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Monitoring Surface Reactions by Combined Western Blot-ELISA Analysis.

Lin Y, Irmscher S, Skerka C.

Methods Mol Biol. 2019;1834:75-83. doi: 10.1007/978-1-4939-8669-9_5.


Aspf2 From Aspergillus fumigatus Recruits Human Immune Regulators for Immune Evasion and Cell Damage.

Dasari P, Shopova IA, Stroe M, Wartenberg D, Martin-Dahse H, Beyersdorf N, Hortschansky P, Dietrich S, Cseresnyés Z, Figge MT, Westermann M, Skerka C, Brakhage AA, Zipfel PF.

Front Immunol. 2018 Aug 3;9:1635. doi: 10.3389/fimmu.2018.01635. eCollection 2018.


Evaluation of serum sphingolipids and the influence of genetic risk factors in age-related macular degeneration.

Pujol-Lereis LM, Liebisch G, Schick T, Lin Y, Grassmann F, Uchida K, Zipfel PF, Fauser S, Skerka C, Weber BHF.

PLoS One. 2018 Aug 2;13(8):e0200739. doi: 10.1371/journal.pone.0200739. eCollection 2018.


Playing 'hide-and-seek' with factor H: game-theoretical analysis of a single nucleotide polymorphism.

Hummert S, Glock C, Lang SN, Hummert C, Skerka C, Zipfel PF, Germerodt S, Schuster S.

J R Soc Interface. 2018 May;15(142). pii: 20170963. doi: 10.1098/rsif.2017.0963.


FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces.

Rudnick RB, Chen Q, Stea ED, Hartmann A, Papac-Milicevic N, Person F, Wiesener M, Binder CJ, Wiech T, Skerka C, Zipfel PF.

J Immunol. 2018 Apr 1;200(7):2280-2290. doi: 10.4049/jimmunol.1701641. Epub 2018 Feb 26.


The MFHR1 Fusion Protein Is a Novel Synthetic Multitarget Complement Inhibitor with Therapeutic Potential.

Michelfelder S, Fischer F, Wäldin A, Hörle KV, Pohl M, Parsons J, Reski R, Decker EL, Zipfel PF, Skerka C, Häffner K.

J Am Soc Nephrol. 2018 Apr;29(4):1141-1153. doi: 10.1681/ASN.2017070738. Epub 2018 Jan 15.


Kallikrein Cleaves C3 and Activates Complement.

Irmscher S, Döring N, Halder LD, Jo EAH, Kopka I, Dunker C, Jacobsen ID, Luo S, Slevogt H, Lorkowski S, Beyersdorf N, Zipfel PF, Skerka C.

J Innate Immun. 2018;10(2):94-105. doi: 10.1159/000484257. Epub 2017 Dec 14.


Streptococcus pneumoniae From Patients With Hemolytic Uremic Syndrome Binds Human Plasminogen via the Surface Protein PspC and Uses Plasmin to Damage Human Endothelial Cells.

Meinel C, Spartà G, Dahse HM, Hörhold F, König R, Westermann M, Coldewey SM, Cseresnyés Z, Figge MT, Hammerschmidt S, Skerka C, Zipfel PF.

J Infect Dis. 2018 Jan 17;217(3):358-370. doi: 10.1093/infdis/jix305.


The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments.

Luo S, Dasari P, Reiher N, Hartmann A, Jacksch S, Wende E, Barz D, Niemiec MJ, Jacobsen I, Beyersdorf N, Hünig T, Klos A, Skerka C, Zipfel PF.

Mol Immunol. 2018 Jan;93:266-277. doi: 10.1016/j.molimm.2017.07.010. Epub 2017 Aug 30.


Anaphylatoxins Activate Ca2+, Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium.

Busch C, Annamalai B, Abdusalamova K, Reichhart N, Huber C, Lin Y, Jo EAH, Zipfel PF, Skerka C, Wildner G, Diedrichs-Möhring M, Rohrer B, Strauß O.

Front Immunol. 2017 Jun 15;8:703. doi: 10.3389/fimmu.2017.00703. eCollection 2017.


Factor H Binds to Extracellular DNA Traps Released from Human Blood Monocytes in Response to Candida albicans.

Halder LD, Abdelfatah MA, Jo EA, Jacobsen ID, Westermann M, Beyersdorf N, Lorkowski S, Zipfel PF, Skerka C.

Front Immunol. 2017 Jan 13;7:671. doi: 10.3389/fimmu.2016.00671. eCollection 2016.


Differential Effects of Vitamins A and D on the Transcriptional Landscape of Human Monocytes during Infection.

Klassert TE, Bräuer J, Hölzer M, Stock M, Riege K, Zubiría-Barrera C, Müller MM, Rummler S, Skerka C, Marz M, Slevogt H.

