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Items: 1 to 50 of 82

1.

Nicotinamide limits replication of Mycobacterium tuberculosis and BCG within macrophages.

Simmons JD, Peterson GJ, Campo M, Lohmiller J, Skerrett SJ, Tunaru S, Offermanns S, Sherman DR, Hawn TR.

J Infect Dis. 2019 Oct 31. pii: jiz541. doi: 10.1093/infdis/jiz541. [Epub ahead of print]

PMID:
31665359
2.

TOLLIP deficiency is associated with increased resistance to Legionella pneumophila pneumonia.

Shah JA, Emery R, Lee B, Venkatasubramanian S, Simmons JD, Brown M, Hung CF, Prins JM, Verbon A, Hawn TR, Skerrett SJ.

Mucosal Immunol. 2019 Nov;12(6):1382-1390. doi: 10.1038/s41385-019-0196-7. Epub 2019 Aug 28.

PMID:
31462698
3.

Prevention of Health Care-Associated Legionnaires Disease.

Skerrett SJ.

JAMA Netw Open. 2018 Jun 1;1(2):e180232. doi: 10.1001/jamanetworkopen.2018.0232. No abstract available.

PMID:
30646069
4.

Glycan targeted polymeric antibiotic prodrugs for alveolar macrophage infections.

Chen J, Su FY, Das D, Srinivasan S, Son HN, Lee B, Radella F 2nd, Whittington D, Monroe-Jones T, West TE, Convertine AJ, Skerrett SJ, Stayton PS, Ratner DM.

Biomaterials. 2019 Mar;195:38-50. doi: 10.1016/j.biomaterials.2018.10.017. Epub 2018 Oct 16.

PMID:
30610992
5.

Macrophage-targeted drugamers with enzyme-cleavable linkers deliver high intracellular drug dosing and sustained drug pharmacokinetics against alveolar pulmonary infections.

Su FY, Srinivasan S, Lee B, Chen J, Convertine AJ, West TE, Ratner DM, Skerrett SJ, Stayton PS.

J Control Release. 2018 Oct 10;287:1-11. doi: 10.1016/j.jconrel.2018.08.014. Epub 2018 Aug 9.

6.

A Phosphatidylinositol 3-Kinase Effector Alters Phagosomal Maturation to Promote Intracellular Growth of Francisella.

Ledvina HE, Kelly KA, Eshraghi A, Plemel RL, Peterson SB, Lee B, Steele S, Adler M, Kawula TH, Merz AJ, Skerrett SJ, Celli J, Mougous JD.

Cell Host Microbe. 2018 Aug 8;24(2):285-295.e8. doi: 10.1016/j.chom.2018.07.003. Epub 2018 Jul 26.

7.

Polymer-augmented liposomes enhancing antibiotic delivery against intracellular infections.

Su FY, Chen J, Son HN, Kelly AM, Convertine AJ, West TE, Skerrett SJ, Ratner DM, Stayton PS.

Biomater Sci. 2018 Jun 25;6(7):1976-1985. doi: 10.1039/c8bm00282g.

8.

Cytometry TOF identifies alveolar macrophage subtypes in acute respiratory distress syndrome.

Morrell ED, Wiedeman A, Long SA, Gharib SA, West TE, Skerrett SJ, Wurfel MM, Mikacenic C.

JCI Insight. 2018 May 17;3(10). pii: 99281. doi: 10.1172/jci.insight.99281. eCollection 2018 May 17.

9.

Toll-like receptor 2 has a prominent but nonessential role in innate immunity to Staphylococcus aureus pneumonia.

Skerrett SJ, Braff MH, Liggitt HD, Rubens CE.

Physiol Rep. 2017 Nov;5(21). pii: e13491. doi: 10.14814/phy2.13491.

10.

Synthetic Macromolecular Antibiotic Platform for Inhalable Therapy against Aerosolized Intracellular Alveolar Infections.

Das D, Chen J, Srinivasan S, Kelly AM, Lee B, Son HN, Radella F, West TE, Ratner DM, Convertine AJ, Skerrett SJ, Stayton PS.

Mol Pharm. 2017 Jun 5;14(6):1988-1997. doi: 10.1021/acs.molpharmaceut.7b00093. Epub 2017 May 9.

PMID:
28394614
11.

CLINICAL PROBLEM-SOLVING. Back to Nature.

