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Intranasal carnosine attenuates transcriptomic alterations and improves mitochondrial function in the Thy1-aSyn mouse model of Parkinson's disease.

Bermúdez ML, Skelton MR, Genter MB.

Mol Genet Metab. 2018 Nov;125(3):305-313. doi: 10.1016/j.ymgme.2018.08.002. Epub 2018 Aug 10.


Cognitive deficits and increases in creatine precursors in a brain-specific knockout of the creatine transporter gene Slc6a8.

Udobi KC, Kokenge AN, Hautman ER, Ullio G, Coene J, Williams MT, Vorhees CV, Mabondzo A, Skelton MR.

Genes Brain Behav. 2018 Jul;17(6):e12461. doi: 10.1111/gbb.12461. Epub 2018 Feb 20.


Phosphodiesterase-1b (Pde1b) knockout mice are resistant to forced swim and tail suspension induced immobility and show upregulation of Pde10a.

Hufgard JR, Williams MT, Skelton MR, Grubisha O, Ferreira FM, Sanger H, Wright ME, Reed-Kessler TM, Rasmussen K, Duman RS, Vorhees CV.

Psychopharmacology (Berl). 2017 Jun;234(12):1803-1813. doi: 10.1007/s00213-017-4587-8. Epub 2017 Mar 23.


Developmental manganese neurotoxicity in rats: Cognitive deficits in allocentric and egocentric learning and memory.

Amos-Kroohs RM, Davenport LL, Atanasova N, Abdulla ZI, Skelton MR, Vorhees CV, Williams MT.

Neurotoxicol Teratol. 2017 Jan - Feb;59:16-26. doi: 10.1016/ Epub 2016 Oct 15.


A heterozygous mutation in tubulin, beta 2B ( Tubb2b ) causes cognitive deficits and hippocampal disorganization.

Stottmann RW, Driver A, Gutierrez A, Skelton MR, Muntifering M, Stepien C, Knudson L, Kofron M, Vorhees CV, Williams MT.

Genes Brain Behav. 2017 Feb;16(2):250-259. doi: 10.1111/gbb.12327. Epub 2016 Oct 3.


Creatine transporter deficiency leads to increased whole body and cellular metabolism.

Perna MK, Kokenge AN, Miles KN, Udobi KC, Clark JF, Pyne-Geithman GJ, Khuchua Z, Skelton MR.

Amino Acids. 2016 Aug;48(8):2057-65. doi: 10.1007/s00726-016-2291-3. Epub 2016 Jul 11.


Developmental stress and lead (Pb): Effects of maternal separation and/or Pb on corticosterone, monoamines, and blood Pb in rats.

Amos-Kroohs RM, Graham DL, Grace CE, Braun AA, Schaefer TL, Skelton MR, Vorhees CV, Williams MT.

Neurotoxicology. 2016 May;54:22-33. doi: 10.1016/j.neuro.2016.02.011. Epub 2016 Mar 2.


Effects of developmental manganese, stress, and the combination of both on monoamines, growth, and corticosterone.

Vorhees CV, Graham DL, Amos-Kroohs RM, Braun AA, Grace CE, Schaefer TL, Skelton MR, Erikson KM, Aschner M, Williams MT.

Toxicol Rep. 2014;1:1046-1061.


Dopamine depletion in either the dorsomedial or dorsolateral striatum impairs egocentric Cincinnati water maze performance while sparing allocentric Morris water maze learning.

Braun AA, Amos-Kroohs RM, Gutierrez A, Lundgren KH, Seroogy KB, Skelton MR, Vorhees CV, Williams MT.

Neurobiol Learn Mem. 2015 Feb;118:55-63. doi: 10.1016/j.nlm.2014.10.009. Epub 2014 Nov 13.


Prenatal immune challenge in rats: effects of polyinosinic-polycytidylic acid on spatial learning, prepulse inhibition, conditioned fear, and responses to MK-801 and amphetamine.

Vorhees CV, Graham DL, Braun AA, Schaefer TL, Skelton MR, Richtand NM, Williams MT.

Neurotoxicol Teratol. 2015 Jan-Feb;47:54-65. doi: 10.1016/ Epub 2014 Nov 8.


