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Oncogenic Kras induces Nix-mediated mitophagy to promote pancreatic cancer.

Humpton TJ, Alagesan B, DeNicola GM, Lu D, Yordanov GN, Leonhardt CS, Yao MA, Alagesan P, Zaatari MN, Park Y, Skepper JN, Macleod KF, Perez-Mancera PA, Murphy MP, Evan GI, Vousden KH, Tuveson DA.

Cancer Discov. 2019 Jul 1. pii: CD-18-1409. doi: 10.1158/2159-8290.CD-18-1409. [Epub ahead of print]


Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization.

Müller KH, Hayward R, Rajan R, Whitehead M, Cobb AM, Ahmad S, Sun M, Goldberga I, Li R, Bashtanova U, Puszkarska AM, Reid DG, Brooks RA, Skepper JN, Bordoloi J, Chow WY, Oschkinat H, Groombridge A, Scherman OA, Harrison JA, Verhulst A, D'Haese PC, Neven E, Needham LM, Lee SF, Shanahan CM, Duer MJ.

Cell Rep. 2019 Jun 11;27(11):3124-3138.e13. doi: 10.1016/j.celrep.2019.05.038.


A 3D tri-culture system reveals that activin receptor-like kinase 5 and connective tissue growth factor drive human glomerulosclerosis.

Waters JP, Richards YC, Skepper JN, Southwood M, Upton PD, Morrell NW, Pober JS, Bradley JR.

J Pathol. 2017 Nov;243(3):390-400. doi: 10.1002/path.4960. Epub 2017 Oct 3.


Development of structural colour in leaf beetles.

Onelli OD, Kamp TV, Skepper JN, Powell J, Rolo TDS, Baumbach T, Vignolini S.

Sci Rep. 2017 May 2;7(1):1373. doi: 10.1038/s41598-017-01496-8.


Inactivation, Clearance, and Functional Effects of Lung-Instilled Short and Long Silver Nanowires in Rats.

Chung KF, Seiffert J, Chen S, Theodorou IG, Goode AE, Leo BF, McGilvery CM, Hussain F, Wiegman C, Rossios C, Zhu J, Gong J, Tariq F, Yufit V, Monteith AJ, Hashimoto T, Skepper JN, Ryan MP, Zhang J, Tetley TD, Porter AE.

ACS Nano. 2017 Mar 28;11(3):2652-2664. doi: 10.1021/acsnano.6b07313. Epub 2017 Feb 24.


A randomised comparison of neurotmesis using scissors or a razor blade for sural nerve graft harvest.

Sharma PR, Rosich-Medina A, Swan MC, Gillespie PH, Skepper JN, Price RD.

J Plast Reconstr Aesthet Surg. 2016 Dec;69(12):1711-1713. doi: 10.1016/j.bjps.2016.09.023. Epub 2016 Oct 5. No abstract available.


α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function.

Kuan WL, Bennett N, He X, Skepper JN, Martynyuk N, Wijeyekoon R, Moghe PV, Williams-Gray CH, Barker RA.

Exp Neurol. 2016 Nov;285(Pt A):72-81. doi: 10.1016/j.expneurol.2016.09.003. Epub 2016 Sep 12.


Translocation of Functionalized Multi-Walled Carbon Nanotubes across Human Pulmonary Alveolar Epithelium: Dominant Role of Epithelial Type 1 Cells.

Ruenraroengsak P, Chen S, Hu S, Melbourne J, Sweeney S, Thorley AJ, Skepper JN, Shaffer MS, Tetley TD, Porter AE.

ACS Nano. 2016 May 24;10(5):5070-85. doi: 10.1021/acsnano.5b08218. Epub 2016 Apr 21.


Characterization and Visualization of Vesicles in the Endo-Lysosomal Pathway with Surface-Enhanced Raman Spectroscopy and Chemometrics.

Huefner A, Kuan WL, Müller KH, Skepper JN, Barker RA, Mahajan S.