Sci Rep. 2017 Jan 17;7:40599. doi: 10.1038/srep40599.


Age-related macular degeneration associated polymorphism rs10490924 in ARMS2 results in deficiency of a complement activator.

Micklisch S, Lin Y, Jacob S, Karlstetter M, Dannhausen K, Dasari P, von der Heide M, Dahse HM, Schmölz L, Grassmann F, Alene M, Fauser S, Neumann H, Lorkowski S, Pauly D, Weber BH, Joussen AM, Langmann T, Zipfel PF, Skerka C.

J Neuroinflammation. 2017 Jan 5;14(1):4. doi: 10.1186/s12974-016-0776-3.


Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina.

Karlstetter M, Kopatz J, Aslanidis A, Shahraz A, Caramoy A, Linnartz-Gerlach B, Lin Y, Lückoff A, Fauser S, Düker K, Claude J, Wang Y, Ackermann J, Schmidt T, Hornung V, Skerka C, Langmann T, Neumann H.

EMBO Mol Med. 2017 Feb;9(2):154-166. doi: 10.15252/emmm.201606627.


Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases.

Schäfer N, Grosche A, Reinders J, Hauck SM, Pouw RB, Kuijpers TW, Wouters D, Ehrenstein B, Enzmann V, Zipfel PF, Skerka C, Pauly D.

Front Immunol. 2016 Nov 28;7:542. eCollection 2016.


FHR3 Blocks C3d-Mediated Coactivation of Human B Cells.

Buhlmann D, Eberhardt HU, Medyukhina A, Prodinger WM, Figge MT, Zipfel PF, Skerka C.

J Immunol. 2016 Jul 15;197(2):620-9. doi: 10.4049/jimmunol.1600053. Epub 2016 Jun 8.


Conserved Patterns of Microbial Immune Escape: Pathogenic Microbes of Diverse Origin Target the Human Terminal Complement Inhibitor Vitronectin via a Single Common Motif.

Hallström T, Singh B, Kraiczy P, Hammerschmidt S, Skerka C, Zipfel PF, Riesbeck K.

PLoS One. 2016 Jan 25;11(1):e0147709. doi: 10.1371/journal.pone.0147709. eCollection 2016.


The Plasmodium falciparum blood stages acquire factor H family proteins to evade destruction by human complement.

Rosa TF, Flammersfeld A, Ngwa CJ, Kiesow M, Fischer R, Zipfel PF, Skerka C, Pradel G.

Cell Microbiol. 2016 Apr;18(4):573-90. doi: 10.1111/cmi.12535. Epub 2015 Nov 12.


BGA66 and BGA71 facilitate complement resistance of Borrelia bavariensis by inhibiting assembly of the membrane attack complex.

Hammerschmidt C, Klevenhaus Y, Koenigs A, Hallström T, Fingerle V, Skerka C, Pos KM, Zipfel PF, Wallich R, Kraiczy P.

Mol Microbiol. 2016 Jan;99(2):407-24. doi: 10.1111/mmi.13239. Epub 2015 Oct 27.


Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces.

Chen Q, Manzke M, Hartmann A, Büttner M, Amann K, Pauly D, Wiesener M, Skerka C, Zipfel PF.

J Am Soc Nephrol. 2016 May;27(5):1413-25. doi: 10.1681/ASN.2015020212. Epub 2015 Oct 2.


Pseudomonas aeruginosa Uses Dihydrolipoamide Dehydrogenase (Lpd) to Bind to the Human Terminal Pathway Regulators Vitronectin and Clusterin to Inhibit Terminal Pathway Complement Attack.

Hallström T, Uhde M, Singh B, Skerka C, Riesbeck K, Zipfel PF.

PLoS One. 2015 Sep 14;10(9):e0137630. doi: 10.1371/journal.pone.0137630. eCollection 2015.


Host-pathogen interactions between the human innate immune system and Candida albicans-understanding and modeling defense and evasion strategies.

Dühring S, Germerodt S, Skerka C, Zipfel PF, Dandekar T, Schuster S.

Front Microbiol. 2015 Jun 30;6:625. doi: 10.3389/fmicb.2015.00625. eCollection 2015. Review.


The role of complement in C3 glomerulopathy.

Zipfel PF, Skerka C, Chen Q, Wiech T, Goodship T, Johnson S, Fremeaux-Bacchi V, Nester C, de Córdoba SR, Noris M, Pickering M, Smith R.

Mol Immunol. 2015 Sep;67(1):21-30. doi: 10.1016/j.molimm.2015.03.012. Epub 2015 Apr 28. Review.


Atypical aHUS: State of the art.

Nester CM, Barbour T, de Cordoba SR, Dragon-Durey MA, Fremeaux-Bacchi V, Goodship TH, Kavanagh D, Noris M, Pickering M, Sanchez-Corral P, Skerka C, Zipfel P, Smith RJ.

