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Impact of aromatase inhibitor treatment on global gene expression and its association with antiproliferative response in ER+ breast cancer in postmenopausal patients.

Gao Q, López-Knowles E, Cheang MCU, Morden J, Ribas R, Sidhu K, Evans D, Martins V, Dodson A, Skene A, Holcombe C, Mallon E, Evans A, Bliss JM, Robertson J, Smith I, Martin LA, Dowsett M; POETIC Trial Management Group and Trialists.

Breast Cancer Res. 2019 Dec 31;22(1):2. doi: 10.1186/s13058-019-1223-z.


Proliferation and AKT activity biomarker analyses after Capivasertib (AZD5363) treatment of patients with ER+ invasive breast cancer (STAKT).

Robertson JF, Coleman RE, Cheung KL, Evans A, Holcombe C, Skene A, Rea D, Ahmed S, Jahan A, Horgan K, Rauchhaus P, Littleford R, Cheung SA, Cullberg M, de Bruin EC, Koulai L, Lindemann JPO, Pass M, Rugman P, Schiavon G, Deb R, Finlay P, Foxley A, Gee JM.

Clin Cancer Res. 2019 Dec 13. pii: clincanres.3053.2019. doi: 10.1158/1078-0432.CCR-19-3053. [Epub ahead of print]


Menstrual cycle associated changes in hormone-related gene expression in oestrogen receptor positive breast cancer.

Haynes BP, Ginsburg O, Gao Q, Folkerd E, Afentakis M, Buus R, Quang LH, Thi Han P, Khoa PH, Dinh NV, To TV, Clemons M, Holcombe C, Osborne C, Evans A, Skene A, Sibbering M, Rogers C, Laws S, Noor L, Smith IE, Dowsett M.

NPJ Breast Cancer. 2019 Nov 15;5:42. doi: 10.1038/s41523-019-0138-2. eCollection 2019.


Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility.

Tan SM, Ziemann M, Thallas-Bonke V, Snelson M, Kumar V, Laskowski A, Nguyen TV, Huynh K, Clarke MV, Libianto R, Baker ST, Skene A, Power DA, MacIsaac RJ, Henstridge DC, Wetsel RA, El-Osta A, Meikle PJ, Wilson SG, Forbes JM, Cooper ME, Ekinci EI, Woodruff TM, Coughlan MT.

Diabetes. 2020 Jan;69(1):83-98. doi: 10.2337/db19-0043. Epub 2019 Oct 17.


Assessment of Molecular Relapse Detection in Early-Stage Breast Cancer.

Garcia-Murillas I, Chopra N, Comino-Méndez I, Beaney M, Tovey H, Cutts RJ, Swift C, Kriplani D, Afentakis M, Hrebien S, Walsh-Crestani G, Barry P, Johnston SRD, Ring A, Bliss J, Russell S, Evans A, Skene A, Wheatley D, Dowsett M, Smith IE, Turner NC.

JAMA Oncol. 2019 Aug 1. doi: 10.1001/jamaoncol.2019.1838. [Epub ahead of print]


Three Dimensional Glomerular Reconstruction: A Novel Approach to Evaluate Renal Microanatomy in Diabetic Kidney Disease.

Torkamani N, Jerums G, Crammer P, Skene A, Power DA, Panagiotopoulos S, Clarke M, MacIsaac RJ, Ekinci EI.

Sci Rep. 2019 Feb 12;9(1):1829. doi: 10.1038/s41598-019-38646-z.


Diagnostic application of kidney allograft-derived absolute cell-free DNA levels during transplant dysfunction.

Whitlam JB, Ling L, Skene A, Kanellis J, Ierino FL, Slater HR, Bruno DL, Power DA.

Am J Transplant. 2019 Apr;19(4):1037-1049. doi: 10.1111/ajt.15142. Epub 2018 Nov 9.


Major Impact of Sampling Methodology on Gene Expression in Estrogen Receptor-Positive Breast Cancer.

Gao Q, López-Knowles E, U Cheang MC, Morden J, Ribas R, Sidhu K, Evans D, Martins V, Dodson A, Skene A, Holcombe C, Mallon E, Evans A, Bliss JM, Robertson J, Smith I, Martin LA, Dowsett M; POETIC Trial Management Group and Trialists.

JNCI Cancer Spectr. 2018 May 22;2(2):pky005. doi: 10.1093/jncics/pky005. eCollection 2018 Apr.


Interobserver agreement for post mortem renal histopathology and diagnosis of acute tubular necrosis in critically ill patients.