ACS Nano. 2016 Jan 26;10(1):307-16. doi: 10.1021/acsnano.5b04456. Epub 2015 Dec 18.


Identifying active vascular microcalcification by (18)F-sodium fluoride positron emission tomography.

Irkle A, Vesey AT, Lewis DY, Skepper JN, Bird JL, Dweck MR, Joshi FR, Gallagher FA, Warburton EA, Bennett MR, Brindle KM, Newby DE, Rudd JH, Davenport AP.

Nat Commun. 2015 Jul 7;6:7495. doi: 10.1038/ncomms8495.


An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells.

Powell JJ, Thomas-McKay E, Thoree V, Robertson J, Hewitt RE, Skepper JN, Brown A, Hernandez-Garrido JC, Midgley PA, Gomez-Morilla I, Grime GW, Kirkby KJ, Mabbott NA, Donaldson DS, Williams IR, Rios D, Girardin SE, Haas CT, Bruggraber SF, Laman JD, Tanriver Y, Lombardi G, Lechler R, Thompson RP, Pele LC.

Nat Nanotechnol. 2015 Apr;10(4):361-9. doi: 10.1038/nnano.2015.19. Epub 2015 Mar 9.


Vascular smooth muscle cell calcification is mediated by regulated exosome secretion.

Kapustin AN, Chatrou ML, Drozdov I, Zheng Y, Davidson SM, Soong D, Furmanik M, Sanchis P, De Rosales RT, Alvarez-Hernandez D, Shroff R, Yin X, Muller K, Skepper JN, Mayr M, Reutelingsperger CP, Chester A, Bertazzo S, Schurgers LJ, Shanahan CM.

Circ Res. 2015 Apr 10;116(8):1312-23. doi: 10.1161/CIRCRESAHA.116.305012. Epub 2015 Feb 23.


Avoiding artefacts during electron microscopy of silver nanomaterials exposed to biological environments.

Chen S, Goode AE, Skepper JN, Thorley AJ, Seiffert JM, Chung KF, Tetley TD, Shaffer MS, Ryan MP, Porter AE.

J Microsc. 2016 Feb;261(2):157-66. doi: 10.1111/jmi.12215. Epub 2015 Jan 21.


The response of Chlamydomonas reinhardtii to nitrogen deprivation: a systems biology analysis.

Park JJ, Wang H, Gargouri M, Deshpande RR, Skepper JN, Holguin FO, Juergens MT, Shachar-Hill Y, Hicks LM, Gang DR.

Plant J. 2015 Feb;81(4):611-24. doi: 10.1111/tpj.12747.


The regulation of photosynthetic structure and function during nitrogen deprivation in Chlamydomonas reinhardtii.

Juergens MT, Deshpande RR, Lucker BF, Park JJ, Wang H, Gargouri M, Holguin FO, Disbrow B, Schaub T, Skepper JN, Kramer DM, Gang DR, Hicks LM, Shachar-Hill Y.

Plant Physiol. 2015 Feb;167(2):558-73. doi: 10.1104/pp.114.250530. Epub 2014 Dec 8.


Fetuin-A and albumin alter cytotoxic effects of calcium phosphate nanoparticles on human vascular smooth muscle cells.

Dautova Y, Kozlova D, Skepper JN, Epple M, Bootman MD, Proudfoot D.

PLoS One. 2014 May 21;9(5):e97565. doi: 10.1371/journal.pone.0097565. eCollection 2014.


NMR spectroscopy of native and in vitro tissues implicates polyADP ribose in biomineralization.

Chow WY, Rajan R, Muller KH, Reid DG, Skepper JN, Wong WC, Brooks RA, Green M, Bihan D, Farndale RW, Slatter DA, Shanahan CM, Duer MJ.

Science. 2014 May 16;344(6185):742-6. doi: 10.1126/science.1248167.


Mutant huntingtin is present in neuronal grafts in Huntington disease patients.

Cicchetti F, Lacroix S, Cisbani G, Vallières N, Saint-Pierre M, St-Amour I, Tolouei R, Skepper JN, Hauser RA, Mantovani D, Barker RA, Freeman TB.