Neuronal reorganization in adult rats neonatally exposed to (±)-3,4-methylenedioxymethamphetamine.

Williams MT, Skelton MR, Longacre ID, Huggins KN, Maple AM, Vorhees CV, Brown RW.

Toxicol Rep. 2014;1:699-706.


Creatine transporter (SLC6A8) knockout mice display an increased capacity for in vitro creatine biosynthesis in skeletal muscle.

Russell AP, Ghobrial L, Wright CR, Lamon S, Brown EL, Kon M, Skelton MR, Snow RJ.

Front Physiol. 2014 Aug 26;5:314. doi: 10.3389/fphys.2014.00314. eCollection 2014.


Female mice heterozygous for creatine transporter deficiency show moderate cognitive deficits.

Hautman ER, Kokenge AN, Udobi KC, Williams MT, Vorhees CV, Skelton MR.

J Inherit Metab Dis. 2014 Jan;37(1):63-8. doi: 10.1007/s10545-013-9619-x. Epub 2013 May 29.


Cognitive impairments from developmental exposure to serotonergic drugs: citalopram and MDMA.

Schaefer TL, Grace CE, Braun AA, Amos-Kroohs RM, Graham DL, Skelton MR, Williams MT, Vorhees CV.

Int J Neuropsychopharmacol. 2013 Jul;16(6):1383-94. doi: 10.1017/S1461145712001447. Epub 2013 Jan 11.


Neonatal citalopram treatment inhibits the 5-HT depleting effects of MDMA exposure in rats.

Schaefer TL, Grace CE, Skelton MR, Graham DL, Gudelsky GA, Vorhees CV, Williams MT.

ACS Chem Neurosci. 2012 Jan 18;3(1):12-21. Epub 2011 Oct 21.


Neonatal +-methamphetamine exposure in rats alters adult locomotor responses to dopamine D1 and D2 agonists and to a glutamate NMDA receptor antagonist, but not to serotonin agonists.

Graham DL, Amos-Kroohs RM, Braun AA, Grace CE, Schaefer TL, Skelton MR, Williams MT, Vorhees CV.

Int J Neuropsychopharmacol. 2013 Mar;16(2):377-91. doi: 10.1017/S1461145712000144. Epub 2012 Mar 6.


Expression and distribution of creatine transporter and creatine kinase (brain isoform) in developing and mature rat cochlear tissues.

Wong AC, Velamoor S, Skelton MR, Thorne PR, Vlajkovic SM.

Histochem Cell Biol. 2012 May;137(5):599-613. doi: 10.1007/s00418-012-0922-7. Epub 2012 Feb 4.


Effects of periadolescent fluoxetine and paroxetine on elevated plus-maze, acoustic startle, and swimming immobility in rats while on and off-drug.

Vorhees CV, Morford LR, Graham DL, Skelton MR, Williams MT.

Behav Brain Funct. 2011 Oct 5;7:41. doi: 10.1186/1744-9081-7-41.


Distinct periods of developmental sensitivity to the effects of 3,4-(±)-methylenedioxymethamphetamine (MDMA) on behaviour and monoamines in rats.

Skelton MR, Graham DL, Schaefer TL, Grace CE, Braun AA, Burns LN, Amos-Kroohs RM, Williams MT, Vorhees CV.

Int J Neuropsychopharmacol. 2012 Jul;15(6):811-24. doi: 10.1017/S1461145711000952. Epub 2011 Jun 28.


In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes.

Curran CP, Nebert DW, Genter MB, Patel KV, Schaefer TL, Skelton MR, Williams MT, Vorhees CV.

Environ Health Perspect. 2011 Sep;119(9):1286-93. doi: 10.1289/ehp.1002965. Epub 2011 May 13.


Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency.

Skelton MR, Schaefer TL, Graham DL, Degrauw TJ, Clark JF, Williams MT, Vorhees CV.

PLoS One. 2011 Jan 13;6(1):e16187. doi: 10.1371/journal.pone.0016187.


Effects of developmental stress and lead (Pb) on corticosterone after chronic and acute stress, brain monoamines, and blood Pb levels in rats.

