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Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity.

Burmeister BT, Wang L, Gold MG, Skidgel RA, O'Bryan JP, Carnegie GK.

J Biol Chem. 2015 May 8;290(19):12058-67. doi: 10.1074/jbc.M115.642983. Epub 2015 Mar 23.


UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy.

Wang L, Burmeister BT, Johnson KR, Baillie GS, Karginov AV, Skidgel RA, O'Bryan JP, Carnegie GK.

Cell Signal. 2015 May;27(5):908-22. doi: 10.1016/j.cellsig.2015.02.003. Epub 2015 Feb 12.


Downregulation of kinin B1 receptor function by B2 receptor heterodimerization and signaling.

Zhang X, Brovkovych V, Zhang Y, Tan F, Skidgel RA.

Cell Signal. 2015 Jan;27(1):90-103. doi: 10.1016/j.cellsig.2014.09.019. Epub 2014 Oct 5.


PR65A phosphorylation regulates PP2A complex signaling.

Kotlo K, Xing Y, Lather S, Grillon JM, Johnson K, Skidgel RA, Solaro RJ, Danziger RS.

PLoS One. 2014 Jan 21;9(1):e85000. doi: 10.1371/journal.pone.0085000. eCollection 2014.


Carboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor.

Zhang X, Tan F, Skidgel RA.

J Biol Chem. 2013 Nov 15;288(46):33226-40. doi: 10.1074/jbc.M113.520791. Epub 2013 Oct 9.


Endothelial nitric-oxide synthase activation generates an inducible nitric-oxide synthase-like output of nitric oxide in inflamed endothelium.

Lowry JL, Brovkovych V, Zhang Y, Skidgel RA.

J Biol Chem. 2013 Feb 8;288(6):4174-93. doi: 10.1074/jbc.M112.436022. Epub 2012 Dec 19.


Carboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide output.

Zhang X, Tan F, Brovkovych V, Zhang Y, Lowry JL, Skidgel RA.

Biol Chem. 2013 Mar;394(3):335-45. doi: 10.1515/hsz-2012-0290. Review.


ICAM-1-activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration.

Liu G, Place AT, Chen Z, Brovkovych VM, Vogel SM, Muller WA, Skidgel RA, Malik AB, Minshall RD.

Blood. 2012 Aug 30;120(9):1942-52. doi: 10.1182/blood-2011-12-397430. Epub 2012 Jul 17.


Characterization of dual agonists for kinin B1 and B2 receptors and their biased activation of B2 receptors.

Zhang X, Lowry JL, Brovkovych V, Skidgel RA.

Cell Signal. 2012 Aug;24(8):1619-31. doi: 10.1016/j.cellsig.2012.04.002. Epub 2012 Apr 12.


Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition.

Chen Z, Bakhshi FR, Shajahan AN, Sharma T, Mao M, Trane A, Bernatchez P, van Nieuw Amerongen GP, Bonini MG, Skidgel RA, Malik AB, Minshall RD.

Mol Biol Cell. 2012 Apr;23(7):1388-98. doi: 10.1091/mbc.E11-09-0811. Epub 2012 Feb 9.


Cross-talk between carboxypeptidase M and the kinin B1 receptor mediates a new mode of G protein-coupled receptor signaling.

Zhang X, Tan F, Brovkovych V, Zhang Y, Skidgel RA.

J Biol Chem. 2011 May 27;286(21):18547-61. doi: 10.1074/jbc.M110.214940. Epub 2011 Mar 31.


Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model.

Zhao Y, Guo C, Hwang D, Lin B, Dingeldein M, Mihailescu D, Sam S, Sidhwani S, Zhang Y, Jain S, Skidgel RA, Prabhakar BS, Mazzone T, Holterman MJ.

Biochem Biophys Res Commun. 2010 Sep 3;399(4):629-36. doi: 10.1016/j.bbrc.2010.07.128. Epub 2010 Aug 4.


Beta-arrestin 2 is required for B1 receptor-dependent post-translational activation of inducible nitric oxide synthase.

Kuhr FK, Zhang Y, Brovkovych V, Skidgel RA.

FASEB J. 2010 Jul;24(7):2475-83. doi: 10.1096/fj.09-148783. Epub 2010 Mar 12.


Angiotensin I-converting enzyme inhibitors are allosteric enhancers of kinin B1 and B2 receptor function.

Erdös EG, Tan F, Skidgel RA.

Hypertension. 2010 Feb;55(2):214-20. doi: 10.1161/HYPERTENSIONAHA.109.144600. Epub 2010 Jan 11. Review.