Ann Neurol. 2014 Jul;76(1):31-42. doi: 10.1002/ana.24174. Epub 2014 Jun 6.


Trophoblast specialisations during pregnancy in the tammar wallaby, Macropus eugenii: a morphological and lectin histochemical study.

Jones CJ, Skepper JN, Renfree MB, Aplin JD.

Placenta. 2014 Jul;35(7):467-75. doi: 10.1016/j.placenta.2014.03.018. Epub 2014 Apr 3.


Citrate bridges between mineral platelets in bone.

Davies E, Müller KH, Wong WC, Pickard CJ, Reid DG, Skepper JN, Duer MJ.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1354-63. doi: 10.1073/pnas.1315080111. Epub 2014 Mar 24.


Human urinary exosomes as innate immune effectors.

Hiemstra TF, Charles PD, Gracia T, Hester SS, Gatto L, Al-Lamki R, Floto RA, Su Y, Skepper JN, Lilley KS, Karet Frankl FE.

J Am Soc Nephrol. 2014 Sep;25(9):2017-27. doi: 10.1681/ASN.2013101066. Epub 2014 Apr 3.


Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells.

Toshner M, Dunmore BJ, McKinney EF, Southwood M, Caruso P, Upton PD, Waters JP, Ormiston ML, Skepper JN, Nash G, Rana AA, Morrell NW.

PLoS One. 2014 Mar 20;9(3):e91334. doi: 10.1371/journal.pone.0091334. eCollection 2014.


The effect of particle agglomeration on the formation of a surface-connected compartment induced by hydroxyapatite nanoparticles in human monocyte-derived macrophages.

Müller KH, Motskin M, Philpott AJ, Routh AF, Shanahan CM, Duer MJ, Skepper JN.

Biomaterials. 2014 Jan;35(3):1074-88. doi: 10.1016/j.biomaterials.2013.10.041. Epub 2013 Oct 30.


Mercury-sensitive water channels as possible sensors of water potentials in pollen.

Shachar-Hill B, Hill AE, Powell J, Skepper JN, Shachar-Hill Y.

J Exp Bot. 2013 Nov;64(16):5195-205. doi: 10.1093/jxb/ert311. Epub 2013 Oct 5.


Memantine block depends on agonist presentation at the NMDA receptor in substantia nigra pars compacta dopamine neurones.

Wild AR, Akyol E, Brothwell SL, Kimkool P, Skepper JN, Gibb AJ, Jones S.

Neuropharmacology. 2013 Oct;73:138-46. doi: 10.1016/j.neuropharm.2013.05.013. Epub 2013 May 28.


In vitro osteoblast response to ferritic stainless steel fiber networks for magneto-active layers on implants.

Malheiro VN, Skepper JN, Brooks RA, Markaki AE.

J Biomed Mater Res A. 2013 Jun;101(6):1588-98. doi: 10.1002/jbm.a.34473. Epub 2012 Nov 9.


Rubisco small-subunit α-helices control pyrenoid formation in Chlamydomonas.

Meyer MT, Genkov T, Skepper JN, Jouhet J, Mitchell MC, Spreitzer RJ, Griffiths H.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19474-9. doi: 10.1073/pnas.1210993109. Epub 2012 Oct 29.


An osmotic model of the growing pollen tube.

Hill AE, Shachar-Hill B, Skepper JN, Powell J, Shachar-Hill Y.

PLoS One. 2012;7(5):e36585. doi: 10.1371/journal.pone.0036585. Epub 2012 May 16.


Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer.

Jacobetz MA, Chan DS, Neesse A, Bapiro TE, Cook N, Frese KK, Feig C, Nakagawa T, Caldwell ME, Zecchini HI, Lolkema MP, Jiang P, Kultti A, Thompson CB, Maneval DC, Jodrell DI, Frost GI, Shepard HM, Skepper JN, Tuveson DA.

