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Items: 1 to 50 of 79

1.

Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.

Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK.

Science. 2019 May 10;364(6440):552-557. doi: 10.1126/science.aaw5188.

PMID:
31073061
2.

Author Correction: Structural insights into the activation of metabotropic glutamate receptors.

Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK.

Nature. 2019 Mar;567(7747):E10. doi: 10.1038/s41586-019-0983-z.

PMID:
30814739
3.

Structural insights into the activation of metabotropic glutamate receptors.

Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK.

Nature. 2019 Feb;566(7742):79-84. doi: 10.1038/s41586-019-0881-4. Epub 2019 Jan 23. Erratum in: Nature. 2019 Mar;567(7747):E10.

PMID:
30675062
4.

Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.

Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, Skiniotis G.

Cell. 2019 Jan 24;176(3):448-458.e12. doi: 10.1016/j.cell.2018.11.040. Epub 2019 Jan 10.

PMID:
30639101
5.

De novo computational RNA modeling into cryo-EM maps of large ribonucleoprotein complexes.

Kappel K, Liu S, Larsen KP, Skiniotis G, Puglisi EV, Puglisi JD, Zhou ZH, Zhao R, Das R.

Nat Methods. 2018 Nov;15(11):947-954. doi: 10.1038/s41592-018-0172-2. Epub 2018 Oct 30.

PMID:
30377372
6.

Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation.

Haddad JF, Yang Y, Takahashi YH, Joshi M, Chaudhary N, Woodfin AR, Benyoucef A, Yeung S, Brunzelle JS, Skiniotis G, Brand M, Shilatifard A, Couture JF.

Structure. 2018 Dec 4;26(12):1594-1603.e4. doi: 10.1016/j.str.2018.08.004. Epub 2018 Sep 27.

PMID:
30270175
7.

Development of an antibody fragment that stabilizes GPCR/G-protein complexes.

Maeda S, Koehl A, Matile H, Hu H, Hilger D, Schertler GFX, Manglik A, Skiniotis G, Dawson RJP, Kobilka BK.

Nat Commun. 2018 Sep 13;9(1):3712. doi: 10.1038/s41467-018-06002-w.

8.

Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex.

Qu Q, Takahashi YH, Yang Y, Hu H, Zhang Y, Brunzelle JS, Couture JF, Shilatifard A, Skiniotis G.

Cell. 2018 Aug 23;174(5):1117-1126.e12. doi: 10.1016/j.cell.2018.07.020. Epub 2018 Aug 9.

PMID:
30100186
9.

Structure of the µ-opioid receptor-Gi protein complex.

Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK.

Nature. 2018 Jun;558(7711):547-552. doi: 10.1038/s41586-018-0219-7. Epub 2018 Jun 13.

10.

Architecture of an HIV-1 reverse transcriptase initiation complex.

Larsen KP, Mathiharan YK, Kappel K, Coey AT, Chen DH, Barrero D, Madigan L, Puglisi JD, Skiniotis G, Puglisi EV.

Nature. 2018 May;557(7703):118-122. doi: 10.1038/s41586-018-0055-9. Epub 2018 Apr 25.

11.

Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse.

Li J, Shalev-Benami M, Sando R, Jiang X, Kibrom A, Wang J, Leon K, Katanski C, Nazarko O, Lu YC, Südhof TC, Skiniotis G, Araç D.

Cell. 2018 Apr 19;173(3):735-748.e15. doi: 10.1016/j.cell.2018.03.036.

12.

Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study.

Sadaf A, Du Y, Santillan C, Mortensen JS, Molist I, Seven AB, Hariharan P, Skiniotis G, Loland CJ, Kobilka BK, Guan L, Byrne B, Chae PS.

Chem Sci. 2017 Dec 1;8(12):8315-8324. doi: 10.1039/c7sc03700g. Epub 2017 Oct 25.

13.

Vitamin E-based glycoside amphiphiles for membrane protein structural studies.

Ehsan M, Du Y, Molist I, Seven AB, Hariharan P, Mortensen JS, Ghani L, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS.

Org Biomol Chem. 2018 Apr 4;16(14):2489-2498. doi: 10.1039/C8OB00270C.

