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Items: 37


Genomewide and Enzymatic Analysis Reveals Efficient d-Galacturonic Acid Metabolism in the Basidiomycete Yeast Rhodosporidium toruloides.

Protzko RJ, Hach CA, Coradetti ST, Hackhofer MA, Magosch S, Thieme N, Geiselman GM, Arkin AP, Skerker JM, Dueber JE, Benz JP.

mSystems. 2019 Dec 17;4(6). pii: e00389-19. doi: 10.1128/mSystems.00389-19.


A toolset of constitutive promoters for metabolic engineering of Rhodosporidium toruloides.

Nora LC, Wehrs M, Kim J, Cheng JF, Tarver A, Simmons BA, Magnuson J, Harmon-Smith M, Silva-Rocha R, Gladden JM, Mukhopadhyay A, Skerker JM, Kirby J.

Microb Cell Fact. 2019 Jun 29;18(1):117. doi: 10.1186/s12934-019-1167-0.


Multiplexed CRISPR-Cas9-Based Genome Editing of Rhodosporidium toruloides.

Otoupal PB, Ito M, Arkin AP, Magnuson JK, Gladden JM, Skerker JM.

mSphere. 2019 Mar 20;4(2). pii: e00099-19. doi: 10.1128/mSphere.00099-19.


Monoterpene production by the carotenogenic yeast Rhodosporidium toruloides.

Zhuang X, Kilian O, Monroe E, Ito M, Tran-Gymfi MB, Liu F, Davis RW, Mirsiaghi M, Sundstrom E, Pray T, Skerker JM, George A, Gladden JM.

Microb Cell Fact. 2019 Mar 18;18(1):54. doi: 10.1186/s12934-019-1099-8.


Transposon insertional mutagenesis in Saccharomyces uvarum reveals trans-acting effects influencing species-dependent essential genes.

Sanchez MR, Payen C, Cheong F, Hovde BT, Bissonnette S, Arkin AP, Skerker JM, Brem RB, Caudy AA, Dunham MJ.

Genome Res. 2019 Mar;29(3):396-406. doi: 10.1101/gr.232330.117. Epub 2019 Jan 11.


Genetic dissection of interspecific differences in yeast thermotolerance.

Weiss CV, Roop JI, Hackley RK, Chuong JN, Grigoriev IV, Arkin AP, Skerker JM, Brem RB.

Nat Genet. 2018 Nov;50(11):1501-1504. doi: 10.1038/s41588-018-0243-4. Epub 2018 Oct 8.


Engineering Kluyveromyces marxianus as a Robust Synthetic Biology Platform Host.

Cernak P, Estrela R, Poddar S, Skerker JM, Cheng YF, Carlson AK, Chen B, Glynn VM, Furlan M, Ryan OW, Donnelly MK, Arkin AP, Taylor JW, Cate JHD.

mBio. 2018 Sep 25;9(5). pii: e01410-18. doi: 10.1128/mBio.01410-18.


Functional genomics of lipid metabolism in the oleaginous yeast Rhodosporidium toruloides.

Coradetti ST, Pinel D, Geiselman GM, Ito M, Mondo SJ, Reilly MC, Cheng YF, Bauer S, Grigoriev IV, Gladden JM, Simmons BA, Brem RB, Arkin AP, Skerker JM.

Elife. 2018 Mar 9;7. pii: e32110. doi: 10.7554/eLife.32110.


Rhodosporidium toruloides: a new platform organism for conversion of lignocellulose into terpene biofuels and bioproducts.

Yaegashi J, Kirby J, Ito M, Sun J, Dutta T, Mirsiaghi M, Sundstrom ER, Rodriguez A, Baidoo E, Tanjore D, Pray T, Sale K, Singh S, Keasling JD, Simmons BA, Singer SW, Magnuson JK, Arkin AP, Skerker JM, Gladden JM.

Biotechnol Biofuels. 2017 Oct 23;10:241. doi: 10.1186/s13068-017-0927-5. eCollection 2017.


Metabolic engineering of a haploid strain derived from a triploid industrial yeast for producing cellulosic ethanol.