Gut. 2013 Jan;62(1):112-20. doi: 10.1136/gutjnl-2012-302529. Epub 2012 Mar 30.


A heterogeneous in vitro three dimensional model of tumour-stroma interactions regulating sprouting angiogenesis.

Correa de Sampaio P, Auslaender D, Krubasik D, Failla AV, Skepper JN, Murphy G, English WR.

PLoS One. 2012;7(2):e30753. doi: 10.1371/journal.pone.0030753. Epub 2012 Feb 20.


The sequestration of hydroxyapatite nanoparticles by human monocyte-macrophages in a compartment that allows free diffusion with the extracellular environment.

Motskin M, Müller KH, Genoud C, Monteith AG, Skepper JN.

Biomaterials. 2011 Dec;32(35):9470-82. doi: 10.1016/j.biomaterials.2011.08.060. Epub 2011 Sep 1.


Tunable chemistry and morphology of multi-wall carbon nanotubes as a route to non-toxic, theranostic systems.

Boncel S, Müller KH, Skepper JN, Walczak KZ, Koziol KK.

Biomaterials. 2011 Oct;32(30):7677-86. doi: 10.1016/j.biomaterials.2011.06.055. Epub 2011 Jul 20.


High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis.

Stijlemans B, Caljon G, Natesan SK, Saerens D, Conrath K, Pérez-Morga D, Skepper JN, Nikolaou A, Brys L, Pays E, Magez S, Field MC, De Baetselier P, Muyldermans S.

PLoS Pathog. 2011 Jun;7(6):e1002072. doi: 10.1371/journal.ppat.1002072. Epub 2011 Jun 16.


Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization.

Kapustin AN, Davies JD, Reynolds JL, McNair R, Jones GT, Sidibe A, Schurgers LJ, Skepper JN, Proudfoot D, Mayr M, Shanahan CM.

Circ Res. 2011 Jun 24;109(1):e1-12. doi: 10.1161/CIRCRESAHA.110.238808. Epub 2011 May 12.


X-ray microanalysis investigation of the changes in Na, K, and hemoglobin concentration in plasmodium falciparum-infected red blood cells.

Mauritz JM, Seear R, Esposito A, Kaminski CF, Skepper JN, Warley A, Lew VL, Tiffert T.

Biophys J. 2011 Mar 16;100(6):1438-45. doi: 10.1016/j.bpj.2011.02.007.


pH-dependent toxicity of high aspect ratio ZnO nanowires in macrophages due to intracellular dissolution.

Müller KH, Kulkarni J, Motskin M, Goode A, Winship P, Skepper JN, Ryan MP, Porter AE.

ACS Nano. 2010 Nov 23;4(11):6767-79. doi: 10.1021/nn101192z. Epub 2010 Oct 15.


Quantitative imaging of human red blood cells infected with Plasmodium falciparum.

Esposito A, Choimet JB, Skepper JN, Mauritz JM, Lew VL, Kaminski CF, Tiffert T.

Biophys J. 2010 Aug 4;99(3):953-60. doi: 10.1016/j.bpj.2010.04.065.


Biophotonic techniques for the study of malaria-infected red blood cells.

Mauritz JM, Esposito A, Tiffert T, Skepper JN, Warley A, Yoon YZ, Cicuta P, Lew VL, Guck JR, Kaminski CF.

Med Biol Eng Comput. 2010 Oct;48(10):1055-63. doi: 10.1007/s11517-010-0668-0. Epub 2010 Jul 27. Review.


Diffusion-weighted magnetic resonance imaging for the detection of lipid-rich necrotic core in carotid atheroma in vivo.

Young VE, Patterson AJ, Sadat U, Bowden DJ, Graves MJ, Tang TY, Priest AN, Skepper JN, Kirkpatrick PJ, Gillard JH.

Neuroradiology. 2010 Oct;52(10):929-36. doi: 10.1007/s00234-010-0680-y. Epub 2010 Apr 1.


The interaction of alphaB-crystallin with mature alpha-synuclein amyloid fibrils inhibits their elongation.