14.

Alternative Mode of E-Site tRNA Binding in the Presence of a Downstream mRNA Stem Loop at the Entrance Channel.

Zhang Y, Hong S, Ruangprasert A, Skiniotis G, Dunham CM.

Structure. 2018 Mar 6;26(3):437-445.e3. doi: 10.1016/j.str.2018.01.013. Epub 2018 Feb 15.

15.

Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10.

Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC.

Cell. 2017 Dec 14;171(7):1638-1648.e7. doi: 10.1016/j.cell.2017.11.014. Epub 2017 Dec 7.

16.

Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.

Shalev-Benami M, Zhang Y, Rozenberg H, Nobe Y, Taoka M, Matzov D, Zimmerman E, Bashan A, Isobe T, Jaffe CL, Yonath A, Skiniotis G.

Nat Commun. 2017 Nov 17;8(1):1589. doi: 10.1038/s41467-017-01664-4.

17.

New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies.

Ehsan M, Ghani L, Du Y, Hariharan P, Mortensen JS, Ribeiro O, Hu H, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS.

Analyst. 2017 Oct 9;142(20):3889-3898. doi: 10.1039/c7an01168g.

18.

Phosphoantigen-induced conformational change of butyrophilin 3A1 (BTN3A1) and its implication on Vγ9Vδ2 T cell activation.

Gu S, Sachleben JR, Boughter CT, Nawrocka WI, Borowska MT, Tarrasch JT, Skiniotis G, Roux B, Adams EJ.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7311-E7320. doi: 10.1073/pnas.1707547114. Epub 2017 Aug 14.

19.

Isolation and structure-function characterization of a signaling-active rhodopsin-G protein complex.

Gao Y, Westfield G, Erickson JW, Cerione RA, Skiniotis G, Ramachandran S.

J Biol Chem. 2017 Aug 25;292(34):14280-14289. doi: 10.1074/jbc.M117.797100. Epub 2017 Jun 27.

20.

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.

Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G.

Nature. 2017 Jun 8;546(7657):248-253. doi: 10.1038/nature22394. Epub 2017 May 24.

21.

Mechanism of Vps4 hexamer function revealed by cryo-EM.

Su M, Guo EZ, Ding X, Li Y, Tarrasch JT, Brooks CL 3rd, Xu Z, Skiniotis G.

Sci Adv. 2017 Apr 14;3(4):e1700325. doi: 10.1126/sciadv.1700325. eCollection 2017 Apr.

22.

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.

Liang YL, Khoshouei M, Radjainia M, Zhang Y, Glukhova A, Tarrasch J, Thal DM, Furness SGB, Christopoulos G, Coudrat T, Danev R, Baumeister W, Miller LJ, Christopoulos A, Kobilka BK, Wootten D, Skiniotis G, Sexton PM.

Nature. 2017 Jun 1;546(7656):118-123. doi: 10.1038/nature22327. Epub 2017 Apr 24.

23.

Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5.

Komolov KE, Du Y, Duc NM, Betz RM, Rodrigues JPGLM, Leib RD, Patra D, Skiniotis G, Adams CM, Dror RO, Chung KY, Kobilka BK, Benovic JL.

Cell. 2017 Apr 20;169(3):407-421.e16. doi: 10.1016/j.cell.2017.03.047.

24.

Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.

Cahill TJ 3rd, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J 4th, Antar A, Blanc A, Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2562-2567. doi: 10.1073/pnas.1701529114. Epub 2017 Feb 21.

25.

Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties.

Das M, Du Y, Ribeiro O, Hariharan P, Mortensen JS, Patra D, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS.

J Am Chem Soc. 2017 Mar 1;139(8):3072-3081. doi: 10.1021/jacs.6b11997. Epub 2017 Feb 20.

26.

The Vps13p-Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion.

De M, Oleskie AN, Ayyash M, Dutta S, Mancour L, Abazeed ME, Brace EJ, Skiniotis G, Fuller RS.

J Cell Biol. 2017 Feb;216(2):425-439. doi: 10.1083/jcb.201606078. Epub 2017 Jan 25.

27.

A snapshot of cryo-EM.