Mol Immunol. 2015 Sep;67(1):31-42. doi: 10.1016/j.molimm.2015.03.246. Epub 2015 Apr 3. Review.


Sequence variations and protein expression levels of the two immune evasion proteins Gpm1 and Pra1 influence virulence of clinical Candida albicans isolates.

Luo S, Hipler UC, Münzberg C, Skerka C, Zipfel PF.

PLoS One. 2015 Feb 18;10(2):e0113192. doi: 10.1371/journal.pone.0113192. eCollection 2015.


Activation of endogenously expressed ion channels by active complement in the retinal pigment epithelium.

Genewsky A, Jost I, Busch C, Huber C, Stindl J, Skerka C, Zipfel PF, Rohrer B, Strauß O.

Pflugers Arch. 2015 Oct;467(10):2179-91. doi: 10.1007/s00424-014-1656-2. Epub 2014 Nov 27.


Virulent strain of Lichtheimia corymbifera shows increased phagocytosis by macrophages as revealed by automated microscopy image analysis.

Kraibooj K, Park HR, Dahse HM, Skerka C, Voigt K, Figge MT.

Mycoses. 2014 Dec;57 Suppl 3:56-66. doi: 10.1111/myc.12237. Epub 2014 Sep 1.


Tuf of Streptococcus pneumoniae is a surface displayed human complement regulator binding protein.

Mohan S, Hertweck C, Dudda A, Hammerschmidt S, Skerka C, Hallström T, Zipfel PF.

Mol Immunol. 2014 Nov;62(1):249-64. doi: 10.1016/j.molimm.2014.06.029.


New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases.

Mehta G, Ferreira VP, Skerka C, Zipfel PF, Banda NK.

Mol Immunol. 2014 Nov;62(1):235-48. doi: 10.1016/j.molimm.2014.06.028. Epub 2014 Jul 15.


A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples.

Pauly D, Nagel BM, Reinders J, Killian T, Wulf M, Ackermann S, Ehrenstein B, Zipfel PF, Skerka C, Weber BH.

PLoS One. 2014 May 5;9(5):e96371. doi: 10.1371/journal.pone.0096371. eCollection 2014.


Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin.

Lopez CM, Wallich R, Riesbeck K, Skerka C, Zipfel PF.

PLoS One. 2014 Mar 13;9(3):e90796. doi: 10.1371/journal.pone.0090796. eCollection 2014.


Staphylococcus aureus: the multi headed hydra resists and controls human complement response in multiple ways.

Zipfel PF, Skerka C.

Int J Med Microbiol. 2014 Mar;304(2):188-94. doi: 10.1016/j.ijmm.2013.11.004. Epub 2013 Dec 1. Review.


Complement factor H-related hybrid protein deregulates complement in dense deposit disease.

Chen Q, Wiesener M, Eberhardt HU, Hartmann A, Uzonyi B, Kirschfink M, Amann K, Buettner M, Goodship T, Hugo C, Skerka C, Zipfel PF.

J Clin Invest. 2014 Jan;124(1):145-55. doi: 10.1172/JCI71866. Epub 2013 Dec 16.


Interaction of Shiga toxin 2 with complement regulators of the factor H protein family.

Poolpol K, Orth-Höller D, Speth C, Zipfel PF, Skerka C, de Córdoba SR, Brockmeyer J, Bielaszewska M, Würzner R.

Mol Immunol. 2014 Mar;58(1):77-84. doi: 10.1016/j.molimm.2013.11.009. Epub 2013 Dec 5.


Human complement factor H and factor H-like protein 1 are expressed in human retinal pigment epithelial cells.

Weinberger AW, Eddahabi C, Carstesen D, Zipfel PF, Walter P, Skerka C.

Ophthalmic Res. 2014;51(2):59-66. doi: 10.1159/000351624. Epub 2013 Nov 21.


Human factor H-related protein 2 (CFHR2) regulates complement activation.

Eberhardt HU, Buhlmann D, Hortschansky P, Chen Q, Böhm S, Kemper MJ, Wallich R, Hartmann A, Hallström T, Zipfel PF, Skerka C.

PLoS One. 2013 Nov 18;8(11):e78617. doi: 10.1371/journal.pone.0078617. eCollection 2013.


Versatile roles of CspA orthologs in complement inactivation of serum-resistant Lyme disease spirochetes.

Hammerschmidt C, Koenigs A, Siegel C, Hallström T, Skerka C, Wallich R, Zipfel PF, Kraiczy P.

Infect Immun. 2014 Jan;82(1):380-92. doi: 10.1128/IAI.01094-13. Epub 2013 Nov 4.


CspA from Borrelia burgdorferi inhibits the terminal complement pathway.