Waudby CA, Knowles TP, Devlin GL, Skepper JN, Ecroyd H, Carver JA, Welland ME, Christodoulou J, Dobson CM, Meehan S.

Biophys J. 2010 Mar 3;98(5):843-51. doi: 10.1016/j.bpj.2009.10.056.


Differential mechanisms of shedding of the glycosylphosphatidylinositol (GPI)-anchored NKG2D ligands.

Fernández-Messina L, Ashiru O, Boutet P, Agüera-González S, Skepper JN, Reyburn HT, Valés-Gómez M.

J Biol Chem. 2010 Mar 19;285(12):8543-51. doi: 10.1074/jbc.M109.045906. Epub 2010 Jan 14.


Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes.

Ashiru O, Boutet P, Fernández-Messina L, Agüera-González S, Skepper JN, Valés-Gómez M, Reyburn HT.

Cancer Res. 2010 Jan 15;70(2):481-9. doi: 10.1158/0008-5472.CAN-09-1688. Epub 2010 Jan 12.


Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC.

Rubio-Cabezas O, Puri V, Murano I, Saudek V, Semple RK, Dash S, Hyden CS, Bottomley W, Vigouroux C, Magré J, Raymond-Barker P, Murgatroyd PR, Chawla A, Skepper JN, Chatterjee VK, Suliman S, Patch AM, Agarwal AK, Garg A, Barroso I, Cinti S, Czech MP, Argente J, O'Rahilly S, Savage DB; LD Screening Consortium.

EMBO Mol Med. 2009 Aug;1(5):280-7. doi: 10.1002/emmm.200900037.


Cs corrected STEM EELS: Analysing beam sensitive carbon nanomaterials in cellular structures.

Gass MH, Porter AE, Bendall JS, Muller K, Skepper JN, Midgley PA, Welland M.

Ultramicroscopy. 2010 Jul;110(8):946-51. doi: 10.1016/j.ultramic.2009.11.005. Epub 2009 Nov 24.


Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification.

Shroff RC, McNair R, Skepper JN, Figg N, Schurgers LJ, Deanfield J, Rees L, Shanahan CM.

J Am Soc Nephrol. 2010 Jan;21(1):103-12. doi: 10.1681/ASN.2009060640. Epub 2009 Dec 3.


The mesoporosity of microparticles spray dried from trehalose and nanoparticle hydroxyapatite depends on the ratio of nanoparticles to sugar and nanoparticle surface charge.

Wright DM, Saracevic ZS, Kyle NH, Motskin M, Skepper JN.

J Mater Sci Mater Med. 2010 Jan;21(1):189-206. doi: 10.1007/s10856-009-3858-2.


Toxicity and imaging of multi-walled carbon nanotubes in human macrophage cells.

Cheng C, Müller KH, Koziol KK, Skepper JN, Midgley PA, Welland ME, Porter AE.

Biomaterials. 2009 Sep;30(25):4152-60. doi: 10.1016/j.biomaterials.2009.04.019. Epub 2009 May 27.


Uptake of noncytotoxic acid-treated single-walled carbon nanotubes into the cytoplasm of human macrophage cells.

Porter AE, Gass M, Bendall JS, Muller K, Goode A, Skepper JN, Midgley PA, Welland M.

ACS Nano. 2009 Jun 23;3(6):1485-92. doi: 10.1021/nn900416z.


Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function.

Ciechomska IA, Goemans GC, Skepper JN, Tolkovsky AM.

Oncogene. 2009 May 28;28(21):2128-41. doi: 10.1038/onc.2009.60. Epub 2009 Apr 6.


Hydroxyapatite nano and microparticles: correlation of particle properties with cytotoxicity and biostability.

Motskin M, Wright DM, Muller K, Kyle N, Gard TG, Porter AE, Skepper JN.

Biomaterials. 2009 Jul;30(19):3307-17. doi: 10.1016/j.biomaterials.2009.02.044. Epub 2009 Mar 21.


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