Skiniotis G.

Protein Sci. 2017 Jan;26(1):5-7. doi: 10.1002/pro.3088. No abstract available.

28.

Conformational Plasticity in the Transsynaptic Neurexin-Cerebellin-Glutamate Receptor Adhesion Complex.

Cheng S, Seven AB, Wang J, Skiniotis G, Özkan E.

Structure. 2016 Dec 6;24(12):2163-2173. doi: 10.1016/j.str.2016.11.004.

29.

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.

Thomsen ARB, Plouffe B, Cahill TJ 3rd, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, Bouvier M, Lefkowitz RJ.

Cell. 2016 Aug 11;166(4):907-919. doi: 10.1016/j.cell.2016.07.004. Epub 2016 Aug 4.

30.

Extended surface for membrane association in Zika virus NS1 structure.

Brown WC, Akey DL, Konwerski JR, Tarrasch JT, Skiniotis G, Kuhn RJ, Smith JL.

Nat Struct Mol Biol. 2016 Sep;23(9):865-7. doi: 10.1038/nsmb.3268. Epub 2016 Jul 25.

31.

Flexible, symmetry-directed approach to assembling protein cages.

Sciore A, Su M, Koldewey P, Eschweiler JD, Diffley KA, Linhares BM, Ruotolo BT, Bardwell JC, Skiniotis G, Marsh EN.

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8681-6. doi: 10.1073/pnas.1606013113. Epub 2016 Jul 18.

32.

2.8-Å Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.

Shalev-Benami M, Zhang Y, Matzov D, Halfon Y, Zackay A, Rozenberg H, Zimmerman E, Bashan A, Jaffe CL, Yonath A, Skiniotis G.

Cell Rep. 2016 Jul 12;16(2):288-294. doi: 10.1016/j.celrep.2016.06.014. Epub 2016 Jun 30.

33.

Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies.

Ehsan M, Du Y, Scull NJ, Tikhonova E, Tarrasch J, Mortensen JS, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS.

J Am Chem Soc. 2016 Mar 23;138(11):3789-96. doi: 10.1021/jacs.5b13233. Epub 2016 Mar 11.

34.

Structures of two distinct conformations of holo-non-ribosomal peptide synthetases.

Drake EJ, Miller BR, Shi C, Tarrasch JT, Sundlov JA, Allen CL, Skiniotis G, Aldrich CC, Gulick AM.

Nature. 2016 Jan 14;529(7585):235-8. doi: 10.1038/nature16163.

35.

Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly.

Xu K, Chan YP, Bradel-Tretheway B, Akyol-Ataman Z, Zhu Y, Dutta S, Yan L, Feng Y, Wang LF, Skiniotis G, Lee B, Zhou ZH, Broder CC, Aguilar HC, Nikolov DB.

PLoS Pathog. 2015 Dec 8;11(12):e1005322. doi: 10.1371/journal.ppat.1005322. eCollection 2015 Dec.

36.

Single-particle cryo-electron microscopy of macromolecular complexes.

Skiniotis G, Southworth DR.

Microscopy (Oxf). 2016 Feb;65(1):9-22. doi: 10.1093/jmicro/dfv366. Epub 2015 Nov 25. Review.

37.

Using Protein Dimers to Maximize the Protein Hybridization Efficiency with Multisite DNA Origami Scaffolds.

Verma V, Mallik L, Hariadi RF, Sivaramakrishnan S, Skiniotis G, Joglekar AP.

PLoS One. 2015 Sep 8;10(9):e0137125. doi: 10.1371/journal.pone.0137125. eCollection 2015.

38.

2D Projection Analysis of GPCR Complexes by Negative Stain Electron Microscopy.

Peisley A, Skiniotis G.

Methods Mol Biol. 2015;1335:29-38. doi: 10.1007/978-1-4939-2914-6_3.

PMID:
26260592
39.

Electron Microscopic Visualization of Protein Assemblies on Flattened DNA Origami.

Mallik L, Dhakal S, Nichols J, Mahoney J, Dosey AM, Jiang S, Sunahara RK, Skiniotis G, Walter NG.