Kim SR, Skerker JM, Kong II, Kim H, Maurer MJ, Zhang GC, Peng D, Wei N, Arkin AP, Jin YS.

Metab Eng. 2017 Mar;40:176-185. doi: 10.1016/j.ymben.2017.02.006. Epub 2017 Feb 16.


Quantitative Trait Loci (QTL)-Guided Metabolic Engineering of a Complex Trait.

Maurer MJ, Sutardja L, Pinel D, Bauer S, Muehlbauer AL, Ames TD, Skerker JM, Arkin AP.

ACS Synth Biol. 2017 Mar 17;6(3):566-581. doi: 10.1021/acssynbio.6b00264. Epub 2016 Dec 28.


Metabolic engineering of the oleaginous yeast Rhodosporidium toruloides IFO0880 for lipid overproduction during high-density fermentation.

Zhang S, Ito M, Skerker JM, Arkin AP, Rao CV.

Appl Microbiol Biotechnol. 2016 Nov;100(21):9393-9405. Epub 2016 Sep 27.


Rapid and efficient galactose fermentation by engineered Saccharomyces cerevisiae.

Quarterman J, Skerker JM, Feng X, Liu IY, Zhao H, Arkin AP, Jin YS.

J Biotechnol. 2016 Jul 10;229:13-21. doi: 10.1016/j.jbiotec.2016.04.041. Epub 2016 Apr 30.


Gene Amplification on Demand Accelerates Cellobiose Utilization in Engineered Saccharomyces cerevisiae.

Oh EJ, Skerker JM, Kim SR, Wei N, Turner TL, Maurer MJ, Arkin AP, Jin YS.

Appl Environ Microbiol. 2016 May 31;82(12):3631-3639. doi: 10.1128/AEM.00410-16. Print 2016 Jun 15.


Complete Genome Sequences of Four Escherichia coli ST95 Isolates from Bloodstream Infections.

Stephens CM, Skerker JM, Sekhon MS, Arkin AP, Riley LW.

Genome Announc. 2015 Nov 5;3(6). pii: e01241-15. doi: 10.1128/genomeA.01241-15.


Engineering Rhodosporidium toruloides for increased lipid production.

Zhang S, Skerker JM, Rutter CD, Maurer MJ, Arkin AP, Rao CV.

Biotechnol Bioeng. 2016 May;113(5):1056-66. doi: 10.1002/bit.25864. Epub 2015 Nov 10.


Complete Genome Sequence of Cupriavidus basilensis 4G11, Isolated from the Oak Ridge Field Research Center Site.

Ray J, Waters RJ, Skerker JM, Kuehl JV, Price MN, Huang J, Chakraborty R, Arkin AP, Deutschbauer A.

Genome Announc. 2015 May 14;3(3). pii: e00322-15. doi: 10.1128/genomeA.00322-15.


Selection of chromosomal DNA libraries using a multiplex CRISPR system.

Ryan OW, Skerker JM, Maurer MJ, Li X, Tsai JC, Poddar S, Lee ME, DeLoache W, Dueber JE, Arkin AP, Cate JH.

Elife. 2014 Aug 19;3. doi: 10.7554/eLife.03703.


Towards an informative mutant phenotype for every bacterial gene.

Deutschbauer A, Price MN, Wetmore KM, Tarjan DR, Xu Z, Shao W, Leon D, Arkin AP, Skerker JM.

J Bacteriol. 2014 Oct;196(20):3643-55. doi: 10.1128/JB.01836-14. Epub 2014 Aug 11.


Dissecting a complex chemical stress: chemogenomic profiling of plant hydrolysates.

Skerker JM, Leon D, Price MN, Mar JS, Tarjan DR, Wetmore KM, Deutschbauer AM, Baumohl JK, Bauer S, Ibáñez AB, Mitchell VD, Wu CH, Hu P, Hazen T, Arkin AP.

Mol Syst Biol. 2013 Jun 18;9:674. doi: 10.1038/msb.2013.30.


Indirect and suboptimal control of gene expression is widespread in bacteria.

