016 Feb 15.


The Levels of the Lectin Pathway Serine Protease MASP-1 and Its Complex Formation with C1 Inhibitor Are Linked to the Severity of Hereditary Angioedema.

Hansen CB, Csuka D, Munthe-Fog L, Varga L, Farkas H, Hansen KM, Koch C, Skjødt K, Garred P, Skjoedt MO.

J Immunol. 2015 Oct 15;195(8):3596-604. doi: 10.4049/jimmunol.1402838. Epub 2015 Sep 14.


Soluble Collectin-12 (CL-12) Is a Pattern Recognition Molecule Initiating Complement Activation via the Alternative Pathway.

Ma YJ, Hein E, Munthe-Fog L, Skjoedt MO, Bayarri-Olmos R, Romani L, Garred P.

J Immunol. 2015 Oct 1;195(7):3365-73. doi: 10.4049/jimmunol.1500493. Epub 2015 Aug 19.


Genetically engineered fusion of MAP-1 and factor H domains 1-5 generates a potent dual upstream inhibitor of both the lectin and alternative complement pathways.

Nordmaj MA, Munthe-Fog L, Hein E, Skjoedt MO, Garred P.

FASEB J. 2015 Dec;29(12):4945-55. doi: 10.1096/fj.15-277103. Epub 2015 Aug 10.


Novel CFI mutation in a patient with leukocytoclastic vasculitis may redefine the clinical spectrum of Complement Factor I deficiency.

Bay JT, Katzenstein TL, Kofoed K, Patel D, Skjoedt MO, Garred P, Schejbel L.

Clin Immunol. 2015 Oct;160(2):315-8. doi: 10.1016/j.clim.2015.05.004. Epub 2015 May 16.


Defining the complement biomarker profile of C3 glomerulopathy.

Zhang Y, Nester CM, Martin B, Skjoedt MO, Meyer NC, Shao D, Borsa N, Palarasah Y, Smith RJ.

Clin J Am Soc Nephrol. 2014 Nov 7;9(11):1876-82. doi: 10.2215/CJN.01820214. Epub 2014 Oct 23.


Pentraxin-3 level at admission is a strong predictor of short-term mortality in a community-based hospital setting.

Bastrup-Birk S, Munthe-Fog L, Skjoedt MO, Ma YJ, Nielsen H, Køber L, Nielsen OW, Iversen K, Garred P.

J Intern Med. 2015 May;277(5):562-72. doi: 10.1111/joim.12294. Epub 2014 Sep 8.


Ficolins and the lectin pathway of complement in patients with systemic lupus erythematosus.

Hein E, Nielsen LA, Nielsen CT, Munthe-Fog L, Skjoedt MO, Jacobsen S, Garred P.

Mol Immunol. 2015 Feb;63(2):209-14. doi: 10.1016/j.molimm.2014.07.003. Epub 2014 Jul 25.


Heterocomplex formation between MBL/ficolin/CL-11-associated serine protease-1 and -3 and MBL/ficolin/CL-11-associated protein-1.

Rosbjerg A, Munthe-Fog L, Garred P, Skjoedt MO.

J Immunol. 2014 May 1;192(9):4352-60. doi: 10.4049/jimmunol.1303263. Epub 2014 Mar 28.


A specific assay for quantification of human C4c by use of an anti-C4c monoclonal antibody.

Pilely K, Skjoedt MO, Nielsen C, Andersen TE, Louise Aabom A, Vitved L, Koch C, Skjødt K, Palarasah Y.

J Immunol Methods. 2014 Mar;405:87-96. doi: 10.1016/j.jim.2014.01.011. Epub 2014 Jan 25.


Pentraxin-3 serum levels are associated with disease severity and mortality in patients with systemic inflammatory response syndrome.

Bastrup-Birk S, Skjoedt MO, Munthe-Fog L, Strom JJ, Ma YJ, Garred P.

PLoS One. 2013 Sep 9;8(9):e73119. doi: 10.1371/journal.pone.0073119. eCollection 2013.


Association of ficolin-3 with severity and outcome of chronic heart failure.