ACS Nano. 2015 Jul 28;9(7):7133-41. doi: 10.1021/acsnano.5b01841. Epub 2015 Jul 13.

40.

ERdj5 Reductase Cooperates with Protein Disulfide Isomerase To Promote Simian Virus 40 Endoplasmic Reticulum Membrane Translocation.

Inoue T, Dosey A, Herbstman JF, Ravindran MS, Skiniotis G, Tsai B.

J Virol. 2015 Sep;89(17):8897-908. doi: 10.1128/JVI.00941-15. Epub 2015 Jun 17.

41.

Visualization of an N-terminal fragment of von Willebrand factor in complex with factor VIII.

Yee A, Oleskie AN, Dosey AM, Kretz CA, Gildersleeve RD, Dutta S, Su M, Ginsburg D, Skiniotis G.

Blood. 2015 Aug 20;126(8):939-42. doi: 10.1182/blood-2015-04-641696. Epub 2015 Jun 11.

42.

Architecture of the polyketide synthase module: surprises from electron cryo-microscopy.

Smith JL, Skiniotis G, Sherman DH.

Curr Opin Struct Biol. 2015 Apr;31:9-19. doi: 10.1016/j.sbi.2015.02.014. Epub 2015 Mar 16. Review.

43.

A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation.

Zhang P, Chaturvedi CP, Tremblay V, Cramet M, Brunzelle JS, Skiniotis G, Brand M, Shilatifard A, Couture JF.

Genes Dev. 2015 Jan 15;29(2):123-8. doi: 10.1101/gad.254870.114.

44.

Molecular basis for DPY-30 association to COMPASS-like and NURF complexes.

Tremblay V, Zhang P, Chaturvedi CP, Thornton J, Brunzelle JS, Skiniotis G, Shilatifard A, Brand M, Couture JF.

Structure. 2014 Dec 2;22(12):1821-1830. doi: 10.1016/j.str.2014.10.002. Epub 2014 Nov 20.

45.

Visualization of arrestin recruitment by a G-protein-coupled receptor.

Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL, Shan JM, Chen X, Hanna R, Choi M, Yao XJ, Klink BU, Kahsai AW, Sidhu SS, Koide S, Penczek PA, Kossiakoff AA, Woods VL Jr, Kobilka BK, Skiniotis G, Lefkowitz RJ.

Nature. 2014 Aug 14;512(7513):218-222. doi: 10.1038/nature13430. Epub 2014 Jun 22.

46.

Structural rearrangements of a polyketide synthase module during its catalytic cycle.

Whicher JR, Dutta S, Hansen DA, Hale WA, Chemler JA, Dosey AM, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G.

Nature. 2014 Jun 26;510(7506):560-4. doi: 10.1038/nature13409. Epub 2014 Jun 18.

47.

Structure of a modular polyketide synthase.

Dutta S, Whicher JR, Hansen DA, Hale WA, Chemler JA, Congdon GR, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G.

Nature. 2014 Jun 26;510(7506):512-7. doi: 10.1038/nature13423. Epub 2014 Jun 18.

48.

Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system.

Akey DL, Brown WC, Dutta S, Konwerski J, Jose J, Jurkiw TJ, DelProposto J, Ogata CM, Skiniotis G, Kuhn RJ, Smith JL.

Science. 2014 Feb 21;343(6173):881-5. doi: 10.1126/science.1247749. Epub 2014 Feb 6.

49.

Collective variable approaches for single molecule flexible fitting and enhanced sampling.

Vashisth H, Skiniotis G, Brooks CL 3rd.

Chem Rev. 2014 Mar 26;114(6):3353-65. doi: 10.1021/cr4005988. Epub 2014 Jan 21. Review. No abstract available.

50.

Context dependency of Set1/COMPASS-mediated histone H3 Lys4 trimethylation.

Thornton JL, Westfield GH, Takahashi YH, Cook M, Gao X, Woodfin AR, Lee JS, Morgan MA, Jackson J, Smith ER, Couture JF, Skiniotis G, Shilatifard A.

Genes Dev. 2014 Jan 15;28(2):115-20. doi: 10.1101/gad.232215.113. Epub 2014 Jan 8.

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