Glassford NJ, Skene A, Guardiola MB, Chan MJ, Bagshaw SM, Bellomo R, Solez K.

Crit Care Resusc. 2017 Dec;19(4):337-343.


NADPH Oxidase Nox5 Accelerates Renal Injury in Diabetic Nephropathy.

Jha JC, Banal C, Okabe J, Gray SP, Hettige T, Chow BSM, Thallas-Bonke V, De Vos L, Holterman CE, Coughlan MT, Power DA, Skene A, Ekinci EI, Cooper ME, Touyz RM, Kennedy CR, Jandeleit-Dahm K.

Diabetes. 2017 Oct;66(10):2691-2703. doi: 10.2337/db16-1585. Epub 2017 Jul 26.


Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation.

Gellert P, Segal CV, Gao Q, López-Knowles E, Martin LA, Dodson A, Li T, Miller CA, Lu C, Mardis ER, Gillman A, Morden J, Graf M, Sidhu K, Evans A, Shere M, Holcombe C, McIntosh SA, Bundred N, Skene A, Maxwell W, Robertson J, Bliss JM, Smith I, Dowsett M; POETIC Trial Management Group and Trialists.

Nat Commun. 2016 Nov 9;7:13294. doi: 10.1038/ncomms13294.


Heterogeneity in global gene expression profiles between biopsy specimens taken peri-surgically from primary ER-positive breast carcinomas.

López-Knowles E, Gao Q, Cheang MC, Morden J, Parker J, Martin LA, Pinhel I, McNeill F, Hills M, Detre S, Afentakis M, Zabaglo L, Dodson A, Skene A, Holcombe C, Robertson J, Smith I, Bliss JM, Dowsett M; POETIC trialists.

Breast Cancer Res. 2016 Apr 1;18(1):39. doi: 10.1186/s13058-016-0696-2.


Deficiency in Apoptosis-Inducing Factor Recapitulates Chronic Kidney Disease via Aberrant Mitochondrial Homeostasis.

Coughlan MT, Higgins GC, Nguyen TV, Penfold SA, Thallas-Bonke V, Tan SM, Ramm G, Van Bergen NJ, Henstridge DC, Sourris KC, Harcourt BE, Trounce IA, Robb PM, Laskowski A, McGee SL, Genders AJ, Walder K, Drew BG, Gregorevic P, Qian H, Thomas MC, Jerums G, Macisaac RJ, Skene A, Power DA, Ekinci EI, Wijeyeratne XW, Gallo LA, Herman-Edelstein M, Ryan MT, Cooper ME, Thorburn DR, Forbes JM.

Diabetes. 2016 Apr;65(4):1085-98. doi: 10.2337/db15-0864. Epub 2016 Jan 28.


Plasmacytoma of the testis in a patient with relapsed and refractory multiple myeloma: Case report and review of the literature.

Khan M, Rajarubendra N, Azer S, Skene A, Harrison SJ, Campbell B, Lawrentschuk N.

Urol Ann. 2015 Oct-Dec;7(4):530-3. doi: 10.4103/0974-7796.164844.


Comparison of multi-frequency bioimpedance with perometry for the early detection and intervention of lymphoedema after axillary node clearance for breast cancer.

Bundred NJ, Stockton C, Keeley V, Riches K, Ashcroft L, Evans A, Skene A, Purushotham A, Bramley M, Hodgkiss T; Investigators of BEA/PLACE studies.

Breast Cancer Res Treat. 2015 May;151(1):121-9. doi: 10.1007/s10549-015-3357-8. Epub 2015 Apr 8.


Extended normothermic extracorporeal perfusion of isolated human liver after warm ischaemia: a preliminary report.

Bellomo R, Marino B, Starkey G, Fink M, Wang BZ, Eastwood GM, Peck L, Young H, Houston S, Skene A, Opdam H, Jones R.

Crit Care Resusc. 2014 Sep;16(3):197-201.


Use of copy number deletion polymorphisms to assess DNA chimerism.

Bruno DL, Ganesamoorthy D, Thorne NP, Ling L, Bahlo M, Forrest S, Veenendaal M, Katerelos M, Skene A, Ierino FL, Power DA, Slater HR.

Clin Chem. 2014 Aug;60(8):1105-14. doi: 10.1373/clinchem.2013.216077. Epub 2014 Jun 4.


Optimum duration of neoadjuvant letrozole to permit breast conserving surgery.