James J, Kaul DR, Goldberger ZD, Saint S, Skerrett SJ.

N Engl J Med. 2015 Dec 3;373(23):2271-6. doi: 10.1056/NEJMcps1407030. No abstract available.

PMID:
26630146
12.

Prior infection with Type A Francisella tularensis antagonizes the pulmonary transcriptional response to an aerosolized Toll-like receptor 4 agonist.

Walters KA, Olsufka R, Kuestner RE, Wu X, Wang K, Skerrett SJ, Ozinsky A.

BMC Genomics. 2015 Oct 28;16:874. doi: 10.1186/s12864-015-2022-2.

13.

NLRC4 and TLR5 each contribute to host defense in respiratory melioidosis.

West TE, Myers ND, Chantratita N, Chierakul W, Limmathurotsakul D, Wuthiekanun V, Miao EA, Hajjar AM, Peacock SJ, Liggitt HD, Skerrett SJ.

PLoS Negl Trop Dis. 2014 Sep 18;8(9):e3178. doi: 10.1371/journal.pntd.0003178. eCollection 2014 Sep.

14.

VgrG-5 is a Burkholderia type VI secretion system-exported protein required for multinucleated giant cell formation and virulence.

Schwarz S, Singh P, Robertson JD, LeRoux M, Skerrett SJ, Goodlett DR, West TE, Mougous JD.

Infect Immun. 2014 Apr;82(4):1445-52. doi: 10.1128/IAI.01368-13. Epub 2014 Jan 22.

15.

The role of NOD2 in murine and human melioidosis.

Myers ND, Chantratita N, Berrington WR, Chierakul W, Limmathurotsakul D, Wuthiekanun V, Robertson JD, Liggitt HD, Peacock SJ, Skerrett SJ, West TE.

J Immunol. 2014 Jan 1;192(1):300-7. doi: 10.4049/jimmunol.1301436. Epub 2013 Dec 2.

17.

A TLR6 polymorphism is associated with increased risk of Legionnaires' disease.

Misch EA, Verbon A, Prins JM, Skerrett SJ, Hawn TR.

Genes Immun. 2013 Oct;14(7):420-6. doi: 10.1038/gene.2013.34. Epub 2013 Jul 4.

18.

Francisella tularensis subsp. tularensis induces a unique pulmonary inflammatory response: role of bacterial gene expression in temporal regulation of host defense responses.

Walters KA, Olsufka R, Kuestner RE, Cho JH, Li H, Zornetzer GA, Wang K, Skerrett SJ, Ozinsky A.

PLoS One. 2013 May 14;8(5):e62412. doi: 10.1371/journal.pone.0062412. Print 2013.

19.

Impaired TLR5 functionality is associated with survival in melioidosis.

West TE, Chantratita N, Chierakul W, Limmathurotsakul D, Wuthiekanun V, Myers ND, Emond MJ, Wurfel MM, Hawn TR, Peacock SJ, Skerrett SJ.

J Immunol. 2013 Apr 1;190(7):3373-9. doi: 10.4049/jimmunol.1202974. Epub 2013 Feb 27.

20.

Murine pulmonary infection and inflammation induced by inhalation of Burkholderia pseudomallei.

West TE, Myers ND, Liggitt HD, Skerrett SJ.

Int J Exp Pathol. 2012 Dec;93(6):421-8. doi: 10.1111/j.1365-2613.2012.00842.x.

21.

Changes in the Staphylococcus aureus transcriptome during early adaptation to the lung.

Chaffin DO, Taylor D, Skerrett SJ, Rubens CE.

PLoS One. 2012;7(8):e41329. doi: 10.1371/journal.pone.0041329. Epub 2012 Aug 2.

22.

Proteomic analysis of bronchoalveolar lavage fluid proteins from mice infected with Francisella tularensis ssp. novicida.

Varnum SM, Webb-Robertson BJ, Pounds JG, Moore RJ, Smith RD, Frevert CW, Skerrett SJ, Wunschel D.

J Proteome Res. 2012 Jul 6;11(7):3690-703. doi: 10.1021/pr3001767. Epub 2012 Jun 22.

23.

Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses.

Kanistanon D, Powell DA, Hajjar AM, Pelletier MR, Cohen IE, Way SS, Skerrett SJ, Wang X, Raetz CR, Ernst RK.