Hallström T, Siegel C, Mörgelin M, Kraiczy P, Skerka C, Zipfel PF.

MBio. 2013 Aug 13;4(4). pii: e00481-13. doi: 10.1128/mBio.00481-13.


Standardisation of the factor H autoantibody assay.

Watson R, Lindner S, Bordereau P, Hunze EM, Tak F, Ngo S, Zipfel PF, Skerka C, Dragon-Durey MA, Marchbank KJ.

Immunobiology. 2014 Jan;219(1):9-16. doi: 10.1016/j.imbio.2013.06.004. Epub 2013 Jun 26.


Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration.

Ansari M, McKeigue PM, Skerka C, Hayward C, Rudan I, Vitart V, Polasek O, Armbrecht AM, Yates JR, Vatavuk Z, Bencic G, Kolcic I, Oostra BA, Van Duijn CM, Campbell S, Stanton CM, Huffman J, Shu X, Khan JC, Shahid H, Harding SP, Bishop PN, Deary IJ, Moore AT, Dhillon B, Rudan P, Zipfel PF, Sim RB, Hastie ND, Campbell H, Wright AF.

Hum Mol Genet. 2013 Dec 1;22(23):4857-69. doi: 10.1093/hmg/ddt336. Epub 2013 Jul 19.


BBA70 of Borrelia burgdorferi is a novel plasminogen-binding protein.

Koenigs A, Hammerschmidt C, Jutras BL, Pogoryelov D, Barthel D, Skerka C, Kugelstadt D, Wallich R, Stevenson B, Zipfel PF, Kraiczy P.

J Biol Chem. 2013 Aug 30;288(35):25229-43. doi: 10.1074/jbc.M112.413872. Epub 2013 Jul 16.


14th European Meeting on Complement in Human Disease, Jena, Germany, August 17-21, 2013.

Zipfel PF, Skerka C, Hallström T, Wolf G.

Mol Immunol. 2013 Dec 15;56(3):151. doi: 10.1016/j.molimm.2013.05.239. Epub 2013 Jul 6. No abstract available.


Complement factor H related proteins (CFHRs).

Skerka C, Chen Q, Fremeaux-Bacchi V, Roumenina LT.

Mol Immunol. 2013 Dec 15;56(3):170-80. doi: 10.1016/j.molimm.2013.06.001. Epub 2013 Jul 3. Review.


Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans.

Luo S, Skerka C, Kurzai O, Zipfel PF.

Mol Immunol. 2013 Dec 15;56(3):161-9. doi: 10.1016/j.molimm.2013.05.218. Epub 2013 Jun 26. Review.


Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut.

Simon N, Lasonder E, Scheuermayer M, Kuehn A, Tews S, Fischer R, Zipfel PF, Skerka C, Pradel G.

Cell Host Microbe. 2013 Jan 16;13(1):29-41. doi: 10.1016/j.chom.2012.11.013. Epub 2013 Jan 16.


Borrelia valaisiana resist complement-mediated killing independently of the recruitment of immune regulators and inactivation of complement components.

Schwab J, Hammerschmidt C, Richter D, Skerka C, Matuschka FR, Wallich R, Zipfel PF, Kraiczy P.

PLoS One. 2013;8(1):e53659. doi: 10.1371/journal.pone.0053659. Epub 2013 Jan 8.


Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis.

Lesher AM, Zhou L, Kimura Y, Sato S, Gullipalli D, Herbert AP, Barlow PN, Eberhardt HU, Skerka C, Zipfel PF, Hamano T, Miwa T, Tung KS, Song WC.

J Am Soc Nephrol. 2013 Jan;24(1):53-65. doi: 10.1681/ASN.2012060570. Epub 2012 Nov 30.


Glycerol-3-phosphate dehydrogenase 2 is a novel factor H-, factor H-like protein 1-, and plasminogen-binding surface protein of Candida albicans.

Luo S, Hoffmann R, Skerka C, Zipfel PF.

J Infect Dis. 2013 Feb 15;207(4):594-603. doi: 10.1093/infdis/jis718. Epub 2012 Nov 29.


Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b.

Koch TK, Reuter M, Barthel D, Böhm S, van den Elsen J, Kraiczy P, Zipfel PF, Skerka C.

PLoS One. 2012;7(10):e47638. doi: 10.1371/journal.pone.0047638. Epub 2012 Oct 11.


Dihydrolipoamide dehydrogenase of Pseudomonas aeruginosa is a surface-exposed immune evasion protein that binds three members of the factor H family and plasminogen.

Hallström T, Mörgelin M, Barthel D, Raguse M, Kunert A, Hoffmann R, Skerka C, Zipfel PF.

J Immunol. 2012 Nov 15;189(10):4939-50. doi: 10.4049/jimmunol.1200386. Epub 2012 Oct 15.

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