Carpenter R, Doughty JC, Cordiner C, Moss N, Gandhi A, Wilson C, Andrews C, Ellis G, Gui G, Skene AI.

Breast Cancer Res Treat. 2014 Apr;144(3):569-76. doi: 10.1007/s10549-014-2835-8. Epub 2014 Feb 23.


Effects of the addition of gemcitabine, and paclitaxel-first sequencing, in neoadjuvant sequential epirubicin, cyclophosphamide, and paclitaxel for women with high-risk early breast cancer (Neo-tAnGo): an open-label, 2×2 factorial randomised phase 3 trial.

Earl HM, Vallier AL, Hiller L, Fenwick N, Young J, Iddawela M, Abraham J, Hughes-Davies L, Gounaris I, McAdam K, Houston S, Hickish T, Skene A, Chan S, Dean S, Ritchie D, Laing R, Harries M, Gallagher C, Wishart G, Dunn J, Provenzano E, Caldas C; Neo-tAnGo Investigators.

Lancet Oncol. 2014 Feb;15(2):201-12. doi: 10.1016/S1470-2045(13)70554-0. Epub 2013 Dec 19.


Normothermic extracorporeal human liver perfusion following donation after cardiac death.

Bellomo R, Marino B, Starkey G, Wang BZ, Fink MA, Zhu N, Suzuki S, Houston S, Eastwood G, Calzavacca P, Glassford N, Chambers B, Skene A, Schneider AG, Jones D, Hilton A, Opdam H, Warrillow S, Gauthier N, Johnson L, Jones R.

Crit Care Resusc. 2013 Jun;15(2):78-82.


Renal structure in normoalbuminuric and albuminuric patients with type 2 diabetes and impaired renal function.

Ekinci EI, Jerums G, Skene A, Crammer P, Power D, Cheong KY, Panagiotopoulos S, McNeil K, Baker ST, Fioretto P, Macisaac RJ.

Diabetes Care. 2013 Nov;36(11):3620-6. doi: 10.2337/dc12-2572. Epub 2013 Jul 8.


Molecular diagnosis of antibody-mediated rejection in human kidney transplants.

Sellarés J, Reeve J, Loupy A, Mengel M, Sis B, Skene A, de Freitas DG, Kreepala C, Hidalgo LG, Famulski KS, Halloran PF.

Am J Transplant. 2013 Apr;13(4):971-983. doi: 10.1111/ajt.12150. Epub 2013 Feb 15.


Molecular diagnosis of T cell-mediated rejection in human kidney transplant biopsies.

Reeve J, Sellarés J, Mengel M, Sis B, Skene A, Hidalgo L, de Freitas DG, Famulski KS, Halloran PF.

Am J Transplant. 2013 Mar;13(3):645-55. doi: 10.1111/ajt.12079. Epub 2013 Jan 28.


Anastomosing haemangioma of the kidney: a rare morphological variant of haemangioma characteristic of genitourinary tract location.

Wetherell DR, Skene A, Manya K, Manecksha RP, Chan Y, Bolton DM.

Pathology. 2013 Feb;45(2):193-6. doi: 10.1097/PAT.0b013e32835c782b. No abstract available.


Normothermic extracorporeal perfusion of isolated porcine liver after warm ischaemia: a preliminary report.

Bellomo R, Suzuki S, Marino B, Starkey GK, Chambers B, Fink MA, Wang BZ, Houston S, Eastwood G, Calzavacca P, Glassford N, Skene A, Jones DA, Jones R.

Crit Care Resusc. 2012 Sep;14(3):173-6.


Improving academic leadership and oversight in large industry-sponsored clinical trials: the ARO-CRO model.

Goldenberg NA, Spyropoulos AC, Halperin JL, Kessler CM, Schulman S, Turpie AG, Skene AM, Cutler NR, Hiatt WR; Antithrombotic Trials Leadership and Steering Group.

Blood. 2011 Feb 17;117(7):2089-92. doi: 10.1182/blood-2010-09-308858. Epub 2010 Nov 10.


Prospective comparison of switches in biomarker status between primary and recurrent breast cancer: the Breast Recurrence In Tissues Study (BRITS).

Thompson AM, Jordan LB, Quinlan P, Anderson E, Skene A, Dewar JA, Purdie CA; Breast Recurrence in Tissues Study Group.

Breast Cancer Res. 2010;12(6):R92. doi: 10.1186/bcr2771. Epub 2010 Nov 8.


Unusual case of initial failure of pacemaker implantation.