Infect Immun. 2012 Mar;80(3):943-51. doi: 10.1128/IAI.06109-11. Epub 2012 Jan 3.

24.

Toll-like receptor 4 region genetic variants are associated with susceptibility to melioidosis.

West TE, Chierakul W, Chantratita N, Limmathurotsakul D, Wuthiekanun V, Emond MJ, Hawn TR, Peacock SJ, Skerrett SJ.

Genes Immun. 2012 Jan;13(1):38-46. doi: 10.1038/gene.2011.49. Epub 2011 Jul 21.

25.

NOD1 and NOD2 regulation of pulmonary innate immunity to Legionella pneumophila.

Berrington WR, Iyer R, Wells RD, Smith KD, Skerrett SJ, Hawn TR.

Eur J Immunol. 2010 Dec;40(12):3519-27. doi: 10.1002/eji.201040518. Epub 2010 Nov 11.

26.

Pathogenicity of high-dose enteral inoculation of Burkholderia pseudomallei to mice.

West TE, Myers ND, Limmathurotsakul D, Liggitt HD, Chantratita N, Peacock SJ, Skerrett SJ.

Am J Trop Med Hyg. 2010 Nov;83(5):1066-9. doi: 10.4269/ajtmh.2010.10-0306.

27.

Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions.

Schwarz S, West TE, Boyer F, Chiang WC, Carl MA, Hood RD, Rohmer L, Tolker-Nielsen T, Skerrett SJ, Mougous JD.

PLoS Pathog. 2010 Aug 26;6(8):e1001068. doi: 10.1371/journal.ppat.1001068.

28.

Role of Toll-like receptor 5 in the innate immune response to acute P. aeruginosa pneumonia.

Morris AE, Liggitt HD, Hawn TR, Skerrett SJ.

Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1112-9. doi: 10.1152/ajplung.00155.2009. Epub 2009 Oct 2.

29.

Toll-like receptor signaling in airborne Burkholderia thailandensis infection.

West TE, Hawn TR, Skerrett SJ.

Infect Immun. 2009 Dec;77(12):5612-22. doi: 10.1128/IAI.00618-09. Epub 2009 Sep 21.

30.

Mutational analysis of Burkholderia thailandensis quorum sensing and self-aggregation.

Chandler JR, Duerkop BA, Hinz A, West TE, Herman JP, Churchill ME, Skerrett SJ, Greenberg EP.

J Bacteriol. 2009 Oct;191(19):5901-9. doi: 10.1128/JB.00591-09. Epub 2009 Jul 31.

31.

Epilysin (MMP-28) restrains early macrophage recruitment in Pseudomonas aeruginosa pneumonia.

Manicone AM, Birkland TP, Lin M, Betsuyaku T, van Rooijen N, Lohi J, Keski-Oja J, Wang Y, Skerrett SJ, Parks WC.

J Immunol. 2009 Mar 15;182(6):3866-76. doi: 10.4049/jimmunol.0713949.

32.

A Bayesian integration model of high-throughput proteomics and metabolomics data for improved early detection of microbial infections.

Webb-Robertson BJ, McCue LA, Beagley N, McDermott JE, Wunschel DS, Varnum SM, Hu JZ, Isern NG, Buchko GW, Mcateer K, Pounds JG, Skerrett SJ, Liggitt D, Frevert CW.

Pac Symp Biocomput. 2009:451-63.

33.

Inhalation of Burkholderia thailandensis results in lethal necrotizing pneumonia in mice: a surrogate model for pneumonic melioidosis.

West TE, Frevert CW, Liggitt HD, Skerrett SJ.

Trans R Soc Trop Med Hyg. 2008 Dec;102 Suppl 1:S119-26. doi: 10.1016/S0035-9203(08)70028-2.

34.

Management of pulmonary nontuberculous mycobacterial disease.

Horan KL, Skerrett SJ.

F1000 Med Rep. 2009 Dec 15;1. pii: 99. doi: 10.3410/M1-99.

35.

Staphylococcus aureus elicits marked alterations in the airway proteome during early pneumonia.

Ventura CL, Higdon R, Hohmann L, Martin D, Kolker E, Liggitt HD, Skerrett SJ, Rubens CE.

Infect Immun. 2008 Dec;76(12):5862-72. doi: 10.1128/IAI.00865-08. Epub 2008 Oct 13.

36.

Burkholderia thailandensis as a model system for the study of the virulence-associated type III secretion system of Burkholderia pseudomallei.