Price MN, Deutschbauer AM, Skerker JM, Wetmore KM, Ruths T, Mar JS, Kuehl JV, Shao W, Arkin AP.

Mol Syst Biol. 2013 Apr 16;9:660. doi: 10.1038/msb.2013.16.


Rational and evolutionary engineering approaches uncover a small set of genetic changes efficient for rapid xylose fermentation in Saccharomyces cerevisiae.

Kim SR, Skerker JM, Kang W, Lesmana A, Wei N, Arkin AP, Jin YS.

PLoS One. 2013;8(2):e57048. doi: 10.1371/journal.pone.0057048. Epub 2013 Feb 26.


Spatial tethering of kinases to their substrates relaxes evolutionary constraints on specificity.

Capra EJ, Perchuk BS, Ashenberg O, Seid CA, Snow HR, Skerker JM, Laub MT.

Mol Microbiol. 2012 Dec;86(6):1393-403. doi: 10.1111/mmi.12064. Epub 2012 Nov 5.


Draft genome sequence of Pelosinus fermentans JBW45, isolated during in situ stimulation for Cr(VI) reduction.

Bowen De León K, Young ML, Camilleri LB, Brown SD, Skerker JM, Deutschbauer AM, Arkin AP, Fields MW.

J Bacteriol. 2012 Oct;194(19):5456-7. doi: 10.1128/JB.01224-12.


Adaptive mutations that prevent crosstalk enable the expansion of paralogous signaling protein families.

Capra EJ, Perchuk BS, Skerker JM, Laub MT.

Cell. 2012 Jul 6;150(1):222-32. doi: 10.1016/j.cell.2012.05.033.


Systematic dissection and trajectory-scanning mutagenesis of the molecular interface that ensures specificity of two-component signaling pathways.

Capra EJ, Perchuk BS, Lubin EA, Ashenberg O, Skerker JM, Laub MT.

PLoS Genet. 2010 Nov 24;6(11):e1001220. doi: 10.1371/journal.pgen.1001220.


Evolution, ecology and the engineered organism: lessons for synthetic biology.

Skerker JM, Lucks JB, Arkin AP.

Genome Biol. 2009;10(11):114. doi: 10.1186/gb-2009-10-11-114. Epub 2009 Nov 30.


Rewiring the specificity of two-component signal transduction systems.

Skerker JM, Perchuk BS, Siryaporn A, Lubin EA, Ashenberg O, Goulian M, Laub MT.

Cell. 2008 Jun 13;133(6):1043-54. doi: 10.1016/j.cell.2008.04.040.


Regulation of the bacterial cell cycle by an integrated genetic circuit.

Biondi EG, Reisinger SJ, Skerker JM, Arif M, Perchuk BS, Ryan KR, Laub MT.

Nature. 2006 Dec 14;444(7121):899-904. Epub 2006 Nov 29.


A phosphorelay system controls stalk biogenesis during cell cycle progression in Caulobacter crescentus.

Biondi EG, Skerker JM, Arif M, Prasol MS, Perchuk BS, Laub MT.

Mol Microbiol. 2006 Jan;59(2):386-401.


Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis.

Skerker JM, Prasol MS, Perchuk BS, Biondi EG, Laub MT.

PLoS Biol. 2005 Oct;3(10):e334. Epub 2005 Sep 27.


Cell-cycle progression and the generation of asymmetry in Caulobacter crescentus.

Skerker JM, Laub MT.

Nat Rev Microbiol. 2004 Apr;2(4):325-37. Review. No abstract available.


Direct observation of extension and retraction of type IV pili.

Skerker JM, Berg HC.

Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6901-4. Epub 2001 May 29.


Regulation of vimentin gene transcription in human breast cancer cell lines.

Sommers CL, Skerker JM, Chrysogelos SA, Bosseler M, Gelmann EP.

Cell Growth Differ. 1994 Aug;5(8):839-46.


Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines.

Sommers CL, Heckford SE, Skerker JM, Worland P, Torri JA, Thompson EW, Byers SW, Gelmann EP.

Cancer Res. 1992 Oct 1;52(19):5190-7.

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