Graham DL, Grace CE, Braun AA, Schaefer TL, Skelton MR, Tang PH, Vorhees CV, Williams MT.

Int J Dev Neurosci. 2011 Feb;29(1):45-55. doi: 10.1016/j.ijdevneu.2010.09.008. Epub 2010 Oct 8.


Comparison of the elevated plus and elevated zero mazes in treated and untreated male Sprague-Dawley rats: effects of anxiolytic and anxiogenic agents.

Braun AA, Skelton MR, Vorhees CV, Williams MT.

Pharmacol Biochem Behav. 2011 Jan;97(3):406-15. doi: 10.1016/j.pbb.2010.09.013. Epub 2010 Sep 24.


Comparison of (+)-methamphetamine, ±-methylenedioxymethamphetamine, (+)-amphetamine and ±-fenfluramine in rats on egocentric learning in the Cincinnati water maze.

Vorhees CV, He E, Skelton MR, Graham DL, Schaefer TL, Grace CE, Braun AA, Amos-Kroohs R, Williams MT.

Synapse. 2011 May;65(5):368-78. doi: 10.1002/syn.20854. Epub 2010 Oct 8.


Effects of inhibiting neonatal methamphetamine-induced corticosterone release in rats by adrenal autotransplantation on later learning, memory, and plasma corticosterone levels.

Grace CE, Schaefer TL, Graham DL, Skelton MR, Williams MT, Vorhees CV.

Int J Dev Neurosci. 2010 Jun;28(4):331-42. doi: 10.1016/j.ijdevneu.2010.02.005. Epub 2010 Feb 23.


Effect of a neurotoxic dose regimen of (+)-methamphetamine on behavior, plasma corticosterone, and brain monoamines in adult C57BL/6 mice.

Grace CE, Schaefer TL, Herring NR, Graham DL, Skelton MR, Gudelsky GA, Williams MT, Vorhees CV.

Neurotoxicol Teratol. 2010 May-Jun;32(3):346-55. doi: 10.1016/ Epub 2010 Jan 21.


Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits.

Sun Y, Liou B, Ran H, Skelton MR, Williams MT, Vorhees CV, Kitatani K, Hannun YA, Witte DP, Xu YH, Grabowski GA.

Hum Mol Genet. 2010 Mar 15;19(6):1088-97. doi: 10.1093/hmg/ddp580. Epub 2010 Jan 4.


Specific saposin C deficiency: CNS impairment and acid beta-glucosidase effects in the mouse.

Sun Y, Ran H, Zamzow M, Kitatani K, Skelton MR, Williams MT, Vorhees CV, Witte DP, Hannun YA, Grabowski GA.

Hum Mol Genet. 2010 Feb 15;19(4):634-47. doi: 10.1093/hmg/ddp531. Epub 2009 Dec 16.


(+/-)3,4-Methylenedioxymethamphetamine (MDMA) dose-dependently impairs spatial learning in the morris water maze after exposure of rats to different five-day intervals from birth to postnatal day twenty.

Vorhees CV, Schaefer TL, Skelton MR, Grace CE, Herring NR, Williams MT.

Dev Neurosci. 2009;31(1-2):107-20. doi: 10.1159/000207499. Epub 2009 Apr 17.


Comparison of the developmental effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (+/-)-3,4-methylenedioxymethamphetamine (ecstasy) in rats.

Skelton MR, Schaefer TL, Herring NR, Grace CE, Vorhees CV, Williams MT.

Psychopharmacology (Berl). 2009 Jun;204(2):287-97. doi: 10.1007/s00213-009-1459-x. Epub 2009 Feb 6.


Effects of (+)-methamphetamine on path integration and spatial learning, but not locomotor activity or acoustic startle, align with the stress hyporesponsive period in rats.

Vorhees CV, Skelton MR, Grace CE, Schaefer TL, Graham DL, Braun AA, Williams MT.

Int J Dev Neurosci. 2009 May;27(3):289-98. doi: 10.1016/j.ijdevneu.2008.12.003. Epub 2008 Dec 24.


(+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks.

Skelton MR, Able JA, Grace CE, Herring NR, Schaefer TL, Gudelsky GA, Vorhees CV, Williams MT.