Prohászka Z, Munthe-Fog L, Ueland T, Gombos T, Yndestad A, Förhécz Z, Skjoedt MO, Pozsonyi Z, Gustavsen A, Jánoskuti L, Karádi I, Gullestad L, Dahl CP, Askevold ET, Füst G, Aukrust P, Mollnes TE, Garred P.

PLoS One. 2013 Apr 15;8(4):e60976. doi: 10.1371/journal.pone.0060976. Print 2013.


Association between lectin complement pathway initiators, C-reactive protein and left ventricular remodeling in myocardial infarction-a magnetic resonance study.

Schoos MM, Munthe-Fog L, Skjoedt MO, Ripa RS, Lønborg J, Kastrup J, Kelbæk H, Clemmensen P, Garred P.

Mol Immunol. 2013 Jul;54(3-4):408-14. doi: 10.1016/j.molimm.2013.01.008. Epub 2013 Feb 11.


The role of ficolins and MASPs in hereditary angioedema due to C1-inhibitor deficiency.

Csuka D, Munthe-Fog L, Skjoedt MO, Kocsis A, Zotter Z, Gál P, Varga L, Farkas H, Füst G, Garred P.

Mol Immunol. 2013 Jul;54(3-4):271-7. doi: 10.1016/j.molimm.2012.12.015. Epub 2013 Jan 12.


Collectin-11/MASP complex formation triggers activation of the lectin complement pathway--the fifth lectin pathway initiation complex.

Ma YJ, Skjoedt MO, Garred P.

J Innate Immun. 2013;5(3):242-50. doi: 10.1159/000345356. Epub 2012 Dec 4.


A novel assay to quantitate MASP-2/ficolin-3 complexes in serum.

Csuka D, Munthe-Fog L, Skjoedt MO, Hein E, Bay JT, Varga L, Füst G, Garred P.

J Immunol Methods. 2013 Jan 31;387(1-2):237-44. doi: 10.1016/j.jim.2012.10.018. Epub 2012 Nov 8.


Endogenous and natural complement inhibitor attenuates myocardial injury and arterial thrombogenesis.

Pavlov VI, Skjoedt MO, Siow Tan Y, Rosbjerg A, Garred P, Stahl GL.

Circulation. 2012 Oct 30;126(18):2227-35. doi: 10.1161/CIRCULATIONAHA.112.123968. Epub 2012 Oct 2.


Crystal structure and functional characterization of the complement regulator mannose-binding lectin (MBL)/ficolin-associated protein-1 (MAP-1).

Skjoedt MO, Roversi P, Hummelshøj T, Palarasah Y, Rosbjerg A, Johnson S, Lea SM, Garred P.

J Biol Chem. 2012 Sep 21;287(39):32913-21. Epub 2012 Aug 1.


Variation in FCN1 affects biosynthesis of ficolin-1 and is associated with outcome of systemic inflammation.

Munthe-Fog L, Hummelshoj T, Honoré C, Moller ME, Skjoedt MO, Palsgaard I, Borregaard N, Madsen HO, Garred P.

Genes Immun. 2012 Oct;13(7):515-22. doi: 10.1038/gene.2012.27. Epub 2012 Jun 7.


The interaction pattern of murine serum ficolin-A with microorganisms.

Hummelshøj T, Ma YJ, Munthe-Fog L, Bjarnsholt T, Moser C, Skjoedt MO, Romani L, Fujita T, Endo Y, Garred P.

PLoS One. 2012;7(5):e38196. doi: 10.1371/journal.pone.0038196. Epub 2012 May 30.


Low ficolin-3 levels in early follow-up serum samples are associated with the severity and unfavorable outcome of acute ischemic stroke.

Füst G, Munthe-Fog L, Illes Z, Széplaki G, Molnar T, Pusch G, Hirschberg K, Szegedi R, Széplaki Z, Prohászka Z, Skjoedt MO, Garred P.

J Neuroinflammation. 2011 Dec 29;8:185. doi: 10.1186/1742-2094-8-185.


Novel assays to assess the functional capacity of the classical, the alternative and the lectin pathways of the complement system.

