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Items: 21


Growth kinetics of Chlamydia trachomatis in primary human Sertoli cells.

Filardo S, Skilton RJ, O'Neill CE, Di Pietro M, Sessa R, Clarke IN.

Sci Rep. 2019 Apr 10;9(1):5847. doi: 10.1038/s41598-019-42396-3.


Genetic Transformation of a C. trachomatis Ocular Isolate With the Functional Tryptophan Synthase Operon Confers an Indole-Rescuable Phenotype.

O'Neill CE, Skilton RJ, Pearson SA, Filardo S, Andersson P, Clarke IN.

Front Cell Infect Microbiol. 2018 Dec 14;8:434. doi: 10.3389/fcimb.2018.00434. eCollection 2018.


The Genetic Transformation of Chlamydia pneumoniae.

Shima K, Wanker M, Skilton RJ, Cutcliffe LT, Schnee C, Kohl TA, Niemann S, Geijo J, Klinger M, Timms P, Rattei T, Sachse K, Clarke IN, Rupp J.

mSphere. 2018 Oct 10;3(5). pii: e00412-18. doi: 10.1128/mSphere.00412-18.


The Chlamydia muridarum plasmid revisited : new insights into growth kinetics.

Skilton RJ, Wang Y, O'Neill C, Filardo S, Marsh P, Bénard A, Thomson NR, Ramsey KH, Clarke IN.

Wellcome Open Res. 2018 Mar 8;3:25. doi: 10.12688/wellcomeopenres.13905.1. eCollection 2018.


Structure-based design and functional studies of novel noroviral 3C protease chimaeras offer insights into substrate specificity.

Herod MR, Prince CA, Skilton RJ, Ward VK, Cooper JB, Clarke IN.

Biochem J. 2014 Dec 15;464(3):461-72. doi: 10.1042/BJ20140959.


Plasmid CDS5 influences infectivity and virulence in a mouse model of Chlamydia trachomatis urogenital infection.

Ramsey KH, Schripsema JH, Smith BJ, Wang Y, Jham BC, O'Hagan KP, Thomson NR, Murthy AK, Skilton RJ, Chu P, Clarke IN.

Infect Immun. 2014 Aug;82(8):3341-9. doi: 10.1128/IAI.01795-14. Epub 2014 May 27.


The genetic basis of plasmid tropism between Chlamydia trachomatis and Chlamydia muridarum.

Wang Y, Cutcliffe LT, Skilton RJ, Ramsey KH, Thomson NR, Clarke IN.

Pathog Dis. 2014 Oct;72(1):19-23. doi: 10.1111/2049-632X.12175. Epub 2014 May 8.


Expression of the murine norovirus (MNV) ORF1 polyprotein is sufficient to induce apoptosis in a virus-free cell model.

Herod MR, Salim O, Skilton RJ, Prince CA, Ward VK, Lambden PR, Clarke IN.

PLoS One. 2014 Mar 5;9(3):e90679. doi: 10.1371/journal.pone.0090679. eCollection 2014.


Transformation of a plasmid-free, genital tract isolate of Chlamydia trachomatis with a plasmid vector carrying a deletion in CDS6 revealed that this gene regulates inclusion phenotype.

Wang Y, Cutcliffe LT, Skilton RJ, Persson K, Bjartling C, Clarke IN.

Pathog Dis. 2013 Mar;67(2):100-3. doi: 10.1111/2049-632X.12024. Epub 2013 Feb 13.


Genetic transformation of a clinical (genital tract), plasmid-free isolate of Chlamydia trachomatis: engineering the plasmid as a cloning vector.

Wang Y, Kahane S, Cutcliffe LT, Skilton RJ, Lambden PR, Persson K, Bjartling C, Clarke IN.

PLoS One. 2013;8(3):e59195. doi: 10.1371/journal.pone.0059195. Epub 2013 Mar 18.


Whole-genome sequences of Chlamydia trachomatis directly from clinical samples without culture.

Seth-Smith HM, Harris SR, Skilton RJ, Radebe FM, Golparian D, Shipitsyna E, Duy PT, Scott P, Cutcliffe LT, O'Neill C, Parmar S, Pitt R, Baker S, Ison CA, Marsh P, Jalal H, Lewis DA, Unemo M, Clarke IN, Parkhill J, Thomson NR.