Differential regulation of inducible and endothelial nitric oxide synthase by kinin B1 and B2 receptors.

Kuhr F, Lowry J, Zhang Y, Brovkovych V, Skidgel RA.

Neuropeptides. 2010 Apr;44(2):145-54. doi: 10.1016/j.npep.2009.12.004. Epub 2010 Jan 4. Review.


A novel pathway for receptor-mediated post-translational activation of inducible nitric oxide synthase.

Brovkovych V, Zhang Y, Brovkovych S, Minshall RD, Skidgel RA.

J Cell Mol Med. 2011 Feb;15(2):258-69. doi: 10.1111/j.1582-4934.2009.00992.x.


Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese diabetic (NOD) mice.

Zhao Y, Lin B, Darflinger R, Zhang Y, Holterman MJ, Skidgel RA.

PLoS One. 2009;4(1):e4226. doi: 10.1371/journal.pone.0004226. Epub 2009 Jan 19.


Signaling-mediated functional activation of inducible nitric-oxide synthase and its role in stimulating platelet activation.

Marjanovic JA, Stojanovic A, Brovkovych VM, Skidgel RA, Du X.

J Biol Chem. 2008 Oct 24;283(43):28827-34. doi: 10.1074/jbc.M801646200. Epub 2008 Aug 27.


Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice.

Brovkovych V, Gao XP, Ong E, Brovkovych S, Brennan ML, Su X, Hazen SL, Malik AB, Skidgel RA.

Am J Physiol Lung Cell Mol Physiol. 2008 Jul;295(1):L96-103. doi: 10.1152/ajplung.00450.2007. Epub 2008 Apr 18.


Carboxypeptidase M and kinin B1 receptors interact to facilitate efficient b1 signaling from B2 agonists.

Zhang X, Tan F, Zhang Y, Skidgel RA.

J Biol Chem. 2008 Mar 21;283(12):7994-8004. doi: 10.1074/jbc.M709837200. Epub 2008 Jan 10.


Structure and function of human plasma carboxypeptidase N, the anaphylatoxin inactivator.

Skidgel RA, Erdös EG.

Int Immunopharmacol. 2007 Dec 20;7(14):1888-99. Epub 2007 Aug 15. Review.


Dynamic receptor-dependent activation of inducible nitric-oxide synthase by ERK-mediated phosphorylation of Ser745.

Zhang Y, Brovkovych V, Brovkovych S, Tan F, Lee BS, Sharma T, Skidgel RA.

J Biol Chem. 2007 Nov 2;282(44):32453-61. Epub 2007 Sep 5.


Aminopeptidase N reduces basolateral Na+ -K+ -ATPase in proximal tubule cells.

Kotlo K, Shukla S, Tawar U, Skidgel RA, Danziger RS.

Am J Physiol Renal Physiol. 2007 Oct;293(4):F1047-53. Epub 2007 Jul 18.


Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain.

Keil C, Maskos K, Than M, Hoopes JT, Huber R, Tan F, Deddish PA, Erdös EG, Skidgel RA, Bode W.

J Mol Biol. 2007 Feb 16;366(2):504-16. Epub 2006 Nov 11.


Novel mechanism of endothelial nitric oxide synthase activation mediated by caveolae internalization in endothelial cells.

Maniatis NA, Brovkovych V, Allen SE, John TA, Shajahan AN, Tiruppathi C, Vogel SM, Skidgel RA, Malik AB, Minshall RD.

Circ Res. 2006 Oct 13;99(8):870-7. Epub 2006 Sep 14.


Caveolin-1 regulates store-operated Ca2+ influx by binding of its scaffolding domain to transient receptor potential channel-1 in endothelial cells.

Kwiatek AM, Minshall RD, Cool DR, Skidgel RA, Malik AB, Tiruppathi C.

Mol Pharmacol. 2006 Oct;70(4):1174-83. Epub 2006 Jul 5.


A phosphoinositide 3-kinase-AKT-nitric oxide-cGMP signaling pathway in stimulating platelet secretion and aggregation.

Stojanovic A, Marjanovic JA, Brovkovych VM, Peng X, Hay N, Skidgel RA, Du X.

J Biol Chem. 2006 Jun 16;281(24):16333-9. Epub 2006 Apr 13.


Kinin- and angiotensin-converting enzyme (ACE) inhibitor-mediated nitric oxide production in endothelial cells.

Skidgel RA, Stanisavljevic S, Erdös EG.

Biol Chem. 2006 Feb;387(2):159-65. Review.