Boullin JP, Skene A, Rozkovec A.

Europace. 2010 Nov;12(11):1651-2. doi: 10.1093/europace/euq270. Epub 2010 Jul 10.


A randomised comparative trial of infusional ECisF versus conventional FEC as adjuvant chemotherapy in early breast cancer: the TRAFIC trial.

Sirohi B, A'Hern R, Coombes G, Bliss JM, Hickish T, Perren T, Crawford M, O'Brien M, Iveson T, Ebbs S, Skene A, Laing R, Smith IE.

Ann Oncol. 2010 Aug;21(8):1623-9. doi: 10.1093/annonc/mdp602. Epub 2010 Jan 21.


Rapidly progressive glomerulonephritis complicating primary AL amyloidosis and multiple myeloma.

Crosthwaite A, Skene A, Mount P.

Nephrol Dial Transplant. 2010 Aug;25(8):2786-9. doi: 10.1093/ndt/gfp715. Epub 2009 Dec 29.


Gamma probe radioguided parathyroid forearm surgery in recurrent hyperparathyroidism.

Cutress RI, Manwaring-White C, Dixon K, Dhir A, Skene AI.

Ann R Coll Surg Engl. 2009 Oct;91(7):W1-3. doi: 10.1308/147870809X401047.


Ticagrelor versus clopidogrel in patients with acute coronary syndromes.

Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, Held C, Horrow J, Husted S, James S, Katus H, Mahaffey KW, Scirica BM, Skene A, Steg PG, Storey RF, Harrington RA; PLATO Investigators, Freij A, Thorsén M.

N Engl J Med. 2009 Sep 10;361(11):1045-57. doi: 10.1056/NEJMoa0904327. Epub 2009 Aug 30.


Proximal esophageal amyloidoma presenting with life-threatening dysphagia.

Chin-Lenn L, Ryan C, Skene A, Mianroodi AA.

Ear Nose Throat J. 2009 Jun;88(6):E4.


Comparison of ticagrelor, the first reversible oral P2Y(12) receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial.

James S, Akerblom A, Cannon CP, Emanuelsson H, Husted S, Katus H, Skene A, Steg PG, Storey RF, Harrington R, Becker R, Wallentin L.

Am Heart J. 2009 Apr;157(4):599-605. doi: 10.1016/j.ahj.2009.01.003.


A single low-fixed dose of rituximab to salvage renal transplants from refractory antibody-mediated rejection.

Mulley WR, Hudson FJ, Tait BD, Skene AM, Dowling JP, Kerr PG, Kanellis J.

Transplantation. 2009 Jan 27;87(2):286-9. doi: 10.1097/TP.0b013e31819389cc.


Patterns and predictors of early recurrence in postmenopausal women with estrogen receptor-positive early breast cancer.

Mansell J, Monypenny IJ, Skene AI, Abram P, Carpenter R, Gattuso JM, Wilson CR, Angerson WJ, Doughty JC.

Breast Cancer Res Treat. 2009 Sep;117(1):91-8. doi: 10.1007/s10549-008-0291-z. Epub 2008 Dec 27.


BK virus RNA can be detected in archival renal transplant biopsies using the reverse trancription polymerase chain reaction.

Wiggins KJ, Gow RM, Kanellis J, Hill P, Kelly DJ, Skene A, Goodman DJ, Langham RG.

Nephrol Dial Transplant. 2009 Feb;24(2):661-6. doi: 10.1093/ndt/gfn656. Epub 2008 Dec 4. No abstract available.


Thoracoscopic excision of mediastinal parathyroid adenomas: a report of two cases.

Burger AE, Skene AI, Lagattolla NR.

Ann R Coll Surg Engl. 2008 Mar;90(2):W1-5. doi: 10.1308/147870808X257175.


A phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer.

Smith IE, Walsh G, Skene A, Llombart A, Mayordomo JI, Detre S, Salter J, Clark E, Magill P, Dowsett M.

J Clin Oncol. 2007 Sep 1;25(25):3816-22. Epub 2007 Aug 6.


Pioglitazone use and heart failure in patients with type 2 diabetes and preexisting cardiovascular disease: data from the PROactive study (PROactive 08).

Erdmann E, Charbonnel B, Wilcox RG, Skene AM, Massi-Benedetti M, Yates J, Tan M, Spanheimer R, Standl E, Dormandy JA; PROactive Investigators.

Diabetes Care. 2007 Nov;30(11):2773-8. Epub 2007 Jul 31.