Neuropharmacology. 2008 Dec;55(7):1121-30. doi: 10.1016/j.neuropharm.2008.07.006. Epub 2008 Jul 12.


Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats.

Herring NR, Schaefer TL, Tang PH, Skelton MR, Lucot JP, Gudelsky GA, Vorhees CV, Williams MT.

BMC Neurosci. 2008 May 30;9:49. doi: 10.1186/1471-2202-9-49.


Effects of neonatal (+)-methamphetamine on path integration and spatial learning in rats: effects of dose and rearing conditions.

Vorhees CV, Herring NR, Schaefer TL, Grace CE, Skelton MR, Johnson HL, Williams MT.

Int J Dev Neurosci. 2008 Oct;26(6):599-610. doi: 10.1016/j.ijdevneu.2008.04.002. Epub 2008 Apr 18.


Neurological deficits and glycosphingolipid accumulation in saposin B deficient mice.

Sun Y, Witte DP, Ran H, Zamzow M, Barnes S, Cheng H, Han X, Williams MT, Skelton MR, Vorhees CV, Grabowski GA.

Hum Mol Genet. 2008 Aug 1;17(15):2345-56. doi: 10.1093/hmg/ddn135. Epub 2008 May 14.


Targeted therapies for hepatocellular carcinoma.

Skelton MR, O'Neil B.

Clin Adv Hematol Oncol. 2008 Mar;6(3):209-18. Review.


Developmental effects of 3,4-methylenedioxymethamphetamine: a review.

Skelton MR, Williams MT, Vorhees CV.

Behav Pharmacol. 2008 Mar;19(2):91-111. doi: 10.1097/FBP.0b013e3282f62c76. Review.


(+)-Methamphetamine increases corticosterone in plasma and BDNF in brain more than forced swim or isolation in neonatal rats.

Grace CE, Schaefer TL, Herring NR, Skelton MR, McCrea AE, Vorhees CV, Williams MT.

Synapse. 2008 Feb;62(2):110-21.


Age-dependent effects of neonatal methamphetamine exposure on spatial learning.

Vorhees CV, Skelton MR, Williams MT.

Behav Pharmacol. 2007 Sep;18(5-6):549-62.


A case of oxaliplatin-related posterior reversible encephalopathy syndrome.

Skelton MR, Goldberg RM, O'Neil BH.

Clin Colorectal Cancer. 2007 Jan;6(5):386-8.


Alterations in body temperature, corticosterone, and behavior following the administration of 5-methoxy-diisopropyltryptamine ('foxy') to adult rats: a new drug of abuse.

Williams MT, Herring NR, Schaefer TL, Skelton MR, Campbell NG, Lipton JW, McCrea AE, Vorhees CV.

Neuropsychopharmacology. 2007 Jun;32(6):1404-20. Epub 2006 Oct 18.


Learning and memory after neonatal exposure to 3,4-methylenedioxymethamphetamine (ecstasy) in rats: interaction with exposure in adulthood.

Cohen MA, Skelton MR, Schaefer TL, Gudelsky GA, Vorhees CV, Williams MT.

Synapse. 2005 Sep 1;57(3):148-59.


Periadolescent rats (P41-50) exhibit increased susceptibility to D-methamphetamine-induced long-term spatial and sequential learning deficits compared to juvenile (P21-30 or P31-40) or adult rats (P51-60).

Vorhees CV, Reed TM, Morford LL, Fukumura M, Wood SL, Brown CA, Skelton MR, McCrea AE, Rock SL, Williams MT.

Neurotoxicol Teratol. 2005 Jan-Feb;27(1):117-34.


Metyrapone attenuates the sequential learning deficits but not monoamine depletions following d,l-fenfluramine administration to adult rats.

Skelton MR, Blankenmeyer TL, Gudelsky GA, Brown-Strittholt CA, Vorhees CV, Williams MT.

Synapse. 2004 Dec 15;54(4):214-22.


Absorption and clearance of +/-3,4-methylenedioxymethamphetamine from the plasma of neonatal rats.

Williams MT, Brown CA, Skelton MR, Vinks AA, Vorhees CV.

Neurotoxicol Teratol. 2004 Nov-Dec;26(6):849-56.


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