Novel mechanisms of G protein-dependent regulation of endothelial nitric-oxide synthase.

Andreeva AV, Vaiskunaite R, Kutuzov MA, Profirovic J, Skidgel RA, Voyno-Yasenetskaya T.

Mol Pharmacol. 2006 Mar;69(3):975-82. Epub 2005 Dec 2.


Angiotensin I-converting enzyme inhibitors block protein kinase C epsilon by activating bradykinin B1 receptors in human endothelial cells.

Stanisavljevic S, Ignjatovic T, Deddish PA, Brovkovych V, Zhang K, Erdös EG, Skidgel RA.

J Pharmacol Exp Ther. 2006 Mar;316(3):1153-8. Epub 2005 Nov 10.


Plasmin alters the activity and quaternary structure of human plasma carboxypeptidase N.

Quagraine MO, Tan F, Tamei H, Erdös EG, Skidgel RA.

Biochem J. 2005 May 15;388(Pt 1):81-91.


Kinin B1 receptors stimulate nitric oxide production in endothelial cells: signaling pathways activated by angiotensin I-converting enzyme inhibitors and peptide ligands.

Ignjatovic T, Stanisavljevic S, Brovkovych V, Skidgel RA, Erdös EG.

Mol Pharmacol. 2004 Nov;66(5):1310-6. Epub 2004 Aug 10.


Expression of the third complement component (C3) and carboxypeptidase N small subunit (CPN1) during mouse embryonic development.

Matthews KW, Drouin SM, Liu C, Martin JF, Skidgel RA, Wetsel RA.

Dev Comp Immunol. 2004 May 17;28(6):647-55.


Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity.

Reverter D, Maskos K, Tan F, Skidgel RA, Bode W.

J Mol Biol. 2004 Apr 23;338(2):257-69.


Carboxypeptidase-mediated enhancement of nitric oxide production in rat lungs and microvascular endothelial cells.

Hadkar V, Sangsree S, Vogel SM, Brovkovych V, Skidgel RA.

Am J Physiol Lung Cell Mol Physiol. 2004 Jul;287(1):L35-45. Epub 2004 Feb 20.


The ectodomain shedding of angiotensin-converting enzyme is independent of its localisation in lipid rafts.

Parkin ET, Tan F, Skidgel RA, Turner AJ, Hooper NM.

J Cell Sci. 2003 Aug 1;116(Pt 15):3079-87. Epub 2003 Jun 10.


Prologue: kinins and related systems. New life for old discoveries.

Skidgel RA, Alhenc-Gelas F, Campbell WB.

Am J Physiol Heart Circ Physiol. 2003 Jun;284(6):H1886-91. Review. No abstract available.


Kininase I-type carboxypeptidases enhance nitric oxide production in endothelial cells by generating bradykinin B1 receptor agonists.

Sangsree S, Brovkovych V, Minshall RD, Skidgel RA.

Am J Physiol Heart Circ Physiol. 2003 Jun;284(6):H1959-68. Epub 2003 Mar 6.


Structural characterization of the human carboxypeptidase D gene and its promoter.

Timblin B, Rehli M, Skidgel RA.

Int Immunopharmacol. 2002 Dec;2(13-14):1907-17.


Activation of bradykinin B1 receptor by ACE inhibitors.

Ignjatovic T, Tan F, Brovkovych V, Skidgel RA, Erdös EG.

Int Immunopharmacol. 2002 Dec;2(13-14):1787-93. Review.


Nitric oxide stimulates macrophage inflammatory protein-2 expression in sepsis.

Skidgel RA, Gao XP, Brovkovych V, Rahman A, Jho D, Predescu S, Standiford TJ, Malik AB.

J Immunol. 2002 Aug 15;169(4):2093-101.


Proliferation of regulatory mechanisms for eNOS: an emerging role for the cytoskeleton.

Skidgel RA.

Am J Physiol Lung Cell Mol Physiol. 2002 Jun;282(6):L1179-82. No abstract available.


Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor.

Ignjatovic T, Tan F, Brovkovych V, Skidgel RA, Erdös EG.

J Biol Chem. 2002 May 10;277(19):16847-52. Epub 2002 Mar 5.


Des-Arg9-bradykinin metabolism in patients who presented hypersensitivity reactions during hemodialysis: role of serum ACE and aminopeptidase P.

Blais C Jr, Marc-Aurèle J, Simmons WH, Loute G, Thibault P, Skidgel RA, Adam A.

Peptides. 1999;20(4):421-30.


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