The effect of pioglitazone on recurrent myocardial infarction in 2,445 patients with type 2 diabetes and previous myocardial infarction: results from the PROactive (PROactive 05) Study.

Erdmann E, Dormandy JA, Charbonnel B, Massi-Benedetti M, Moules IK, Skene AM; PROactive Investigators.

J Am Coll Cardiol. 2007 May 1;49(17):1772-80. Epub 2007 Apr 16.


Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial.

Morrow DA, Scirica BM, Karwatowska-Prokopczuk E, Murphy SA, Budaj A, Varshavsky S, Wolff AA, Skene A, McCabe CH, Braunwald E; MERLIN-TIMI 36 Trial Investigators.

JAMA. 2007 Apr 25;297(16):1775-83.


Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer.

Dowsett M, Smith IE, Ebbs SR, Dixon JM, Skene A, A'Hern R, Salter J, Detre S, Hills M, Walsh G; IMPACT Trialists Group.

J Natl Cancer Inst. 2007 Jan 17;99(2):167-70.


Drug-induced thrombocytopenia and thrombosis: evidence from patients receiving an oral glycoprotein IIb/IIIa inhibitor in the Orbofiban in Patients with Unstable coronary Syndromes- (OPUS-TIMI 16) trial.

Scirica BM, Cannon CP, Cooper R, Aster RH, Brassard J, McCabe CH, Charlesworth A, Skene AM, Braunwald E.

J Thromb Thrombolysis. 2006 Oct;22(2):95-102.


Cardiovascular outcomes with atrial-based pacing compared with ventricular pacing: meta-analysis of randomized trials, using individual patient data.

Healey JS, Toff WD, Lamas GA, Andersen HR, Thorpe KE, Ellenbogen KA, Lee KL, Skene AM, Schron EB, Skehan JD, Goldman L, Roberts RS, Camm AJ, Yusuf S, Connolly SJ.

Circulation. 2006 Jul 4;114(1):11-7. Epub 2006 Jun 26.


Evaluation of a novel anti-ischemic agent in acute coronary syndromes: design and rationale for the Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-elevation acute coronary syndromes (MERLIN)-TIMI 36 trial.

Morrow DA, Scirica BM, Karwatowska-Prokopczuk E, Skene A, McCabe CH, Braunwald E; MERLIN-TIMI 36 Investigators.

Am Heart J. 2006 Jun;151(6):1186.e1-9.


Proliferation and apoptosis as markers of benefit in neoadjuvant endocrine therapy of breast cancer.

Dowsett M, Smith IE, Ebbs SR, Dixon JM, Skene A, Griffith C, Boeddinghaus I, Salter J, Detre S, Hills M, Ashley S, Francis S, Walsh G, A'Hern R.

Clin Cancer Res. 2006 Feb 1;12(3 Pt 2):1024s-1030s.


Relationship between uncontrolled risk factors and C-reactive protein levels in patients receiving standard or intensive statin therapy for acute coronary syndromes in the PROVE IT-TIMI 22 trial.

Ray KK, Cannon CP, Cairns R, Morrow DA, Rifai N, Kirtane AJ, McCabe CH, Skene AM, Gibson CM, Ridker PM, Braunwald E; PROVE IT-TIMI 22 Investigators.

J Am Coll Cardiol. 2005 Oct 18;46(8):1417-24.


Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial.

Dormandy JA, Charbonnel B, Eckland DJ, Erdmann E, Massi-Benedetti M, Moules IK, Skene AM, Tan MH, Lefèbvre PJ, Murray GD, Standl E, Wilcox RG, Wilhelmsen L, Betteridge J, Birkeland K, Golay A, Heine RJ, Korányi L, Laakso M, Mokán M, Norkus A, Pirags V, Podar T, Scheen A, Scherbaum W, Schernthaner G, Schmitz O, Skrha J, Smith U, Taton J; PROactive Investigators.

Lancet. 2005 Oct 8;366(9493):1279-89.


Effect on survival and hospitalization of initiating treatment for chronic heart failure with bisoprolol followed by enalapril, as compared with the opposite sequence: results of the randomized Cardiac Insufficiency Bisoprolol Study (CIBIS) III.

Willenheimer R, van Veldhuisen DJ, Silke B, Erdmann E, Follath F, Krum H, Ponikowski P, Skene A, van de Ven L, Verkenne P, Lechat P; CIBIS III Investigators.

Circulation. 2005 Oct 18;112(16):2426-35. Epub 2005 Sep 4.


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