Haraga A, West TE, Brittnacher MJ, Skerrett SJ, Miller SI.

Infect Immun. 2008 Nov;76(11):5402-11. doi: 10.1128/IAI.00626-08. Epub 2008 Sep 8.

37.

Activation of Toll-like receptors by Burkholderia pseudomallei.

West TE, Ernst RK, Jansson-Hutson MJ, Skerrett SJ.

BMC Immunol. 2008 Aug 8;9:46. doi: 10.1186/1471-2172-9-46.

38.

Inhalation of Francisella novicida Delta mglA causes replicative infection that elicits innate and adaptive responses but is not protective against invasive pneumonic tularemia.

West TE, Pelletier MR, Majure MC, Lembo A, Hajjar AM, Skerrett SJ.

Microbes Infect. 2008 Jun;10(7):773-80. doi: 10.1016/j.micinf.2008.04.008. Epub 2008 Apr 22.

39.

Development of a guideline for the management of ventilator-associated pneumonia based on local microbiologic findings and impact of the guideline on antimicrobial use practices.

Dellit TH, Chan JD, Skerrett SJ, Nathens AB.

Infect Control Hosp Epidemiol. 2008 Jun;29(6):525-33. doi: 10.1086/588160.

PMID:
18510462
40.

Administration of a synthetic TLR4 agonist protects mice from pneumonic tularemia.

Lembo A, Pelletier M, Iyer R, Timko M, Dudda JC, West TE, Wilson CB, Hajjar AM, Skerrett SJ.

J Immunol. 2008 Jun 1;180(11):7574-81.

41.

A Francisella mutant in lipid A carbohydrate modification elicits protective immunity.

Kanistanon D, Hajjar AM, Pelletier MR, Gallagher LA, Kalhorn T, Shaffer SA, Goodlett DR, Rohmer L, Brittnacher MJ, Skerrett SJ, Ernst RK.

PLoS Pathog. 2008 Feb 8;4(2):e24. doi: 10.1371/journal.ppat.0040024.

42.

Host airway proteins interact with Staphylococcus aureus during early pneumonia.

Ventura CL, Higdon R, Kolker E, Skerrett SJ, Rubens CE.

Infect Immun. 2008 Mar;76(3):888-98. doi: 10.1128/IAI.01301-07. Epub 2008 Jan 14.

43.

Animal models of human pneumonia.

Mizgerd JP, Skerrett SJ.

Am J Physiol Lung Cell Mol Physiol. 2008 Mar;294(3):L387-98. Epub 2007 Dec 27. Review.

44.

Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila.

Hawn TR, Berrington WR, Smith IA, Uematsu S, Akira S, Aderem A, Smith KD, Skerrett SJ.

J Immunol. 2007 Nov 15;179(10):6981-7.

45.
46.

Functions and regulation of NF-kappaB RelA during pneumococcal pneumonia.

Quinton LJ, Jones MR, Simms BT, Kogan MS, Robson BE, Skerrett SJ, Mizgerd JP.

J Immunol. 2007 Feb 1;178(3):1896-903.

47.

Type IV pili-mediated secretion modulates Francisella virulence.

Hager AJ, Bolton DL, Pelletier MR, Brittnacher MJ, Gallagher LA, Kaul R, Skerrett SJ, Miller SI, Guina T.

Mol Microbiol. 2006 Oct;62(1):227-37.

48.

Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors.

Hajjar AM, Harvey MD, Shaffer SA, Goodlett DR, Sjöstedt A, Edebro H, Forsman M, Byström M, Pelletier M, Wilson CB, Miller SI, Skerrett SJ, Ernst RK.

Infect Immun. 2006 Dec;74(12):6730-8. Epub 2006 Sep 18.

49.

Redundant Toll-like receptor signaling in the pulmonary host response to Pseudomonas aeruginosa.

Skerrett SJ, Wilson CB, Liggitt HD, Hajjar AM.

Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L312-22. Epub 2006 Aug 25.

50.

Myeloid differentiation primary response gene (88)- and toll-like receptor 2-deficient mice are susceptible to infection with aerosolized Legionella pneumophila.

Hawn TR, Smith KD, Aderem A, Skerrett SJ.

J Infect Dis. 2006 Jun 15;193(12):1693-702. Epub 2006 May 11.

PMID:
16703513

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