Palarasah Y, Nielsen C, Sprogøe U, Christensen ML, Lillevang S, Madsen HO, Bygum A, Koch C, Skjodt K, Skjoedt MO.

Clin Exp Immunol. 2011 Jun;164(3):388-95. doi: 10.1111/j.1365-2249.2011.04322.x. Epub 2011 Mar 14.


Heterocomplexes of mannose-binding lectin and the pentraxins PTX3 or serum amyloid P component trigger cross-activation of the complement system.

Ma YJ, Doni A, Skjoedt MO, Honoré C, Arendrup M, Mantovani A, Garred P.

J Biol Chem. 2011 Feb 4;286(5):3405-17. doi: 10.1074/jbc.M110.190637. Epub 2010 Nov 24.


Functional analysis of Ficolin-3 mediated complement activation.

Hein E, Honoré C, Skjoedt MO, Munthe-Fog L, Hummelshøj T, Garred P.

PLoS One. 2010 Nov 10;5(11):e15443. doi: 10.1371/journal.pone.0015443.


Serum concentration and interaction properties of MBL/ficolin associated protein-1.

Skjoedt MO, Hummelshoj T, Palarasah Y, Hein E, Munthe-Fog L, Koch C, Skjodt K, Garred P.

Immunobiology. 2011 May;216(5):625-32. doi: 10.1016/j.imbio.2010.09.011. Epub 2010 Sep 24.


Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity.

Hansen S, Selman L, Palaniyar N, Ziegler K, Brandt J, Kliem A, Jonasson M, Skjoedt MO, Nielsen O, Hartshorn K, Jørgensen TJ, Skjødt K, Holmskov U.

J Immunol. 2010 Nov 15;185(10):6096-104. doi: 10.4049/jimmunol.1002185. Epub 2010 Oct 18.


Generation of a C3c specific monoclonal antibody and assessment of C3c as a putative inflammatory marker derived from complement factor C3.

Palarasah Y, Skjodt K, Brandt J, Teisner B, Koch C, Vitved L, Skjoedt MO.

J Immunol Methods. 2010 Oct 31;362(1-2):142-50. doi: 10.1016/j.jim.2010.09.024. Epub 2010 Sep 24.


Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain.

Honoré C, Rørvig S, Hummelshøj T, Skjoedt MO, Borregaard N, Garred P.

J Leukoc Biol. 2010 Jul;88(1):145-58. doi: 10.1189/jlb.1209802. Epub 2010 Apr 16.


A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation.

Skjoedt MO, Hummelshoj T, Palarasah Y, Honore C, Koch C, Skjodt K, Garred P.

J Biol Chem. 2010 Mar 12;285(11):8234-43. doi: 10.1074/jbc.M109.065805. Epub 2010 Jan 6.


Sodium polyanethole sulfonate as an inhibitor of activation of complement function in blood culture systems.

Palarasah Y, Skjoedt MO, Vitved L, Andersen TE, Skjoedt K, Koch C.

J Clin Microbiol. 2010 Mar;48(3):908-14. doi: 10.1128/JCM.01985-09. Epub 2009 Dec 30.


MBL-associated serine protease-3 circulates in high serum concentrations predominantly in complex with Ficolin-3 and regulates Ficolin-3 mediated complement activation.

Skjoedt MO, Palarasah Y, Munthe-Fog L, Jie Ma Y, Weiss G, Skjodt K, Koch C, Garred P.

Immunobiology. 2010 Nov;215(11):921-31. doi: 10.1016/j.imbio.2009.10.006. Epub 2009 Nov 24.


Two mannose-binding lectin homologues and an MBL-associated serine protease are expressed in the gut epithelia of the urochordate species Ciona intestinalis.

Skjoedt MO, Palarasah Y, Rasmussen K, Vitved L, Salomonsen J, Kliem A, Hansen S, Koch C, Skjodt K.

Dev Comp Immunol. 2010 Jan;34(1):59-68. doi: 10.1016/j.dci.2009.08.004. Epub 2009 Aug 29.


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