Genome Res. 2013 May;23(5):855-66. doi: 10.1101/gr.150037.112. Epub 2013 Mar 22.


Genotyping markers used for multi locus VNTR analysis with ompA (MLVA-ompA) and multi sequence typing (MST) retain stability in Chlamydia trachomatis.

Labiran C, Clarke IN, Cutcliffe LT, Wang Y, Skilton RJ, Persson K, Bjartling C, Herrmann B, Christerson L, Marsh P.

Front Cell Infect Microbiol. 2012 May 17;2:68. doi: 10.3389/fcimb.2012.00068. eCollection 2012.


Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing.

Harris SR, Clarke IN, Seth-Smith HM, Solomon AW, Cutcliffe LT, Marsh P, Skilton RJ, Holland MJ, Mabey D, Peeling RW, Lewis DA, Spratt BG, Unemo M, Persson K, Bjartling C, Brunham R, de Vries HJ, Morré SA, Speksnijder A, Bébéar CM, Clerc M, de Barbeyrac B, Parkhill J, Thomson NR.

Nat Genet. 2012 Mar 11;44(4):413-9, S1. doi: 10.1038/ng.2214.


Development of a transformation system for Chlamydia trachomatis: restoration of glycogen biosynthesis by acquisition of a plasmid shuttle vector.

Wang Y, Kahane S, Cutcliffe LT, Skilton RJ, Lambden PR, Clarke IN.

PLoS Pathog. 2011 Sep;7(9):e1002258. doi: 10.1371/journal.ppat.1002258. Epub 2011 Sep 22.


Evaluation of a high resolution genotyping method for Chlamydia trachomatis using routine clinical samples.

Wang Y, Skilton RJ, Cutcliffe LT, Andrews E, Clarke IN, Marsh P.

PLoS One. 2011 Feb 11;6(2):e16971. doi: 10.1371/journal.pone.0016971.


Genome sequence of the zoonotic pathogen Chlamydophila psittaci.

Seth-Smith HM, Harris SR, Rance R, West AP, Severin JA, Ossewaarde JM, Cutcliffe LT, Skilton RJ, Marsh P, Parkhill J, Clarke IN, Thomson NR.

J Bacteriol. 2011 Mar;193(5):1282-3. doi: 10.1128/JB.01435-10. Epub 2010 Dec 23.


The Swedish new variant of Chlamydia trachomatis: genome sequence, morphology, cell tropism and phenotypic characterization.

Unemo M, Seth-Smith HM, Cutcliffe LT, Skilton RJ, Barlow D, Goulding D, Persson K, Harris SR, Kelly A, Bjartling C, Fredlund H, Olcén P, Thomson NR, Clarke IN.

Microbiology. 2010 May;156(Pt 5):1394-404. doi: 10.1099/mic.0.036830-0. Epub 2010 Jan 21.


Penicillin induced persistence in Chlamydia trachomatis: high quality time lapse video analysis of the developmental cycle.

Skilton RJ, Cutcliffen LT, Barlow D, Wang Y, Salim O, Lambden PR, Clarke IN.

PLoS One. 2009 Nov 6;4(11):e7723. doi: 10.1371/journal.pone.0007723.


Co-evolution of genomes and plasmids within Chlamydia trachomatis and the emergence in Sweden of a new variant strain.

Seth-Smith HM, Harris SR, Persson K, Marsh P, Barron A, Bignell A, Bjartling C, Clark L, Cutcliffe LT, Lambden PR, Lennard N, Lockey SJ, Quail MA, Salim O, Skilton RJ, Wang Y, Holland MJ, Parkhill J, Thomson NR, Clarke IN.

BMC Genomics. 2009 May 21;10:239. doi: 10.1186/1471-2164-10-239.


Behind the chlamydial cloak: the replication cycle of chlamydiaphage Chp2, revealed.

Salim O, Skilton RJ, Lambden PR, Fane BA, Clarke IN.

Virology. 2008 Aug 1;377(2):440-5. doi: 10.1016/j.virol.2008.05.001.


Intracellular parasitism of chlamydiae: specific infectivity of chlamydiaphage Chp2 in Chlamydophila abortus.

Skilton RJ, Cutcliffe LT, Pickett MA, Lambden PR, Fane BA, Clarke IN.

J Bacteriol. 2007 Jul;189(13):4957-9. Epub 2007 Apr 27.

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